{"id":"https://openalex.org/W2164829352","doi":"https://doi.org/10.1126/science.1116269","title":"Crystal Structure of a Mammalian Voltage-Dependent Shaker Family K + Channel","display_name":"Crystal Structure of a Mammalian Voltage-Dependent Shaker Family K + Channel","publication_year":2005,"publication_date":"2005-07-07","ids":{"openalex":"https://openalex.org/W2164829352","doi":"https://doi.org/10.1126/science.1116269","mag":"2164829352","pmid":"https://pubmed.ncbi.nlm.nih.gov/16002581"},"language":"en","primary_location":{"id":"doi:10.1126/science.1116269","doi":"https://doi.org/10.1126/science.1116269","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.1116269","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012409339","display_name":"Stephen Barstow Long","orcid":"https://orcid.org/0000-0002-8144-1398","observed_orcids":["https://orcid.org/0000-0002-8144-1398"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen B. Long","raw_affiliation_strings":["Howard Hughes Medical Institute, Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110030471","display_name":"Ernest B. Campbell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ernest B. Campbell","raw_affiliation_strings":["Howard Hughes Medical Institute, Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I83399316"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025045433","display_name":"Roderick MacKinnon","orcid":"https://orcid.org/0000-0001-7605-4679","observed_orcids":["https://orcid.org/0000-0001-7605-4679"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Roderick MacKinnon","raw_affiliation_strings":["Howard Hughes Medical Institute, Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I83399316"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5025045433"],"corresponding_institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I83399316"],"apc_list":null,"apc_paid":null,"fwci":60.6038,"has_fulltext":false,"cited_by_count":2187,"citation_normalized_percentile":{"value":0.99989577,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"309","issue":"5736","first_page":"897","last_page":"903"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/shaker-potassium-channel","display_name":"Shaker potassium channel","score":0.777999997138977},{"id":"https://openalex.org/keywords/kv1-2","display_name":"Kv1.2","score":0.9950000047683716},{"id":"https://openalex.org/keywords/voltage-gated-potassium-channels","display_name":"voltage-gated potassium channels","score":0.8190000057220459},{"id":"https://openalex.org/keywords/crystal-structure","display_name":"crystal structure","score":0.8309999704360962},{"id":"https://openalex.org/keywords/beta-subunit","display_name":"beta subunit","score":0.7599999904632568},{"id":"https://openalex.org/keywords/potassium-channel-modulation","display_name":"potassium channel regulation","score":0.6019999980926514},{"id":"https://openalex.org/keywords/pore-gating","display_name":"pore gating","score":0.5130000114440918},{"id":"https://openalex.org/keywords/t1-domain","display_name":"T1 domain","score":0.8820000290870667}],"concepts":[{"id":"https://openalex.org/C2779421379","wikidata":"https://www.wikidata.org/wiki/Q898872","display_name":"Shaker","level":3,"score":0.9453767538070679},{"id":"https://openalex.org/C2781285689","wikidata":"https://www.wikidata.org/wiki/Q21921428","display_name":"Crystal (programming language)","level":2,"score":0.5209328532218933},{"id":"https://openalex.org/C127162648","wikidata":"https://www.wikidata.org/wiki/Q16858953","display_name":"Channel (broadcasting)","level":2,"score":0.5205665230751038},{"id":"https://openalex.org/C165801399","wikidata":"https://www.wikidata.org/wiki/Q25428","display_name":"Voltage","level":2,"score":0.4809088706970215},{"id":"https://openalex.org/C115624301","wikidata":"https://www.wikidata.org/wiki/Q895901","display_name":"Crystal structure","level":2,"score":0.4601353704929352},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.3965820074081421},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.3754056692123413},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3674966096878052},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.344412237405777},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.20441290736198425},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.11935397982597351},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.11272698640823364},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.11180686950683594},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C198394728","wikidata":"https://www.wikidata.org/wiki/Q3695508","display_name":"Vibration","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004563","descriptor_name":"Electrochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010843","descriptor_name":"Pichia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D024642","descriptor_name":"Potassium Channels, Voltage-Gated","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051663","descriptor_name":"Kv1.2 Potassium Channel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1126/science.1116269","doi":"https://doi.org/10.1126/science.1116269","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.1116269","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},{"id":"pmid:16002581","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16002581","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science (New York, N.Y.)","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.162.2916","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.162.2916","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://bass.bio.uci.edu/~hudel/m160/presentations/5_Kv1.2_channel.