{"id":"https://openalex.org/W2164046938","doi":"https://doi.org/10.1089/wound.2014.0572","title":"Ophthalmic Uses of a Thiol-Modified Hyaluronan-Based Hydrogel","display_name":"Ophthalmic Uses of a Thiol-Modified Hyaluronan-Based Hydrogel","publication_year":2014,"publication_date":"2014-10-14","ids":{"openalex":"https://openalex.org/W2164046938","doi":"https://doi.org/10.1089/wound.2014.0572","mag":"2164046938","pmid":"https://pubmed.ncbi.nlm.nih.gov/25371853","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4217024"},"language":"en","primary_location":{"id":"doi:10.1089/wound.2014.0572","doi":"https://doi.org/10.1089/wound.2014.0572","is_oa":false,"landing_page_url":"https://doi.org/10.1089/wound.2014.0572","pdf_url":null,"source":{"id":"https://openalex.org/S2764409288","display_name":"Advances in Wound Care","issn_l":"2162-1918","issn":["2162-1918","2162-1934"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Wound Care","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4217024","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109031496","display_name":"Barbara M. Wirostko","orcid":"https://orcid.org/0000-0002-7142-3241","observed_orcids":["https://orcid.org/0000-0002-7142-3241"]},"institutions":[{"id":"https://openalex.org/I341704201","display_name":"Utah State Historical Society","ror":"https://ror.org/02pxj5t37","country_code":"US","type":"government","lineage":["https://openalex.org/I341704201"]},{"id":"https://openalex.org/I4210116175","display_name":"Utah Department of Natural Resources","ror":"https://ror.org/02f7d6n92","country_code":"US","type":"government","lineage":["https://openalex.org/I4210116175"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barbara Wirostko","raw_affiliation_strings":["Jade Therapeutics, Inc., Salt Lake City, Utah"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jade Therapeutics, Inc., Salt Lake City, Utah","institution_ids":["https://openalex.org/I341704201","https://openalex.org/I4210116175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076647430","display_name":"Brenda K. Mann","orcid":"https://orcid.org/0000-0002-5810-2857","observed_orcids":["https://orcid.org/0000-0002-5810-2857"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I341704201","display_name":"Utah State Historical Society","ror":"https://ror.org/02pxj5t37","country_code":"US","type":"government","lineage":["https://openalex.org/I341704201"]},{"id":"https://openalex.org/I4210116175","display_name":"Utah Department of Natural Resources","ror":"https://ror.org/02f7d6n92","country_code":"US","type":"government","lineage":["https://openalex.org/I4210116175"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brenda K. Mann","raw_affiliation_strings":["Department of Bioengineering, University of Utah, Salt Lake City, Utah","SentrX Animal Care, Inc., Salt Lake City, Utah"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of Utah, Salt Lake City, Utah","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"SentrX Animal Care, Inc., Salt Lake City, Utah","institution_ids":["https://openalex.org/I341704201","https://openalex.org/I4210116175"]}]},{"author_position":"middle","author":{"id":null,"display_name":"David L. Williams","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David L. Williams","raw_affiliation_strings":["Department of Veterinary Medicine, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Medicine, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021550395","display_name":"Glenn D. Prestwich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Glenn D. Prestwich","raw_affiliation_strings":["Department of Medicinal Chemistry, The University of Utah, Salt Lake City, Utah"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, The University of Utah, Salt Lake City, Utah","institution_ids":["https://openalex.org/I223532165"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2229,"has_fulltext":false,"cited_by_count":44,"citation_normalized_percentile":{"value":0.17881944,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"3","issue":"11","first_page":"708","last_page":"716"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.9442999958992004,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.9442999958992004,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.02370000071823597,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11828","display_name":"Corneal Surgery and Treatments","score":0.010300000198185444,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hyaluronic-acid","display_name":"hyaluronic acid","score":0.847000002861023},{"id":"https://openalex.org/keywords/crosslinked-hydrogels","display_name":"crosslinked