{"id":"https://openalex.org/W2164591127","doi":"https://doi.org/10.1161/01.cir.98.13.1302","title":"1,25-Dihydroxyvitamin D 3 Increases In Vitro Vascular Calcification by Modulating Secretion of Endogenous Parathyroid Hormone\u2013Related Peptide","display_name":"1,25-Dihydroxyvitamin D 3 Increases In Vitro Vascular Calcification by Modulating Secretion of Endogenous Parathyroid Hormone\u2013Related Peptide","publication_year":1998,"publication_date":"1998-09-29","ids":{"openalex":"https://openalex.org/W2164591127","doi":"https://doi.org/10.1161/01.cir.98.13.1302","mag":"2164591127","pmid":"https://pubmed.ncbi.nlm.nih.gov/9751679"},"language":"en","primary_location":{"id":"doi:10.1161/01.cir.98.13.1302","doi":"https://doi.org/10.1161/01.cir.98.13.1302","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.cir.98.13.1302","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2164591127"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049510620","display_name":"Shuichi Jono","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I317356780","display_name":"Osaka City University","ror":"https://ror.org/02skfsw40","country_code":"JP","type":"education","lineage":["https://openalex.org/I317356780","https://openalex.org/I4387152983"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shuichi Jono","raw_affiliation_strings":["From the Second Department of Internal Medicine, Osaka City University Medical School, Osaka 545, Japan","Shuichi Jono From the Second Department of Internal Medicine, Osaka City University Medical School, Osaka 545, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Second Department of Internal Medicine, Osaka City University Medical School, Osaka 545, Japan","institution_ids":["https://openalex.org/I317356780"]},{"raw_affiliation_string":"Shuichi Jono From the Second Department of Internal Medicine, Osaka City University Medical School, Osaka 545, Japan","institution_ids":["https://openalex.org/I317356780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112830935","display_name":"Yoshiki Nishizaw\u00e0","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I317356780","display_name":"Osaka City University","ror":"https://ror.org/02skfsw40","country_code":"JP","type":"education","lineage":["https://openalex.org/I317356780","https://openalex.org/I4387152983"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshiki Nishizawa","raw_affiliation_strings":["From the Second Department of Internal Medicine, Osaka City University Medical School, Osaka 545, Japan","Yoshiki Nishizawa From the Second Department of Internal Medicine, Osaka City University Medical School, Osaka 545, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Second Department of Internal Medicine, Osaka City University Medical School, Osaka 545, Japan","institution_ids":["https://openalex.org/I317356780"]},{"raw_affiliation_string":"Yoshiki Nishizawa From the Second Department of Internal Medicine, Osaka City University Medical School, Osaka 545, Japan","institution_ids":["https://openalex.org/I317356780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072795713","display_name":"Atsushi Shioi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I317356780","display_name":"Osaka City University","ror":"https://ror.org/02skfsw40","country_code":"JP","type":"education","lineage":["https://openalex.org/I317356780","https://openalex.org/I4387152983"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Atsushi Shioi","raw_affiliation_strings":["From the Second Department of Internal Medicine, Osaka City University Medical School, Osaka 545, Japan","Atsushi Shioi From the Second Department of Internal Medicine, Osaka City University Medical School, Osaka 545, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Second Department of Internal Medicine, Osaka City University Medical School, Osaka 545, Japan","institution_ids":["https://openalex.org/I317356780"]},{"raw_affiliation_string":"Atsushi Shioi From the Second Department of Internal Medicine, Osaka City University Medical School, Osaka 545, Japan","institution_ids":["https://openalex.org/I317356780"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5105304668","display_name":"Hirotoshi Morii","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I317356780","display_name":"Osaka City University","ror":"https://ror.org/02skfsw40","country_code":"JP","type":"education","lineage":["https://openalex.org/I317356780","https://openalex.org/I4387152983"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hirotoshi Morii","raw_affiliation_strings":["From the Second Department of Internal Medicine, Osaka City University Medical School, Osaka 545, Japan","Hirotoshi Morii From the Second Department of Internal Medicine, Osaka City University Medical School, Osaka 545, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Second Department of Internal Medicine, Osaka City University Medical School, Osaka 545, Japan","institution_ids":["https://openalex.org/I317356780"]},{"raw_affiliation_string":"Hirotoshi Morii From the Second Department of Internal Medicine, Osaka City University Medical School, Osaka 545, Japan","institution_ids":["https://openalex.org/I317356780"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5072795713"],"corresponding_institution_ids":["https://openalex.org/I317356780"],"apc_list":null,"apc_paid":null,"fwci":3.0632,"has_fulltext":false,"cited_by_count":310,"citation_normalized_percentile":{"value":0.90995111,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"98","issue":"13","first_page":"1302","last_page":"1306"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.02370000071823597,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12924","display_name":"Dermatological and Skeletal Disorders","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/1-25-dihydroxyvitamin-d3","display_name":"1,25-dihydroxyvitamin D3","score":0.9810000061988831},{"id":"https://openalex.org/keywords/vascular-calcification","display_name":"vascular calcification","score":0.7590000033378601},{"id":"https://openalex.org/keywords/parathyroid-hormone-related-protein","display_name":"parathyroid hormone-related protein","score":0.996999979019165},{"id":"https://openalex.org/keywords/vascular-smooth-muscle-cells","display_name":"vascular smooth muscle cells","score":0.8889999985694885},{"id":"https://openalex.org/keywords/osteopontin","display_name":"osteopontin","score":0.9259999990463257},{"id":"https://openalex.org/keywords/alkaline-phosphatase","display_name":"alkaline phosphatase","score":0.9449999928474426},{"id":"https://openalex.org/keywords/calcium-homeostasis","display_name":"calcium homeostasis","score":0.9240000247955322},{"id":"https://openalex.org/keywords/osteoporosis","display_name":"osteoporosis","score":0.7120000123977661},{"id":"https://openalex.org/keywords/calcification-inhibition","display_name":"calcification inhibition","score":0.4230000078678131}],"concepts":[{"id":"https://openalex.org/C2780804394","wikidata":"https://www.wikidata.org/wiki/Q411994","display_name":"Osteopontin","level":2,"score":0.8444430828094482},{"id":"https://openalex.org/C2780309369","wikidata":"https://www.wikidata.org/wiki/Q933382","display_name":"Calcification","level":2,"score":0.8358981013298035},{"id":"https://openalex.org/C2779395532","wikidata":"https://www.wikidata.org/wiki/Q7916469","display_name":"Vascular smooth muscle","level":3,"score":0.8164901733398438},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7874053716659546},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7688748836517334},{"id":"https://openalex.org/C2781208988","wikidata":"https://www.wikidata.org/wiki/Q202476","display_name":"Parathyroid hormone","level":3,"score":0.6775769591331482},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.5667979717254639},{"id":"https://openalex.org/C160160445","wikidata":"https://www.wikidata.org/wiki/Q24769688","display_name":"Alkaline phosphatase","level":3,"score":0.5487960577011108},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.47018468379974365},{"id":"https://openalex.org/C2776079296","wikidata":"https://www.wikidata.org/wiki/Q139195","display_name":"Calcitriol","level":3,"score":0.4465569257736206},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3135688006877899},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12961924076080322},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.07392051815986633},{"id":"https://openalex.org/C2992686903","wikidata":"https://www.wikidata.org/wiki/Q208453","display_name":"Smooth muscle","level":2,"score":0.06290078163146973}],"mesh":[{"descriptor_ui":"D000469","descriptor_name":"Alkaline Phosphatase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002114","descriptor_name":"Calcinosis","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D002117","descriptor_name":"Calcitriol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010024","descriptor_name":"Osteoporosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012795","descriptor_name":"Sialoglycoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014807","descriptor_name":"Vitamin D","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D044162","descriptor_name":"Parathyroid Hormone-Related Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053495","descriptor_name":"Osteopontin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1161/01.cir.98.13.1302","doi":"https://doi.org/10.1161/01.cir.98.13.1302","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.cir.98.13.1302","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},{"id":"pmid:9751679","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9751679","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"Journal Article"},{"id":"mag:2884918336","doi":null,"is_oa":false,"landing_page_url":"https://www.ahajournals.org/doi/10.1161/circ.98.13.1302","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Circulation","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.1021.2672","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1021.2672","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://circ.ahajournals.org/content/circulationaha/98/13/1302.