{"id":"https://openalex.org/W2164355186","doi":"https://doi.org/10.1007/s00396-010-2304-9","title":"Properties of small molecular drug loading and diffusion in a fluorinated PEG hydrogel studied by 1H molecular diffusion NMR and 19F spin diffusion NMR","display_name":"Properties of small molecular drug loading and diffusion in a fluorinated PEG hydrogel studied by 1H molecular diffusion NMR and 19F spin diffusion NMR","publication_year":2010,"publication_date":"2010-10-04","ids":{"openalex":"https://openalex.org/W2164355186","doi":"https://doi.org/10.1007/s00396-010-2304-9","mag":"2164355186","pmid":"https://pubmed.ncbi.nlm.nih.gov/21170115","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2982959"},"language":"en","primary_location":{"id":"doi:10.1007/s00396-010-2304-9","doi":"https://doi.org/10.1007/s00396-010-2304-9","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00396-010-2304-9","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00396-010-2304-9.pdf","source":{"id":"https://openalex.org/S100444939","display_name":"Colloid & Polymer Science","issn_l":"0303-402X","issn":["0303-402X","1435-1536"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Colloid and Polymer Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s00396-010-2304-9.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051036721","display_name":"Errol V. Mathias","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27825529","display_name":"California State University Los Angeles","ror":"https://ror.org/0294hxs80","country_code":"US","type":"education","lineage":["https://openalex.org/I27825529"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Errol V. Mathias","raw_affiliation_strings":["Department of Chemistry and Biochemistry, California State University Los Angeles, Los Angeles, CA, 90032, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, California State University Los Angeles, Los Angeles, CA, 90032, USA","institution_ids":["https://openalex.org/I27825529"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052195422","display_name":"Julia Aponte","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27825529","display_name":"California State University Los Angeles","ror":"https://ror.org/0294hxs80","country_code":"US","type":"education","lineage":["https://openalex.org/I27825529"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julia Aponte","raw_affiliation_strings":["Department of Chemistry and Biochemistry, California State University Los Angeles, Los Angeles, CA, 90032, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, California State University Los Angeles, Los Angeles, CA, 90032, USA","institution_ids":["https://openalex.org/I27825529"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027193673","display_name":"Julia  Ann Kornfield","orcid":"https://orcid.org/0000-0001-6746-8634","observed_orcids":["https://orcid.org/0000-0001-6746-8634"]},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julia A. Kornfield","raw_affiliation_strings":["Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, 91125, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, 91125, USA","institution_ids":["https://openalex.org/I122411786"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011509212","display_name":"Yong Ba","orcid":"https://orcid.org/0000-0003-1079-4708","observed_orcids":["https://orcid.org/0000-0003-1079-4708"]},"institutions":[{"id":"https://openalex.org/I27825529","display_name":"California State University Los Angeles","ror":"https://ror.org/0294hxs80","country_code":"US","type":"education","lineage":["https://openalex.org/I27825529"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yong Ba","raw_affiliation_strings":["Department of Chemistry and Biochemistry, California State University Los Angeles, Los Angeles, CA, 90032, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, California State University Los Angeles, Los Angeles, CA, 90032, USA","institution_ids":["https://openalex.org/I27825529"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5011509212"],"corresponding_institution_ids":["https://openalex.org/I27825529"],"apc_list":{"value":3990,"currency":"USD","value_usd":3990},"apc_paid":{"value":3990,"currency":"USD","value_usd":3990},"fwci":0.1493,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.54337437,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"288","issue":"18","first_page":"1655","last_page":"1663"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.7211999893188477,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.7211999893188477,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12603","display_name":"NMR spectroscopy and applications","score":0.2572999894618988,"subfield":{"id":"https://openalex.org/subfields/3106","display_name":"Nuclear and High Energy Physics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.006099999882280827,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug-loading","display_name":"drug loading","score":0.8610000014305115},{"id":"https://openalex.org/keywords/drug-diffusion","display_name":"drug