hydrogels","score":0.8690000176429749},{"id":"https://openalex.org/keywords/ocular-wound-healing","display_name":"ocular wound healing","score":0.8429999947547913},{"id":"https://openalex.org/keywords/corneal-injury","display_name":"corneal injury","score":0.8619999885559082},{"id":"https://openalex.org/keywords/limbal-stem-cell-deficiency","display_name":"limbal stem cell deficiency","score":0.9079999923706055},{"id":"https://openalex.org/keywords/limbal-stem-cell-transplantation","display_name":"limbal stem cell transplantation","score":0.7599999904632568},{"id":"https://openalex.org/keywords/ocular-drug-delivery","display_name":"ocular drug delivery","score":0.9390000104904175},{"id":"https://openalex.org/keywords/in-vivo-cross-linking","display_name":"in vivo cross-linking","score":0.7329999804496765},{"id":"https://openalex.org/keywords/disulfide-bond-formation","display_name":"disulfide bond formation","score":0.8690000176429749},{"id":"https://openalex.org/keywords/wound-dressings","display_name":"wound dressings","score":0.3889999985694885},{"id":"https://openalex.org/keywords/veterinary-ophthalmology","display_name":"veterinary ophthalmology","score":0.6690000295639038}],"concepts":[{"id":"https://openalex.org/C108586683","wikidata":"https://www.wikidata.org/wiki/Q17164826","display_name":"Self-healing hydrogels","level":2,"score":0.9450989961624146},{"id":"https://openalex.org/C2777529286","wikidata":"https://www.wikidata.org/wiki/Q337231","display_name":"Hyaluronic acid","level":2,"score":0.8154072761535645},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.6169561147689819},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.599663496017456},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.5777063965797424},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.5030550360679626},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.4414479732513428},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.36798417568206787},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3214232325553894},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.19682666659355164},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18701127171516418},{"id":"https://openalex.org/C188027245","wikidata":"https://www.wikidata.org/wiki/Q750446","display_name":"Polymer chemistry","level":1,"score":0.15778958797454834},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.08688384294509888},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1089/wound.2014.0572","doi":"https://doi.org/10.1089/wound.2014.0572","is_oa":false,"landing_page_url":"https://doi.org/10.1089/wound.2014.0572","pdf_url":null,"source":{"id":"https://openalex.org/S2764409288","display_name":"Advances in Wound Care","issn_l":"2162-1918","issn":["2162-1918","2162-1934"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Wound Care","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4217024","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4217024","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Adv Wound Care (New Rochelle)","raw_type":"Text"},{"id":"pmid:25371853","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25371853","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in wound care","raw_type":"Review"},{"id":"pmh:oai:www.repository.cam.ac.uk:1810/246538","doi":null,"is_oa":false,"landing_page_url":"https://www.repository.cam.ac.uk/handle/1810/246538","pdf_url":null,"source":{"id":"https://openalex.org/S4306401777","display_name":"Apollo (University of Cambridge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I241749","host_organization_name":"University of Cambridge","host_organization_lineage":["https://openalex.org/I241749"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4217024","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4217024","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Adv Wound Care (New Rochelle)","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9074000120162964,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4119534169","display_name":null,"funder_award_id":"W81XWH","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G4534197634","display_name":"SBIR Phase I:  Hyaluronan-Based Ocular Delivery of