{"id":"https://openalex.org/W2163973379","doi":"https://doi.org/10.1200/jco.2007.25.18_suppl.10006","title":"Mechanisms of sunitinib malate (SU) resistance in gastrointestinal stromal tumors (GISTs)","display_name":"Mechanisms of sunitinib malate (SU) resistance in gastrointestinal stromal tumors (GISTs)","publication_year":2007,"publication_date":"2007-06-20","ids":{"openalex":"https://openalex.org/W2163973379","doi":"https://doi.org/10.1200/jco.2007.25.18_suppl.10006","mag":"2163973379"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2007.25.18_suppl.10006","doi":"https://doi.org/10.1200/jco.2007.25.18_suppl.10006","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2007.25.18_suppl.10006","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091057405","display_name":"Michael Charles Heinrich","orcid":"https://orcid.org/0000-0003-3790-0478","observed_orcids":["https://orcid.org/0000-0003-3790-0478"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I2803065977","display_name":"Portland VA Medical Center","ror":"https://ror.org/02v3txv81","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2803065977","https://openalex.org/I4210144745"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. C. Heinrich","raw_affiliation_strings":["Portland VAMC, Portland, OR; OHSU Cancer Institute, Portland, OR; Brigham and Women's Hospital, Boston, MA; Ludwig Center at Dana-Farber/Harvard, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Portland VAMC, Portland, OR; OHSU Cancer Institute, Portland, OR; Brigham and Women's Hospital, Boston, MA; Ludwig Center at Dana-Farber/Harvard, Boston, MA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I165690674","https://openalex.org/I2803065977"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026593581","display_name":"Christopher L. Corless","orcid":"https://orcid.org/0000-0003-4871-8364","observed_orcids":["https://orcid.org/0000-0003-4871-8364"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I2803065977","display_name":"Portland VA Medical Center","ror":"https://ror.org/02v3txv81","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2803065977","https://openalex.org/I4210144745"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. L. Corless","raw_affiliation_strings":["Portland VAMC, Portland, OR; OHSU Cancer Institute, Portland, OR; Brigham and Women's Hospital, Boston, MA; Ludwig Center at Dana-Farber/Harvard, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Portland VAMC, Portland, OR; OHSU Cancer Institute, Portland, OR; Brigham and Women's Hospital, Boston, MA; Ludwig Center at Dana-Farber/Harvard, Boston, MA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I165690674","https://openalex.org/I2803065977"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040870651","display_name":"Bernadette Liegl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I2803065977","display_name":"Portland VA Medical Center","ror":"https://ror.org/02v3txv81","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2803065977","https://openalex.org/I4210144745"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B. Liegl","raw_affiliation_strings":["Portland VAMC, Portland, OR; OHSU Cancer Institute, Portland, OR; Brigham and Women's Hospital, Boston, MA; Ludwig Center at Dana-Farber/Harvard, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Portland VAMC, Portland, OR; OHSU Cancer Institute, Portland, OR; Brigham and Women's Hospital, Boston, MA; Ludwig Center at Dana-Farber/Harvard, Boston, MA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I165690674","https://openalex.org/I2803065977"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050651568","display_name":"Christopher D.\ufffdM. Fletcher","orcid":"https://orcid.org/0000-0002-8053-9537","observed_orcids":["https://orcid.org/0000-0002-8053-9537"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I2803065977","display_name":"Portland VA Medical Center","ror":"https://ror.org/02v3txv81","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2803065977","https://openalex.org/I4210144745"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. D. Fletcher","raw_affiliation_strings":["Portland VAMC, Portland, OR; OHSU Cancer Institute, Portland, OR; Brigham and Women's Hospital, Boston, MA; Ludwig Center at Dana-Farber/Harvard, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Portland VAMC, Portland, OR; OHSU Cancer Institute, Portland, OR; Brigham and Women's Hospital, Boston, MA; Ludwig Center at