{"id":"https://openalex.org/W2164560653","doi":"https://doi.org/10.1073/pnas.97.17.9413","title":"The crystal structure of d- lactate dehydrogenase, a peripheral membrane respiratory enzyme","display_name":"The crystal structure of d- lactate dehydrogenase, a peripheral membrane respiratory enzyme","publication_year":2000,"publication_date":"2000-08-15","ids":{"openalex":"https://openalex.org/W2164560653","doi":"https://doi.org/10.1073/pnas.97.17.9413","mag":"2164560653","pmid":"https://pubmed.ncbi.nlm.nih.gov/10944213","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/16878"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.97.17.9413","doi":"https://doi.org/10.1073/pnas.97.17.9413","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.97.17.9413","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC16878","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027545846","display_name":"Orly Dym","orcid":"https://orcid.org/0000-0002-4394-4971","observed_orcids":["https://orcid.org/0000-0002-4394-4971"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I74973139","display_name":"Carnegie Mellon University","ror":"https://ror.org/05x2bcf33","country_code":"US","type":"education","lineage":["https://openalex.org/I74973139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Orly Dym","raw_affiliation_strings":["Department of Energy Laboratory of Structural Biology and Molecular Medicine, Department of Chemistry and Biochemistry, Molecular Biology Institute, and Department of Biological Chemistry, University of California, Los Angeles, CA 90095; and Department of Biological Sciences, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, PA 15213"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Energy Laboratory of Structural Biology and Molecular Medicine, Department of Chemistry and Biochemistry, Molecular Biology Institute, and Department of Biological Chemistry, University of California, Los Angeles, CA 90095; and Department of Biological Sciences, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, PA 15213","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I74973139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087798666","display_name":"E.A. Pratt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I74973139","display_name":"Carnegie Mellon University","ror":"https://ror.org/05x2bcf33","country_code":"US","type":"education","lineage":["https://openalex.org/I74973139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth Ann Pratt","raw_affiliation_strings":["Department of Energy Laboratory of Structural Biology and Molecular Medicine, Department of Chemistry and Biochemistry, Molecular Biology Institute, and Department of Biological Chemistry, University of California, Los Angeles, CA 90095; and Department of Biological Sciences, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, PA 15213"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Energy Laboratory of Structural Biology and Molecular Medicine, Department of Chemistry and Biochemistry, Molecular Biology Institute, and Department of Biological Chemistry, University of California, Los Angeles, CA 90095; and Department of Biological Sciences, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, PA 15213","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I74973139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102955816","display_name":"Chien Ho","orcid":"https://orcid.org/0000-0002-4094-9232","observed_orcids":["https://orcid.org/0000-0002-4094-9232"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I74973139","display_name":"Carnegie Mellon University","ror":"https://ror.org/05x2bcf33","country_code":"US","type":"education","lineage":["https://openalex.org/I74973139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chien Ho","raw_affiliation_strings":["Department of Energy Laboratory of Structural Biology and Molecular Medicine, Department of Chemistry and Biochemistry, Molecular Biology Institute, and Department of Biological Chemistry, University of California, Los Angeles, CA 90095; and Department of Biological Sciences, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, PA 15213"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Energy Laboratory of Structural Biology and Molecular Medicine, Department of Chemistry and Biochemistry, Molecular Biology Institute, and Department of Biological Chemistry, University of California, Los Angeles, CA 90095; and Department of Biological Sciences, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, PA 15213","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I74973139"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080439570","display_name":"David S Eisenberg","orcid":"https://orcid.org/0000-0003-2432-5419","observed_orcids":["https://orcid.org/0000-0003-2432-5419"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I74973139","display_name":"Carnegie Mellon