{"id":"https://openalex.org/W2164819220","doi":"https://doi.org/10.1158/1078-0432.ccr-1052-03","title":"Ki-67 Staining Index Predicts Distant Metastasis and Survival in Locally Advanced Prostate Cancer Treated With Radiotherapy","display_name":"Ki-67 Staining Index Predicts Distant Metastasis and Survival in Locally Advanced Prostate Cancer Treated With Radiotherapy","publication_year":2004,"publication_date":"2004-06-15","ids":{"openalex":"https://openalex.org/W2164819220","doi":"https://doi.org/10.1158/1078-0432.ccr-1052-03","mag":"2164819220","pmid":"https://pubmed.ncbi.nlm.nih.gov/15217948"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.ccr-1052-03","doi":"https://doi.org/10.1158/1078-0432.ccr-1052-03","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-1052-03","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036667861","display_name":"Rile Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rile Li","raw_affiliation_strings":["1Department of Pathology, Baylor College of Medicine, Houston, Texas;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Pathology, Baylor College of Medicine, Houston, Texas;","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044994296","display_name":"Kateri H. Heydon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kateri Heydon","raw_affiliation_strings":["2American College of Radiology Headquarters, Philadelphia, Pennsylvania;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2American College of Radiology Headquarters, Philadelphia, Pennsylvania;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110564591","display_name":"M. Elizabeth Hammond","orcid":"https://orcid.org/0000-0001-9676-3261","observed_orcids":["https://orcid.org/0000-0001-9676-3261"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Elizabeth Hammond","raw_affiliation_strings":["3Department of Pathology, Latter Day Saints Hospital, Salt Lake City, Utah;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Department of Pathology, Latter Day Saints Hospital, Salt Lake City, Utah;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014281092","display_name":"David J. Grignon","orcid":"https://orcid.org/0000-0001-5287-8497","observed_orcids":["https://orcid.org/0000-0001-5287-8497"]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]},{"id":"https://openalex.org/I4210090317","display_name":"The Barbara Ann Karmanos Cancer Institute","ror":"https://ror.org/00ee40h97","country_code":"US","type":"facility","lineage":["https://openalex.org/I2800590384","https://openalex.org/I4210090317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David J. Grignon","raw_affiliation_strings":["4Department of Pathology, Karmanos Cancer Institute and Wayne State University, Detroit, Michigan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Department of Pathology, Karmanos Cancer Institute and Wayne State University, Detroit, Michigan;","institution_ids":["https://openalex.org/I185443292","https://openalex.org/I4210090317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089472018","display_name":"Mack Roach","orcid":"https://orcid.org/0000-0002-3546-8565","observed_orcids":["https://orcid.org/0000-0002-3546-8565"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mack Roach","raw_affiliation_strings":["5Department of Radiation Oncology, University of California at San Francisco, San Francisco, California;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Department of Radiation Oncology, University of California at San Francisco, San Francisco, California;","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081123864","display_name":"Harvey B. Wolkov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799793717","display_name":"Sutter Medical Center","ror":"https://ror.org/03zk9v026","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I114073160","https://openalex.org/I2799793717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harvey B. Wolkov","raw_affiliation_strings":["6Radiation Oncology Center, Sutter Cancer Center, Sacramento, California;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Radiation Oncology Center, Sutter Cancer Center, Sacramento, California;","institution_ids":["https://openalex.org/I2799793717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045162411","display_name":"Howard Mark Sandler","orcid":"https://orcid.org/0000-0002-8193-5769","observed_orcids":["https://orcid.org/0000-0002-8193-5769"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Howard