{"id":"https://openalex.org/W2164192095","doi":"https://doi.org/10.1161/01.cir.103.19.2382","title":"Paradoxically Enhanced Endothelin-B Receptor\u2013Mediated Vasoconstriction in Conscious Old Monkeys","display_name":"Paradoxically Enhanced Endothelin-B Receptor\u2013Mediated Vasoconstriction in Conscious Old Monkeys","publication_year":2001,"publication_date":"2001-05-15","ids":{"openalex":"https://openalex.org/W2164192095","doi":"https://doi.org/10.1161/01.cir.103.19.2382","mag":"2164192095","pmid":"https://pubmed.ncbi.nlm.nih.gov/11352888"},"language":"en","primary_location":{"id":"doi:10.1161/01.cir.103.19.2382","doi":"https://doi.org/10.1161/01.cir.103.19.2382","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.cir.103.19.2382","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019147041","display_name":"Kuniya Asai","orcid":"https://orcid.org/0000-0003-3469-2167","observed_orcids":["https://orcid.org/0000-0003-3469-2167"]},"institutions":[{"id":"https://openalex.org/I1324520350","display_name":"Hackensack University Medical Center","ror":"https://ror.org/008zj0x80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1324520350"]},{"id":"https://openalex.org/I4402554120","display_name":"Rutgers New Jersey Medical School","ror":"https://ror.org/014ye1258","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4402554120"]},{"id":"https://openalex.org/I4405286694","display_name":"University of Medicine and Dentistry of New Jersey","ror":"https://ror.org/02tvvmk84","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4405286694"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kuniya Asai","raw_affiliation_strings":["From the Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, and Hackensack University Medical Center, Hackensack, NJ","Kuniya Asai From the Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, and Hackensack University Medical Center, Hackensack, NJ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, and Hackensack University Medical Center, Hackensack, NJ","institution_ids":["https://openalex.org/I1324520350","https://openalex.org/I4402554120","https://openalex.org/I4405286694"]},{"raw_affiliation_string":"Kuniya Asai From the Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, and Hackensack University Medical Center, Hackensack, NJ","institution_ids":["https://openalex.org/I1324520350","https://openalex.org/I4402554120","https://openalex.org/I4405286694"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054165152","display_name":"Raymond K. Kudej","orcid":"https://orcid.org/0009-0009-9540-3796","observed_orcids":["https://orcid.org/0009-0009-9540-3796"]},"institutions":[{"id":"https://openalex.org/I1324520350","display_name":"Hackensack University Medical Center","ror":"https://ror.org/008zj0x80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1324520350"]},{"id":"https://openalex.org/I4402554120","display_name":"Rutgers New Jersey Medical School","ror":"https://ror.org/014ye1258","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4402554120"]},{"id":"https://openalex.org/I4405286694","display_name":"University of Medicine and Dentistry of New Jersey","ror":"https://ror.org/02tvvmk84","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4405286694"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raymond K. Kudej","raw_affiliation_strings":["From the Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, and Hackensack University Medical Center, Hackensack, NJ","Raymond K. Kudej From the Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, and Hackensack University Medical Center, Hackensack, NJ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, and Hackensack University Medical Center, Hackensack, NJ","institution_ids":["https://openalex.org/I1324520350","https://openalex.org/I4402554120","https://openalex.org/I4405286694"]},{"raw_affiliation_string":"Raymond K. Kudej From the Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, and Hackensack University Medical Center, Hackensack, NJ","institution_ids":["https://openalex.org/I1324520350","https://openalex.org/I4402554120","https://openalex.org/I4405286694"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066792341","display_name":"Gen Takagi","orcid":"https://orcid.org/0000-0002-9527-5220","observed_orcids":["https://orcid.org/0000-0002-9527-5220"]},"institutions":[{"id":"https://openalex.org/I1324520350","display_name":"Hackensack University Medical Center","ror":"https://ror.org/008zj0x80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1324520350"]},{"id":"https://openalex.org/I4402554120","display_name":"Rutgers New Jersey Medical School","ror":"https://ror.org/014ye1258","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4402554120"]},{"id":"https://openalex.org/I4405286694","display_name":"University of Medicine and Dentistry of New Jersey","ror":"https://ror.org/02tvvmk84","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4405286694"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gen