{"id":"https://openalex.org/W2163857095","doi":"https://doi.org/10.1186/1749-8104-8-21","title":"Acute inactivation of the serine-threonine kinase Stk25 disrupts neuronal migration","display_name":"Acute inactivation of the serine-threonine kinase Stk25 disrupts neuronal migration","publication_year":2013,"publication_date":"2013-11-13","ids":{"openalex":"https://openalex.org/W2163857095","doi":"https://doi.org/10.1186/1749-8104-8-21","mag":"2163857095","pmid":"https://pubmed.ncbi.nlm.nih.gov/24225308","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3874637"},"language":"en","primary_location":{"id":"doi:10.1186/1749-8104-8-21","doi":"https://doi.org/10.1186/1749-8104-8-21","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1749-8104-8-21","pdf_url":"https://neuraldevelopment.biomedcentral.com/counter/pdf/10.1186/1749-8104-8-21","source":{"id":"https://openalex.org/S99482838","display_name":"Neural Development","issn_l":"1749-8104","issn":["1749-8104"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","poland-70"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neural Development","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://neuraldevelopment.biomedcentral.com/counter/pdf/10.1186/1749-8104-8-21","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5105651953","display_name":"Tohru Matsuki","orcid":"https://orcid.org/0000-0003-1832-2406","observed_orcids":["https://orcid.org/0000-0003-1832-2406"]},"institutions":[{"id":"https://openalex.org/I20388574","display_name":"SUNY Upstate Medical University","ror":"https://ror.org/040kfrw16","country_code":"US","type":"education","lineage":["https://openalex.org/I20388574"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tohru Matsuki","raw_affiliation_strings":["Department of Neuroscience and Physiology, SUNY Upstate Medical University, 750 E. Adams St, Syracuse, NY, 13210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience and Physiology, SUNY Upstate Medical University, 750 E. Adams St, Syracuse, NY, 13210, USA","institution_ids":["https://openalex.org/I20388574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100385458","display_name":"Jianhua Chen","orcid":"https://orcid.org/0000-0003-4778-8053","observed_orcids":["https://orcid.org/0000-0003-4778-8053"]},"institutions":[{"id":"https://openalex.org/I20388574","display_name":"SUNY Upstate Medical University","ror":"https://ror.org/040kfrw16","country_code":"US","type":"education","lineage":["https://openalex.org/I20388574"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jianhua Chen","raw_affiliation_strings":["Department of Neuroscience and Physiology, SUNY Upstate Medical University, 750 E. Adams St, Syracuse, NY, 13210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience and Physiology, SUNY Upstate Medical University, 750 E. Adams St, Syracuse, NY, 13210, USA","institution_ids":["https://openalex.org/I20388574"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033347099","display_name":"Brian W. Howell","orcid":"https://orcid.org/0000-0002-0204-0773","observed_orcids":["https://orcid.org/0000-0002-0204-0773"]},"institutions":[{"id":"https://openalex.org/I20388574","display_name":"SUNY Upstate Medical University","ror":"https://ror.org/040kfrw16","country_code":"US","type":"education","lineage":["https://openalex.org/I20388574"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Brian W Howell","raw_affiliation_strings":["Department of Neuroscience and Physiology, SUNY Upstate Medical University, 750 E, Adams St, Syracuse, NY 13210, USA. howellb@upstate.edu","Department of Neuroscience and Physiology, SUNY Upstate Medical University, 750 E. Adams St, Syracuse, NY, 13210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience and Physiology, SUNY Upstate Medical University, 750 E, Adams St, Syracuse, NY 13210, USA. howellb@upstate.edu","institution_ids":["https://openalex.org/I20388574"]},{"raw_affiliation_string":"Department of Neuroscience and Physiology, SUNY Upstate Medical University, 750 E. Adams St, Syracuse, NY, 13210, USA","institution_ids":["https://openalex.org/I20388574"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5033347099"],"corresponding_institution_ids":["https://openalex.org/I20388574"],"apc_list":{"value":2890,"currency":"USD","value_usd":2890},"apc_paid":{"value":2890,"currency":"USD","value_usd":2890},"fwci":0.822,"has_fulltext":true,"cited_by_count":47,"citation_normalized_percentile":{"value":0.64231419,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"8","issue":"1","first_page":"21","last_page":"21"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.9585000276565552,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.9585000276565552,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12061","display_name":"Axon