{"id":"https://openalex.org/W2164293318","doi":"https://doi.org/10.1016/j.abb.2013.10.012","title":"14-3-3\u03b5 and NAV2 interact to regulate neurite outgrowth and axon elongation","display_name":"14-3-3\u03b5 and NAV2 interact to regulate neurite outgrowth and axon elongation","publication_year":2013,"publication_date":"2013-10-23","ids":{"openalex":"https://openalex.org/W2164293318","doi":"https://doi.org/10.1016/j.abb.2013.10.012","mag":"2164293318","pmid":"https://pubmed.ncbi.nlm.nih.gov/24161943","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4120646"},"language":"en","primary_location":{"id":"doi:10.1016/j.abb.2013.10.012","doi":"https://doi.org/10.1016/j.abb.2013.10.012","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.abb.2013.10.012","pdf_url":"https://www.sciencedirect.com/science/article/pii/S000398611300324X/pdf","source":{"id":"https://openalex.org/S153476765","display_name":"Archives of Biochemistry and Biophysics","issn_l":"0003-9861","issn":["0003-9861","1096-0384"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Biochemistry and Biophysics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.sciencedirect.com/science/article/pii/S000398611300324X/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082007029","display_name":"Mark A. Marzinke","orcid":"https://orcid.org/0000-0003-1670-8786","observed_orcids":["https://orcid.org/0000-0003-1670-8786"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark A. Marzinke","raw_affiliation_strings":["Department of Biochemistry, College of Agricultural and Life Sciences, University of Wisconsin-Madison, Madison, WI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, College of Agricultural and Life Sciences, University of Wisconsin-Madison, Madison, WI, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057618048","display_name":"Terri Mavencamp","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Terri Mavencamp","raw_affiliation_strings":["Department of Biochemistry, College of Agricultural and Life Sciences, University of Wisconsin\u2013Madison, Madison, WI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, College of Agricultural and Life Sciences, University of Wisconsin\u2013Madison, Madison, WI, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009855800","display_name":"Joseph Duratinsky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph Duratinsky","raw_affiliation_strings":["Department of Biochemistry, College of Agricultural and Life Sciences, University of Wisconsin\u2013Madison, Madison, WI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, College of Agricultural and Life Sciences, University of Wisconsin\u2013Madison, Madison, WI, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053558865","display_name":"Margaret Clagett\u2010Dame","orcid":"https://orcid.org/0000-0002-0364-9855","observed_orcids":["https://orcid.org/0000-0002-0364-9855"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Margaret Clagett-Dame","raw_affiliation_strings":["Department of Biochemistry, College of Agricultural and Life Sciences, University of Wisconsin\u2013Madison, Madison, WI, USA","Pharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin\u2013Madison, Madison, WI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, College of Agricultural and Life Sciences, University of Wisconsin\u2013Madison, Madison, WI, USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Pharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin\u2013Madison, Madison, WI, USA","institution_ids":["https://openalex.org/I135310074"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5053558865"],"corresponding_institution_ids":["https://openalex.org/I135310074"],"apc_list":{"value":3170,"currency":"USD","value_usd":3170},"apc_paid":{"value":3170,"currency":"USD","value_usd":3170},"fwci":1.2365,"has_fulltext":true,"cited_by_count":34,"citation_normalized_percentile":{"value":0.78552874,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"540","issue":"1-2","first_page":"94","last_page":"100"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13526","display_name":"14-3-3 protein interactions","score":0.7792999744415283,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13526","display_name":"14-3-3 protein interactions","score":0.7792999744415283,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12061","display_name":"Axon Guidance and Neuronal