{"id":"https://openalex.org/W2164496121","doi":null,"title":"Common genes in coronary artery disease from Europe, Asia and North America regardless of race and lifestyle.","display_name":"Common genes in coronary artery disease from Europe, Asia and North America regardless of race and lifestyle.","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2164496121","mag":"2164496121","pmid":"https://pubmed.ncbi.nlm.nih.gov/25855937"},"language":"en","primary_location":{"id":"pmid:25855937","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25855937","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European review for medical and pharmacological sciences","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081381508","display_name":"Rui Gong","orcid":"https://orcid.org/0000-0001-9942-5655","observed_orcids":["https://orcid.org/0000-0001-9942-5655","https://orcid.org/0009-0006-8540-5235"]},"institutions":[{"id":"https://openalex.org/I4210088328","display_name":"Third Hospital of Hebei Medical University","ror":"https://ror.org/004eknx63","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210088328"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"R Gong","raw_affiliation_strings":["Department of Gerontology, and Department of Cardiothoracic Surgery; The Third Municipal Hospital of Shijiazhuang City, Hebei, China. rui_gong619@163.com","Department of Gerontology, and Department of Cardiothoracic Surgery; The Third Municipal Hospital of Shijiazhuang City, Hebei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gerontology, and Department of Cardiothoracic Surgery; The Third Municipal Hospital of Shijiazhuang City, Hebei, China. rui_gong619@163.com","institution_ids":["https://openalex.org/I4210088328"]},{"raw_affiliation_string":"Department of Gerontology, and Department of Cardiothoracic Surgery; The Third Municipal Hospital of Shijiazhuang City, Hebei, China","institution_ids":["https://openalex.org/I4210088328"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108697503","display_name":"Chen Mh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M-H Chen","raw_affiliation_strings":["The Third Municipal Hospital of Shijiazhuang City, Hebei, China. rui_gong619@163.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Third Municipal Hospital of Shijiazhuang City, Hebei, China. rui_gong619@163.com","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015461050","display_name":"Peng Ls","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L-S Peng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5068143798","display_name":"Wei Sl","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S-L Wei","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3459,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.5354598,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"19","issue":"6","first_page":"1092","last_page":"100"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.6172000169754028,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.6172000169754028,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.1793999969959259,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.13009999692440033,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/coronary-artery-disease","display_name":"coronary artery disease","score":1.0},{"id":"https://openalex.org/keywords/differentially-expressed-genes","display_name":"differentially expressed genes","score":0.9390000104904175},{"id":"https://openalex.org/keywords/blood-gene-expression","display_name":"blood gene expression","score":0.6769999861717224},{"id":"https://openalex.org/keywords/protein-protein-interaction-network","display_name":"protein-protein interaction network","score":0.8769999742507935},{"id":"https://openalex.org/keywords/irf4","display_name":"IRF4","score":0.8849999904632568},{"id":"https://openalex.org/keywords/plaur","display_name":"PLAUR","score":0.9980000257492065},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.9089999794960022},{"id":"https://openalex.org/keywords/hub-proteins","display_name":"hub proteins","score":0.6110000014305115},{"id":"https://openalex.org/keywords/diagnostic-biomarkers","display_name":"diagnostic biomarkers","score":0.7580000162124634},{"id":"https://openalex.org/keywords/ethnic-differences","display_name":"ethnic differences","score":0.6169999837875366}],"concepts":[{"id":"https://openalex.org/C2778213512","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary artery disease","level":2,"score":0.6411924362182617},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.565441906452179},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5169781446456909},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5105994343757629},{"id":"https://openalex.org/C194789388","wikidata":"https://www.wikidata.org/wiki/Q17855283","display_name":"CAD","level":2,"score":0.5077729821205139},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4929642677307129},{"id":"https://openalex.org/C76509639","wikidata":"https://www.wikidata.org/wiki/Q918036","display_name":"Race (biology)","level":2,"score":0.43005338311195374},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4260433614253998},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3500819504261017},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3356744647026062},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20044836401939392},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.09050941467285156},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001208","descriptor_name":"Asia","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D003324","descriptor_name":"Coronary