Takagi","raw_affiliation_strings":["From the Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, and Hackensack University Medical Center, Hackensack, NJ","Gen Takagi From the Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, and Hackensack University Medical Center, Hackensack, NJ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, and Hackensack University Medical Center, Hackensack, NJ","institution_ids":["https://openalex.org/I1324520350","https://openalex.org/I4402554120","https://openalex.org/I4405286694"]},{"raw_affiliation_string":"Gen Takagi From the Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, and Hackensack University Medical Center, Hackensack, NJ","institution_ids":["https://openalex.org/I1324520350","https://openalex.org/I4402554120","https://openalex.org/I4405286694"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066839426","display_name":"Amelia B. Kudej","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1324520350","display_name":"Hackensack University Medical Center","ror":"https://ror.org/008zj0x80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1324520350"]},{"id":"https://openalex.org/I4402554120","display_name":"Rutgers New Jersey Medical School","ror":"https://ror.org/014ye1258","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4402554120"]},{"id":"https://openalex.org/I4405286694","display_name":"University of Medicine and Dentistry of New Jersey","ror":"https://ror.org/02tvvmk84","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4405286694"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amelia B. Kudej","raw_affiliation_strings":["From the Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, and Hackensack University Medical Center, Hackensack, NJ","Amelia B. Kudej From the Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, and Hackensack University Medical Center, Hackensack, NJ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, and Hackensack University Medical Center, Hackensack, NJ","institution_ids":["https://openalex.org/I1324520350","https://openalex.org/I4402554120","https://openalex.org/I4405286694"]},{"raw_affiliation_string":"Amelia B. Kudej From the Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, and Hackensack University Medical Center, Hackensack, NJ","institution_ids":["https://openalex.org/I1324520350","https://openalex.org/I4402554120","https://openalex.org/I4405286694"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021320719","display_name":"Filipinas Florendo Natividad","orcid":"https://orcid.org/0000-0003-2738-887X","observed_orcids":["https://orcid.org/0000-0003-2738-887X"]},"institutions":[{"id":"https://openalex.org/I1324520350","display_name":"Hackensack University Medical Center","ror":"https://ror.org/008zj0x80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1324520350"]},{"id":"https://openalex.org/I4402554120","display_name":"Rutgers New Jersey Medical School","ror":"https://ror.org/014ye1258","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4402554120"]},{"id":"https://openalex.org/I4405286694","display_name":"University of Medicine and Dentistry of New Jersey","ror":"https://ror.org/02tvvmk84","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4405286694"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Filipinas Natividad","raw_affiliation_strings":["From the Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, and Hackensack University Medical Center, Hackensack, NJ","Filipinas Natividad From the Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, and Hackensack University Medical Center, Hackensack, NJ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, and Hackensack University Medical Center, Hackensack, NJ","institution_ids":["https://openalex.org/I1324520350","https://openalex.org/I4402554120","https://openalex.org/I4405286694"]},{"raw_affiliation_string":"Filipinas Natividad From the Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, and Hackensack University Medical Center, Hackensack, NJ","institution_ids":["https://openalex.org/I1324520350","https://openalex.org/I4402554120","https://openalex.org/I4405286694"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110222639","display_name":"You\u2010Tang Shen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1324520350","display_name":"Hackensack University Medical Center","ror":"https://ror.org/008zj0x80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1324520350"]},{"id":"https://openalex.org/I4402554120","display_name":"Rutgers New Jersey Medical School","ror":"https://ror.org/014ye1258","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4402554120"]},{"id":"https://openalex.org/I4405286694","display_name":"University of Medicine and Dentistry of New Jersey","ror":"https://ror.org/02tvvmk84","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4405286694"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"You-Tang Shen","raw_affiliation_strings":["From the Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, and Hackensack University Medical Center, Hackensack, NJ","You-Tang Shen From the Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, and Hackensack University Medical Center, Hackensack, NJ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, and Hackensack University Medical Center, Hackensack, NJ","institution_ids":["https://openalex.org/I1324520350","https://openalex.org/I4402554120","https://openalex.org/I4405286694"]},{"raw_affiliation_string":"You-Tang Shen From the Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, and Hackensack University Medical Center, Hackensack, NJ","institution_ids":["https://openalex.org/I1324520350","https://openalex.org/I4402554120","https://openalex.org/I4405286694"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056890673","display_name":"Dorothy E. Vatner","orcid":"https://orcid.org/0000-0002-2628-6217","observed_orcids":["https://orcid.org/0000-0002-2628-6217"]},"institutions":[{"id":"https://openalex.org/I1324520350","display_name":"Hackensack University Medical Center","ror":"https://ror.org/008zj0x80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1324520350"]},{"id":"https://openalex.org/I4402554120","display_name":"Rutgers New Jersey Medical School","ror":"https://ror.org/014ye1258","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4402554120"]},{"id":"https://openalex.org/I4405286694","display_name":"University of Medicine and Dentistry of New Jersey","ror":"https://ror.org/02tvvmk84","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4405286694"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dorothy E. Vatner","raw_affiliation_strings":["From the Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, and Hackensack University Medical Center, Hackensack, NJ","Dorothy E. Vatner From the Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, and Hackensack University Medical Center, Hackensack, NJ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, and Hackensack University Medical Center, Hackensack, NJ","institution_ids":["https://openalex.org/I1324520350","https://openalex.org/I4402554120","https://openalex.org/I4405286694"]},{"raw_affiliation_string":"Dorothy E. Vatner From the Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, and Hackensack University Medical Center, Hackensack, NJ","institution_ids":["https://openalex.org/I1324520350","https://openalex.org/I4402554120","https://openalex.org/I4405286694"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051551818","display_name":"Stephen F. Vatner","orcid":"https://orcid.org/0000-0003-0521-8634","observed_orcids":["https://orcid.org/0000-0003-0521-8634"]},"institutions":[{"id":"https://openalex.org/I1324520350","display_name":"Hackensack University Medical Center","ror":"https://ror.org/008zj0x80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1324520350"]},{"id":"https://openalex.org/I4402554120","display_name":"Rutgers New Jersey Medical School","ror":"https://ror.org/014ye1258","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4402554120"]},{"id":"https://openalex.org/I4405286694","display_name":"University of Medicine and Dentistry of New Jersey","ror":"https://ror.org/02tvvmk84","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4405286694"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen F. Vatner","raw_affiliation_strings":["From the Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, and Hackensack University Medical Center, Hackensack, NJ","Stephen F. Vatner From the Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, and Hackensack University Medical Center, Hackensack, NJ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, and Hackensack University Medical Center, Hackensack, NJ","institution_ids":["https://openalex.org/I1324520350","https://openalex.org/I4402554120","https://openalex.org/I4405286694"]},{"raw_affiliation_string":"Stephen F. Vatner From the Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, and Hackensack University Medical Center, Hackensack, NJ","institution_ids":["https://openalex.org/I1324520350","https://openalex.org/I4402554120","https://openalex.org/I4405286694"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9521,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.75720197,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"103","issue":"19","first_page":"2382","last_page":"2386"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14486","display_name":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endothelin-1","display_name":"endothelin-1","score":0.9070000052452087},{"id":"https://openalex.org/keywords/endothelin-b-receptor","display_name":"endothelin B receptor","score":0.9120000004768372},{"id":"https://openalex.org/keywords/vasoconstriction","display_name":"vasoconstriction","score":0.8629999756813049},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.9850000143051147},{"id":"https://openalex.org/keywords/endothelium-dependent-vasodilation","display_name":"endothelium-dependent