{"id":"https://openalex.org/W2164811317","doi":"https://doi.org/10.1002/pros.20969","title":"Ubiquitous mitochondrial creatine kinase is overexpressed in the conditioned medium and the extract of LNCaP lineaged androgen independent cell lines and facilitates prostate cancer progression","display_name":"Ubiquitous mitochondrial creatine kinase is overexpressed in the conditioned medium and the extract of LNCaP lineaged androgen independent cell lines and facilitates prostate cancer progression","publication_year":2009,"publication_date":"2009-05-04","ids":{"openalex":"https://openalex.org/W2164811317","doi":"https://doi.org/10.1002/pros.20969","mag":"2164811317","pmid":"https://pubmed.ncbi.nlm.nih.gov/19415690"},"language":"en","primary_location":{"id":"doi:10.1002/pros.20969","doi":"https://doi.org/10.1002/pros.20969","is_oa":false,"landing_page_url":"https://doi.org/10.1002/pros.20969","pdf_url":null,"source":{"id":"https://openalex.org/S197000376","display_name":"The Prostate","issn_l":"0270-4137","issn":["0270-4137","1097-0045"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Prostate","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039225458","display_name":"Bo Pang","orcid":"https://orcid.org/0000-0001-9664-3972","observed_orcids":["https://orcid.org/0000-0001-9664-3972","https://orcid.org/0000-0002-7408-1355"]},"institutions":[{"id":"https://openalex.org/I4210088305","display_name":"Chinese People's Armed Police Force Medical College Affiliated Hospital","ror":"https://ror.org/00768sz96","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210088305"]},{"id":"https://openalex.org/I4396570617","display_name":"Chinese People's Armed Police Force","ror":"https://ror.org/011gh0524","country_code":"CN","type":"funder","lineage":["https://openalex.org/I4210133972","https://openalex.org/I4396570617"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bo Pang","raw_affiliation_strings":["The Laboratory of Molecular Oncology, Beijing Institute of Biotechnology, Beijing 100850, P.R. China","Department of Clinical Laboratory, Affiliated Hospital of Medical College of Chinese People's Armed Police Force, Tianjin, P. R. China","The Laboratory of Molecular Oncology, Beijing Institute of Biotechnology, Beijing, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Laboratory of Molecular Oncology, Beijing Institute of Biotechnology, Beijing 100850, P.R. China","institution_ids":[]},{"raw_affiliation_string":"Department of Clinical Laboratory, Affiliated Hospital of Medical College of Chinese People's Armed Police Force, Tianjin, P. R. China","institution_ids":["https://openalex.org/I4210088305","https://openalex.org/I4396570617"]},{"raw_affiliation_string":"The Laboratory of Molecular Oncology, Beijing Institute of Biotechnology, Beijing, P. R. China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100323343","display_name":"Hui Zhang","orcid":"https://orcid.org/0000-0001-6825-5649","observed_orcids":["https://orcid.org/0000-0001-6825-5649","https://orcid.org/0009-0005-7364-5138"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hui Zhang","raw_affiliation_strings":["The Laboratory of Molecular Oncology, Beijing Institute of Biotechnology, Beijing, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Laboratory of Molecular Oncology, Beijing Institute of Biotechnology, Beijing, P. R. China","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jian Wang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jian Wang","raw_affiliation_strings":["The Laboratory of Molecular Oncology, Beijing Institute of Biotechnology, Beijing, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Laboratory of Molecular Oncology, Beijing Institute of Biotechnology, Beijing, P. R. China","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Wen\u2010Zheng Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wen\u2010Zheng Chen","raw_affiliation_strings":["Department of Urology, Chinese PLA General Hospital, Beijing, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Chinese PLA General Hospital, Beijing, P. R. China","institution_ids":["https://openalex.org/I2802939634"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041019792","display_name":"Shan\u2010Hu Li","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shan\u2010Hu Li","raw_affiliation_strings":["The Laboratory of Molecular Oncology, Beijing Institute of Biotechnology, Beijing, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Laboratory of Molecular