diffusion","score":0.8529999852180481},{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":0.9210000038146973},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.6579999923706055},{"id":"https://openalex.org/keywords/diffusion-coefficient","display_name":"diffusion coefficient","score":0.6549999713897705},{"id":"https://openalex.org/keywords/hindered-diffusion","display_name":"hindered diffusion","score":0.8130000233650208},{"id":"https://openalex.org/keywords/diffusion-models","display_name":"diffusion models","score":0.7699999809265137}],"concepts":[{"id":"https://openalex.org/C69357855","wikidata":"https://www.wikidata.org/wiki/Q163214","display_name":"Diffusion","level":2,"score":0.7294015884399414},{"id":"https://openalex.org/C54400483","wikidata":"https://www.wikidata.org/wiki/Q1793202","display_name":"PEG ratio","level":2,"score":0.6568594574928284},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5904120802879333},{"id":"https://openalex.org/C103319777","wikidata":"https://www.wikidata.org/wiki/Q1979695","display_name":"Proton NMR","level":2,"score":0.5864923000335693},{"id":"https://openalex.org/C2778928649","wikidata":"https://www.wikidata.org/wiki/Q7577402","display_name":"Spin diffusion","level":3,"score":0.5491634607315063},{"id":"https://openalex.org/C57736034","wikidata":"https://www.wikidata.org/wiki/Q17104113","display_name":"Molecular diffusion","level":3,"score":0.5355714559555054},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.5182716250419617},{"id":"https://openalex.org/C65177555","wikidata":"https://www.wikidata.org/wiki/Q4162539","display_name":"Diffusion layer","level":3,"score":0.49194595217704773},{"id":"https://openalex.org/C2777516009","wikidata":"https://www.wikidata.org/wiki/Q194207","display_name":"Ethylene glycol","level":2,"score":0.4857357144355774},{"id":"https://openalex.org/C44280652","wikidata":"https://www.wikidata.org/wiki/Q104837","display_name":"Phase (matter)","level":2,"score":0.47165051102638245},{"id":"https://openalex.org/C113196181","wikidata":"https://www.wikidata.org/wiki/Q485223","display_name":"Analytical Chemistry (journal)","level":2,"score":0.3343903422355652},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.2501102387905121},{"id":"https://openalex.org/C2779227376","wikidata":"https://www.wikidata.org/wiki/Q6505497","display_name":"Layer (electronics)","level":2,"score":0.2280537486076355},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.1047258973121643},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C10138342","wikidata":"https://www.wikidata.org/wiki/Q43015","display_name":"Finance","level":1,"score":0.0},{"id":"https://openalex.org/C176217482","wikidata":"https://www.wikidata.org/wiki/Q860554","display_name":"Metric (unit)","level":2,"score":0.0},{"id":"https://openalex.org/C21547014","wikidata":"https://www.wikidata.org/wiki/Q1423657","display_name":"Operations management","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1007/s00396-010-2304-9","doi":"https://doi.org/10.1007/s00396-010-2304-9","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00396-010-2304-9","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00396-010-2304-9.pdf","source":{"id":"https://openalex.org/S100444939","display_name":"Colloid & Polymer Science","issn_l":"0303-402X","issn":["0303-402X","1435-1536"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Colloid and Polymer Science","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2982959","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2982959","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Colloid Polym Sci","raw_type":"Text"},{"id":"pmid:21170115","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21170115","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Colloid and polymer science","raw_type":"Journal Article"},{"id":"pmh:oai:authors.library.caltech.edu:104627","doi":null,"is_oa":true,"landing_page_url":"https://resolver.caltech.edu/CaltechAUTHORS:20200728-174942361","pdf_url":null,"source":{"id":"https://openalex.org/S4306402161","display_name":"CaltechAUTHORS (California Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I122411786","host_organization_name":"California Institute of Technology","host_organization_lineage":["https://openalex.org/I122411786"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:authors.library.caltech.edu:21386","doi":null,"is_oa":true,"landing_page_url":"https://authors.library.caltech.edu/21386/","pdf_url":null,"source":{"id":"https://openalex.org/S4306402161","display_name":"CaltechAUTHORS (California Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I122411786","host_organization_name":"California Institute of Technology","host_organization_lineage":["https://openalex.org/I122411786"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1007/s00396-010-2304-9","doi":"https://doi.org/10.1007/s00396-010-2304-9","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00396-010-2304-9","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00396-010-2304-9.pdf","source":{"id":"https://openalex.org/S100444939","display_name":"Colloid & Polymer Science","issn_l":"0303-402X","issn":["0303-402X","1435-1536"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Colloid and Polymer Science","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4210713355","display_name":"MRI:  Acquisition of Instrumentation for Upgrading NMR Facilities at California State University, Los Angeles (CSULA)","funder_award_id":"0619147","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G4974634683","display_name":"CSULA-Caltech PREM Collaborative","funder_award_id":"0351848","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2164355186.pdf","grobid_xml":"https://content.openalex.org/works/W2164355186.