University","ror":"https://ror.org/05x2bcf33","country_code":"US","type":"education","lineage":["https://openalex.org/I74973139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Eisenberg","raw_affiliation_strings":["Department of Energy Laboratory of Structural Biology and Molecular Medicine, Department of Chemistry and Biochemistry, Molecular Biology Institute, and Department of Biological Chemistry, University of California, Los Angeles, CA 90095; and Department of Biological Sciences, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, PA 15213"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Energy Laboratory of Structural Biology and Molecular Medicine, Department of Chemistry and Biochemistry, Molecular Biology Institute, and Department of Biological Chemistry, University of California, Los Angeles, CA 90095; and Department of Biological Sciences, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, PA 15213","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I74973139"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.8192,"has_fulltext":false,"cited_by_count":120,"citation_normalized_percentile":{"value":0.90824181,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"97","issue":"17","first_page":"9413","last_page":"9418"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/d-lactate-dehydrogenase","display_name":"D-lactate dehydrogenase","score":0.9610000252723694},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.9940000176429749},{"id":"https://openalex.org/keywords/peripheral-membrane-proteins","display_name":"peripheral membrane proteins","score":0.6650000214576721},{"id":"https://openalex.org/keywords/fad-binding-domain","display_name":"FAD-binding domain","score":0.8209999799728394},{"id":"https://openalex.org/keywords/cap-domain","display_name":"cap domain","score":0.9290000200271606},{"id":"https://openalex.org/keywords/membrane-binding-domain","display_name":"membrane-binding domain","score":0.9990000128746033},{"id":"https://openalex.org/keywords/electron-transfer","display_name":"electron transfer","score":0.5320000052452087},{"id":"https://openalex.org/keywords/inner-membrane","display_name":"inner membrane","score":0.671999990940094},{"id":"https://openalex.org/keywords/protein-crystal-structure","display_name":"protein crystal structure","score":0.5080000162124634}],"concepts":[{"id":"https://openalex.org/C197957613","wikidata":"https://www.wikidata.org/wiki/Q407280","display_name":"Cofactor","level":3,"score":0.6363025307655334},{"id":"https://openalex.org/C2775859393","wikidata":"https://www.wikidata.org/wiki/Q28746","display_name":"Flavin adenine dinucleotide","level":4,"score":0.6259035468101501},{"id":"https://openalex.org/C2777318727","wikidata":"https://www.wikidata.org/wiki/Q409464","display_name":"Lactate dehydrogenase","level":3,"score":0.545326828956604},{"id":"https://openalex.org/C33093398","wikidata":"https://www.wikidata.org/wiki/Q174337","display_name":"Flavin group","level":3,"score":0.5442264080047607},{"id":"https://openalex.org/C2779268744","wikidata":"https://www.wikidata.org/wiki/Q407479","display_name":"Oxidoreductase","level":3,"score":0.5181794762611389},{"id":"https://openalex.org/C560191","wikidata":"https://www.wikidata.org/wiki/Q417736","display_name":"Peripheral membrane protein","level":5,"score":0.5164225697517395},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5146992802619934},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.48008543252944946},{"id":"https://openalex.org/C2776317432","wikidata":"https://www.wikidata.org/wiki/Q412547","display_name":"Dehydrogenase","level":3,"score":0.4553632140159607},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.45475518703460693},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.45383548736572266},{"id":"https://openalex.org/C24530287","wikidata":"https://www.wikidata.org/wiki/Q424204","display_name":"Transmembrane protein","level":3,"score":0.4299900531768799},{"id":"https://openalex.org/C118892022","wikidata":"https://www.wikidata.org/wiki/Q7834587","display_name":"Transmembrane domain","level":3,"score":0.4201153516769409},{"id":"https://openalex.org/C144647389","wikidata":"https://www.wikidata.org/wiki/Q423042","display_name":"Membrane protein","level":3,"score":0.39494797587394714},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3742212653160095},{"id":"https://openalex.org/C161200384","wikidata":"https://www.wikidata.org/wiki/Q1757382","display_name":"Integral membrane protein","level":4,"score":0.3402057886123657},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.10894030332565308}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D005182","descriptor_name":"Flavin-Adenine Dinucleotide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007770","descriptor_name":"L-Lactate Dehydrogenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007770","descriptor_name":"L-Lactate Dehydrogenase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019069","descriptor_name":"Cell