{"id":"https://openalex.org/W2163972907","doi":"https://doi.org/10.1158/1055-9965.epi-08-0048","title":"Serum Concentrations of Insulin-Like Growth Factor and Insulin-Like Growth Factor Binding Protein 3 and Recurrent Colorectal Adenomas","display_name":"Serum Concentrations of Insulin-Like Growth Factor and Insulin-Like Growth Factor Binding Protein 3 and Recurrent Colorectal Adenomas","publication_year":2008,"publication_date":"2008-06-01","ids":{"openalex":"https://openalex.org/W2163972907","doi":"https://doi.org/10.1158/1055-9965.epi-08-0048","mag":"2163972907","pmid":"https://pubmed.ncbi.nlm.nih.gov/18559566","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2597396"},"language":"en","primary_location":{"id":"doi:10.1158/1055-9965.epi-08-0048","doi":"https://doi.org/10.1158/1055-9965.epi-08-0048","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1055-9965.epi-08-0048","pdf_url":"https://aacrjournals.org/cebp/article-pdf/17/6/1493/2267667/1493.pdf","source":{"id":"https://openalex.org/S8391440","display_name":"Cancer Epidemiology Biomarkers & Prevention","issn_l":"1055-9965","issn":["1055-9965","1538-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Epidemiology, Biomarkers & Prevention","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://aacrjournals.org/cebp/article-pdf/17/6/1493/2267667/1493.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064012323","display_name":"Andrew P. Flood","orcid":"https://orcid.org/0000-0001-7295-4901","observed_orcids":["https://orcid.org/0000-0001-7295-4901"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I4390039358","display_name":"Masonic Cancer Center","ror":"https://ror.org/05x083d20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Flood","raw_affiliation_strings":["1Division of Epidemiology and Community Health, University of Minnesota and","2Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Division of Epidemiology and Community Health, University of Minnesota and","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"2Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota;","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048359764","display_name":"Volker Mai","orcid":"https://orcid.org/0000-0002-6997-9750","observed_orcids":["https://orcid.org/0000-0002-6997-9750"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Volker Mai","raw_affiliation_strings":["3University of Florida, Gainesville, Florida;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3University of Florida, Gainesville, Florida;","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037297600","display_name":"Ruth M. Pfeiffer","orcid":"https://orcid.org/0000-0001-7791-2698","observed_orcids":["https://orcid.org/0000-0001-7791-2698"]},"institutions":[{"id":"https://openalex.org/I4210123359","display_name":"National Cancer Institute","ror":"https://ror.org/02t771148","country_code":"UA","type":"facility","lineage":["https://openalex.org/I4210123359"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4391012607","display_name":"Division of Cancer Epidemiology and Genetics","ror":"https://ror.org/00vkwep27","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4391012607"]}],"countries":["UA","US"],"is_corresponding":false,"raw_author_name":"Ruth Pfeiffer","raw_affiliation_strings":["4Division of Cancer Epidemiology and Genetics, National Cancer Institute and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Division of Cancer Epidemiology and Genetics, National Cancer Institute and","institution_ids":["https://openalex.org/I4210123359","https://openalex.org/I4210140884","https://openalex.org/I4391012607"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010107362","display_name":"Lisa Kahle","orcid":"https://orcid.org/0000-0002-1783-7240","observed_orcids":["https://orcid.org/0000-0002-1783-7240"]},"institutions":[{"id":"https://openalex.org/I4210110061","display_name":"Information Management Services","ror":"https://ror.org/020k7fn51","country_code":"US","type":"company","lineage":["https://openalex.org/I4210110061"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lisa Kahle","raw_affiliation_strings":["6Information Management Services, Inc., Silver Spring, Maryland; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Information Management Services, Inc., Silver Spring, Maryland; and","institution_ids":["https://openalex.org/I4210110061"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047044979","display_name":"Clifford james Rosen","orcid":"https://orcid.org/0000-0003-3436-8199","observed_orcids":["https://orcid.org/0000-0003-3436-8199"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Clifford J. Rosen","raw_affiliation_strings":["7Maine Center for Osteoporosis Research and Education, Bangor, Maine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"7Maine Center for Osteoporosis Research and Education, Bangor, Maine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110126095","display_name":"Elaine Lanza","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elaine Lanza","raw_affiliation_strings":["5Center for Cancer Research, National Cancer Institute, Bethesda, Maryland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Center for Cancer Research, National Cancer