Guidance and Neuronal Signaling","score":0.02669999934732914,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.009200000204145908,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stk25","display_name":"STK25","score":0.9980000257492065},{"id":"https://openalex.org/keywords/neuronal-migration","display_name":"neuronal migration","score":0.902999997138977},{"id":"https://openalex.org/keywords/liver-kinase-b1","display_name":"LKB1","score":0.9110000133514404},{"id":"https://openalex.org/keywords/strad","display_name":"STRAD","score":0.9990000128746033},{"id":"https://openalex.org/keywords/gm130","display_name":"GM130","score":0.9990000128746033},{"id":"https://openalex.org/keywords/neuronal-polarity","display_name":"neuronal polarity","score":0.8560000061988831},{"id":"https://openalex.org/keywords/dendritogenesis","display_name":"dendritogenesis","score":0.8029999732971191},{"id":"https://openalex.org/keywords/neuronal-positioning","display_name":"neuronal positioning","score":0.6549999713897705},{"id":"https://openalex.org/keywords/serine-threonine-kinase","display_name":"serine/threonine kinase","score":0.8399999737739563}],"concepts":[{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.751459538936615},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6404733657836914},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.605890154838562},{"id":"https://openalex.org/C2778063154","wikidata":"https://www.wikidata.org/wiki/Q13561329","display_name":"Reelin","level":3,"score":0.5966441035270691},{"id":"https://openalex.org/C188209991","wikidata":"https://www.wikidata.org/wiki/Q14916487","display_name":"DAB1","level":4,"score":0.5800760984420776},{"id":"https://openalex.org/C74254510","wikidata":"https://www.wikidata.org/wiki/Q7240508","display_name":"Premovement neuronal activity","level":2,"score":0.5225731134414673},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.49374303221702576},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4927509129047394},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4532982409000397},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4514275789260864},{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.41325676441192627},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18996429443359375},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15636950731277466},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000091042","descriptor_name":"Reelin Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000099317","descriptor_name":"Hippo Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/1749-8104-8-21","doi":"https://doi.org/10.1186/1749-8104-8-21","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1749-8104-8-21","pdf_url":"https://neuraldevelopment.biomedcentral.com/counter/pdf/10.1186/1749-8104-8-21","source":{"id":"https://openalex.org/S99482838","display_name":"Neural Development","issn_l":"1749-8104","issn":["1749-8104"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","poland-70"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neural Development","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2857967","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3874637","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:24225308","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24225308","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neural development","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3874637","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3874637/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neural Dev","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1749-8104-8-21","doi":"https://doi.org/10.1186/1749-8104-8-21","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1749-8104-8-21","pdf_url":"https://neuraldevelopment.biomedcentral.com/counter/pdf/10.1186/1749-8104-8-21","source":{"id":"https://openalex.org/S99482838","display_name":"Neural Development","issn_l":"1749-8104","issn":["1749-8104"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","poland-70"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neural Development","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.4043000042438507,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1073272279","display_name":"Regulation of Neuronal Lamination and Dendritogenesis by Reelin-Dab1 Signaling","funder_award_id":"R01NS073662","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2163857095.pdf","grobid_xml":"https://content.openalex.org/works/W2163857095.