{"id":"https://openalex.org/W2164728374","doi":null,"title":"Cancer morbidity among methyl isocyanate exposed long- term survivors and their offspring: a hospital-based five year descriptive study (2006 - 2011) and future directions to predict cancer risk in the affected population.","display_name":"Cancer morbidity among methyl isocyanate exposed long- term survivors and their offspring: a hospital-based five year descriptive study (2006 - 2011) and future directions to predict cancer risk in the affected population.","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W2164728374","mag":"2164728374","pmid":"https://pubmed.ncbi.nlm.nih.gov/22471495"},"language":"en","primary_location":{"id":"pmid:22471495","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22471495","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Pacific journal of cancer prevention : APJCP","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071684048","display_name":"Chinnu Sugavanam Senthilkumar","orcid":"https://orcid.org/0000-0002-3638-8719","observed_orcids":["https://orcid.org/0000-0002-3638-8719"]},"institutions":[{"id":"https://openalex.org/I4210104322","display_name":"Jawaharlal Nehru Cancer Hospital and Research Centre","ror":"https://ror.org/00x9ph686","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210104322"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Chinnu Sugavanam Senthilkumar","raw_affiliation_strings":["Department of Research, Jawaharlal Nehru Cancer Hospital and Research Centre, India. sengenetics@gmail.com","Department of Research, Jawaharlal Nehru Cancer Hospital and Research Centre, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Research, Jawaharlal Nehru Cancer Hospital and Research Centre, India. sengenetics@gmail.com","institution_ids":["https://openalex.org/I4210104322"]},{"raw_affiliation_string":"Department of Research, Jawaharlal Nehru Cancer Hospital and Research Centre, India","institution_ids":["https://openalex.org/I4210104322"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073637330","display_name":"Tahir Mohiuddin Malla","orcid":"https://orcid.org/0000-0001-9266-6413","observed_orcids":["https://orcid.org/0000-0001-9266-6413"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tahir Mohi-ud-Din Malla","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055117737","display_name":"Nand Kishore Sah","orcid":"https://orcid.org/0000-0002-8083-523X","observed_orcids":["https://orcid.org/0000-0002-8083-523X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nand Kishore Sah","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5103026652","display_name":"Narayanan Ganesh","orcid":"https://orcid.org/0000-0002-6735-3420","observed_orcids":["https://orcid.org/0000-0002-6735-3420"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Narayanan Ganesh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6337,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.67467992,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"12","issue":"12","first_page":"3443","last_page":"52"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.4706999957561493,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.4706999957561493,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10556","display_name":"Global Cancer Incidence and Screening","score":0.2793000042438507,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10875","display_name":"Pesticide Exposure and Toxicity","score":0.07750000059604645,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/methyl-isocyanate","display_name":"methyl isocyanate","score":0.972000002861023},{"id":"https://openalex.org/keywords/bhopal-disaster","display_name":"Bhopal disaster","score":0.8889999985694885},{"id":"https://openalex.org/keywords/long-term-survivors","display_name":"long-term survivors","score":0.7580000162124634},{"id":"https://openalex.org/keywords/cancer-incidence","display_name":"cancer incidence","score":0.8109999895095825},{"id":"https://openalex.org/keywords/tumor-site-distribution","display_name":"tumor site distribution","score":0.6539999842643738},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8479999899864197},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.9259999990463257},{"id":"https://openalex.org/keywords/tongue-cancer","display_name":"tongue