Institute, Bethesda, Maryland;","institution_ids":["https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060407594","display_name":"Arthur G. Schatzkin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123359","display_name":"National Cancer Institute","ror":"https://ror.org/02t771148","country_code":"UA","type":"facility","lineage":["https://openalex.org/I4210123359"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4391012607","display_name":"Division of Cancer Epidemiology and Genetics","ror":"https://ror.org/00vkwep27","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4391012607"]}],"countries":["UA","US"],"is_corresponding":false,"raw_author_name":"Arthur Schatzkin","raw_affiliation_strings":["4Division of Cancer Epidemiology and Genetics, National Cancer Institute and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Division of Cancer Epidemiology and Genetics, National Cancer Institute and","institution_ids":["https://openalex.org/I4210123359","https://openalex.org/I4210140884","https://openalex.org/I4391012607"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.448,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.84876779,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"17","issue":"6","first_page":"1493","last_page":"1498"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10552","display_name":"Colorectal Cancer Screening and Detection","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.9980000257492065},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-binding-protein-3","display_name":"insulin-like growth factor binding protein-3","score":0.9380000233650208},{"id":"https://openalex.org/keywords/colorectal-adenoma-recurrence","display_name":"colorectal adenoma recurrence","score":0.9160000085830688},{"id":"https://openalex.org/keywords/advanced-adenoma","display_name":"advanced adenoma","score":0.8009999990463257},{"id":"https://openalex.org/keywords/colorectal-cancer-risk","display_name":"colorectal cancer risk","score":0.8019999861717224},{"id":"https://openalex.org/keywords/serum-biomarkers","display_name":"serum biomarkers","score":0.8330000042915344},{"id":"https://openalex.org/keywords/polyp-prevention-trial","display_name":"Polyp Prevention Trial","score":0.8840000033378601},{"id":"https://openalex.org/keywords/colorectal-polyps","display_name":"colorectal polyps","score":0.5979999899864197}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7690478563308716},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7324771285057068},{"id":"https://openalex.org/C2776861080","wikidata":"https://www.wikidata.org/wiki/Q2825480","display_name":"Colorectal adenoma","level":4,"score":0.7244552373886108},{"id":"https://openalex.org/C2777428134","wikidata":"https://www.wikidata.org/wiki/Q272741","display_name":"Adenoma","level":2,"score":0.6766873002052307},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.5970321297645569},{"id":"https://openalex.org/C68443243","wikidata":"https://www.wikidata.org/wiki/Q2786686","display_name":"Quartile","level":3,"score":0.5953305959701538},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.524039089679718},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5218352675437927},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5131416916847229},{"id":"https://openalex.org/C2777628954","wikidata":"https://www.wikidata.org/wiki/Q18216","display_name":"Aspirin","level":2,"score":0.5048897862434387},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.49668222665786743},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.48181238770484924},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.4817826449871063},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.4593328535556793},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.44340625405311584},{"id":"https://openalex.org/C2780689927","wikidata":"https://www.wikidata.org/wiki/Q24766801","display_name":"Insulin-like growth factor","level":4,"score":0.4275318682193756},{"id":"https://openalex.org/C2780378035","wikidata":"https://www.wikidata.org/wiki/Q17143674","display_name":"Insulin-like growth factor-binding protein","level":5,"score":0.4253278374671936},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.3261241018772125},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.23264607787132263},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.09807899594306946}],"mesh":[{"descriptor_ui":"D000236","descriptor_name":"Adenoma","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000236","descriptor_name":"Adenoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003113","descriptor_name":"Colonoscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007334","descriptor_name":"Insulin-Like Growth Factor I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016015","descriptor_name":"Logistic Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018972","descriptor_name":"Insulin-Like Growth Factor Binding Protein 3","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1158/1055-9965.epi-08-0048","doi":"https://doi.org/10.1158/1055-9965.epi-08-0048","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1055-9965.epi-08-0048","pdf_url":"https://aacrjournals.org/cebp/article-pdf/17/6/1493/2267667/1493.pdf","source":{"id":"https://openalex.org/S8391440","display_name":"Cancer