vasodilation","score":0.8220000267028809},{"id":"https://openalex.org/keywords/nitric-oxide-synthase","display_name":"nitric oxide synthase","score":0.902999997138977},{"id":"https://openalex.org/keywords/sarafotoxin-s6c","display_name":"sarafotoxin S6c","score":0.8759999871253967},{"id":"https://openalex.org/keywords/bq-123","display_name":"BQ-123","score":0.9419999718666077},{"id":"https://openalex.org/keywords/angiotensin-ii","display_name":"angiotensin II","score":0.8529999852180481},{"id":"https://openalex.org/keywords/phenylephrine","display_name":"phenylephrine","score":0.9959999918937683},{"id":"https://openalex.org/keywords/systemic-vascular-resistance","display_name":"systemic vascular resistance","score":0.9679999947547913},{"id":"https://openalex.org/keywords/cynomolgus-monkeys","display_name":"Macaca fascicularis","score":0.7310000061988831}],"concepts":[{"id":"https://openalex.org/C2779961880","wikidata":"https://www.wikidata.org/wiki/Q1067506","display_name":"Vasoconstriction","level":2,"score":0.8407280445098877},{"id":"https://openalex.org/C144980905","wikidata":"https://www.wikidata.org/wiki/Q24721308","display_name":"Endothelin receptor","level":3,"score":0.6877737641334534},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6424780488014221},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6392013430595398},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6126475930213928},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.5888683199882507},{"id":"https://openalex.org/C149601957","wikidata":"https://www.wikidata.org/wiki/Q390566","display_name":"Endothelin 1","level":3,"score":0.5778020024299622},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.5450780987739563},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.5274598598480225},{"id":"https://openalex.org/C2777952589","wikidata":"https://www.wikidata.org/wiki/Q421910","display_name":"Phenylephrine","level":3,"score":0.4985041618347168},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.4472115635871887},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.4263139069080353},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.34296685457229614},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.19126954674720764}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000804","descriptor_name":"Angiotensin II","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003243","descriptor_name":"Consciousness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008252","descriptor_name":"Macaca fascicularis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010456","descriptor_name":"Peptides, Cyclic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010656","descriptor_name":"Phenylephrine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014661","descriptor_name":"Vasoconstriction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014661","descriptor_name":"Vasoconstriction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014662","descriptor_name":"Vasoconstrictor Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014757","descriptor_name":"Viper Venoms","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017466","descriptor_name":"Receptors, Endothelin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D019001","descriptor_name":"Nitric Oxide Synthase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D019331","descriptor_name":"NG-Nitroarginine Methyl Ester","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019332","descriptor_name":"Endothelin-1","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D044022","descriptor_name":"Receptor, Endothelin A","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044023","descriptor_name":"Receptor, Endothelin B","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065128","descriptor_name":"Endothelin Receptor Antagonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1161/01.cir.103.19.2382","doi":"https://doi.org/10.1161/01.cir.103.19.2382","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.cir.103.19.2382","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},{"id":"pmid:11352888","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11352888","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.583.3153","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.583.3153","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://circ.ahajournals.org/content/103/19/2382.