Respiration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019344","descriptor_name":"Lactic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055672","descriptor_name":"Static Electricity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.97.17.9413","doi":"https://doi.org/10.1073/pnas.97.17.9413","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.97.17.9413","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:188496","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC16878","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:16878","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/16878","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:10944213","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10944213","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:188496","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC16878","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W1127888983","https://openalex.org/W1525759724","https://openalex.org/W1539796472","https://openalex.org/W1583493118","https://openalex.org/W1600281368","https://openalex.org/W1936207504","https://openalex.org/W1964442771","https://openalex.org/W1965277349","https://openalex.org/W1970269905","https://openalex.org/W1985062030","https://openalex.org/W1986191025","https://openalex.org/W1990549357","https://openalex.org/W1991655565","https://openalex.org/W1993404146","https://openalex.org/W1995017064","https://openalex.org/W1997199912","https://openalex.org/W2001641653","https://openalex.org/W2004202306","https://openalex.org/W2013083986","https://openalex.org/W2014774062","https://openalex.org/W2017900528","https://openalex.org/W2022058405","https://openalex.org/W2022681616","https://openalex.org/W2027573930","https://openalex.org/W2028231353","https://openalex.org/W2032371938","https://openalex.org/W2040952692","https://openalex.org/W2044082153","https://openalex.org/W2052588312","https://openalex.org/W2055043387","https://openalex.org/W2058222339","https://openalex.org/W2060214074","https://openalex.org/W2071486470","https://openalex.org/W2072472542","https://openalex.org/W2078248419","https://openalex.org/W2080476827","https://openalex.org/W2081912151","https://openalex.org/W2102993309","https://openalex.org/W2106315897","https://openalex.org/W2115350007","https://openalex.org/W2122519344","https://openalex.org/W2125635028","https://openalex.org/W2485071058"],"related_works":["https://openalex.org/W2072472542","https://openalex.org/W2017900528","https://openalex.org/W2074316307","https://openalex.org/W2032371938","https://openalex.org/W2058222339","https://openalex.org/W1979238462","https://openalex.org/W1874661165","https://openalex.org/W1971653971","https://openalex.org/W2042737404","https://openalex.org/W1990133970"],"abstract_inverted_index":{"d-Lactate":[0],"dehydrogenase":[1],"(d-LDH)":[2],"of":[3,21,29,39,54,58,79,97,103,125,139,170],"Escherichia":[4],"coli":[5],"is":[6,34,129,134],"a":[7,83,98],"peripheral":[8],"membrane":[9,179],"respiratory":[10],"enzyme":[11],"involved":[12],"in":[13,137],"electron":[14],"transfer,":[15],"located":[16],"on":[17],"the":[18,22,27,47,55,60,66,70,77,110,122,126,130,164,171,178],"cytoplasmic":[19],"side":[20],"inner":[23],"membrane.":[24,172],"d-LDH":[25,120,146,174],"catalyzes":[26],"oxidation":[28],"d-lactate":[30,80],"to":[31,36,94,109,176],"pyruvate,":[32],"which":[33,133,160],"coupled":[35],"transmembrane":[37],"transport":[38],"amino":[40],"acids":[41],"and":[42,69,88,121,156],"sugars.":[43],"Here":[44],"we":[45],"describe":[46],"crystal":[48],"structure":[49],"at":[50],"1.9":[51],"A":[52],"resolution":[53],"three":[56],"domains":[57],"d-LDH:":[59],"flavin":[61],"adenine":[62],"dinucleotide":[63],"(FAD)-binding":[64],"domain,":[65,68,132],"cap":[67,111],"membrane-binding":[71,131,147],"domain.":[72],"The":[73,115,145],"FAD-binding":[74],"domain":[75,112,148],"contains":[76],"site":[78],"reduction":[81],"by":[82],"noncovalently":[84],"bound":[85],"FAD":[86],"cofactor":[87],"has":[89],"an":[90,150],"overall":[91],"fold":[92],"similar":[93],"other":[95,123],"members":[96,124],"recently":[99],"discovered":[100],"FAD-containing":[101,127],"family":[102,128],"proteins.":[104],"This":[105],"structural":[106],"similarity":[107],"extends":[108],"as":[113],"well.":[114],"most":[116],"prominent":[117],"difference":[118],"between":[119],"either":[135],"absent":[136],"some":[138],"these":[140],"proteins":[141],"or":[142],"differs":[143],"significantly.":[144],"presents":[149],"electropositive":[151],"surface":[152],"with":[153,163],"six":[154],"Arg":[155],"five":[157],"Lys":[158],"residues,":[159],"presumably":[161],"interacts":[162],"negatively":[165],"charged":[166],"phospholipid":[167],"head":[168],"groups":[169],"Thus,":[173],"appears":[175],"bind":[177],"through":[180],"electrostatic":[181],"rather":[182],"than":[183],"hydrophobic":[184],"forces.":[185]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