cancer","score":0.7179999947547913},{"id":"https://openalex.org/keywords/buccal-mucosa-carcinoma","display_name":"buccal mucosa cancer","score":0.8870000243186951},{"id":"https://openalex.org/keywords/cervical-cancer","display_name":"cervical cancer","score":0.7770000100135803},{"id":"https://openalex.org/keywords/esophageal-cancer","display_name":"esophageal cancer","score":0.9860000014305115},{"id":"https://openalex.org/keywords/leukemia","display_name":"leukemia","score":0.5379999876022339},{"id":"https://openalex.org/keywords/cancer-risk-prediction","display_name":"cancer risk prediction","score":0.6370000243186951},{"id":"https://openalex.org/keywords/occupational-exposure","display_name":"occupational exposure","score":0.3540000021457672}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7660508155822754},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.7076608538627625},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5672828555107117},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.49078473448753357},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4810671806335449},{"id":"https://openalex.org/C2777740455","wikidata":"https://www.wikidata.org/wiki/Q666412","display_name":"Cervix","level":3,"score":0.4701521396636963},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.45348235964775085},{"id":"https://openalex.org/C2781074409","wikidata":"https://www.wikidata.org/wiki/Q158716","display_name":"Rectum","level":2,"score":0.41457685828208923},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000986","descriptor_name":"Antisickling Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005190","descriptor_name":"Family","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009017","descriptor_name":"Morbidity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017741","descriptor_name":"Survivors","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D017953","descriptor_name":"Isocyanates","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:22471495","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22471495","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Pacific journal of cancer prevention : APJCP","raw_type":"Journal Article"},{"id":"mag:2164728374","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22471495","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":72,"referenced_works":["https://openalex.org/W19744801","https://openalex.org/W193404298","https://openalex.org/W197938495","https://openalex.org/W1515078119","https://openalex.org/W1519731306","https://openalex.org/W1538063201","https://openalex.org/W1573775632","https://openalex.org/W1831259184","https://openalex.org/W1855688891","https://openalex.org/W1969532008","https://openalex.org/W1970329931","https://openalex.org/W1970806096","https://openalex.org/W1975656662","https://openalex.org/W1978643374","https://openalex.org/W1983474075","https://openalex.org/W1984399156","https://openalex.org/W1986264624","https://openalex.org/W1986851962","https://openalex.org/W1995007546","https://openalex.org/W2004576039","https://openalex.org/W2009946265","https://openalex.org/W2010094441","https://openalex.org/W2021132345","https://openalex.org/W2023978203","https://openalex.org/W2024200554","https://openalex.org/W2032810925","https://openalex.org/W2035229444","https://openalex.org/W2040233957","https://openalex.org/W2046675678","https://openalex.org/W2055869166","https://openalex.org/W2056204961","https://openalex.org/W2070681640","https://openalex.org/W2071689676","https://openalex.org/W2072630011","https://openalex.org/W2076110072","https://openalex.org/W2076244798","https://openalex.org/W2078022931","https://openalex.org/W2085862904","https://openalex.org/W2086492426","https://openalex.org/W2086828878","https://openalex.org/W2088424513","https://openalex.org/W2089415609","https://openalex.org/W2094665470","https://openalex.org/W2094759376","https://openalex.org/W2097007458","https://openalex.org/W2097940406","https://openalex.org/W2102758456","https://openalex.org/W2106625186","https://openalex.org/W2106673456","https://openalex.org/W2112798642","https://openalex.org/W2112865167","https://openalex.org/W2119285674","https://openalex.org/W2120778435","https://openalex.org/W2