{"id":"https://openalex.org/W2164331874","doi":"https://doi.org/10.1172/jci115738","title":"Neutrophil elastase in respiratory epithelial lining fluid of individuals with cystic fibrosis induces interleukin-8 gene expression in a human bronchial epithelial cell line.","display_name":"Neutrophil elastase in respiratory epithelial lining fluid of individuals with cystic fibrosis induces interleukin-8 gene expression in a human bronchial epithelial cell line.","publication_year":1992,"publication_date":"1992-05-01","ids":{"openalex":"https://openalex.org/W2164331874","doi":"https://doi.org/10.1172/jci115738","mag":"2164331874","pmid":"https://pubmed.ncbi.nlm.nih.gov/1569186","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/443018"},"language":"en","primary_location":{"id":"doi:10.1172/jci115738","doi":"https://doi.org/10.1172/jci115738","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci115738","pdf_url":"http://www.jci.org/articles/view/115738/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jci.org/articles/view/115738/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101418971","display_name":"Hidenori Nakamura","orcid":"https://orcid.org/0000-0001-9603-2805","observed_orcids":["https://orcid.org/0000-0001-9603-2805"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H Nakamura","raw_affiliation_strings":["Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]},{"author_position":"middle","author":{"id":null,"display_name":"K Yoshimura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K Yoshimura","raw_affiliation_strings":["Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes ofHealth, Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes ofHealth, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034535949","display_name":"Noel Gerard McElvaney","orcid":"https://orcid.org/0000-0002-0152-4370","observed_orcids":["https://orcid.org/0000-0002-0152-4370"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N G McElvaney","raw_affiliation_strings":["Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes ofHealth, Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes ofHealth, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064433832","display_name":"Ronald G. Crystal","orcid":"https://orcid.org/0000-0001-6177-6839","observed_orcids":["https://orcid.org/0000-0001-6177-6839"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R G Crystal","raw_affiliation_strings":["Pulmonary Branch, Building 10, Room 6D03, National Institutes of Health, Be-thesda, MD 20892","Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes ofHealth, Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary Branch, Building 10, Room 6D03, National Institutes of Health, Be-thesda, MD 20892","institution_ids":["https://openalex.org/I1299303238"]},{"raw_affiliation_string":"Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes ofHealth, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":26.0088,"has_fulltext":true,"cited_by_count":479,"citation_normalized_percentile":{"value":0.99757715,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"89","issue":"5","first_page":"1478","last_page":"1484"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cystic-fibrosis","display_name":"cystic fibrosis","score":0.8809999823570251},{"id":"https://openalex.org/keywords/neutrophil-elastase","display_name":"neutrophil elastase","score":0.9940000176429749},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":0.8769999742507935},{"id":"https://openalex.org/keywords/bronchial-epithelial-cells","display_name":"bronchial epithelial cells","score":0.9210000038146973},{"id":"https://openalex.org/keywords/serine-protease-inhibitors","display_name":"serine protease inhibitors","score":0.9039999842643738},{"id":"https://openalex.org/keywords/airway-inflammation","display_name":"airway inflammation","score":0.7730000019073486},{"id":"https://openalex.org/keywords/neutrophil-chemotaxis","display_name":"neutrophil chemotaxis","score":0.8169999718666077}],"concepts":[{"id":"https://openalex.org/C2776317360","wikidata":"https://www.wikidata.org/wiki/Q14905648","display_name":"Neutrophil elastase","level":3,"score":0.8339167833328247},{"id":"https://openalex.org/C68324877","wikidata":"https://www.wikidata.org/wiki/Q421859","display_name":"Interleukin 8","level":3,"score":0.664352536201477},{"id":"https://openalex.org/C87568996","wikidata":"https://www.wikidata.org/wiki/Q1428754","display_name":"Respiratory epithelium","level":3,"score":0.6401232481002808},{"id":"https://openalex.org/C2776938444","wikidata":"https://www.wikidata.org/wiki/Q178194","display_name":"Cystic fibrosis","level":2,"score":0.6119992136955261},{"id":"https://openalex.org/C2781044401","wikidata":"https://www.wikidata.org/wiki/Q418897","display_name":"Elastase","level":3,"score":0.5533463954925537},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.5528382062911987},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.5503152012825012},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.548714816570282},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5197274684906006},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.48816806077957153},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.4827941656112671},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4554256796836853},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.4348582923412323},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.43287092447280884},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.4282689094543457},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.218978613615036},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.09834316372871399},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06719619035720825},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001980","descriptor_name":"Bronchi","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D001992","descriptor_name":"Bronchoalveolar Lavage Fluid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002634","descriptor_name":"Chemotaxis, Leukocyte","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003550","descriptor_name":"Cystic