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W1667992367","https://openalex.org/W1966133006","https://openalex.org/W1966161684","https://openalex.org/W1967606063","https://openalex.org/W1970302470","https://openalex.org/W1973059673","https://openalex.org/W1979890518","https://openalex.org/W1988033732","https://openalex.org/W1992692192","https://openalex.org/W1993155860","https://openalex.org/W2004919635","https://openalex.org/W2008441088","https://openalex.org/W2013210636","https://openalex.org/W2014095197","https://openalex.org/W2018754444","https://openalex.org/W2020614042","https://openalex.org/W2027922031","https://openalex.org/W2033822739","https://openalex.org/W2036838270","https://openalex.org/W2041559415","https://openalex.org/W2041622179","https://openalex.org/W2048621255","https://openalex.org/W2050642338","https://openalex.org/W2058476273","https://openalex.org/W2059114536","https://openalex.org/W2063086906","https://openalex.org/W2070996331","https://openalex.org/W2079396188","https://openalex.org/W2082785179","https://openalex.org/W2082937530","https://openalex.org/W2088680750","https://openalex.org/W2089518215","https://openalex.org/W2094267814","https://openalex.org/W2098955633","https://openalex.org/W2099343588","https://openalex.org/W2108867585","https://openalex.org/W2114605993","https://openalex.org/W2118059649","https://openalex.org/W2118947728","https://openalex.org/W2121361182","https://openalex.org/W2127220436","https://openalex.org/W2133082302","https://openalex.org/W2135778913","https://openalex.org/W2138319716","https://openalex.org/W2140625846","https://openalex.org/W2140916429","https://openalex.org/W2169448800","https://openalex.org/W2169520827"],"related_works":["https://openalex.org/W3199399157","https://openalex.org/W2008441088","https://openalex.org/W2128500531","https://openalex.org/W1803926019","https://openalex.org/W159303731","https://openalex.org/W3185696486","https://openalex.org/W2015328304","https://openalex.org/W2020793386","https://openalex.org/W2148582904","https://openalex.org/W1993155860"],"abstract_inverted_index":{"BACKGROUND:":[0],"Neuronal":[1],"migration":[2,6,14,98],"involves":[3],"the":[4,13,33,151],"directional":[5],"of":[7,12,105,126,150],"immature":[8],"neurons.":[9],"During":[10],"much":[11],"period":[15],"these":[16],"neurons":[17],"are":[18],"polarized":[19],"with":[20,116],"defined":[21],"leading":[22],"and":[23,37,41,108],"trailing":[24],"processes.":[25],"Stk25":[26,56,76,127,143],"has":[27],"been":[28,114],"shown":[29,157],"to":[30,32,47,81,134,158],"bind":[31],"LKB1":[34],"activator":[35],"STRAD":[36,107],"regulate":[38],"neuronal":[39,58,82,97,122,141,145,162],"polarization":[40],"dendritogenesis":[42],"in":[43,121,130,140],"an":[44],"opposing":[45],"manner":[46],"Reelin-Dab1":[48,66],"signaling.":[49],"It":[50],"is":[51],"not":[52,79],"known,":[53],"however,":[54],"whether":[55],"controls":[57],"migration,":[59],"a":[60,95],"key":[61],"developmental":[62,96],"process":[63],"regulated":[64],"by":[65,86,92],"signal":[67],"transduction.":[68],"FINDINGS:":[69],"Here":[70],"we":[71,101],"find":[72,102],"that":[73,103,111,154],"while":[74],"constitutive":[75],"deficiency":[77],"does":[78],"lead":[80],"phenotypes,":[83],"acute":[84],"reduction":[85],"either":[87],"Cre-mediated":[88],"gene":[89],"inactivation":[90],"or":[91],"knockdown":[93,104],"causes":[94,118],"error.":[99],"Furthermore,":[100],"LKB1,":[106],"GM130,":[109],"molecules":[110],"have":[112],"previously":[113,156],"implicated":[115],"Stk25,":[117],"similar":[119],"aberrations":[120],"migration.":[123],"CONCLUSIONS:":[124],"Loss":[125],"function":[128],"early":[129],"development":[131],"likely":[132],"leads":[133],"functional":[135],"compensation":[136],"for":[137,161],"its":[138],"roles":[139],"development.":[142],"regulates":[144],"positioning,":[146],"possibly":[147],"as":[148],"part":[149],"LKB1-STRAD-Stk25-GM130":[152],"pathway":[153],"was":[155],"be":[159],"important":[160],"polarization.":[163]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}
