{"id":"https://openalex.org/W2164228218","doi":"https://doi.org/10.1128/aac.41.7.1594","title":"In vitro activity of BAY 12-8039, a novel 8-methoxyquinolone, compared to activities of six fluoroquinolones against Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis","display_name":"In vitro activity of BAY 12-8039, a novel 8-methoxyquinolone, compared to activities of six fluoroquinolones against Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis","publication_year":1997,"publication_date":"1997-07-01","ids":{"openalex":"https://openalex.org/W2164228218","doi":"https://doi.org/10.1128/aac.41.7.1594","mag":"2164228218","pmid":"https://pubmed.ncbi.nlm.nih.gov/9210692","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/163966"},"language":"en","primary_location":{"id":"doi:10.1128/aac.41.7.1594","doi":"https://doi.org/10.1128/aac.41.7.1594","is_oa":false,"landing_page_url":"https://doi.org/10.1128/aac.41.7.1594","pdf_url":null,"source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC163966","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002892761","display_name":"Angela B. Brueggemann","orcid":"https://orcid.org/0000-0002-2329-1934","observed_orcids":["https://orcid.org/0000-0002-2329-1934"]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A B Brueggemann","raw_affiliation_strings":["Clinical Microbiology Laboratories, University of Massachusetts Medical Center, Worcester 01655, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Microbiology Laboratories, University of Massachusetts Medical Center, Worcester 01655, USA","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057553771","display_name":"Kari C. Kugler","orcid":"https://orcid.org/0000-0001-6971-4827","observed_orcids":["https://orcid.org/0000-0001-6971-4827"]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K C Kugler","raw_affiliation_strings":["Clinical Microbiology Laboratories, University of Massachusetts Medical Center, Worcester 01655, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Microbiology Laboratories, University of Massachusetts Medical Center, Worcester 01655, USA","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109224208","display_name":"Gary V. Doern","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G V Doern","raw_affiliation_strings":["Clinical Microbiology Laboratories, University of Massachusetts Medical Center, Worcester 01655, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Microbiology Laboratories, University of Massachusetts Medical Center, Worcester 01655, USA","institution_ids":["https://openalex.org/I166722992"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I166722992"],"apc_list":null,"apc_paid":null,"fwci":12.2007,"has_fulltext":false,"cited_by_count":106,"citation_normalized_percentile":{"value":0.99315068,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"41","issue":"7","first_page":"1594","last_page":"1597"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.7182999849319458,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.7182999849319458,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10654","display_name":"Pneumonia and Respiratory Infections","score":0.11469999700784683,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.09350000321865082,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fluoroquinolones","display_name":"fluoroquinolones","score":0.968999981880188},{"id":"https://openalex.org/keywords/streptococcus-pneumoniae","display_name":"Streptococcus pneumoniae","score":0.9649999737739563},{"id":"https://openalex.org/keywords/haemophilus-influenzae","display_name":"Haemophilus influenzae","score":1.0},{"id":"https://openalex.org/keywords/moraxella-catarrhalis","display_name":"Moraxella catarrhalis","score":1.0},{"id":"https://openalex.org/keywords/antimicrobial-susceptibility","display_name":"antimicrobial susceptibility","score":0.7360000014305115},{"id":"https://openalex.org/keywords/minimum-inhibitory-concentration","display_name":"minimum inhibitory