M. Sandler","raw_affiliation_strings":["7University of Michigan, Ann Arbor, Michigan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"7University of Michigan, Ann Arbor, Michigan;","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012866369","display_name":"William U. Shipley","orcid":"https://orcid.org/0009-0008-0887-8391","observed_orcids":["https://orcid.org/0009-0008-0887-8391"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William U. Shipley","raw_affiliation_strings":["8Massachusetts General Hospital, Boston, Massachusetts; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"8Massachusetts General Hospital, Boston, Massachusetts; and","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063389942","display_name":"Alan S Pollack","orcid":"https://orcid.org/0000-0002-1801-2865","observed_orcids":["https://orcid.org/0000-0002-1801-2865"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan Pollack","raw_affiliation_strings":["9Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"9Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I1289437631"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.7522,"has_fulltext":false,"cited_by_count":110,"citation_normalized_percentile":{"value":0.95252172,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":92,"max":99},"biblio":{"volume":"10","issue":"12","first_page":"4118","last_page":"4124"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.9721999764442444,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.9721999764442444,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.01209999993443489,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.007499999832361937,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.7269999980926514},{"id":"https://openalex.org/keywords/distant-metastasis","display_name":"distant metastasis","score":0.7950000166893005},{"id":"https://openalex.org/keywords/disease-specific-survival","display_name":"disease-specific survival","score":0.9319999814033508},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.8500000238418579},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8999999761581421},{"id":"https://openalex.org/keywords/mib-1","display_name":"MIB-1","score":0.7260000109672546},{"id":"https://openalex.org/keywords/androgen-deprivation-therapy","display_name":"androgen deprivation therapy","score":0.7350000143051147},{"id":"https://openalex.org/keywords/external-beam-radiotherapy","display_name":"external beam radiotherapy","score":0.9890000224113464},{"id":"https://openalex.org/keywords/locally-advanced-prostate-cancer","display_name":"locally advanced prostate cancer","score":0.9169999957084656},{"id":"https://openalex.org/keywords/tumor-cell-proliferation","display_name":"tumor cell proliferation","score":0.45899999141693115}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8324668407440186},{"id":"https://openalex.org/C2777751288","wikidata":"https://www.wikidata.org/wiki/Q409106","display_name":"Ki-67","level":3,"score":0.7107151746749878},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.7011340856552124},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.6829166412353516},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.5577274560928345},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5506413578987122},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5443903207778931},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5136122703552246},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.49190378189086914},{"id":"https://openalex.org/C2775908122","wikidata":"https://www.wikidata.org/wiki/Q3070621","display_name":"External beam radiotherapy","level":4,"score":0.4857388138771057},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.4697188436985016},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.4602358341217041},{"id":"https://openalex.org/C2781415353","wikidata":"https://www.wikidata.org/wiki/Q5196602","display_name":"Cut-point","level":2,"score":0.4492206275463104},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.4467233419418335},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3496524691581726},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.2629619538784027},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016017","descriptor_name":"Odds Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016158","descriptor_name":"Genes, p53","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019394","descriptor_name":"Ki-67 