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W110285710","https://openalex.org/W170942342","https://openalex.org/W1800156099","https://openalex.org/W1970439684","https://openalex.org/W1974096024","https://openalex.org/W1977029845","https://openalex.org/W1979475736","https://openalex.org/W1984804624","https://openalex.org/W1993651535","https://openalex.org/W1996648993","https://openalex.org/W1997040041","https://openalex.org/W1998982814","https://openalex.org/W2007136633","https://openalex.org/W2011906397","https://openalex.org/W2022803091","https://openalex.org/W2026404635","https://openalex.org/W2035564283","https://openalex.org/W2037099613","https://openalex.org/W2038475538","https://openalex.org/W2046072169","https://openalex.org/W2053617401","https://openalex.org/W2061863119","https://openalex.org/W2061959155","https://openalex.org/W2063425838","https://openalex.org/W2063612662","https://openalex.org/W2068860991","https://openalex.org/W2074770586","https://openalex.org/W2075233173","https://openalex.org/W2077046455","https://openalex.org/W2084761689","https://openalex.org/W2100485464","https://openalex.org/W2104630973","https://openalex.org/W2104877590","https://openalex.org/W2117025288","https://openalex.org/W2139278311","https://openalex.org/W2161611257","https://openalex.org/W2163206218","https://openalex.org/W2285380671","https://openalex.org/W2950630380","https://openalex.org/W4253345956","https://openalex.org/W6837471679"],"related_works":["https://openalex.org/W7100892693","https://openalex.org/W2061863119","https://openalex.org/W4410416704","https://openalex.org/W1852131831","https://openalex.org/W2114606344","https://openalex.org/W7100274626","https://openalex.org/W2197726151","https://openalex.org/W4212908067","https://openalex.org/W2065346641","https://openalex.org/W2439898864"],"abstract_inverted_index":{"R(f)-PEG":[0,54],"(fluoroalkyl":[1],"double-ended":[2],"poly(ethylene":[3],"glycol))":[4],"hydrogel":[5,55],"is":[6,143,213],"potentially":[7],"useful":[8,214],"as":[9,124],"a":[10,74,106,125,154],"drug":[11,47,166,179,218,229],"delivery":[12,230],"depot":[13],"due":[14],"to":[15,44,121,127,159],"its":[16,63],"advanced":[17],"properties":[18,51,222],"of":[19,52,81,86,94,109,138,164,177,191,228],"sol-gel":[20],"two-phase":[21],"coexistence":[22],"and":[23,37,49,62,83,132,187,220],"low":[24],"surface":[25],"erosion.":[26],"In":[27],"this":[28],"study,":[29],"(1)H":[30],"molecular":[31,205],"diffusion":[32,40,50,77,85,97,155,163,176,206,211,221],"nuclear":[33],"magnetic":[34],"resonance":[35],"(NMR)":[36],"(19)F":[38,95],"spin":[39,96,210],"NMR":[41,98,207,212],"were":[42],"used":[43],"probe":[45,193],"the":[46,53,84,87,100,113,129,133,141,146,151,165,169,178,182,192,196,217,226],"loading":[48,219],"for":[56,99,225],"small":[57],"anticancer":[58],"drugs,":[59],"5-fluorouracil":[60],"(FU)":[61],"hydrophobic":[64],"analog,":[65],"1,3-dimethyl-5-fluorouracil":[66],"(DMFU).":[67],"It":[68],"was":[69,89,157],"found":[70],"that":[71,80,105,137,204],"FU":[72,139],"has":[73],"larger":[75,107],"apparent":[76],"coefficient":[78],"than":[79,136],"DMFU,":[82],"latter":[88],"more":[90],"hindered.":[91],"The":[92],"result":[93],"corresponding":[101],"freeze-dried":[102],"samples":[103],"indicates":[104],"portion":[108],"DMFU":[110],"resided":[111],"in":[112,145,168,181,215,223],"R(f)":[114,130,170],"core/IPDU":[115],"intermediate-layer":[116],"region":[117],"(where":[118],"IPDU":[119],"refers":[120],"isophorone":[122],"diurethane,":[123],"linker":[126],"interconnect":[128],"group":[131],"PEG":[134],"chain)":[135],"while":[140],"opposite":[142],"true":[144],"PEG-water":[147,183],"phase.":[148],"To":[149],"understand":[150],"experimental":[152],"data,":[153],"model":[156],"proposed":[158],"include:":[160],"(1)":[161],"hindered":[162],"molecules":[167,180,194],"core/IPDU-intermediate-layer":[171],"region;":[172],"(2)":[173],"relatively":[174],"free":[175],"phase":[184],"(or":[185],"region);":[186],"(3)":[188],"diffusive":[189],"exchange":[190],"between":[195],"above":[197],"two":[198],"regions.":[199],"This":[200],"study":[201],"also":[202],"shows":[203],"combined":[208],"with":[209],"studying":[216],"hydrogels":[224],"purpose":[227],"applications.":[231]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}