Oncology, Beijing Institute of Biotechnology, Beijing, P. R. China","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Qing\u2010Guo Shi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qing\u2010Guo Shi","raw_affiliation_strings":["The Laboratory of Molecular Oncology, Beijing Institute of Biotechnology, Beijing, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Laboratory of Molecular Oncology, Beijing Institute of Biotechnology, Beijing, P. R. China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111984603","display_name":"Rei\u2010Xia Liang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rei\u2010Xia Liang","raw_affiliation_strings":["The Laboratory of Molecular Oncology, Beijing Institute of Biotechnology, Beijing, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Laboratory of Molecular Oncology, Beijing Institute of Biotechnology, Beijing, P. R. China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063680626","display_name":"Bangxiang Xie","orcid":"https://orcid.org/0000-0002-8174-9771","observed_orcids":["https://orcid.org/0000-0002-8174-9771"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bang\u2010Xiang Xie","raw_affiliation_strings":["The Laboratory of Molecular Oncology, Beijing Institute of Biotechnology, Beijing, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Laboratory of Molecular Oncology, Beijing Institute of Biotechnology, Beijing, P. R. China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112750902","display_name":"Ruiqin Wu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rui\u2010Qin Wu","raw_affiliation_strings":["The Laboratory of Molecular Oncology, Beijing Institute of Biotechnology, Beijing, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Laboratory of Molecular Oncology, Beijing Institute of Biotechnology, Beijing, P. R. China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069157891","display_name":"Xiaolong Qian","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiao\u2010Long Qian","raw_affiliation_strings":["The Laboratory of Molecular Oncology, Beijing Institute of Biotechnology, Beijing, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Laboratory of Molecular Oncology, Beijing Institute of Biotechnology, Beijing, P. R. China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070448613","display_name":"Yu Lan","orcid":"https://orcid.org/0000-0002-4731-5945","observed_orcids":["https://orcid.org/0000-0002-4731-5945"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lan Yu","raw_affiliation_strings":["The Laboratory of Molecular Oncology, Beijing Institute of Biotechnology, Beijing, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Laboratory of Molecular Oncology, Beijing Institute of Biotechnology, Beijing, P. R. China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109249617","display_name":"Qi\u2010Man Li","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qi\u2010Man Li","raw_affiliation_strings":["The Laboratory of Molecular Oncology, Beijing Institute of Biotechnology, Beijing, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Laboratory of Molecular Oncology, Beijing Institute of Biotechnology, Beijing, P. R. China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111417628","display_name":"Cuifen Huang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cui\u2010Fen Huang","raw_affiliation_strings":["The Laboratory of Molecular Oncology, Beijing Institute of Biotechnology, Beijing, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Laboratory of Molecular Oncology, Beijing Institute of Biotechnology, Beijing, P. R. China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087848418","display_name":"Jian\u2010Guang Zhou","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jian\u2010Guang Zhou","raw_affiliation_strings":["The Laboratory of Molecular Oncology, Beijing Institute of Biotechnology, Beijing, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Laboratory of Molecular Oncology, Beijing Institute of Biotechnology, Beijing, P. R. China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5087848418"],"corresponding_institution_ids":[],"apc_list":{"value":4600,"currency":"USD","value_usd":4600},"apc_paid":null,"fwci":2.8048,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.9094287,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"69","issue":"11","first_page":"1176","last_page":"1187"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/castration-resistant-prostate-cancer","display_name":"castration-resistant