{"id":"https://openalex.org/W2164536686","doi":"https://doi.org/10.1038/sj.bjc.6603322","title":"CPT-11 and concomitant hyperfractionated accelerated radiotherapy induce efficient local control in rectal cancer patients: results from a phase II","display_name":"CPT-11 and concomitant hyperfractionated accelerated radiotherapy induce efficient local control in rectal cancer patients: results from a phase II","publication_year":2006,"publication_date":"2006-08-29","ids":{"openalex":"https://openalex.org/W2164536686","doi":"https://doi.org/10.1038/sj.bjc.6603322","mag":"2164536686","pmid":"https://pubmed.ncbi.nlm.nih.gov/16940980","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2360515"},"language":"en","primary_location":{"id":"doi:10.1038/sj.bjc.6603322","doi":"https://doi.org/10.1038/sj.bjc.6603322","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.bjc.6603322","pdf_url":"https://www.nature.com/articles/6603322.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.nature.com/articles/6603322.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043292602","display_name":"Verena Voelter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802229882","display_name":"Centre Hospitalier Universitaire Vaudois","ror":"https://ror.org/05a353079","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802229882"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"V Voelter","raw_affiliation_strings":["Multidisciplinary Oncology Centre, The University of Lausanne Hospitals, Rue du Bugnon 46, CH 1011, Lausanne, Switzerland. Verena.Voelter@chuv.ch","Multidisciplinary Oncology Centre, The University of Lausanne Hospitals, Rue du Bugnon 46, Lausanne, 1011, CH, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Multidisciplinary Oncology Centre, The University of Lausanne Hospitals, Rue du Bugnon 46, CH 1011, Lausanne, Switzerland. Verena.Voelter@chuv.ch","institution_ids":["https://openalex.org/I2802229882"]},{"raw_affiliation_string":"Multidisciplinary Oncology Centre, The University of Lausanne Hospitals, Rue du Bugnon 46, Lausanne, 1011, CH, Switzerland","institution_ids":["https://openalex.org/I2802229882"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111769011","display_name":"A. Zouhair","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802229882","display_name":"Centre Hospitalier Universitaire Vaudois","ror":"https://ror.org/05a353079","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802229882"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"A Zouhair","raw_affiliation_strings":["Department of Radio-Oncology, The University of Lausanne Hospitals, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radio-Oncology, The University of Lausanne Hospitals, Lausanne, Switzerland","institution_ids":["https://openalex.org/I2802229882"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041116028","display_name":"Henri Vuilleumier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802229882","display_name":"Centre Hospitalier Universitaire Vaudois","ror":"https://ror.org/05a353079","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802229882"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"H Vuilleumier","raw_affiliation_strings":["Department of Surgery, The University of Lausanne Hospitals, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, The University of Lausanne Hospitals, Lausanne, Switzerland","institution_ids":["https://openalex.org/I2802229882"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036254537","display_name":"Maurice Matter","orcid":"https://orcid.org/0000-0003-1816-3003","observed_orcids":["https://orcid.org/0000-0003-1816-3003"]},"institutions":[{"id":"https://openalex.org/I2802229882","display_name":"Centre Hospitalier Universitaire Vaudois","ror":"https://ror.org/05a353079","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802229882"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"M Matter","raw_affiliation_strings":["Department of Surgery, The University of Lausanne Hospitals, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, The University of Lausanne Hospitals, Lausanne, Switzerland","institution_ids":["https://openalex.org/I2802229882"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083567824","display_name":"Hanifa Bouzour\u00e8ne","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802229882","display_name":"Centre Hospitalier Universitaire Vaudois","ror":"https://ror.org/05a353079","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802229882"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"H Bouzourene","raw_affiliation_strings":["Department of Pathology, The University of Lausanne