Signaling","score":0.21559999883174896,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/14-3-3epsilon","display_name":"14-3-3\u03b5","score":0.9860000014305115},{"id":"https://openalex.org/keywords/nav2","display_name":"Nav2","score":0.968999981880188},{"id":"https://openalex.org/keywords/neurite-outgrowth","display_name":"neurite outgrowth","score":0.9440000057220459},{"id":"https://openalex.org/keywords/axonal-elongation","display_name":"axon elongation","score":0.9980000257492065},{"id":"https://openalex.org/keywords/all-trans-retinoic-acid","display_name":"all-trans retinoic acid","score":0.968999981880188},{"id":"https://openalex.org/keywords/cytoskeleton","display_name":"cytoskeleton","score":0.6620000004768372},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.8999999761581421},{"id":"https://openalex.org/keywords/neuronal-migration","display_name":"neuronal migration","score":0.6179999709129333},{"id":"https://openalex.org/keywords/caenorhabditis-elegans","display_name":"Caenorhabditis elegans","score":0.8799999952316284},{"id":"https://openalex.org/keywords/neuroblastoma-cells","display_name":"neuroblastoma cells","score":0.9319999814033508}],"concepts":[{"id":"https://openalex.org/C113246987","wikidata":"https://www.wikidata.org/wiki/Q1534415","display_name":"Neurite","level":3,"score":0.8801414966583252},{"id":"https://openalex.org/C2778944004","wikidata":"https://www.wikidata.org/wiki/Q91703","display_name":"Caenorhabditis elegans","level":3,"score":0.7559984922409058},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7083556056022644},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.6954450607299805},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.6073013544082642},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5821213126182556},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5549576282501221},{"id":"https://openalex.org/C2781121885","wikidata":"https://www.wikidata.org/wiki/Q425517","display_name":"Retinoic acid","level":3,"score":0.5461004376411438},{"id":"https://openalex.org/C71829478","wikidata":"https://www.wikidata.org/wiki/Q901305","display_name":"Immunoprecipitation","level":3,"score":0.5343842506408691},{"id":"https://openalex.org/C20418707","wikidata":"https://www.wikidata.org/wiki/Q189933","display_name":"Microtubule","level":2,"score":0.5281733870506287},{"id":"https://openalex.org/C33947775","wikidata":"https://www.wikidata.org/wiki/Q271439","display_name":"Elongation","level":3,"score":0.4935246706008911},{"id":"https://openalex.org/C2779530196","wikidata":"https://www.wikidata.org/wiki/Q178999","display_name":"Axon","level":2,"score":0.4211842119693756},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23757991194725037},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1490541696548462},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.0772026777267456},{"id":"https://openalex.org/C112950240","wikidata":"https://www.wikidata.org/wiki/Q76005","display_name":"Ultimate tensile strength","level":2,"score":0.0},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004265","descriptor_name":"DNA Helicases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008840","descriptor_name":"Microfilament Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014212","descriptor_name":"Tretinoin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016501","descriptor_name":"Neurites","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016501","descriptor_name":"Neurites","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D029742","descriptor_name":"Caenorhabditis elegans Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048948","descriptor_name":"14-3-3 Proteins","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D048948","descriptor_name":"14-3-3 Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D048948","descriptor_name":"14-3-3 Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055785","descriptor_name":"Gene Knockdown Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.abb.2013.10.012","doi":"https://doi.org/10.1016/j.abb.2013.10.012","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.abb.2013.10.012","pdf_url":"https://www.sciencedirect.com/science/article/pii/S000398611300324X/pdf","source":{"id":"https://openalex.org/S153476765","display_name":"Archives of Biochemistry and Biophysics","issn_l":"0003-9861","issn":["0003-9861","1096-0384"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Biochemistry and Biophysics","raw_type":"journal-article"},{"id":"pmid:24161943","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24161943","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of