Artery Disease","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D003324","descriptor_name":"Coronary Artery Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003324","descriptor_name":"Coronary Artery Disease","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D005060","descriptor_name":"Europe","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008019","descriptor_name":"Life Style","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009656","descriptor_name":"North America","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044469","descriptor_name":"Racial Groups","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:25855937","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25855937","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European review for medical and pharmacological sciences","raw_type":"Journal Article"},{"id":"mag:2164496121","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25855937","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W87932531","https://openalex.org/W1578780319","https://openalex.org/W1964873147","https://openalex.org/W2025001402","https://openalex.org/W2033782300","https://openalex.org/W2044833183","https://openalex.org/W2055669325","https://openalex.org/W2079604465","https://openalex.org/W2083403064","https://openalex.org/W2097831116","https://openalex.org/W2104315543","https://openalex.org/W2113111275","https://openalex.org/W2116212222","https://openalex.org/W2118258530","https://openalex.org/W2121459369","https://openalex.org/W2131594005","https://openalex.org/W2139294174","https://openalex.org/W2142663409","https://openalex.org/W2147340189","https://openalex.org/W2159030877","https://openalex.org/W2159087408","https://openalex.org/W2159675211","https://openalex.org/W2161653644","https://openalex.org/W2163963420","https://openalex.org/W2184466156","https://openalex.org/W2185681744","https://openalex.org/W2300596722"],"related_works":["https://openalex.org/W2216788527","https://openalex.org/W2018819581","https://openalex.org/W3134728196","https://openalex.org/W2106751798","https://openalex.org/W4294577921","https://openalex.org/W7130400160","https://openalex.org/W2012953300","https://openalex.org/W2756351165","https://openalex.org/W3194137039","https://openalex.org/W3139397115"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Coronary":[1],"artery":[2],"disease":[3],"(CAD)":[4],"remains":[5],"one":[6],"of":[7,11,22,50,61,79,97,112,116,133,224,233,237,256,262],"the":[8,18,48,58,69,94,113,177,180,208,225,254],"major":[9],"causes":[10],"death":[12],"worldwide.":[13],"Despite":[14],"considerable":[15],"advances":[16],"in":[17,47,57,89,128,151,162,207,215],"prevention":[19],"and":[20,27,33,85,92,105,136,149,154,166,193,213,218,244,258],"treatment":[21],"CAD,":[23,51],"its":[24],"complications,":[25],"morbidity":[26],"mortality":[28],"still":[29],"remain":[30],"very":[31],"high,":[32],"vary":[34],"widely":[35],"across":[36,107],"different":[37,65,108,164],"ethnic":[38],"groups.":[39],"MATERIALS":[40],"AND":[41],"METHODS:":[42],"To":[43],"detect":[44,203],"genes":[45,100,138,158,168,235],"involved":[46],"development":[49,261],"we":[52,202],"collected":[53],"gene":[54,80,204],"expression":[55,81,205],"studies":[56],"blood":[59,209],"samples":[60,210],"CAD":[62,83,103,147,173,212,257],"patients":[63,84,104,148],"from":[64],"continents":[66],"by":[67,120],"searching":[68],"Gene":[70],"Expression":[71],"Omnibus":[72],"database":[73],"(GEO),":[74],"performed":[75],"a":[76,230],"comparative":[77],"analysis":[78,223],"between":[82,102,146,211],"normal":[86],"controls":[87],"(NC)":[88],"each":[90],"continent":[91],"identified":[93,140],"common":[95,114,161,231],"set":[96,115,232],"differentially":[98,144],"expressed":[99,145],"(DEGs)":[101],"NC":[106,150,214],"continents.":[109],"PPI":[110],"networks":[111],"DEGs":[117],"were":[118,139,159,169],"established":[119],"Cytoscape":[121],"software":[122],"to":[123,141,172,240,252,260],"understand":[124,253],"their":[125],"biological":[126],"role":[127],"CAD.":[129],"RESULTS:":[130],"A":[131],"total":[132],"575,":[134],"868":[135],"476":[137],"be":[142],"significantly":[143],"Asia,":[152,216],"Europe":[153,217],"North":[155,219],"America.":[156],"24":[157,234],"found":[160],"three":[163,226],"continents,":[165],"6":[167],"previously":[170],"linked":[171],"or":[174],"atherosclerosis.":[175],"In":[176],"PPIs":[178],"network":[179],"significant":[181],"hub":[182],"proteins":[183],"contained":[184],"IRF4":[185],"(Degree":[186,190,195],"=":[187,191,196],"23),":[188],"PLAUR":[189],"17)":[192],"HIST1H2AE":[194],"15).":[197],"CONCLUSIONS:":[198],"Not":[199],"only":[200],"did":[201],"differences":[206,238],"America":[220],"population,":[221],"but":[222],"population":[227],"groups":[228],"revealed":[229],"regardless":[236],"related":[239],"race,":[241],"ethnicity,":[242],"lifestyle,":[243],"environmental":[245],"factor":[246],"which":[247],"may":[248],"provide":[249],"key":[250],"factors":[251],"pathogenesis":[255],"lead":[259],"diagnostic":[263],"markers":[264],"and/or":[265],"effective":[266],"therapeutic":[267],"strategies.":[268]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}