{"id":"https://openalex.org/W2164727209","doi":"https://doi.org/10.1074/jbc.m408090200","title":"Reconstitution and Analysis of Soluble Inhibin and Activin Receptor Complexes in a Cell-free System","display_name":"Reconstitution and Analysis of Soluble Inhibin and Activin Receptor Complexes in a Cell-free System","publication_year":2004,"publication_date":"2004-10-09","ids":{"openalex":"https://openalex.org/W2164727209","doi":"https://doi.org/10.1074/jbc.m408090200","mag":"2164727209","pmid":"https://pubmed.ncbi.nlm.nih.gov/15475360"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m408090200","doi":"https://doi.org/10.1074/jbc.m408090200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m408090200","pdf_url":"http://www.jbc.org/article/S0021925818819494/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925818819494/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036781427","display_name":"Elisabetta C. del Re","orcid":"https://orcid.org/0000-0002-9645-4845","observed_orcids":["https://orcid.org/0000-0002-9645-4845"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elisabetta del Re","raw_affiliation_strings":["Program in Membrane Biology and the Renal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA","Program in Membrane Biology and the Renal Unit, Boston, Massachusetts 02114"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program in Membrane Biology and the Renal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Program in Membrane Biology and the Renal Unit, Boston, Massachusetts 02114","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014403256","display_name":"Yisrael Sidis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yisrael Sidis","raw_affiliation_strings":["Reproductive Endocrine Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reproductive Endocrine Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002641296","display_name":"David A. Fabrizio","orcid":"https://orcid.org/0000-0001-8088-9476","observed_orcids":["https://orcid.org/0000-0001-8088-9476"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David A. Fabrizio","raw_affiliation_strings":["Program in Membrane Biology and the Renal Unit, Boston, Massachusetts 02114"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program in Membrane Biology and the Renal Unit, Boston, Massachusetts 02114","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105935846","display_name":"Herbert Yih-Fuu Lin","orcid":"https://orcid.org/0009-0008-4774-0627","observed_orcids":["https://orcid.org/0009-0008-4774-0627"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Herbert Y. Lin","raw_affiliation_strings":["Program in Membrane Biology and the Renal Unit, Boston, Massachusetts 02114"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program in Membrane Biology and the Renal Unit, Boston, Massachusetts 02114","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044854798","display_name":"Alan L. Schneyer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alan Schneyer","raw_affiliation_strings":["Reproductive Endocrine Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reproductive Endocrine Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5044854798"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":0.5918,"has_fulltext":true,"cited_by_count":28,"citation_normalized_percentile":{"value":0.63538496,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"279","issue":"51","first_page":"53126","last_page":"53135"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/activin","display_name":"activin","score":0.753000020980835},{"id":"https://openalex.org/keywords/inhibin","display_name":"inhibin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tgf-beta-superfamily","display_name":"TGF-beta superfamily","score":0.9070000052452087},{"id":"https://openalex.org/keywords/receptor-complex","display_name":"receptor complex","score":0.4880000054836273},{"id":"https://openalex.org/keywords/activin-type-ii-receptor","display_name":"activin type II receptor","score":0.8309999704360962},{"id":"https://openalex.org/keywords/activin-type-i-receptor","display_name":"activin type I receptor","score":0.8579999804496765},{"id":"https://openalex.org/keywords/tgf-beta-type-iii-receptor","display_name":"TGF-beta type III receptor","score":0.8679999709129333},{"id":"https://openalex.org/keywords/betaglycan","display_name":"betaglycan","score":0.9850000143051147},{"id":"https://openalex.org/keywords/receptor-binding-affinity","display_name":"receptor binding affinity","score":0.5950000286102295},{"id":"https://openalex.org/keywords/cooperative-binding","display_name":"cooperative binding","score":0.5450000166893005},{"id":"https://openalex.org/keywords/activin-a","display_name":"activin A","score":0.7200000286102295},{"id":"https://openalex.org/keywords/activin-b","display_name":"activin B","score":0.9430000185966492},{"id":"https://openalex.org/keywords/inhibin-a","display_name":"inhibin A","score":0.968999981880188},{"id":"https://openalex.org/keywords/inhibin-b","display_name":"inhibin B","score":0.9990000128746033}],"concepts":[{"id":"https://openalex.org/C22517002","wikidata":"https://www.wikidata.org/wiki/Q14905179","display_name":"ACVR2B","level":4,"score":0.9383928775787354},{"id":"https://openalex.org/C2778649528","wikidata":"https://www.wikidata.org/wiki/Q4677603","display_name":"Activin receptor","level":3,"score":0.8834483027458191},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.8260639309883118},{"id":"https://openalex.org/C38643226","wikidata":"https://www.wikidata.org/wiki/Q4677604","display_name":"Activin type 2 receptors","level":4,"score":0.8238092660903931},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5703955888748169},{"id":"https://openalex.org/C111001777","wikidata":"https://www.wikidata.org/wiki/Q3562192","display_name":"TGF beta signaling