prostate cancer","score":0.8970000147819519},{"id":"https://openalex.org/keywords/prostate-cancer-progression","display_name":"prostate cancer progression","score":0.8220000267028809},{"id":"https://openalex.org/keywords/conditioned-medium","display_name":"conditioned medium","score":0.8009999990463257},{"id":"https://openalex.org/keywords/lncap-cells","display_name":"LNCaP cells","score":0.9800000190734863},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.8920000195503235},{"id":"https://openalex.org/keywords/akt-signaling","display_name":"Akt signaling","score":0.9869999885559082},{"id":"https://openalex.org/keywords/androgen-independence","display_name":"androgen independence","score":0.7559999823570251},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.6349999904632568},{"id":"https://openalex.org/keywords/bicalutamide-resistance","display_name":"bicalutamide resistance","score":0.6480000019073486},{"id":"https://openalex.org/keywords/prostate-cancer-cell-lines","display_name":"prostate cancer cell lines","score":0.42399999499320984}],"concepts":[{"id":"https://openalex.org/C2779723316","wikidata":"https://www.wikidata.org/wiki/Q6459234","display_name":"LNCaP","level":4,"score":0.9743592739105225},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.814729630947113},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.6518231630325317},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6437475681304932},{"id":"https://openalex.org/C2780962315","wikidata":"https://www.wikidata.org/wiki/Q1988832","display_name":"Bicalutamide","level":5,"score":0.6181084513664246},{"id":"https://openalex.org/C2777911890","wikidata":"https://www.wikidata.org/wiki/Q62614","display_name":"Androgen","level":3,"score":0.47575849294662476},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4685099124908447},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4561554193496704},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.42216306924819946},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.4196265935897827},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.37314632534980774},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3613489270210266},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35055577754974365},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.34358906745910645},{"id":"https://openalex.org/C61367390","wikidata":"https://www.wikidata.org/wiki/Q416601","display_name":"Androgen receptor","level":4,"score":0.28507351875305176},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.24411004781723022},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11616671085357666},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.05527278780937195}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000728","descriptor_name":"Androgens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017077","descriptor_name":"Culture Media, Conditioned","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017430","descriptor_name":"Prostate-Specific Antigen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018971","descriptor_name":"Insulin-Like Growth Factor Binding Protein 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D052281","descriptor_name":"Creatine Kinase, Mitochondrial Form","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D052281","descriptor_name":"Creatine Kinase, Mitochondrial Form","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/pros.20969","doi":"https://doi.org/10.1002/pros.20969","is_oa":false,"landing_page_url":"https://doi.org/10.1002/pros.20969","pdf_url":null,"source":{"id":"https://openalex.org/S197000376","display_name":"The Prostate","issn_l":"0270-4137","issn":["0270-4137","1097-0045"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Prostate","raw_type":"journal-article"},{"id":"pmid:19415690","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19415690","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Prostate","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8425478023","display_name":"PC-1\u6291\u5236AR\u8f6c\u5f55\u6d3b\u6027\u53ca\u5728\u524d\u5217\u817a\u764c\u8fdb\u5c55\u4e2d\u7684\u4f5c\u7528\u7814\u7a76","funder_award_id":"30770834","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8798355305","display_name":"EphA3\u8868\u8fbe\u5728\u524d\u5217\u817a\u764c\u8fdb\u5c55\u4e0e\u8f6c\u79fb\u4e2d\u7684\u4f5c\u7528\u7814\u7a76","funder_award_id":"30870961","