{"id":"https://openalex.org/W2164835554","doi":"https://doi.org/10.1124/jpet.103.051037","title":"Renal Action of Acute Chloroquine and Paracetamol Administration in the Anesthetized, Fluid-Balanced Rat","display_name":"Renal Action of Acute Chloroquine and Paracetamol Administration in the Anesthetized, Fluid-Balanced Rat","publication_year":2003,"publication_date":"2003-07-18","ids":{"openalex":"https://openalex.org/W2164835554","doi":"https://doi.org/10.1124/jpet.103.051037","mag":"2164835554","pmid":"https://pubmed.ncbi.nlm.nih.gov/12721325"},"language":"en","primary_location":{"id":"doi:10.1124/jpet.103.051037","doi":"https://doi.org/10.1124/jpet.103.051037","is_oa":false,"landing_page_url":"https://doi.org/10.1124/jpet.103.051037","pdf_url":null,"source":{"id":"https://openalex.org/S102125482","display_name":"Journal of Pharmacology and Experimental Therapeutics","issn_l":"0022-3565","issn":["0022-3565","1521-0103"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Pharmacology and Experimental Therapeutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5105841930","display_name":"Mohamed Hassan Ahmed","orcid":"https://orcid.org/0000-0003-2254-1169","observed_orcids":["https://orcid.org/0000-0003-2254-1169"]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mohamed H. Ahmed","raw_affiliation_strings":["School of Biological Sciences, University of Manchester, Manchester M13 9PT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biological Sciences, University of Manchester, Manchester M13 9PT, UK","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111975275","display_name":"RICHARD J. BALMENT","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard J. Balment","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5107969359","display_name":"Nick Ashton","orcid":"https://orcid.org/0000-0003-3366-1617","observed_orcids":["https://orcid.org/0000-0003-3366-1617"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nick Ashton","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"306","issue":"2","first_page":"478","last_page":"483"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.5565999746322632,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.5565999746322632,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12962","display_name":"Nephrotoxicity and Medicinal Plants","score":0.155799999833107,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.05220000073313713,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chloroquine","display_name":"chloroquine","score":0.9869999885559082},{"id":"https://openalex.org/keywords/paracetamol","display_name":"paracetamol","score":0.9980000257492065},{"id":"https://openalex.org/keywords/analgesic-nephropathy","display_name":"analgesic nephropathy","score":0.9760000109672546},{"id":"https://openalex.org/keywords/renal-function","display_name":"renal function","score":0.6449999809265137},{"id":"https://openalex.org/keywords/diuresis","display_name":"diuresis","score":0.8579999804496765},{"id":"https://openalex.org/keywords/sodium-excretion","display_name":"sodium excretion","score":1.0},{"id":"https://openalex.org/keywords/glomerular-filtration-rate","display_name":"glomerular filtration rate","score":0.996999979019165},{"id":"https://openalex.org/keywords/urine-osmolality","display_name":"urine osmolality","score":0.8140000104904175},{"id":"https://openalex.org/keywords/drug-drug-interactions","display_name":"drug-drug interactions","score":0.7360000014305115},{"id":"https://openalex.org/keywords/acute-administration","display_name":"acute drug administration","score":0.4569999873638153},{"id":"https://openalex.org/keywords/fluid-balance","display_name":"fluid balance","score":0.5120000243186951},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.5989999771118164},{"id":"https://openalex.org/keywords/intravenous-infusion","display_name":"intravenous infusion","score":0.5490000247955322},{"id":"https://openalex.org/keywords/glucose-infusion","display_name":"glucose infusion","score":0.6520000100135803},{"id":"https://openalex.org/keywords/urinary-flow","display_name":"urine flow","score":0.382999986410141}],"concepts":[{"id":"https://openalex.org/C2779547328","wikidata":"https://www.wikidata.org/wiki/Q584691","display_name":"Diuresis","level":3,"score":0.7003477215766907},{"id":"https://openalex.org/C2778534349","wikidata":"https://www.wikidata.org/wiki/Q7900633","display_name":"Urine osmolality","level":3,"score":0.6543837189674377},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.6194427013397217},{"id":"https://openalex.org/C174459258","wikidata":"https://www.wikidata.org/wiki/Q6980232","display_name":"Natriuresis","level":3,"score":0.6131646037101746},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5365725755691528},{"id":"https://openalex.org/C2778722691","wikidata":"https://www.wikidata.org/wiki/Q57055","display_name":"Acetaminophen","level":2,"score":0.4849974811077118},{"id":"https://openalex.org/C33893070","wikidata":"https://www.wikidata.org/wiki/Q5500348","display_name":"Free