Dana-Farber/Harvard, Boston, MA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I165690674","https://openalex.org/I2803065977"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056266239","display_name":"Chandrajit P. Raut","orcid":"https://orcid.org/0000-0001-7297-3221","observed_orcids":["https://orcid.org/0000-0001-7297-3221"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I2803065977","display_name":"Portland VA Medical Center","ror":"https://ror.org/02v3txv81","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2803065977","https://openalex.org/I4210144745"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. P. Raut","raw_affiliation_strings":["Portland VAMC, Portland, OR; OHSU Cancer Institute, Portland, OR; Brigham and Women's Hospital, Boston, MA; Ludwig Center at Dana-Farber/Harvard, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Portland VAMC, Portland, OR; OHSU Cancer Institute, Portland, OR; Brigham and Women's Hospital, Boston, MA; Ludwig Center at Dana-Farber/Harvard, Boston, MA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I165690674","https://openalex.org/I2803065977"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034899077","display_name":"Rachel Donsky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I2803065977","display_name":"Portland VA Medical Center","ror":"https://ror.org/02v3txv81","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2803065977","https://openalex.org/I4210144745"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Donsky","raw_affiliation_strings":["Portland VAMC, Portland, OR; OHSU Cancer Institute, Portland, OR; Brigham and Women's Hospital, Boston, MA; Ludwig Center at Dana-Farber/Harvard, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Portland VAMC, Portland, OR; OHSU Cancer Institute, Portland, OR; Brigham and Women's Hospital, Boston, MA; Ludwig Center at Dana-Farber/Harvard, Boston, MA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I165690674","https://openalex.org/I2803065977"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017709484","display_name":"Monica M. Bertagnolli","orcid":"https://orcid.org/0000-0002-0248-3849","observed_orcids":["https://orcid.org/0000-0002-0248-3849"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I2803065977","display_name":"Portland VA Medical Center","ror":"https://ror.org/02v3txv81","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2803065977","https://openalex.org/I4210144745"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. M. Bertagnolli","raw_affiliation_strings":["Portland VAMC, Portland, OR; OHSU Cancer Institute, Portland, OR; Brigham and Women's Hospital, Boston, MA; Ludwig Center at Dana-Farber/Harvard, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Portland VAMC, Portland, OR; OHSU Cancer Institute, Portland, OR; Brigham and Women's Hospital, Boston, MA; Ludwig Center at Dana-Farber/Harvard, Boston, MA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I165690674","https://openalex.org/I2803065977"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037170632","display_name":"Amy Harlow","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I2803065977","display_name":"Portland VA Medical Center","ror":"https://ror.org/02v3txv81","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2803065977","https://openalex.org/I4210144745"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Harlow","raw_affiliation_strings":["Portland VAMC, Portland, OR; OHSU Cancer Institute, Portland, OR; Brigham and Women's Hospital, Boston, MA; Ludwig Center at Dana-Farber/Harvard, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Portland VAMC, Portland, OR; OHSU Cancer Institute, Portland, OR; Brigham and Women's Hospital, Boston, MA; Ludwig Center at Dana-Farber/Harvard, Boston, MA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I165690674","https://openalex.org/I2803065977"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108548434","display_name":"G. D. Demetri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I2803065977","display_name":"Portland VA Medical Center","ror":"https://ror.org/02v3txv81","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2803065977","https://openalex.org/I4210144745"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G. D. Demetri","raw_affiliation_strings":["Portland VAMC, Portland, OR; OHSU Cancer Institute, Portland, OR; Brigham and Women's Hospital, Boston, MA; Ludwig Center at Dana-Farber/Harvard, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Portland VAMC, Portland, OR; OHSU Cancer