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W331454092","https://openalex.org/W1575179156","https://openalex.org/W1591646293","https://openalex.org/W1809723326","https://openalex.org/W1849159432","https://openalex.org/W1854303582","https://openalex.org/W1924066395","https://openalex.org/W1939850652","https://openalex.org/W1970225749","https://openalex.org/W1973423407","https://openalex.org/W1988655372","https://openalex.org/W1990176822","https://openalex.org/W1992918484","https://openalex.org/W2011006339","https://openalex.org/W2017757468","https://openalex.org/W2018606154","https://openalex.org/W2019933034","https://openalex.org/W2021117030","https://openalex.org/W2047382816","https://openalex.org/W2051933521","https://openalex.org/W2053641018","https://openalex.org/W2056528819","https://openalex.org/W2066077760","https://openalex.org/W2067287983","https://openalex.org/W2072985278","https://openalex.org/W2082227406","https://openalex.org/W2086543549","https://openalex.org/W2090551359","https://openalex.org/W2091316489","https://openalex.org/W2124076983","https://openalex.org/W2125463628","https://openalex.org/W2132270233","https://openalex.org/W2134017403","https://openalex.org/W2142629312","https://openalex.org/W2150769574","https://openalex.org/W2154176338","https://openalex.org/W2291421883"],"related_works":["https://openalex.org/W2233416627","https://openalex.org/W2516080218","https://openalex.org/W1608446642","https://openalex.org/W1545299473","https://openalex.org/W2011732151","https://openalex.org/W2155228264","https://openalex.org/W1269609943","https://openalex.org/W1978940286","https://openalex.org/W2083473946","https://openalex.org/W2738524689"],"abstract_inverted_index":{"BACKGROUND:":[0],"Androgen":[1],"independent":[2],"prostate":[3,51,93,120,149],"cancer":[4,52,94,150],"(AIPC)":[5],"is":[6,37],"not":[7],"responsive":[8],"to":[9,83,222],"androgen":[10,49,236],"ablation":[11],"therapy.":[12],"The":[13],"biomarkers":[14],"of":[15,28,61,88,109,137,185,210,224,227],"AIPC":[16,29,47,138,144,213],"are":[17],"lack.":[18],"Numerous":[19],"proteomics":[20],"studies":[21,80],"have":[22],"focused":[23],"on":[24],"finding":[25],"new":[26],"markers":[27],"and":[30,48,66,78,97,107,124,146,188,231],"exploring":[31],"their":[32],"possible":[33,105],"functions,":[34],"but":[35],"little":[36],"known":[38],"about":[39],"the":[40,85,89,104,110,135],"difference":[41],"between":[42],"conditioned":[43],"medium":[44],"(CM)":[45],"from":[46,63],"dependent":[50],"(ADPC)":[53],"cells.":[54,139,198,214],"METHODS:":[55],"We":[56,200],"performed":[57],"a":[58,70,161],"proteome":[59],"analysis":[60],"CM":[62,136,209],"LNCaP,":[64],"C4-2,":[65],"C4-2B":[67],"cells":[68,145,219],"by":[69],"two":[71],"dimensional":[72],"electrophoresis":[73],"based":[74],"technology.":[75],"Western":[76],"blots":[77],"immunohistochemical":[79],"were":[81],"employed":[82],"explore":[84],"expression":[86],"pattern":[87],"identified":[90,133],"protein":[91],"in":[92,116,134,143,147,169,176,193,196,208,217],"cell":[95],"lines":[96],"clinical":[98],"specimens,":[99],"respectively.":[100],"Then":[101],"we":[102],"examined":[103],"roles":[106],"mechanisms":[108],"ubiquitous":[111],"mitochondrial":[112],"creatine":[113],"kinase":[114],"(uMtCK)":[115],"vitro.":[117],"RESULTS:":[118],"Besides":[119],"specific":[121],"antigen":[122],"(PSA)":[123],"insulin-like":[125],"growth":[126,162],"factor":[127],"binding":[128],"protein-2":[129],"(IGFBP2),":[130],"uMtCK":[131,140,159,203,216],"was":[132,141],"up-regulated":[142],"human":[148],"tissues":[151],"at":[152],"WHO":[153],"grade":[154],"III.":[155],"Stably":[156],"transfected":[157],"exogenous":[158],"showed":[160,181,201],"promoting":[163],"effect":[164],"rather":[165],"than":[166,195],"mock":[167],"vector":[168],"LNCaP":[170,211,218],"cells,":[171],"with":[172],"or":[173],"without":[174],"bicalutamide":[175],"culture":[177],"medium.":[178],"Further":[179],"assays":[180],"that":[182,202],"higher":[183],"degrees":[184],"ROS":[186],"generation":[187],"Akt":[189,228],"signaling":[190,229],"pathway":[191,230],"activation":[192,226],"LNCaP-uMtCK":[194],"LNCaP-neo":[197],"CONCLUSIONS:":[199],"could":[204],"be":[205],"easily":[206],"detected":[207],"lineaged":[212],"Exogenous":[215],"surprisingly":[220],"contributed":[221],"overproduction":[223],"ROS,":[225],"more":[232],"aggressive":[233],"phenotypes":[234],"including":[235],"independence":[237],"development.":[238]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}