Hospitals, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, The University of Lausanne Hospitals, Lausanne, Switzerland","institution_ids":["https://openalex.org/I2802229882"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031165822","display_name":"Serge Leyvraz","orcid":"https://orcid.org/0000-0002-5705-6799","observed_orcids":["https://orcid.org/0000-0002-5705-6799"]},"institutions":[{"id":"https://openalex.org/I2802229882","display_name":"Centre Hospitalier Universitaire Vaudois","ror":"https://ror.org/05a353079","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802229882"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"S Leyvraz","raw_affiliation_strings":["Multidisciplinary Oncology Centre, The University of Lausanne Hospitals, Rue du Bugnon 46, Lausanne, 1011, CH, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Multidisciplinary Oncology Centre, The University of Lausanne Hospitals, Rue du Bugnon 46, Lausanne, 1011, CH, Switzerland","institution_ids":["https://openalex.org/I2802229882"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082203249","display_name":"Jean Bauer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802229882","display_name":"Centre Hospitalier Universitaire Vaudois","ror":"https://ror.org/05a353079","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802229882"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"J Bauer","raw_affiliation_strings":["Multidisciplinary Oncology Centre, The University of Lausanne Hospitals, Rue du Bugnon 46, Lausanne, 1011, CH, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Multidisciplinary Oncology Centre, The University of Lausanne Hospitals, Rue du Bugnon 46, Lausanne, 1011, CH, Switzerland","institution_ids":["https://openalex.org/I2802229882"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059710149","display_name":"Philippe Antoine Coucke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802229882","display_name":"Centre Hospitalier Universitaire Vaudois","ror":"https://ror.org/05a353079","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802229882"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"P Coucke","raw_affiliation_strings":["Department of Radio-Oncology, The University of Lausanne Hospitals, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radio-Oncology, The University of Lausanne Hospitals, Lausanne, Switzerland","institution_ids":["https://openalex.org/I2802229882"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053052330","display_name":"Roger Stupp","orcid":"https://orcid.org/0000-0002-5483-3118","observed_orcids":["https://orcid.org/0000-0002-5483-3118"]},"institutions":[{"id":"https://openalex.org/I2802229882","display_name":"Centre Hospitalier Universitaire Vaudois","ror":"https://ror.org/05a353079","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802229882"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"R Stupp","raw_affiliation_strings":["Multidisciplinary Oncology Centre, The University of Lausanne Hospitals, Rue du Bugnon 46, Lausanne, 1011, CH, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Multidisciplinary Oncology Centre, The University of Lausanne Hospitals, Rue du Bugnon 46, Lausanne, 1011, CH, Switzerland","institution_ids":["https://openalex.org/I2802229882"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5043292602"],"corresponding_institution_ids":["https://openalex.org/I2802229882"],"apc_list":{"value":5190,"currency":"USD","value_usd":5190},"apc_paid":{"value":5190,"currency":"USD","value_usd":5190},"fwci":1.8704,"has_fulltext":true,"cited_by_count":24,"citation_normalized_percentile":{"value":0.85591681,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"95","issue":"6","first_page":"710","last_page":"716"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13110","display_name":"Colorectal and Anal Carcinomas","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rectal-cancer","display_name":"rectal cancer","score":0.949999988079071},{"id":"https://openalex.org/keywords/irinotecan","display_name":"irinotecan","score":0.9020000100135803},{"id":"https://openalex.org/keywords/hyperfractionated-accelerated-radiotherapy","display_name":"accelerated hyperfractionated radiotherapy","score":0.9900000095367432},{"id":"https://openalex.org/keywords/neoadjuvant-chemoradiotherapy","display_name":"neoadjuvant chemoradiotherapy","score":0.9850000143051147},{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":0.9160000085830688},{"id":"https://openalex.org/keywords/local-control","display_name":"local control","score":0.7160000205039978},{"id":"https://openalex.org/keywords/distant-metastasis","display_name":"distant