Antigen","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1158/1078-0432.ccr-1052-03","doi":"https://doi.org/10.1158/1078-0432.ccr-1052-03","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-1052-03","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},{"id":"pmid:15217948","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15217948","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1580788756","https://openalex.org/W1979300931","https://openalex.org/W1983704893","https://openalex.org/W1985704318","https://openalex.org/W1995220528","https://openalex.org/W2055478303","https://openalex.org/W2057192900","https://openalex.org/W2064660203","https://openalex.org/W2065128803","https://openalex.org/W2072448326","https://openalex.org/W2085947150","https://openalex.org/W2094315815","https://openalex.org/W2101794839","https://openalex.org/W2154055662","https://openalex.org/W2163120057","https://openalex.org/W2324490223","https://openalex.org/W2416044893","https://openalex.org/W2796700885","https://openalex.org/W3041047318","https://openalex.org/W3147894994","https://openalex.org/W3166948199","https://openalex.org/W4256632378","https://openalex.org/W4300692967","https://openalex.org/W4301383607"],"related_works":["https://openalex.org/W2034990685","https://openalex.org/W2145847071","https://openalex.org/W2325351136","https://openalex.org/W1986631676","https://openalex.org/W2058779870","https://openalex.org/W2057192900","https://openalex.org/W2665457297","https://openalex.org/W2065128803","https://openalex.org/W2346720680","https://openalex.org/W4391879994"],"abstract_inverted_index":{"PURPOSE:":[0],"Proliferative":[1],"activity":[2],"defined":[3],"by":[4],"Ki-67":[5,30,50,72,99,136,153,191,202,238,246],"staining":[6],"index":[7],"(SI)":[8],"has":[9],"been":[10],"correlated":[11],"with":[12,39,56,108,119,137,165,196,240,251],"progression":[13],"and":[14,74,114,144,167,179,198,206,215,221,229,257],"prognosis":[15],"in":[16,32,84,259],"a":[17,43,49,177,252],"number":[18],"of":[19,52,62,71,135,183,211,225,237,255],"malignant":[20],"tumors":[21],"including":[22],"prostate":[23,262],"cancer.":[24],"However,":[25],"few":[26],"studies":[27],"have":[28],"examined":[29],"SI":[31,51,73,154,192,203,239,247],"pretreatment":[33],"diagnostic":[34,91],"material":[35,92],"from":[36,93],"patients":[37,83,95,105,116],"treated":[38,107,118],"definitive":[40,265],"radiotherapy.":[41],"In":[42,186],"prior":[44],"study,":[45],"we":[46],"found":[47],"that":[48],">3.5%":[53],"was":[54,96,127,148,155,163,174,180,193,204,213,227,242,248],"associated":[55,164,195,250],"poorer":[57],"patient":[58],"outcome.":[59],"The":[60,133,151,159],"goals":[61],"this":[63,75,184],"analysis":[64,100],"were":[65,106,117],"to":[66],"validate":[67],"the":[68,170,181,201,208,222],"prognostic":[69],"value":[70],"cut":[76,161,172],"point.":[77],"EXPERIMENTAL":[78],"DESIGN:":[79],"Of":[80],"456":[81],"assessable":[82],"Radiation":[85],"Therapy":[86],"Oncology":[87],"Group":[88],"Protocol":[89],"86-10,":[90],"108":[94],"available":[97],"for":[98,130],"using":[101],"MIB-1":[102],"antibody.":[103],"Sixty":[104],"external":[109],"beam":[110],"radiotherapy":[111],"(EBRT)":[112],"alone,":[113],"48":[115],"short-term":[120],"androgen":[121],"deprivation":[122],"+":[123,269],"EBRT.":[124,270],"Median":[125],"follow-up":[126],"9":[128],"years":[129],"those":[131],"living.":[132],"relationship":[134],"distant":[138],"metastasis":[139],"(DM),":[140],"disease-specific":[141],"survival":[142,146],"(DSS),":[143],"overall":[145],"(OS)":[147],"examined.":[149],"RESULTS:":[150],"median":[152],"7.1%":[156,160],"(range,":[157],"0.2-45.5%).":[158],"point":[162,173],"DM":[166,197,212,256],"DSS;":[168],"however,":[169],"3.5%":[171],"as":[175],"strong":[176],"determinant":[178],"focus":[182],"analysis.":[185],"Cox":[187],"proportional":[188],"hazards":[189],"regression,":[190],"independently":[194],"DSS.":[199],"When":[200],"</=3.5%":[205],">3.5%,":[207],"5-year":[209,223],"risk":[210,224,254],"13.5%":[214],"50.8%":[216],"(P":[217,231],"=":[218,232],"0.0005),":[219],"respectively,":[220],"DSS":[226,258],"97.3%":[228],"67.7%":[230],"0.0039),":[233],"respectively.":[234],"No":[235],"association":[236],"OS":[241],"observed.":[243],"CONCLUSIONS:":[244],"Higher":[245],"significantly":[249],"greater":[253],"locally":[260],"advanced":[261],"cancer":[263],"after":[264],"EBRT":[266],"or":[267],"AD":[268]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}