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1594977492","display_name":"AUTONOMIC RECEPTOR FUNCTION IN LV HYPERTROPHY &FAILURE","funder_award_id":"R01HL037404","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G241436969","display_name":null,"funder_award_id":"HL59139","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2530483454","display_name":"Aging Effects on Cardiovascular Function","funder_award_id":"R01AG014121","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G2911865521","display_name":null,"funder_award_id":"AG14121-03","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G4533333338","display_name":null,"funder_award_id":"HL-33107","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4567760082","display_name":null,"funder_award_id":"HL37404","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5564612264","display_name":"Myocardial Hypertrophy and Heart Failure","funder_award_id":"P01HL059139","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W202058787","https://openalex.org/W1964734395","https://openalex.org/W1973003414","https://openalex.org/W1974821785","https://openalex.org/W1986941247","https://openalex.org/W1992583442","https://openalex.org/W1992980606","https://openalex.org/W2004485634","https://openalex.org/W2004601169","https://openalex.org/W2014912739","https://openalex.org/W2018651370","https://openalex.org/W2021367876","https://openalex.org/W2033383283","https://openalex.org/W2043199191","https://openalex.org/W2058940411","https://openalex.org/W2066357069","https://openalex.org/W2072102602","https://openalex.org/W2079063592","https://openalex.org/W2085271574","https://openalex.org/W2087234757","https://openalex.org/W2088143270","https://openalex.org/W2098055944","https://openalex.org/W2104840130","https://openalex.org/W2114778001","https://openalex.org/W2133960302","https://openalex.org/W2141307244","https://openalex.org/W2151869895","https://openalex.org/W2161976449","https://openalex.org/W2165521770","https://openalex.org/W2169628553","https://openalex.org/W2207964858","https://openalex.org/W2262103849","https://openalex.org/W2281814905","https://openalex.org/W2322933975","https://openalex.org/W2328998090","https://openalex.org/W2401947029","https://openalex.org/W2402443131","https://openalex.org/W2416759357","https://openalex.org/W2418449470"],"related_works":["https://openalex.org/W2087234757","https://openalex.org/W2083471524","https://openalex.org/W2111060977","https://openalex.org/W1998628608","https://openalex.org/W4251180831","https://openalex.org/W2139594973","https://openalex.org/W2169887452","https://openalex.org/W1974821785","https://openalex.org/W2019536000","https://openalex.org/W2000735652"],"abstract_inverted_index":{"BACKGROUND:":[0],"We":[1],"investigated":[2],"the":[3,8,60,123,150,247],"effects":[4],"of":[5,30,125,152,238],"aging":[6],"on":[7],"responses":[9,197],"to":[10,198,234],"endothelin":[11],"(ET)":[12],"in":[13,73,78,101,106,122,140,145,177,186,204,216,229],"conscious":[14],"old":[15,74,102,141,187,205,217,230],"(19.8+/-0.6":[16],"years)":[17,22],"and":[18,24,36,211],"young":[19,79,107,146,178],"adult":[20],"(6.8+/-0.3":[21],"monkeys":[23,45,75,80,103,108,142,147,179,188],"compared":[25],"these":[26,134],"results":[27],"with":[28,69,86,94,158,171,243],"those":[29],"other":[31],"vasoconstrictors,":[32],"eg,":[33],"phenylephrine":[34],"(PE)":[35],"angiotensin":[37],"II":[38],"(Ang":[39],"II).":[40],"METHODS":[41],"AND":[42],"RESULTS:":[43],"The":[44],"(Macaca":[46],"fascicularis)":[47],"were":[48,200],"chronically":[49],"instrumented.":[50],"Baseline":[51],"total":[52],"peripheral":[53],"resistance":[54],"(TPR)":[55],"was":[56,120,175,226],"not":[57,185],"different":[58],"between":[59],"2":[61],"groups.":[62],"As":[63],"expected,":[64],"TPR":[65,82,90,136],"rose":[66,84,91],"less":[67,85],"(P<0.05)":[68,93,139,180],"PE":[70],"(5":[71],"microgram/kg)":[72],"(34+/-3%)":[76],"than":[77,105,144],"(57+/-6%);":[81],"also":[83],"Ang":[87,212],"II.":[88],"Surprisingly,":[89],"more":[92,138],"endothelin-1":[95],"(ET-1,":[96],"25":[97],"ng.":[98,117],"kg(-1).":[99,118],"min(-1))":[100,119],"(36+/-6%)":[104],"(10+/-2%).":[109],"An":[110],"ET(B)":[111,248],"receptor":[112,128],"agonist,":[113],"sarafotoxin":[114],"(S6c,":[115],"30":[116],"administered":[121],"presence":[124,151],"an":[126],"ET(A)":[127],"antagonist,":[129],"BQ-123":[130],"(1":[131],"mg/kg).":[132],"Under":[133],"conditions,":[135],"increased":[137],"(59+/-10%)":[143],"(31+/-4%).":[148],"In":[149],"nitric":[153],"oxide":[154],"synthase":[155],"(NOS)":[156],"inhibition":[157],"N(W)-nitro-L-arginine":[159],"methyl":[160],"ester":[161],"(60":[162],"mg/kg),":[163],"vasoconstriction":[164,209,222],"induced":[165,223],"by":[166,224],"S6c":[167],"no":[168,201],"longer":[169,202],"differed":[170],"age,":[172],"because":[173],"it":[174],"enhanced":[176,203,228],"(68+/-9%":[181],"versus":[182,190],"31+/-4%)":[183],"but":[184],"(58+/-6%":[189],"59+/-10%).":[191],"Thus,":[192],"after":[193],"NOS":[194],"inhibition,":[195],"vasoconstrictor":[196],"ET":[199],"monkeys.":[206],"CONCLUSIONS:":[207],"Peripheral":[208],"(PE":[210],"II)":[213],"is":[214],"reduced":[215],"monkeys,":[218,231],"as":[219],"expected.":[220],"Paradoxically,":[221],"ET-1":[225,244],"actually":[227],"which":[232,242],"appears":[233],"be":[235],"a":[236],"result":[237],"impaired":[239],"endothelium-dependent":[240],"vasodilation,":[241],"should":[245],"involve":[246],"receptor.":[249]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}