Epidemiology Biomarkers & Prevention","issn_l":"1055-9965","issn":["1055-9965","1538-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Epidemiology, Biomarkers & Prevention","raw_type":"journal-article"},{"id":"pmid:18559566","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18559566","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2597396","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2597396","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cancer Epidemiol Biomarkers Prev","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/1055-9965.epi-08-0048","doi":"https://doi.org/10.1158/1055-9965.epi-08-0048","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1055-9965.epi-08-0048","pdf_url":"https://aacrjournals.org/cebp/article-pdf/17/6/1493/2267667/1493.pdf","source":{"id":"https://openalex.org/S8391440","display_name":"Cancer Epidemiology Biomarkers & Prevention","issn_l":"1055-9965","issn":["1055-9965","1538-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Epidemiology, Biomarkers & Prevention","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.8700000047683716,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3227974648","display_name":"Insulin Resistance, the IGF Axis, and Colorectal Cancer","funder_award_id":"K07CA108910","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2163972907.pdf","grobid_xml":"https://content.openalex.org/works/W2163972907.grobid-xml"},"referenced_works_count":19,"referenced_works":["https://openalex.org/W69315939","https://openalex.org/W1494121940","https://openalex.org/W1984794598","https://openalex.org/W2012505775","https://openalex.org/W2065096639","https://openalex.org/W2073533462","https://openalex.org/W2091081328","https://openalex.org/W2111843196","https://openalex.org/W2114613406","https://openalex.org/W2117530385","https://openalex.org/W2135645166","https://openalex.org/W2141163594","https://openalex.org/W2144224364","https://openalex.org/W2150081825","https://openalex.org/W2154929552","https://openalex.org/W2156982018","https://openalex.org/W2161150757","https://openalex.org/W2167726756","https://openalex.org/W2328253827"],"related_works":["https://openalex.org/W2161150757","https://openalex.org/W1712137236","https://openalex.org/W3143581172","https://openalex.org/W2078447501","https://openalex.org/W2239523844","https://openalex.org/W2092172594","https://openalex.org/W4242601153","https://openalex.org/W2587001207","https://openalex.org/W2006969357","https://openalex.org/W2078874563"],"abstract_inverted_index":{"Insulin-like":[0],"growth":[1],"factor":[2],"I":[3],"(IGF-I)":[4],"and":[5,31,45,47,61,82,110,132,137],"its":[6],"primary":[7],"binding":[8],"protein,":[9],"IGFBP-3,":[10,138],"have":[11],"been":[12,51],"associated":[13],"with":[14,60,151,210,218],"colorectal":[15,237],"cancer":[16],"incidence":[17],"in":[18,28,36,147,205],"prior":[19,41],"epidemiologic":[20],"studies.":[21],"High":[22],"concentrations":[23,33,79],"of":[24,34,43,71,80,88,94,97,101,202,221,228],"IGF-I":[25,44,81,136,224],"generally":[26],"result":[27],"increasing":[29],"risk":[30,87,144,206,227],"high":[32,149,213,219],"IGFBP-3":[35,46,214],"decreasing":[37],"risk.":[38],"Only":[39],"one":[40],"study":[42],"adenoma":[48,67,89,230,235],"recurrence":[49,90],"has":[50],"reported.":[52],"We":[53],"assayed":[54],"fasting":[55],"serum":[56,103],"from":[57,233],"375":[58,62],"subjects":[59,63,146],"without":[64],"a":[65,203],"recurrent":[66,208,229],"during":[68],"the":[69,72,92,148,152,200],"course":[70,93],"Polyp":[73],"Prevention":[74],"Trial":[75],"to":[76],"determine":[77],"baseline":[78],"IGFBP-3.":[83],"To":[84],"estimate":[85],"relative":[86],"over":[91],"4":[95],"years":[96],"follow-up":[98],"for":[99,121,145,162,174,184,207],"each":[100],"these":[102],"measures,":[104],"we":[105,139],"calculated":[106],"odds":[107],"ratios":[108],"(OR)":[109],"95%":[111,159,166,181,188],"confidence":[112],"intervals":[113],"(CI)":[114],"using":[115],"multivariable":[116],"logistic":[117],"regression":[118],"models":[119],"adjusting":[120],"age,":[122],"gender,":[123],"body":[124],"mass":[125],"index,":[126],"intervention":[127],"group,":[128],"aspirin,":[129],"smoking,":[130],"ethnicity,":[131],"education.":[133],"For":[134],"both":[135],"found":[140],"trends":[141],"indicating":[142],"decreased":[143],"compared":[150],"low":[153],"quartile":[154],"(for":[155,177],"IGF-I:":[156,178],"OR,":[157,164,179,186],"0.65;":[158],"CI":[160],"0.41-1.01;":[161],"IGFBP-3:":[163,185],"0.66;":[165],"CI,":[167,182,189],"0.42-1.05).":[168],"The":[169],"associations":[170],"were":[171],"even":[172,199],"greater":[173],"advanced":[175],"adenomas":[176],"0.51;":[180],"0.21-1.29;":[183],"0.32;":[187],"0.13-0.82).":[190],"These":[191],"results":[192],"showed":[193],"an":[194],"unexpected":[195],"null":[196],"association,":[197],"or":[198,236],"suggestion":[201],"reduction":[204],"adenoma,":[209],"not":[211,240],"just":[212],"concentration":[215],"but":[216],"also":[217],"levels":[220],"IGF-I.":[222],"Why":[223],"would":[225],"decrease":[226],"(as":[231],"distinct":[232],"incident":[234],"cancer)":[238],"is":[239],"clear.":[241]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}