121732515","https://openalex.org/W2126673711","https://openalex.org/W2126694469","https://openalex.org/W2134298546","https://openalex.org/W2140194403","https://openalex.org/W2146016400","https://openalex.org/W2149312363","https://openalex.org/W2149644733","https://openalex.org/W2151867783","https://openalex.org/W2157817289","https://openalex.org/W2164491820","https://openalex.org/W2169962212","https://openalex.org/W2183964943","https://openalex.org/W2302150357","https://openalex.org/W2341256906","https://openalex.org/W2394877253","https://openalex.org/W3156591552","https://openalex.org/W3206419194","https://openalex.org/W4300388289"],"related_works":["https://openalex.org/W7095913189","https://openalex.org/W638047422","https://openalex.org/W2772873760","https://openalex.org/W2943438071","https://openalex.org/W2068452679","https://openalex.org/W2978381033","https://openalex.org/W2764079279","https://openalex.org/W75057661","https://openalex.org/W193404298","https://openalex.org/W2106605444"],"abstract_inverted_index":{"The":[0,210],"purpose":[1],"of":[2,63,84,193,250,258],"this":[3,222,251],"study":[4,57,212],"was":[5,39,79],"to":[6,47,100,236,268],"update":[7],"both":[8],"researchers":[9],"and":[10,23,72,88,117,145,181,198,207,243,265,278],"clinicians":[11],"about":[12],"the":[13,29,33,42,82,203,229,248,256,270,274],"cancer":[14,37,65,238,271],"incidence":[15],"in":[16,24,41,53,123,202,221,240,273],"methyl":[17],"isocyanate":[18],"(MIC)":[19,48],"exposed":[20,276],"long-term":[21,241],"survivors":[22,206,242],"their":[25,73,208,244,279],"offspring,":[26],"focusing":[27],"on":[28,49,60,81,94,195],"etiological":[30],"plausibility.":[31],"In":[32,224],"time":[34],"period":[35],"2006-2011,":[36],"morbidity":[38,252],"evaluated":[40],"population":[43,277],"surviving":[44],"after":[45],"exposure":[46],"December":[50],"3rd,":[51],"1984,":[52],"Bhopal.":[54],"This":[55],"descriptive":[56],"is":[58],"based":[59],"hospital":[61],"registration":[62],"1261":[64],"patients":[66],"those":[67],"are":[68],"MIC":[69,275],"gas":[70],"victims":[71],"subsequently":[74],"born":[75],"offspring.":[76,209,280],"Morbidity":[77],"status":[78],"studied":[80],"basis":[83,249],"gender,":[85],"age,":[86],"organ":[87],"site":[89],"with":[90,97,233],"relative":[91],"percentages.":[92],"Cancers":[93],"specific":[95],"sites,":[96],"special":[98],"reference":[99],"breast":[101],"(n=231)":[102],"(18.31%),":[103],"lung":[104],"(n=103)":[105,108],"(8.16%),":[106,109],"tongue":[107],"buccal":[110],"mucosa":[111],"(n=94)":[112],"(7.45%),":[113],"cervix":[114],"(n=72)":[115],"(5.70%),":[116],"esophagus":[118],"(n=68)":[119],"(5.39%)":[120],"were":[121,186,200,217],"found":[122],"high":[124],"proportions.":[125],"Ovary":[126],"(n=43)":[127],"(3.40%),":[128],"brain":[129],"(n=42)":[130],"(3.33%),":[131],"larynx":[132],"(n=40)":[133],"(3.17%),":[134],"non-Hodgkin's":[135],"(n=31)":[136],"(2.45%),":[137],"gallbladder":[138],"(n=29)":[139],"(2.29%),":[140],"stomach":[141],"(n=28)":[142,147],"(2.22%),":[143,148],"head":[144],"neck":[146],"liver":[149],"(n=27)":[150],"(2.14%),":[151],"acute":[152],"lymphoid":[153],"leukemia":[154,165],"(n=24)":[155],"(1.90%),":[156],"rectum":[157],"(n=20)":[158,161],"(1.58%),":[159,162],"colon":[160],"chronic":[163],"myeloid":[164],"(n=17)":[166,169],"(1.34%),":[167,170],"alveolus":[168],"Hodgkin's":[171],"(n=14)":[172,175,179],"(1.11%),":[173,176,180],"uterus":[174],"multiple":[177],"myeloma":[178],"prostate":[182],"(n=11)":[183],"(0.87%)":[184],"lesions":[185],"observed":[187,201,213],"less":[188],"frequently.":[189],"Remarkably,":[190],"gradual":[191],"increase":[192],"cancers":[194,215],"different":[196],"organs":[197],"sites":[199],"long-":[204],"term":[205],"present":[211,228],"some":[214],"which":[216],"not":[218],"previously":[219],"reported":[220],"population.":[223],"addition,":[225],"we":[226,254],"also":[227],"future":[230,245],"research":[231],"directions":[232],"systematic":[234],"approaches":[235],"predict":[237,269],"risk":[239,272],"generations.":[246],"On":[247],"report,":[253],"suggest":[255],"need":[257],"biological":[259],"surveillance":[260],"through":[261],"immune":[262],"system":[263],"biomonitoring":[264],"cytogenetic":[266],"screening":[267]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}