Institute, Portland, OR; Brigham and Women's Hospital, Boston, MA; Ludwig Center at Dana-Farber/Harvard, Boston, MA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I165690674","https://openalex.org/I2803065977"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110474862","display_name":"Jonathan A. Fletcher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I2803065977","display_name":"Portland VA Medical Center","ror":"https://ror.org/02v3txv81","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2803065977","https://openalex.org/I4210144745"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. A. Fletcher","raw_affiliation_strings":["Portland VAMC, Portland, OR; OHSU Cancer Institute, Portland, OR; Brigham and Women's Hospital, Boston, MA; Ludwig Center at Dana-Farber/Harvard, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Portland VAMC, Portland, OR; OHSU Cancer Institute, Portland, OR; Brigham and Women's Hospital, Boston, MA; Ludwig Center at Dana-Farber/Harvard, Boston, MA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I165690674","https://openalex.org/I2803065977"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"25","issue":"18_suppl","first_page":"10006","last_page":"10006"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11485","display_name":"Gastrointestinal Tumor Research and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11485","display_name":"Gastrointestinal Tumor Research and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sunitinib-resistance","display_name":"sunitinib resistance","score":0.9039999842643738},{"id":"https://openalex.org/keywords/gastrointestinal-stromal-tumor","display_name":"gastrointestinal stromal tumor","score":0.9150000214576721},{"id":"https://openalex.org/keywords/imatinib-resistance","display_name":"imatinib resistance","score":0.8840000033378601},{"id":"https://openalex.org/keywords/kit-exon-11-mutation","display_name":"KIT exon 11 mutation","score":0.9240000247955322},{"id":"https://openalex.org/keywords/imatinib","display_name":"imatinib","score":0.46799999475479126},{"id":"https://openalex.org/keywords/anti-angiogenic-therapy","display_name":"anti-angiogenic therapy","score":0.6480000019073486},{"id":"https://openalex.org/keywords/patient-derived-tumors","display_name":"patient-derived tumors","score":0.652999997138977},{"id":"https://openalex.org/keywords/salvage-surgery","display_name":"salvage surgery","score":0.597000002861023},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitors","display_name":"tyrosine kinase inhibitors","score":0.7210000157356262}],"concepts":[{"id":"https://openalex.org/C2779490328","wikidata":"https://www.wikidata.org/wiki/Q417542","display_name":"Sunitinib","level":3,"score":0.8417571783065796},{"id":"https://openalex.org/C2908861226","wikidata":"https://www.wikidata.org/wiki/Q417542","display_name":"Sunitinib malate","level":4,"score":0.7412533760070801},{"id":"https://openalex.org/C37307934","wikidata":"https://www.wikidata.org/wiki/Q18030422","display_name":"PDGFRA","level":4,"score":0.704396665096283},{"id":"https://openalex.org/C2775922572","wikidata":"https://www.wikidata.org/wiki/Q83567","display_name":"GiST","level":3,"score":0.7015870809555054},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6353227496147156},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6274315118789673},{"id":"https://openalex.org/C3019892230","wikidata":"https://www.wikidata.org/wiki/Q177094","display_name":"Imatinib mesylate","level":4,"score":0.6003615856170654},{"id":"https://openalex.org/C2778820342","wikidata":"https://www.wikidata.org/wiki/Q906415","display_name":"Tyrosine-kinase inhibitor","level":3,"score":0.5908271670341492},{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.5359882116317749},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.495580792427063},{"id":"https://openalex.org/C2777007597","wikidata":"https://www.wikidata.org/wiki/Q16869243","display_name":"Stromal