Antibiotics","funder_award_id":"1315150","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G6055959616","display_name":null,"funder_award_id":"W81XWH-14-C-0025","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W764947212","https://openalex.org/W858313163","https://openalex.org/W1230936899","https://openalex.org/W1541960278","https://openalex.org/W1588430132","https://openalex.org/W1600572967","https://openalex.org/W1624186696","https://openalex.org/W1823827557","https://openalex.org/W1832496054","https://openalex.org/W1963566022","https://openalex.org/W1966764114","https://openalex.org/W1976171524","https://openalex.org/W1977784832","https://openalex.org/W1985516113","https://openalex.org/W1989726643","https://openalex.org/W1994329884","https://openalex.org/W2004650888","https://openalex.org/W2007357724","https://openalex.org/W2012420763","https://openalex.org/W2024335985","https://openalex.org/W2024384507","https://openalex.org/W2025044654","https://openalex.org/W2027130651","https://openalex.org/W2027680361","https://openalex.org/W2036075940","https://openalex.org/W2041778522","https://openalex.org/W2045660999","https://openalex.org/W2048508823","https://openalex.org/W2068289128","https://openalex.org/W2068681375","https://openalex.org/W2069202243","https://openalex.org/W2069934178","https://openalex.org/W2076747129","https://openalex.org/W2098748129","https://openalex.org/W2105758002","https://openalex.org/W2106459991","https://openalex.org/W2110947634","https://openalex.org/W2113894096","https://openalex.org/W2123381052","https://openalex.org/W2127075175","https://openalex.org/W2133385478","https://openalex.org/W2134115573","https://openalex.org/W2139966914","https://openalex.org/W2151623096","https://openalex.org/W2156773190","https://openalex.org/W2314804041","https://openalex.org/W2321484840","https://openalex.org/W4243231451"],"related_works":["https://openalex.org/W2048508823","https://openalex.org/W2938096766","https://openalex.org/W3126022079","https://openalex.org/W2736413002","https://openalex.org/W4235387409","https://openalex.org/W2778268412","https://openalex.org/W3200967413","https://openalex.org/W2045660999","https://openalex.org/W7154828880","https://openalex.org/W4220665161"],"abstract_inverted_index":{"Significance:":[0],"Hyaluronic":[1],"acid":[2],"(HA,":[3],"or":[4,73,101,132],"hyaluronan)":[5],"is":[6],"a":[7,14,65,78,98,204],"ubiquitous":[8],"naturally":[9],"occurring":[10],"polysaccharide":[11],"that":[12,241],"plays":[13],"role":[15],"in":[16,20,59,149,157,160,165],"virtually":[17],"all":[18],"tissues":[19],"vertebrate":[21],"organisms.":[22],"HA-based":[23,189],"hydrogels":[24,41,124],"have":[25,143],"wound-healing":[26,71],"properties,":[27],"support":[28],"cell":[29,231],"delivery,":[30,213],"and":[31,49,90,115,141,155,163,214,251],"can":[32,42,94,120,125,184,194,200],"deliver":[33,207,216],"drugs":[34,208],"locally.":[35],"Recent":[36],"Advances:":[37],"A":[38],"few":[39],"HA":[40,55,81],"be":[43,95,121,126,147,185,201,243],"customized":[44],"for":[45,58,151,168,209,245],"composition,":[46],"physical":[47],"form,":[48],"biomechanical":[50],"properties.":[51],"No":[52],"clinically":[53],"approved":[54],"hydrogel":[56,237],"allows":[57],"vivo":[60,150],"crosslinking":[61],"on":[62],"administration,":[63],"has":[64],"tunable":[66],"gelation":[67],"time":[68],"to":[69,85,107,129,134,146,178,206,221],"meet":[70],"needs,":[72],"enables":[74],"drug":[75,212],"delivery.":[76],"Recently,":[77],"thiolated":[79],"carboxymethyl":[80],"(CMHA-S)":[82],"was":[83],"developed":[84],"produce":[86],"crosslinked":[87,96,190],"hydrogels,":[88],"sponges,":[89],"thin":[91,136],"films.":[92,137],"CMHA-S":[93,138,192,236],"with":[97,228],"thiol-reactive":[99],"crosslinker":[100],"by":[102],"oxidative":[103],"disulfide":[104],"bond":[105],"formation":[106],"form":[108,116,130,135],"hydrogels.":[109],"By":[110],"controlled":[111],"crosslinking,":[112],"the":[113,158,239],"shape":[114],"of":[117],"this":[118,188],"material":[119],"manipulated.":[122],"These":[123],"subsequently":[127],"lyophilized":[128],"sponges":[131],"air-dried":[133],"films,":[139],"liquids,":[140],"gels":[142],"been":[144],"shown":[145],"effective":[148],"treating":[152],"various":[153],"injuries":[154],"wounds":[156,183],"eye":[159],"veterinary":[161],"use,":[162],"are":[164,176],"clinical":[166,174],"development":[167],"human":[169],"use.":[170],"Critical":[171],"Issues:":[172],"Better":[173],"therapies":[175],"needed":[177],"treat":[179,222],"ophthalmic":[180],"injuries.":[181],"Corneal":[182],"treated":[186],"using":[187],"hydrogel.":[191],"biomaterials":[193],"help":[195],"heal":[196],"ocular":[197,211,224,247],"surface":[198,225],"defects,":[199],"formed":[202],"into":[203],"film":[205],"local":[210],"could":[215,242],"autologous":[217],"limbal":[218,229],"stem":[219,230],"cells":[220],"extreme":[223],"damage":[226],"associated":[227],"deficiencies.":[232],"Future":[233],"Directions:":[234],"This":[235],"increases":[238],"options":[240],"available":[244],"improved":[246],"wound":[248],"care,":[249],"healing,":[250],"regenerative":[252],"medicine.":[253]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