Fibrosis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D009838","descriptor_name":"Oligodeoxyribonucleotides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010196","descriptor_name":"Pancreatic Elastase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016209","descriptor_name":"Interleukin-8","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1172/jci115738","doi":"https://doi.org/10.1172/jci115738","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci115738","pdf_url":"http://www.jci.org/articles/view/115738/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:443018","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/443018","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"},{"id":"pmid:1569186","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1569186","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.1032.2640","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1032.2640","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://dm5migu4zj3pb.cloudfront.net/manuscripts/115000/115738/JCI92115738.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1172/jci115738","doi":"https://doi.org/10.1172/jci115738","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci115738","pdf_url":"http://www.jci.org/articles/view/115738/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2164331874.pdf","grobid_xml":"https://content.openalex.org/works/W2164331874.grobid-xml"},"referenced_works_count":59,"referenced_works":["https://openalex.org/W93674685","https://openalex.org/W1490744061","https://openalex.org/W1499193732","https://openalex.org/W1516696899","https://openalex.org/W1550521303","https://openalex.org/W1553673732","https://openalex.org/W1587291838","https://openalex.org/W1597016336","https://openalex.org/W1631703988","https://openalex.org/W1786021994","https://openalex.org/W1845152202","https://openalex.org/W1900601853","https://openalex.org/W1969427484","https://openalex.org/W1969697265","https://openalex.org/W1969904510","https://openalex.org/W1971302885","https://openalex.org/W1975971473","https://openalex.org/W1982071077","https://openalex.org/W1992766625","https://openalex.org/W2003676640","https://openalex.org/W2010349134","https://openalex.org/W2014669590","https://openalex.org/W2018292747","https://openalex.org/W2032118018","https://openalex.org/W2039599894","https://openalex.org/W2046626781","https://openalex.org/W2049525643","https://openalex.org/W2049914201","https://openalex.org/W2050734291","https://openalex.org/W2056283531","https://openalex.org/W2060333964","https://openalex.org/W2064864590","https://openalex.org/W2065467878","https://openalex.org/W2069707457","https://openalex.org/W2074430638","https://openalex.org/W2078078890","https://openalex.org/W2078380427","https://openalex.org/W2081462803","https://openalex.org/W2083430194","https://openalex.org/W2094651135","https://openalex.org/W2100432609","https://openalex.org/W2114733293","https://openalex.org/W2117424591","https://openalex.org/W2122794487","https://openalex.org/W2123884323","https://openalex.org/W2125391335","https://openalex.org/W2125771292","https://openalex.org/W2129119043","https://openalex.org/W2129707656","https://openalex.org/W2134812217","https://openalex.org/W2142800802","https://openalex.org/W2150548162","https://openalex.org/W2156118816","https://openalex.org/W2170960160","https://openalex.org/W2224929038","https://openalex.org/W2305521218","https://openalex.org/W2323886210","https://openalex.org/W2576734941","https://openalex.org/W4247400397"],"related_works":["https://openalex.org/W7095677235","https://openalex.org/W2015501603","https://openalex.org/W2004999743","https://openalex.org/W2187543149","https://openalex.org/W2127491155","https://openalex.org/W2014745588","https://openalex.org/W2132347745","https://openalex.org/W1981428780","https://openalex.org/W1984870545","https://openalex.org/W2159491733"],"abstract_inverted_index":{"The":[0,132],"respiratory":[1,41],"manifestations":[2],"of":[3,16,21,46,99,134,147],"cystic":[4],"fibrosis":[5],"(CF)":[6],"are":[7,19],"characterized":[8],"by":[9,53,172],"neutrophil-dominated":[10],"airway":[11],"inflammation.":[12],"Since":[13],"a":[14,32,85,160],"variety":[15],"inflammatory":[17,162],"stimuli":[18],"capable":[20],"inducing":[22,112],"bronchial":[23,64,167,176,189],"epithelial":[24,42,54,65],"cells":[25,66,139],"to":[26,59,140,151,178,187],"express":[27],"the":[28,60,123,165,175,188],"gene":[29,77,114,143],"for":[30,126],"IL-8,":[31,180],"cytokine":[33],"that":[34,120],"attracts":[35],"and":[36,103,150],"activates":[37],"neutrophils,":[38],"mediators":[39],"in":[40,88,116,129,182],"lining":[43],"fluid":[44],"(ELF)":[45],"CF":[47,83,94,109,130,166],"individuals":[48],"might":[49],"induce":[50],"IL-8":[51,76,89,113,127,142],"production":[52,128],"cells,":[55,118],"thus":[56],"recruiting":[57],"neutrophils":[58,173,186],"airways.":[61],"BET-1A":[62,117,138],"human":[63],"at":[67],"rest":[68],"or":[69],"incubated":[70],"with":[71,82,145],"normal":[72],"ELF":[73,95,110],"showed":[74],"little":[75],"expression,":[78],"but":[79],"after":[80],"incubation":[81],"ELF,":[84],"marked":[86],"increase":[87,141],"transcript":[90],"levels":[91,98],"was":[92,122],"observed.":[93],"contained":[96],"high":[97],"neutrophil":[100,154],"elastase":[101],"(NE)":[102],"various":[104],"serine":[105],"protease":[106],"inhibitors":[107],"prevented":[108],"from":[111],"expression":[115],"suggesting":[119],"NE":[121,136,170],"dominant":[124],"inducer":[125],"ELF.":[131],"addition":[133],"purified":[135],"caused":[137],"transcription":[144],"accumulation":[146],"mRNA":[148],"transcripts":[149],"release":[152],"IL-8-like":[153],"chemotactic":[155],"activity.":[156],"These":[157],"observations":[158],"suggest":[159],"self-perpetuating":[161],"process":[163],"on":[164],"surface":[168],"where":[169],"released":[171],"induced":[174],"epithelium":[177],"secrete":[179],"which":[181],"turn":[183],"recruits":[184],"additional":[185],"surface.":[190]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":16},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":11}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}