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.459.9395","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.459.9395","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://shaker.umh.es/Publications/pdb_ionchannel3D/PDFs/16002581.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2509980943","display_name":"Natl Resource for Mass Spectrom of Biolog Macromolecules","funder_award_id":"P41RR000862","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G7830722536","display_name":"Molecular Structure and Function of the Piezo1 Ion Channel","funder_award_id":"R01GM043949","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W1517714742","https://openalex.org/W1600171386","https://openalex.org/W1643706501","https://openalex.org/W1830737945","https://openalex.org/W1947481567","https://openalex.org/W1963652804","https://openalex.org/W1964501667","https://openalex.org/W1966667742","https://openalex.org/W1967297467","https://openalex.org/W1969442520","https://openalex.org/W1969870358","https://openalex.org/W1983519301","https://openalex.org/W1987182471","https://openalex.org/W2006090981","https://openalex.org/W2012422753","https://openalex.org/W2013083986","https://openalex.org/W2013988104","https://openalex.org/W2015031388","https://openalex.org/W2019280851","https://openalex.org/W2027808289","https://openalex.org/W2028231353","https://openalex.org/W2032734987","https://openalex.org/W2034129859","https://openalex.org/W2038321772","https://openalex.org/W2038827150","https://openalex.org/W2044341713","https://openalex.org/W2049490722","https://openalex.org/W2050185244","https://openalex.org/W2053695860","https://openalex.org/W2056776817","https://openalex.org/W2059957319","https://openalex.org/W2063773297","https://openalex.org/W2065197175","https://openalex.org/W2072782308","https://openalex.org/W2072972683","https://openalex.org/W2079859799","https://openalex.org/W2101204196","https://openalex.org/W2103142377","https://openalex.org/W2106315897","https://openalex.org/W2111436711","https://openalex.org/W2122167535","https://openalex.org/W2124653618","https://openalex.org/W2128420761","https://openalex.org/W2133719258","https://openalex.org/W2136894332","https://openalex.org/W2139852988","https://openalex.org/W2143070723","https://openalex.org/W2147885377","https://openalex.org/W2151525286","https://openalex.org/W2164415168","https://openalex.org/W2166283865","https://openalex.org/W2166674578","https://openalex.org/W4239023878","https://openalex.org/W6630609662"],"related_works":["https://openalex.org/W7095523295","https://openalex.org/W7100287017","https://openalex.org/W1970064151","https://openalex.org/W4205249260","https://openalex.org/W2050185244","https://openalex.org/W2009648894","https://openalex.org/W2064675421","https://openalex.org/W1964501667","https://openalex.org/W1983519301","https://openalex.org/W2029434109"],"abstract_inverted_index":{"Voltage-dependent":[0],"potassium":[1],"ion":[2],"(K+)":[3],"channels":[4,81],"(Kv":[5],"channels)":[6],"conduct":[7],"K+":[8,60,133],"ions":[9],"across":[10],"the":[11,19,28,38,58,74,91,100,103,108,114,130,137],"cell":[12,85],"membrane":[13,20],"in":[14,18,66,82],"response":[15],"to":[16],"changes":[17],"voltage,":[21],"thereby":[22],"regulating":[23],"neuronal":[24],"excitability":[25],"by":[26,136],"modulating":[27],"shape":[29],"and":[30,102,111,117,128],"frequency":[31],"of":[32,44,47,57,73,90,107,113,125,132],"action":[33],"potentials.":[34],"Here":[35],"we":[36],"report":[37],"crystal":[39],"structure,":[40],"at":[41],"a":[42,48,55],"resolution":[43],"2.9":[45],"angstroms,":[46],"mammalian":[49,79],"Kv":[50,80],"channel,":[51],"Kv1.2,":[52],"which":[53],"is":[54,65,93],"member":[56],"Shaker":[59],"channel":[61,134],"family.":[62],"This":[63],"structure":[64],"complex":[67],"with":[68,122,129],"an":[69],"oxido-reductase":[70],"beta":[71,118,138],"subunit":[72,119],"kind":[75],"that":[76],"can":[77],"regulate":[78],"their":[83],"native":[84],"environment.":[86],"The":[87],"activation":[88],"gate":[89],"pore":[92,101],"open.":[94],"Large":[95],"side":[96,109],"portals":[97,110],"communicate":[98],"between":[99],"cytoplasm.":[104],"Electrostatic":[105],"properties":[106],"positions":[112],"T1":[115],"domain":[116],"are":[120],"consistent":[121],"electrophysiological":[123],"studies":[124],"inactivation":[126],"gating":[127],"possibility":[131],"regulation":[135],"subunit.":[139]},"counts_by_year":[{"year":2026,"cited_by_count":27},{"year":2025,"cited_by_count":44},{"year":2024,"cited_by_count":36},{"year":2023,"cited_by_count":53},{"year":2022,"cited_by_count":69},{"year":2021,"cited_by_count":60},{"year":2020,"cited_by_count":53},{"year":2019,"cited_by_count":69},{"year":2018,"cited_by_count":83},{"year":2017,"cited_by_count":95},{"year":2016,"cited_by_count":92},{"year":2015,"cited_by_count":101},{"year":2014,"cited_by_count":110},{"year":2013,"cited_by_count":121},{"year":2012,"cited_by_count":151}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}