metastasis","score":0.6869999766349792},{"id":"https://openalex.org/keywords/disease-free-survival","display_name":"disease-free survival","score":0.8629999756813049},{"id":"https://openalex.org/keywords/total-mesorectal-excision","display_name":"total mesorectal excision","score":0.949999988079071},{"id":"https://openalex.org/keywords/locally-advanced-rectal-adenocarcinoma","display_name":"locally advanced rectal adenocarcinoma","score":0.8930000066757202}],"concepts":[{"id":"https://openalex.org/C2779384505","wikidata":"https://www.wikidata.org/wiki/Q17007513","display_name":"Concomitant","level":2,"score":0.8440650105476379},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6469382643699646},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.5778436660766602},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.49743250012397766},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4106655716896057},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3769243359565735},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3689113259315491},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.33084964752197266}],"mesh":[{"descriptor_ui":"D000077146","descriptor_name":"Irinotecan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002166","descriptor_name":"Camptothecin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002166","descriptor_name":"Camptothecin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D002166","descriptor_name":"Camptothecin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012004","descriptor_name":"Rectal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012004","descriptor_name":"Rectal Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D012004","descriptor_name":"Rectal Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017024","descriptor_name":"Chemotherapy, Adjuvant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018572","descriptor_name":"Disease-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019583","descriptor_name":"Dose Fractionation, Radiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1038/sj.bjc.6603322","doi":"https://doi.org/10.1038/sj.bjc.6603322","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.bjc.6603322","pdf_url":"https://www.nature.com/articles/6603322.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2360515","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2360515","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Cancer","raw_type":"Text"},{"id":"pmid:16940980","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16940980","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of cancer","raw_type":"Clinical Trial, Phase II"},{"id":"pmh:oai:serval.unil.ch:BIB_B1D318829039","doi":null,"is_oa":false,"landing_page_url":"https://serval.unil.ch/notice/serval:BIB_B1D318829039","pdf_url":null,"source":{"id":"https://openalex.org/S4306401797","display_name":"SERVAL (Universit\u00e9 de Lausanne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210093590","host_organization_name":"Swiss School of Archaeology in Greece","host_organization_lineage":["https://openalex.org/I4210093590"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of cancer, vol. 95, no. 6, pp. 710-6","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.281.5212","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.281.5212","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/e2/93/Br_J_Cancer_2006_Sep_18_95(6)_710-716.tar.gz","raw_type":"text"},{"id":"pmh:oai:iris.unil.ch:iris/134344","doi":null,"is_oa":false,"landing_page_url":"https://iris.unil.ch/handle/iris/134344","pdf_url":null,"source":{"id":"https://openalex.org/S7407055444","display_name":"IRIS","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"pmh:oai:orbi.ulg.ac.be:2268/16971","doi":null,"is_oa":true,"landing_page_url":"https://orbi.uliege.be/handle/2268/16971","pdf_url":null,"source":{"id":"https://openalex.org/S4306401300","display_name":"ORBi (University of Li\u00e8ge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I157674565","host_organization_name":"University of Li\u00e8ge","host_organization_lineage":["https://openalex.org/I157674565"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"British Journal of Cancer, 95, 710 \u2013 716 (2006)","raw_type":"http://purl.org/coar/resource_type/c_6501"}],"best_oa_location":{"id":"doi:10.1038/sj.bjc.6603322","doi":"https://doi.org/10.1038/sj.bjc.6603322","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.bjc.6603322","pdf_url":"https://www.nature.com/articles/6603322.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2164536686.pdf","grobid_xml":"https://content.openalex.org/works/W2164536686.