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W55215458","https://openalex.org/W294180112","https://openalex.org/W342690822","https://openalex.org/W1831770943","https://openalex.org/W1965142759","https://openalex.org/W1966120281","https://openalex.org/W1985227017","https://openalex.org/W1991353944","https://openalex.org/W1995591865","https://openalex.org/W1999373176","https://openalex.org/W2000458563","https://openalex.org/W2001954819","https://openalex.org/W2007990336","https://openalex.org/W2011566523","https://openalex.org/W2014130178","https://openalex.org/W2020067119","https://openalex.org/W2028995035","https://openalex.org/W2045812196","https://openalex.org/W2047173144","https://openalex.org/W2059092365","https://openalex.org/W2060829846","https://openalex.org/W2063079389","https://openalex.org/W2069258124","https://openalex.org/W2071154926","https://openalex.org/W2076649968","https://openalex.org/W2083894784","https://openalex.org/W2084979251","https://openalex.org/W2090080506","https://openalex.org/W2090668361","https://openalex.org/W2094291999","https://openalex.org/W2101334610","https://openalex.org/W2112692194","https://openalex.org/W2134294326","https://openalex.org/W2147834547","https://openalex.org/W2159593975","https://openalex.org/W2166158412","https://openalex.org/W2314110838","https://openalex.org/W2324018828","https://openalex.org/W4252543199"],"related_works":["https://openalex.org/W2159593975","https://openalex.org/W2002744984","https://openalex.org/W2171778929","https://openalex.org/W2001746382","https://openalex.org/W2035156297","https://openalex.org/W2041091710","https://openalex.org/W2092993166","https://openalex.org/W1562365304","https://openalex.org/W2109451187"],"abstract_inverted_index":{"BACKGROUND:":[0],"A":[1],"significant":[2],"association":[3],"between":[4],"vascular":[5,19,44,63,73,90,173,190,212],"calcification":[6,20,87,100,174],"and":[7,101,117,202],"osteoporosis":[8],"has":[9],"been":[10],"noted,":[11],"suggesting":[12],"that":[13,33,49,166],"calcium":[14,71],"homeostasis":[15],"is":[16],"important":[17],"in":[18,24,68,72,85,113,152,183,211],"as":[21,23,37,185],"well":[22],"osteoporosis.":[25],"Moreover,":[26,192],"results":[27],"of":[28,62,70,82,109,131,142,147,178,181,189,196],"our":[29],"previous":[30],"studies":[31],"suggest":[32,165],"calcium-regulating":[34,60],"hormones":[35],"such":[36],"parathyroid":[38],"hormone-related":[39],"peptide":[40],"(PTHrP)":[41],"may":[42,53,205],"modulate":[43],"calcification.":[45,161,191,213],"Therefore,":[46],"we":[47],"hypothesized":[48],"1alpha,25-dihydroxyvitamin":[50],"D3":[51],"[1,25(OH)2D3]":[52],"have":[54],"a":[55,114,169],"direct":[56,176],"impact":[57],"on":[58,84,133,159,172,198],"the":[59,80,128,140,143,148,179,193],"system":[61],"smooth":[64,91],"muscle":[65,92],"cells,":[66],"resulting":[67],"deposition":[69],"wall.":[74],"METHODS":[75],"AND":[76],"RESULTS:":[77],"We":[78],"investigated":[79],"effect":[81,130,171],"1,25(OH)2D3":[83,95,105,132,136,167,197],"vitro":[86],"by":[88,111],"bovine":[89],"cells":[93],"(BVSMCs).":[94],"dose":[96,137],"dependently":[97,138],"increased":[98,139],"BVSMC":[99,160],"alkaline":[102,199],"phosphatase":[103,200],"activity.":[104],"also":[106],"decreased":[107],"secretion":[108],"PTHrP":[110,124,182],"BVSMCs":[112,184],"dose-dependent":[115],"manner":[116],"depressed":[118],"its":[119,156,208],"gene":[120],"expression.":[121],"Furthermore,":[122],"exogenous":[123],"(fragment":[125],"1-34)":[126],"antagonized":[127],"stimulatory":[129,157,170,194],"BVSMCs.":[134],"Finally,":[135],"expression":[141,180,204],"osteopontin":[144,203],"gene,":[145],"one":[146],"bone":[149],"matrix":[150],"proteins":[151],"BVSMCs,":[153],"contributing":[154],"to":[155,207],"action":[158,210],"CONCLUSIONS:":[162],"These":[163],"data":[164],"exerts":[168],"through":[175],"inhibition":[177],"an":[186],"endogenous":[187],"inhibitor":[188],"effects":[195],"activity":[201],"contribute":[206],"promoting":[209]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":15},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-15T12:55:33.944570","created_date":"2016-06-24T00:00:00"}
