{"id":"https://openalex.org/W2164736711","doi":"https://doi.org/10.1093/carcin/22.11.1765","title":"Overexpression of 15-lipoxygenase-1 in PC-3 human prostate cancer cells increases tumorigenesis","display_name":"Overexpression of 15-lipoxygenase-1 in PC-3 human prostate cancer cells increases tumorigenesis","publication_year":2001,"publication_date":"2001-11-01","ids":{"openalex":"https://openalex.org/W2164736711","doi":"https://doi.org/10.1093/carcin/22.11.1765","mag":"2164736711","pmid":"https://pubmed.ncbi.nlm.nih.gov/11698337"},"language":"en","primary_location":{"id":"doi:10.1093/carcin/22.11.1765","doi":"https://doi.org/10.1093/carcin/22.11.1765","is_oa":true,"landing_page_url":"https://doi.org/10.1093/carcin/22.11.1765","pdf_url":"https://academic.oup.com/carcin/article-pdf/22/11/1765/19253742/221765.pdf","source":{"id":"https://openalex.org/S184620562","display_name":"Carcinogenesis","issn_l":"0143-3334","issn":["0143-3334","1460-2180"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Carcinogenesis","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/carcin/article-pdf/22/11/1765/19253742/221765.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112000546","display_name":"Uddhav P. Kelavkar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Uddhav P. Kelavkar","raw_affiliation_strings":["Department of Anatomic Pathology, Emory University, 1639 Pierce Drive, Atlanta, GA 30322, USA. kelavkar@emory.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomic Pathology, Emory University, 1639 Pierce Drive, Atlanta, GA 30322, USA. kelavkar@emory.edu","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049772176","display_name":"Jennifer B. Nixon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer B. Nixon","raw_affiliation_strings":["Laboratory of Molecular Carcinogenesis , National Institutes of Environmental Health , Research Triangle Park , NC 27709 , USA and","National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Carcinogenesis , National Institutes of Environmental Health , Research Triangle Park , NC 27709 , USA and","institution_ids":["https://openalex.org/I4210095140"]},{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Cynthia Cohen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cynthia Cohen","raw_affiliation_strings":["Renal Division and Department of Anatomic Pathology , Emory University , 1639 Pierce Drive , Atlanta , GA 30322 , USA,","Emory University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Renal Division and Department of Anatomic Pathology , Emory University , 1639 Pierce Drive , Atlanta , GA 30322 , USA,","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Emory University","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035434011","display_name":"Dirk Dillehay","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dirk Dillehay","raw_affiliation_strings":["Renal Division and Department of Anatomic Pathology , Emory University , 1639 Pierce Drive , Atlanta , GA 30322 , USA,","Emory University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Renal Division and Department of Anatomic Pathology , Emory University , 1639 Pierce Drive , Atlanta , GA 30322 , USA,","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Emory University","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064125146","display_name":"Thomas E. Eling","orcid":"https://orcid.org/0009-0006-5980-1189","observed_orcids":["https://orcid.org/0009-0006-5980-1189"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas E. Eling","raw_affiliation_strings":["Laboratory of Molecular Carcinogenesis , National Institutes of Environmental Health , Research Triangle Park , NC 27709 , USA and","National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Carcinogenesis , National Institutes of Environmental Health , Research Triangle Park , NC 27709 , USA and","institution_ids":["https://openalex.org/I4210095140"]},{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113594095","display_name":"Kamal F. Badr","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98635879","display_name":"American University of Beirut","ror":"https://ror.org/04pznsd21","country_code":"LB","type":"education","lineage":["https://openalex.org/I98635879"]}],"countries":["LB"],"is_corresponding":false,"raw_author_name":"Kamal F. Badr","raw_affiliation_strings":["Department of Internal Medicine , American University of Beirut , Lebanon","American University of Beirut"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine , American University of Beirut , Lebanon","institution_ids":["https://openalex.org/I98635879"]},{"raw_affiliation_string":"American University of Beirut","institution_ids":["https://openalex.org/I98635879"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4835,"currency":"USD","value_usd":4835},"apc_paid":null,"fwci":4.258,"has_fulltext":true,"cited_by_count":137,"citation_normalized_percentile":{"value":0.94422172,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"22","issue":"11","first_page":"1765","last_page":"1773"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.6532999873161316,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.6532999873161316,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.1282999962568283,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.08510000258684158,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/15-lipoxygenase-1","display_name":"15-lipoxygenase-1","score":0.9919999837875366},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.7850000262260437},{"id":"https://openalex.org/keywords/pc-3-cells","display_name":"PC-3 cells","score":0.9869999885559082},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.9409999847412109},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.5580000281333923},{"id":"https://openalex.org/keywords/anchorage-independent-growth","display_name":"anchorage-independent growth","score":0.9739999771118164},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.6959999799728394},{"id":"https://openalex.org/keywords/factor-viii","display_name":"factor