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W129238531","https://openalex.org/W1492190372","https://openalex.org/W1585172067","https://openalex.org/W1709006658","https://openalex.org/W1835830368","https://openalex.org/W1971877017","https://openalex.org/W1974902120","https://openalex.org/W1975570770","https://openalex.org/W1979300931","https://openalex.org/W1992134664","https://openalex.org/W1994513558","https://openalex.org/W2020956130","https://openalex.org/W2021416608","https://openalex.org/W2025170170","https://openalex.org/W2033210451","https://openalex.org/W2038118262","https://openalex.org/W2040927823","https://openalex.org/W2043317119","https://openalex.org/W2048049867","https://openalex.org/W2051900682","https://openalex.org/W2054385160","https://openalex.org/W2065526182","https://openalex.org/W2073690763","https://openalex.org/W2077582039","https://openalex.org/W2079015451","https://openalex.org/W2092476472","https://openalex.org/W2097096324","https://openalex.org/W2107371365","https://openalex.org/W2108165913","https://openalex.org/W2111369433","https://openalex.org/W2125452425","https://openalex.org/W2130647939","https://openalex.org/W2132565869","https://openalex.org/W2134785449","https://openalex.org/W2141619797","https://openalex.org/W2155789163","https://openalex.org/W2161376219","https://openalex.org/W2164773004","https://openalex.org/W2170182865","https://openalex.org/W2171232394","https://openalex.org/W2223793069","https://openalex.org/W2226502249","https://openalex.org/W2230940273","https://openalex.org/W2247538063","https://openalex.org/W2265393882","https://openalex.org/W2289638457","https://openalex.org/W2314927739","https://openalex.org/W2323020638","https://openalex.org/W2508832878","https://openalex.org/W2589583141","https://openalex.org/W3041047318","https://openalex.org/W4233200910","https://openalex.org/W4233272864","https://openalex.org/W4248032641"],"related_works":["https://openalex.org/W2111369433","https://openalex.org/W2591225501","https://openalex.org/W7099705597","https://openalex.org/W4236637684","https://openalex.org/W2784182996","https://openalex.org/W2604258773","https://openalex.org/W4206693293","https://openalex.org/W7096791212","https://openalex.org/W2610177354","https://openalex.org/W2247538063"],"abstract_inverted_index":{"Patients":[0],"with":[1,14,30,65,116],"rectal":[2],"cancer":[3],"are":[4],"at":[5],"high":[6],"risk":[7],"of":[8,40,70,104,137,152],"disease":[9],"recurrence":[10,157],"despite":[11],"neoadjuvant":[12,41],"radiochemotherapy":[13],"5-Fluorouracil":[15],"(5FU),":[16],"a":[17,28,66,149,188],"regimen":[18,29],"that":[19,144],"is":[20],"now":[21],"widely":[22],"applied.":[23],"In":[24],"order":[25],"to":[26,50],"develop":[27],"increased":[31],"antitumour":[32],"activity,":[33],"we":[34],"previously":[35],"established":[36],"the":[37,71,138],"recommended":[38],"dose":[39],"CPT-11":[42,105,176],"(three":[43],"times":[44],"weekly":[45],"90":[46],"mg":[47],"m(-2))":[48],"concomitant":[49],"hyperfractionated":[51],"accelerated":[52],"radiotherapy":[53,112],"(HART)":[54],"followed":[55],"by":[56],"surgery":[57],"within":[58,123],"1":[59,124],"week.":[60],"Thirty-three":[61],"patients":[62,99,110,139,161],"(20":[63],"men)":[64],"locally":[67],"advanced":[68],"adenocarcinoma":[69],"rectum":[72],"were":[73],"enrolled":[74],"in":[75,190],"this":[76,191],"prospective":[77],"phase":[78],"II":[79],"trial":[80],"(1":[81],"cT2,":[82],"29":[83],"cT3,":[84],"3":[85,142],"cT4":[86],"and":[87,106,177],"21":[88],"cN+).":[89],"Median":[90],"age":[91],"was":[92,121,132,145,169],"60":[93],"years":[94,154],"(range":[95,126],"43-75":[96],"years).":[97],"All":[98],"received":[100],"all":[101,107],"three":[102],"injections":[103],"but":[108],"two":[109],"completed":[111],"as":[113],"planned.":[114],"Surgery":[115],"total":[117],"mesorectal":[118],"excision":[119],"(TME)":[120],"performed":[122],"week":[125],"2-15":[127],"days).":[128],"The":[129,165],"preoperative":[130],"chemoradiotherapy":[131],"overall":[133],"well":[134],"tolerated,":[135],"24%":[136],"experienced":[140],"grade":[141],"diarrhoea":[143],"easily":[146],"manageable.":[147],"At":[148],"median":[150],"follow-up":[151],"2":[153],"no":[155],"local":[156,182],"occurred,":[158],"however,":[159,184],"nine":[160],"developed":[162],"distant":[163,185],"metastases.":[164],"2-year":[166],"disease-free":[167],"survival":[168],"66%":[170],"(95%":[171],"confidence":[172],"interval":[173],"0.48-0.83).":[174],"Neoadjuvant":[175],"HART":[178],"allow":[179],"for":[180],"excellent":[181],"control;":[183],"relapse":[186],"remains":[187],"concern":[189],"patient":[192],"population.":[193]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