concentration","score":0.9100000262260437},{"id":"https://openalex.org/keywords/clinafloxacin","display_name":"clinafloxacin","score":0.9100000262260437},{"id":"https://openalex.org/keywords/trovafloxacin","display_name":"trovafloxacin","score":0.8360000252723694},{"id":"https://openalex.org/keywords/sparfloxacin","display_name":"sparfloxacin","score":0.9950000047683716},{"id":"https://openalex.org/keywords/ciprofloxacin","display_name":"ciprofloxacin","score":0.8690000176429749},{"id":"https://openalex.org/keywords/levofloxacin","display_name":"levofloxacin","score":0.9869999885559082},{"id":"https://openalex.org/keywords/ofloxacin","display_name":"ofloxacin","score":0.9909999966621399},{"id":"https://openalex.org/keywords/penicillin-resistance","display_name":"penicillin resistance","score":0.7940000295639038}],"concepts":[{"id":"https://openalex.org/C2780926990","wikidata":"https://www.wikidata.org/wiki/Q976559","display_name":"Sparfloxacin","level":5,"score":0.8833878040313721},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.8708600401878357},{"id":"https://openalex.org/C2776551000","wikidata":"https://www.wikidata.org/wiki/Q2046669","display_name":"Moraxella catarrhalis","level":4,"score":0.8589205145835876},{"id":"https://openalex.org/C2779499321","wikidata":"https://www.wikidata.org/wiki/Q544393","display_name":"Trovafloxacin","level":4,"score":0.8519573211669922},{"id":"https://openalex.org/C2781253189","wikidata":"https://www.wikidata.org/wiki/Q221179","display_name":"Streptococcus pneumoniae","level":3,"score":0.7608599662780762},{"id":"https://openalex.org/C2776925733","wikidata":"https://www.wikidata.org/wiki/Q1141979","display_name":"Haemophilus influenzae","level":3,"score":0.757897138595581},{"id":"https://openalex.org/C2778836808","wikidata":"https://www.wikidata.org/wiki/Q424940","display_name":"Moxifloxacin","level":3,"score":0.536060094833374},{"id":"https://openalex.org/C3019249092","wikidata":"https://www.wikidata.org/wiki/Q274493","display_name":"Antibacterial agent","level":3,"score":0.5195620059967041},{"id":"https://openalex.org/C2778049240","wikidata":"https://www.wikidata.org/wiki/Q411447","display_name":"Ofloxacin","level":4,"score":0.5022926330566406},{"id":"https://openalex.org/C2780950330","wikidata":"https://www.wikidata.org/wiki/Q19903614","display_name":"Broth microdilution","level":4,"score":0.48468664288520813},{"id":"https://openalex.org/C2780493024","wikidata":"https://www.wikidata.org/wiki/Q19903202","display_name":"Agar dilution","level":4,"score":0.4529418647289276},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4510495066642761},{"id":"https://openalex.org/C2910443534","wikidata":"https://www.wikidata.org/wiki/Q2046669","display_name":"Moraxella (Branhamella) catarrhalis","level":5,"score":0.4481460750102997},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.42766305804252625},{"id":"https://openalex.org/C2778512257","wikidata":"https://www.wikidata.org/wiki/Q256602","display_name":"Ciprofloxacin","level":3,"score":0.4081392288208008},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.29182273149490356},{"id":"https://openalex.org/C176947019","wikidata":"https://www.wikidata.org/wiki/Q597889","display_name":"Minimum inhibitory concentration","level":3,"score":0.253518283367157},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21172448992729187},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077266","descriptor_name":"Moxifloxacin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000890","descriptor_name":"Anti-Infective Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001372","descriptor_name":"Aza Compounds","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001936","descriptor_name":"Moraxella catarrhalis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006193","descriptor_name":"Haemophilus influenzae","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011804","descriptor_name":"Quinolines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013296","descriptor_name":"Streptococcus pneumoniae","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015363","descriptor_name":"Quinolones","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D024841","descriptor_name":"Fluoroquinolones","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1128/aac.41.7.1594","doi":"https://doi.org/10.1128/aac.41.7.1594","is_oa":false,"landing_page_url":"https://doi.org/10.1128/aac.41.7.1594","pdf_url":null,"source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:210043","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC163966","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:163966","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/163966","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrob Agents Chemother","raw_type":"Text"},{"id":"pmid:9210692","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9210692","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial agents and chemotherapy","raw_type":"Comparative Study"},{"id":"pmh:oai:escholarship.umassmed.edu:oapubs-1183","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.umassmed.edu/oapubs/184","pdf_url":null,"source":{"id":"https://openalex.org/S7407064370","display_name":"eScholarship@UMassChan","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Open Access Publications by UMass Chan Authors","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:210043","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC163966","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320335359","display_name":"Pharmaceuticals Bayer","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1581962345","https://openalex.org/W1596159114","https://openalex.org/W1861102076","https://openalex.org/W1962928558","https://openalex.org/W1970009804","https://openalex.org/W1984784577","https://openalex.org/W1987345344","https://openalex.org/W2015506614","https://openalex.org/W2042708570","https://openalex.org/W2051039256","https://openalex.org/W2062414916","https://openalex.org/W2084437173","https://openalex.org/W2097635951","https://openalex.org/W2105007601","https://openalex.org/W2107131874","https://openalex.org/W2132092782","https://openalex.org/W2138129420","https://openalex.org/W2145564885","https://openalex.org/W2162622417","https://openalex.org/W2165128354","https://openalex.org/W2319438985","https://openalex.org/W2409988851"],"related_works":["https://openalex.org/W2162622417","https://openalex.org/W2007489189","https://openalex.org/W2023705813","https://openalex.org/W92625682","https://openalex.org/W2129439275","https://openalex.org/W1999116707","https://openalex.org/W2098806358","https://openalex.org/W2126611758","https://openalex.org/W2106359757","https://openalex.org/W7036686157"],"abstract_inverted_index":{"The":[0,138],"in":[1,96,200],"vitro":[2],"activity":[3,58,97,173],"of":[4,14,38,57,69,75,104,111,143,149,163,167,174,192],"a":[5,64],"novel":[6],"8-methoxyquinolone,":[7],"BAY":[8,49,175],"12-8039,":[9],"against":[10,59,98],"recent":[11],"clinical":[12],"isolates":[13,71],"Streptococcus":[15],"pneumoniae":[16,89,106,145,179],"(n":[17,22,28],"=":[18,23,29,91],"404),":[19],"Haemophilus":[20],"influenzae":[21,128,151],"330),":[24],"and":[25,47,51,79,129,146],"Moraxella":[26],"catarrhalis":[27],"250)":[30],"was":[31,34,180],"evaluated.":[32],"Activity":[33],"compared":[35],"to":[36,123,132,154,182,202],"those":[37,158],"six":[39],"other":[40],"fluoroquinolones:":[41],"ciprofloxacin,":[42],"clinafloxacin,":[43],"levofloxacin,":[44],"ofloxacin,":[45],"sparfloxacin":[46,80],"trovafloxacin.":[48],"12-8039":[50,176],"clinafloxacin":[52],"had":[53],"the":[54,70,82,112,117,160,168,172],"highest":[55],"levels":[56],"S.":[60,88,105,144,178],"pneumoniae,":[61],"both":[62],"with":[63,190],"MIC":[65,186],"at":[66],"which":[67],"90%":[68],"were":[72,81,107,152,188],"inhibited":[73],"(MIC90)":[74],"0.06":[76,124],"microg/ml.":[77],"Trovafloxacin":[78],"next":[83],"most":[84],"active":[85],"agents":[86],"versus":[87,126,177,205],"(MIC90s":[90],"0.12":[92,133],"microg/ml).":[93],"No":[94],"differences":[95],"penicillin-susceptible,":[99],"-intermediate,":[100],"or":[101,196],"-resistant":[102],"strains":[103,142],"noted":[108,153],"for":[109,116,135,140,159,165],"any":[110],"fluoroquinolones":[113,119,169],"tested.":[114,170],"MIC90s":[115],"seven":[118],"ranged":[120],"from":[121,130],"0.008":[122,131],"microg/ml":[125,134],"H.":[127,150],"M.":[136],"catarrhalis.":[137],"MICs":[139],"two":[141],"one":[147],"strain":[148],"be":[155,183],"higher":[156],"than":[157],"general":[161],"population":[162],"organisms":[164],"all":[166],"Finally,":[171],"found":[181],"diminished":[184],"when":[185],"determinations":[187],"performed":[189],"incubation":[191],"agar":[193],"dilution":[194],"plates":[195],"broth":[197],"microdilution":[198],"trays":[199],"5":[201],"7%":[203],"CO2":[204],"ambient":[206],"air.":[207]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