VIII","score":0.9350000023841858},{"id":"https://openalex.org/keywords/stable-transfection","display_name":"stable transfection","score":0.5090000033378601},{"id":"https://openalex.org/keywords/tumor-growth-in-nude-mice","display_name":"tumor growth in nude mice","score":0.7649999856948853},{"id":"https://openalex.org/keywords/omega-3-fatty-acid-metabolism","display_name":"omega-3 fatty acid metabolism","score":0.5509999990463257},{"id":"https://openalex.org/keywords/gene-overexpression","display_name":"gene overexpression","score":0.44999998807907104},{"id":"https://openalex.org/keywords/gene-silencing","display_name":"gene silencing","score":0.33899998664855957}],"concepts":[{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.7191908359527588},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.703848123550415},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.6302921175956726},{"id":"https://openalex.org/C81089528","wikidata":"https://www.wikidata.org/wiki/Q5134986","display_name":"clone (Java method)","level":3,"score":0.6233793497085571},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6062710285186768},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.5150325298309326},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5087345242500305},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.49945688247680664},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4980032444000244},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.44127583503723145},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.42765042185783386},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34797364473342896},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2950083315372467},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17119455337524414},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06276604533195496},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001093","descriptor_name":"Arachidonate 15-Lipoxygenase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001093","descriptor_name":"Arachidonate 15-Lipoxygenase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001093","descriptor_name":"Arachidonate 15-Lipoxygenase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001093","descriptor_name":"Arachidonate 15-Lipoxygenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001093","descriptor_name":"Arachidonate 15-Lipoxygenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001093","descriptor_name":"Arachidonate 15-Lipoxygenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003114","descriptor_name":"Colony-Forming Units Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003114","descriptor_name":"Colony-Forming Units Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003114","descriptor_name":"Colony-Forming Units Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004591","descriptor_name":"Electrophoresis, Polyacrylamide Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004591","descriptor_name":"Electrophoresis, Polyacrylamide Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004591","descriptor_name":"Electrophoresis, Polyacrylamide Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004790","descriptor_name":"Enzyme Induction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004790","descriptor_name":"Enzyme Induction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004790","descriptor_name":"Enzyme Induction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005169","descriptor_name":"Factor VIII","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005169","descriptor_name":"Factor VIII","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005169","descriptor_name":"Factor VIII","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007124","descriptor_name":"Immunoenzyme Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007124","descriptor_name":"Immunoenzyme Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007124","descriptor_name":"Immunoenzyme Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008041","descriptor_name":"Linoleic Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008041","descriptor_name":"Linoleic Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008041","descriptor_name":"Linoleic Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008222","descriptor_name":"Lymphokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008222","descriptor_name":"Lymphokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008222","descriptor_name":"Lymphokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016228","descriptor_name":"Endothelial Growth Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016228","descriptor_name":"Endothelial Growth Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016228","descriptor_name":"Endothelial Growth Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019787","descriptor_name":"Linoleic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019787","descriptor_name":"Linoleic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019787","descriptor_name":"Linoleic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042442","descriptor_name":"Vascular Endothelial Growth Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042442","descriptor_name":"Vascular Endothelial Growth Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042442","descriptor_name":"Vascular Endothelial Growth Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/carcin/22.11.1765","doi":"https://doi.org/10.1093/carcin/22.11.1765","is_oa":true,"landing_page_url":"https://doi.org/10.1093/carcin/22.11.1765","pdf_url":"https://academic.oup.com/carcin/article-pdf/22/11/1765/19253742/221765.pdf","source":{"id":"https://openalex.org/S184620562","display_name":"Carcinogenesis","issn_l":"0143-3334","issn":["0143-3334","1460-2180"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Carcinogenesis","raw_type":"journal-article"},{"id":"pmid:11698337","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11698337","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Carcinogenesis","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1093/carcin/22.11.1765","doi":"https://doi.org/10.1093/carcin/22.11.1765","is_oa":true,"landing_page_url":"https://doi.org/10.1093/carcin/22.11.1765","pdf_url":"https://academic.oup.com/carcin/article-pdf/22/11/1765/19253742/221765.pdf","source":{"id":"https://openalex.org/S184620562","display_name":"Carcinogenesis","issn_l":"0143-3334","issn":["0143-3334","1460-2180"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Carcinogenesis","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.838100016117096,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.6399999856948853,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2164736711.pdf","grobid_xml":"https://content.openalex.org/works/W2164736711.