water clearance","level":3,"score":0.4743337035179138},{"id":"https://openalex.org/C2779805383","wikidata":"https://www.wikidata.org/wiki/Q2500975","display_name":"Urine flow rate","level":3,"score":0.46450990438461304},{"id":"https://openalex.org/C142225936","wikidata":"https://www.wikidata.org/wiki/Q1129139","display_name":"Renal blood flow","level":3,"score":0.46244722604751587},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.45099306106567383},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.44673678278923035},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4164677560329437},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39137572050094604},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.34736910462379456}],"mesh":[{"descriptor_ui":"D000082","descriptor_name":"Acetaminophen","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000082","descriptor_name":"Acetaminophen","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000758","descriptor_name":"Anesthesia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002738","descriptor_name":"Chloroquine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002738","descriptor_name":"Chloroquine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005919","descriptor_name":"Glomerular Filtration Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009994","descriptor_name":"Osmolar Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012964","descriptor_name":"Sodium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014554","descriptor_name":"Urination","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018712","descriptor_name":"Analgesics, Non-Narcotic","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D018712","descriptor_name":"Analgesics, Non-Narcotic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1124/jpet.103.051037","doi":"https://doi.org/10.1124/jpet.103.051037","is_oa":false,"landing_page_url":"https://doi.org/10.1124/jpet.103.051037","pdf_url":null,"source":{"id":"https://openalex.org/S102125482","display_name":"Journal of Pharmacology and Experimental Therapeutics","issn_l":"0022-3565","issn":["0022-3565","1521-0103"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Pharmacology and Experimental Therapeutics","raw_type":"journal-article"},{"id":"pmid:12721325","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12721325","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of pharmacology and experimental therapeutics","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/541e3469-021d-46d5-a3df-146a17fb4401","doi":null,"is_oa":false,"landing_page_url":"https://research.manchester.ac.uk/en/publications/541e3469-021d-46d5-a3df-146a17fb4401","pdf_url":null,"source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ahmed, M H, Balment, R J & Ashton, N 2003, 'Renal action of acute chloroquine and paracetamol administration in the anesthetized, fluid-balanced rat', Journal of Pharmacology and Experimental Therapeutics, vol. 306, no. 2, pp. 478-483. https://doi.org/10.1124/jpet.103.051037","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W157312921","https://openalex.org/W1057109913","https://openalex.org/W1593010684","https://openalex.org/W1902405081","https://openalex.org/W1969466652","https://openalex.org/W1972679755","https://openalex.org/W1994343930","https://openalex.org/W2004226325","https://openalex.org/W2004946085","https://openalex.org/W2008839228","https://openalex.org/W2031584399","https://openalex.org/W2050617259","https://openalex.org/W2059485107","https://openalex.org/W2066082990","https://openalex.org/W2071540339","https://openalex.org/W2088485169","https://openalex.org/W2089156678","https://openalex.org/W2089747387","https://openalex.org/W2134014301","https://openalex.org/W2152912596","https://openalex.org/W2154266443","https://openalex.org/W2160733066","https://openalex.org/W2165765856","https://openalex.org/W2167349547","https://openalex.org/W2171772418","https://openalex.org/W2182715141","https://openalex.org/W2183444574","https://openalex.org/W2232760473","https://openalex.org/W2252748294","https://openalex.org/W2282062090","https://openalex.org/W2282190723","https://openalex.org/W2419027239","https://openalex.org/W2791114118"],"related_works":["https://openalex.org/W2160733066","https://openalex.org/W2760088349","https://openalex.org/W2114239986","https://openalex.org/W2033879728","https://openalex.org/W7210489976","https://openalex.org/W2283941945","https://openalex.org/W2147382779","https://openalex.org/W2089156678","https://openalex.org/W1953503812","https://openalex.org/W2137296359"],"abstract_inverted_index":null,"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}