pathway","level":3,"score":0.5534440279006958},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5426169037818909},{"id":"https://openalex.org/C50929876","wikidata":"https://www.wikidata.org/wiki/Q164280","display_name":"Subfamily","level":3,"score":0.5327873826026917},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4865909814834595},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.4821776747703552},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3676828145980835},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36664313077926636},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26324042677879333},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09501376748085022},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002474","descriptor_name":"Cell-Free System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004591","descriptor_name":"Electrophoresis, Polyacrylamide Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006031","descriptor_name":"Glycosylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007265","descriptor_name":"Inhibins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D007455","descriptor_name":"Iodine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011961","descriptor_name":"Receptors, Fc","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029404","descriptor_name":"Activin Receptors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.m408090200","doi":"https://doi.org/10.1074/jbc.m408090200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m408090200","pdf_url":"http://www.jbc.org/article/S0021925818819494/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:15475360","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15475360","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m408090200","doi":"https://doi.org/10.1074/jbc.m408090200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m408090200","pdf_url":"http://www.jbc.org/article/S0021925818819494/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2164727209.pdf","grobid_xml":"https://content.openalex.org/works/W2164727209.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W111634514","https://openalex.org/W1526657273","https://openalex.org/W1602020625","https://openalex.org/W1868384341","https://openalex.org/W1903013422","https://openalex.org/W1965980379","https://openalex.org/W1973403657","https://openalex.org/W1976428568","https://openalex.org/W1980755859","https://openalex.org/W1985411380","https://openalex.org/W1991046191","https://openalex.org/W1992768239","https://openalex.org/W1997492479","https://openalex.org/W2000991526","https://openalex.org/W2006632995","https://openalex.org/W2011334059","https://openalex.org/W2016791091","https://openalex.org/W2023920437","https://openalex.org/W2035066075","https://openalex.org/W2036509369","https://openalex.org/W2037917812","https://openalex.org/W2043813981","https://openalex.org/W2047335815","https://openalex.org/W2047843624","https://openalex.org/W2049586866","https://openalex.org/W2069117573","https://openalex.org/W2077243848","https://openalex.org/W2085321659","https://openalex.org/W2085484334","https://openalex.org/W2112802518","https://openalex.org/W2122446021","https://openalex.org/W2137230520","https://openalex.org/W2154564110","https://openalex.org/W2154568166","https://openalex.org/W2155539632","https://openalex.org/W2159249860","https://openalex.org/W2160199212","https://openalex.org/W2163120774","https://openalex.org/W2164615751","https://openalex.org/W2409456257","https://openalex.org/W2414298882"],"related_works":["https://openalex.org/W2086576477","https://openalex.org/W1997492479","https://openalex.org/W1973403657","https://openalex.org/W4250768699","https://openalex.org/W4255946357","https://openalex.org/W2147612074","https://openalex.org/W2149066998","https://openalex.org/W4244662542","https://openalex.org/W2169863019","https://openalex.org/W2093392304"],"abstract_inverted_index":{"Activins":[0],"and":[1,16,25,38,49,55,109,192,203,208],"inhibins":[2],"compose":[3],"a":[4,30,64,83,97,141,171,195],"heterogeneous":[5],"subfamily":[6],"within":[7],"the":[8,46,59,125,177,219],"transforming":[9],"growth":[10,15],"factor-beta":[11],"(TGF-beta)":[12],"superfamily":[13],"of":[14,33,51,127,174,198,221,228],"differentiation":[17],"factors":[18],"with":[19,91,116,132,156],"critical":[20],"biological":[21],"activities":[22],"in":[23,56],"embryos":[24],"adults.":[26],"They":[27],"signal":[28],"through":[29],"heteromeric":[31],"complex":[32,196,230],"type":[34,36,41,76,121,129,135,153,159,190,200],"II,":[35],"I,":[37],"for":[39,58,87,100,176,184,210,225],"inhibin,":[40],"III":[42,136],"receptors.":[43],"To":[44],"characterize":[45],"affinity,":[47],"specificity,":[48],"activity":[50],"these":[52],"receptors":[53,95,161,186,202],"(alone":[54],"combination)":[57],"inhibin/activin":[60],"subfamily,":[61],"we":[62],"developed":[63],"cell-free":[65,223],"assay":[66],"system":[67,224],"using":[68],"soluble":[69,74,133,142,151,157],"receptor-Fc":[70],"fusion":[71,80],"proteins.":[72],"The":[73],"activin":[75,88,101,104,117,152,158,166,185,199],"II":[77,122,130,154,188,201],"receptor":[78,123,131,137,155,179,229],"(sActRII)-Fc":[79],"protein":[81],"had":[82,96],"7-fold":[84],"higher":[85],"affinity":[86,144,212],"A":[89,102,108],"compared":[90,115],"sActRIIB-Fc,":[92],"whereas":[93],"both":[94,206],"marked":[98],"preference":[99],"over":[103],"B.":[105],"Although":[106],"inhibin":[107,145,178,213],"B":[110],"binding":[111,118,175],"was":[112],"20-fold":[113],"lower":[114],"to":[119],"either":[120,128,150],"alone,":[124],"mixture":[126],"TGF-beta":[134],"(TbetaRIII;":[138],"betaglycan)-Fc":[139],"reconstituted":[140],"high":[143,211],"receptor.":[146],"In":[147],"contrast,":[148],"mixing":[149],"I":[160],"did":[162],"not":[163,183],"substantially":[164],"enhance":[165],"binding.":[167,214],"Our":[168],"results":[169],"support":[170],"cooperative":[172],"model":[173],"(ActRII.sTbetaRIII":[180],"complex)":[181],"but":[182],"(type":[187],"+":[189],"I)":[191],"demonstrate":[193],"that":[194],"composed":[197],"TbetaRIII":[204],"is":[205],"necessary":[207],"sufficient":[209],"This":[215],"study":[216],"also":[217],"illustrates":[218],"utility":[220],"this":[222],"investigating":[226],"hypotheses":[227],"mechanisms":[231],"resulting":[232],"from":[233],"crystal":[234],"structure":[235],"analyses.":[236]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}