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W83643349","https://openalex.org/W299510166","https://openalex.org/W1492551494","https://openalex.org/W1872874293","https://openalex.org/W1965551017","https://openalex.org/W1969390245","https://openalex.org/W1973820835","https://openalex.org/W1974542837","https://openalex.org/W1981676373","https://openalex.org/W1985841114","https://openalex.org/W1987476058","https://openalex.org/W1987883076","https://openalex.org/W2000000541","https://openalex.org/W2000912603","https://openalex.org/W2007454357","https://openalex.org/W2017917918","https://openalex.org/W2025229172","https://openalex.org/W2038194865","https://openalex.org/W2050888137","https://openalex.org/W2052964069","https://openalex.org/W2065964273","https://openalex.org/W2076677399","https://openalex.org/W2079415755","https://openalex.org/W2094298112","https://openalex.org/W2095378845","https://openalex.org/W2107938935","https://openalex.org/W2126242637","https://openalex.org/W2139567512","https://openalex.org/W2148022591","https://openalex.org/W2149233326","https://openalex.org/W2149423279","https://openalex.org/W2159973565","https://openalex.org/W2160234181","https://openalex.org/W2167750045","https://openalex.org/W2319962899","https://openalex.org/W2376146086","https://openalex.org/W2443673815","https://openalex.org/W4242442904"],"related_works":["https://openalex.org/W2377327490","https://openalex.org/W2385328945","https://openalex.org/W2469005932","https://openalex.org/W2034515275","https://openalex.org/W2285828597","https://openalex.org/W2350002661","https://openalex.org/W1985998670","https://openalex.org/W2072481810","https://openalex.org/W2347992620","https://openalex.org/W4307860292"],"abstract_inverted_index":{"The":[0,60,79,192,203,242],"effect":[1,178],"of":[2,4,77,82,97,107,112,138,173,179,185,205,213,239,244,284,297],"overexpression":[3],"15-lipoxygenase-1":[5],"(15-LO-1)":[6],"was":[7,47,190,208,253,301],"studied":[8],"in":[9,109,143,152,163,166,175,187,220,250,255,263,294,303,319,324],"the":[10,83,136,171,177,183,211,214,221,237,240,280,308,325],"human":[11],"prostate":[12],"cancer":[13],"cell":[14,19,71,84,194,310],"line,":[15],"PC-3.":[16],"Stable":[17],"PC-3":[18,58,70,91,139,164,193,227,292],"lines":[20,72,85,195],"were":[21,73,86,196,217],"generated":[22],"by":[23,39,120,149,282,291],"transfection":[24],"with":[25,35,56,126,224,269,307],"15-LO-1-sense":[26],"(15-LOS),":[27],"15-LO-1-antisense":[28],"(15-LOAS)":[29],"or":[30,65,273],"vector":[31],"(Zeo)":[32],"and":[33,42,128,210,228,261],"selection":[34],"Zeocin.":[36],"After":[37],"characterization":[38],"RT-PCR,":[40],"western":[41],"HPLC,":[43],"a":[44,98,104,158,315,320],"PC3-15LOS":[45,89,131,222,259,304],"clone":[46,62],"selected":[48],"that":[49],"possessed":[50],"10-fold":[51],"15-LO-1":[52,67,100,113,162,174,180,233,318],"enzyme":[53],"activity":[54],"compared":[55,223,268,306],"parental":[57,127,226,272],"cells.":[59,230,275],"PC3-15LOAS":[61,134,266],"displayed":[63],"little":[64],"no":[66],"activity.":[68],"These":[69,155,276,312],"characterized":[74],"for":[75,161,232,317],"properties":[76],"tumorigenesis.":[78],"proliferation":[80,108],"rates":[81],"as":[87,147],"follows:":[88],">":[90,94],"=":[92],"PC3-Zeo":[93],"PC3-15LOAS.":[95],"Addition":[96],"specific":[99],"inhibitor,":[101],"PD146176,":[102],"caused":[103,115],"dose-dependent":[105],"inhibition":[106],"vitro.":[110,167],"Overexpression":[111],"also":[114],"[(3)H]thymidine":[116],"incorporation":[117],"to":[118,141,169],"increase":[119],"4.0-fold":[121],"(P":[122],"<":[123],"0.01).":[124],"Compared":[125],"PC-3-Zeo":[129,229],"cells,":[130],"enhanced":[132],"whereas":[133],"reduced":[135],"ability":[137],"cells":[140,165,260,267,293,305],"grow":[142],"an":[144,247],"anchorage-independent":[145],"manner,":[146],"assessed":[148],"colony":[150],"formation":[151,207],"soft":[153],"agar.":[154],"data":[156,277],"suggested":[157],"pro-tumorigenic":[159],"role":[160,172,316],"Therefore,":[168],"clarify":[170],"vivo,":[176],"expression":[181,235,243],"on":[182],"growth":[184,287],"tumors":[186,215,256,270],"nude":[188,201],"mice":[189],"investigated.":[191],"inoculated":[197],"subcutaneously":[198],"into":[199],"athymic":[200],"mice.":[202],"frequency":[204],"tumor":[206,251],"increased":[209,254],"sizes":[212],"formed":[216],"much":[218],"larger":[219],"PC3-15LOAS,":[225],"Immunohistochemistry":[231],"confirmed":[234],"throughout":[236],"duration":[238],"experiment.":[241],"factor":[245,288,300],"VIII,":[246],"angiogenesis":[248],"marker,":[249],"sections":[252],"derived":[257],"from":[258,265,271],"decreased":[262],"those":[264],"Zeo":[274],"further":[278],"supported":[279],"evaluation":[281],"ELISA":[283],"vascular":[285],"endothelial":[286],"(VEGF)":[289],"secretion":[290],"culture.":[295],"Secretion":[296],"this":[298],"angiogenic":[299],"elevated":[302],"other":[309],"lines.":[311],"results":[313],"support":[314],"novel":[321],"growth-promoting":[322],"pathway":[323],"prostate.":[326]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":10}],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2025-10-10T00:00:00"}