biochemistry and biophysics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4120646","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4120646","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Arch Biochem Biophys","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.abb.2013.10.012","doi":"https://doi.org/10.1016/j.abb.2013.10.012","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.abb.2013.10.012","pdf_url":"https://www.sciencedirect.com/science/article/pii/S000398611300324X/pdf","source":{"id":"https://openalex.org/S153476765","display_name":"Archives of Biochemistry and Biophysics","issn_l":"0003-9861","issn":["0003-9861","1096-0384"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Biochemistry and Biophysics","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000876911","display_name":"Metabolism and Nutrition Training Program","funder_award_id":"T32DK007665","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2164293318.pdf","grobid_xml":"https://content.openalex.org/works/W2164293318.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W299108795","https://openalex.org/W1667125033","https://openalex.org/W1896987527","https://openalex.org/W1944127002","https://openalex.org/W1966610111","https://openalex.org/W1972008234","https://openalex.org/W1976338973","https://openalex.org/W1987240473","https://openalex.org/W1992170226","https://openalex.org/W1992778999","https://openalex.org/W1997426410","https://openalex.org/W2001181990","https://openalex.org/W2004513287","https://openalex.org/W2006374858","https://openalex.org/W2025154183","https://openalex.org/W2030660530","https://openalex.org/W2036623899","https://openalex.org/W2037835429","https://openalex.org/W2039298117","https://openalex.org/W2041344619","https://openalex.org/W2044694582","https://openalex.org/W2048168473","https://openalex.org/W2055181592","https://openalex.org/W2058320026","https://openalex.org/W2067080402","https://openalex.org/W2077659175","https://openalex.org/W2079505152","https://openalex.org/W2134505334","https://openalex.org/W2146533779","https://openalex.org/W2150105460","https://openalex.org/W2307219516"],"related_works":["https://openalex.org/W2077659175","https://openalex.org/W2125084404","https://openalex.org/W1966610111","https://openalex.org/W2328834653","https://openalex.org/W647070657","https://openalex.org/W2057204775","https://openalex.org/W2119838858","https://openalex.org/W2055323321","https://openalex.org/W2333650958","https://openalex.org/W1973524445"],"abstract_inverted_index":{"Neuron":[0],"navigator":[1],"2":[2],"(NAV2)":[3],"is":[4,107],"required":[5],"for":[6],"all-trans":[7],"retinoic":[8],"acid":[9],"(atRA)":[10],"to":[11,72,92,100,125],"induce":[12],"neurite":[13,97],"outgrowth":[14],"in":[15,31,52,95,117,151],"human":[16,24],"neuroblastoma":[17],"cells.":[18],"Further,":[19],"ectopic":[20],"overexpression":[21],"of":[22,42,68,89,134],"full-length":[23],"NAV2":[25,43,62,69,106,138,149],"rescues":[26],"an":[27,135],"axonal":[28],"elongation":[29,102],"defect":[30],"the":[32,48,101,145],"Caenorhabditis":[33],"elegans":[34,119],"unc-53":[35,121],"(NAV2":[36],"ortholog)":[37],"mutant.":[38],"Using":[39],"a":[40,53,60,74,82,93],"region":[41],"that":[44],"independently":[45],"associates":[46],"with":[47,77],"cytoskeleton":[49],"as":[50,59,79],"bait":[51],"yeast-two-hybrid":[54],"screen,":[55],"14-3-3\u03b5":[56,78,90,140],"was":[57],"identified":[58],"novel":[61],"interacting":[63],"partner.":[64],"Amino":[65],"acids":[66],"761-960":[67],"are":[70,123],"sufficient":[71],"confer":[73],"positive":[75],"interaction":[76,136],"evidenced":[80],"by":[81,147],"two-hybrid":[83],"screen":[84],"and":[85,139,155],"co-immunoprecipitation":[86],"assay.":[87],"Knockdown":[88],"leads":[91],"decrease":[94],"atRA-mediated":[96],"outgrowth,":[98],"similar":[99,124],"defects":[103,116],"observed":[104],"when":[105],"depleted":[108],"or":[109],"mutated.":[110],"Likewise,":[111],"posterior":[112],"lateral":[113],"microtubule":[114],"(PLM)":[115],"C.":[118],"fed":[120,127],"RNAi":[122],"those":[126],"ftt-2":[128],"(14-3-3":[129],"homolog)":[130],"RNAi.":[131],"The":[132],"discovery":[133],"between":[137],"could":[141],"provide":[142],"insight":[143],"into":[144],"mechanism":[146],"which":[148],"participates":[150],"promoting":[152],"cell":[153],"migration":[154],"neuronal":[156],"elongation.":[157]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}