tumor","level":3,"score":0.4724099040031433},{"id":"https://openalex.org/C2777583451","wikidata":"https://www.wikidata.org/wiki/Q177094","display_name":"Imatinib","level":3,"score":0.4105684161186218},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.3690008521080017},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3207363486289978},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31450843811035156},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2931489050388336},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.240081787109375},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23079431056976318},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1078241765499115},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0915631353855133},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2007.25.18_suppl.10006","doi":"https://doi.org/10.1200/jco.2007.25.18_suppl.10006","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2007.25.18_suppl.10006","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2252961166","https://openalex.org/W2603969996","https://openalex.org/W2081016143","https://openalex.org/W2563088196","https://openalex.org/W2005081096","https://openalex.org/W1975562029","https://openalex.org/W3028750840","https://openalex.org/W2590381267","https://openalex.org/W1969600134","https://openalex.org/W2579928778"],"abstract_inverted_index":{"10006":[0],"Background:":[1],"SU,":[2],"an":[3],"oral,":[4],"multitargeted":[5],"inhibitor":[6],"of":[7,24,42,51,59,72,88,103,169,207,277,317],"KIT,":[8],"PDGFRs,":[9],"VEGFRs,":[10],"FLT3,":[11],"and":[12,61,66,74,93,146,222,249,291],"RET":[13],"receptor":[14],"tyrosine":[15],"kinases,":[16],"is":[17,36,47],"now":[18],"the":[19,39,85,100,167,173,204,212,278,314,327],"standard":[20],"therapy":[21],"for":[22,144],"treatment":[23,138],"imatinib":[25],"mesylate":[26],"(IM)-resistant":[27],"GIST":[28,32,230,283,324],"tumors":[29,262],"or":[30,69,105,116,178],"IM-intolerant":[31],"patients.":[33],"However,":[34,196],"it":[35],"unclear":[37],"if":[38],"clinical":[40,234,287,307],"efficacy":[41],"SU":[43,89,106,137,150,184,197,290,308,318],"in":[44,55,63,91,94,117,245,282],"this":[45,81],"setting":[46],"due":[48],"to":[49,79,194,289,306,322],"inhibition":[50,58],"KIT":[52,110,161,213,279],"and/or":[53],"PDGFRA":[54],"tumor":[56,128],"cells,":[57],"VEGFRs":[60],"PDGFRs":[62],"endothelial":[64],"cells":[65,108],"pericytes,":[67],"respectively,":[68],"a":[70,251,265],"combination":[71,118],"antitumor":[73],"antiangiogenic":[75,315],"effects.":[76],"In":[77,124,165,186,258,293],"order":[78],"address":[80],"question,":[82],"we":[83,126],"studied":[84,99],"molecular":[86],"mechanisms":[87],"resistance":[90,193,288,303],"vitro":[92],"patient-derived":[95],"tumors.":[96],"Methods:":[97],"We":[98],"in-vitro":[101,272],"effects":[102,316],"IM":[104,157,302],"on":[107,203,228,236],"with":[109,119,271,286,301],"exon":[111,162],"11":[112,163],"mutations,":[113],"either":[114],"alone":[115],"known":[120],"IM-resistant":[121,209,275],"secondary":[122,147,170,208,267],"mutations.":[123,148,164],"addition,":[125,166,294],"analyzed":[127],"samples":[129],"obtained":[130],"from":[131],"patients":[132,231],"undergoing":[133],"salvage":[134],"surgery":[135],"after":[136],"failure.":[139],"Tumor":[140],"specimens":[141],"were":[142,243],"genotyped":[143],"primary":[145],"Results:":[149],"was":[151,226,255],"approximately":[152],"2\u20135-fold":[153],"more":[154],"potent":[155],"than":[156],"against":[158],"typical":[159],"GIST-associated":[160],"presence":[168],"mutations":[171,190,210,276,297],"involving":[172,211],"ATP/drug":[174],"binding":[175],"pocket":[176],"(V654A":[177],"T670I)":[179],"did":[180],"not":[181,298],"substantially":[182],"alter":[183],"potency.":[185],"contrast,":[187,259],"these":[188],"ATP/drug-binding-pocket":[189],"conferred":[191],"high-level":[192],"IM.":[195,292],"had":[198,233],"no":[199],"significant":[200],"inhibitory":[201],"effect":[202],"kinase":[205,296,330],"activity":[206],"activation":[214,280],"loop":[215,281],"(exon":[216],"17,":[217],"codons":[218,246],"816,":[219,247],"820,":[220,248],"822,":[221],"823).":[223],"Surgical":[224],"resection":[225],"performed":[227],"two":[229,260],"who":[232],"progression":[235,325],"SU.":[237],"Among":[238],"nine":[239],"progressing":[240],"lesions,":[241],"substitutions":[242],"detected":[244],"822;":[250],"novel":[252,295],"mutation,":[253],"L783V,":[254],"also":[256],"identified.":[257],"non-progressing":[261],"both":[263],"contained":[264],"V654A":[266],"mutation.":[268],"Conclusions:":[269],"Consistent":[270],"studies,":[273],"acquired":[274],"are":[284],"associated":[285,300],"previously":[299],"may":[304,319],"contribute":[305],"resistance.":[309],"These":[310],"findings":[311],"suggest":[312],"that":[313],"be":[320],"insufficient":[321],"inhibit":[323],"when":[326],"targeted":[328],"oncogenic":[329],"remains":[331],"active.":[332],"[Table:":[333],"see":[334],"text]":[335]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2015,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}