{"id":"https://openalex.org/W2163840402","doi":"https://doi.org/10.5897/ajb09.1896","title":"Anti-nociceptive, anti-inflammatory and antipyretic effects of the methanolic extract of Bombax buonopozense leaves in rats and mice","display_name":"Anti-nociceptive, anti-inflammatory and antipyretic effects of the methanolic extract of Bombax buonopozense leaves in rats and mice","publication_year":2011,"publication_date":"2011-04-18","ids":{"openalex":"https://openalex.org/W2163840402","doi":"https://doi.org/10.5897/ajb09.1896","mag":"2163840402"},"language":"en","primary_location":{"id":"doi:10.5897/ajb09.1896","doi":"https://doi.org/10.5897/ajb09.1896","is_oa":true,"landing_page_url":"https://doi.org/10.5897/ajb09.1896","pdf_url":"https://academicjournals.org/journal/AJB/article-full-text-pdf/D27695327550.pdf","source":{"id":"https://openalex.org/S118568332","display_name":"AFRICAN JOURNAL OF BIOTECHNOLOGY","issn_l":"1684-5315","issn":["1684-5315"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310321074","host_organization_name":"Academic Journals","host_organization_lineage":["https://openalex.org/P4310321074"],"host_organization_lineage_names":["Academic Journals"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"African Journal of Biotechnology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://academicjournals.org/journal/AJB/article-full-text-pdf/D27695327550.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"C Akuodor G","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104694","display_name":"National Institute for Pharmaceutical Research and Development","ror":"https://ror.org/01c7jsk34","country_code":"NG","type":"government","lineage":["https://openalex.org/I4210104694"]}],"countries":["NG"],"is_corresponding":true,"raw_author_name":"C Akuodor G","raw_affiliation_strings":["Depatment of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development (NIPRD), P.M.B. 21, Garki, Abuja, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Depatment of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development (NIPRD), P.M.B. 21, Garki, Abuja, Nigeria","institution_ids":["https://openalex.org/I4210104694"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103578440","display_name":"Idris Usman M","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104694","display_name":"National Institute for Pharmaceutical Research and Development","ror":"https://ror.org/01c7jsk34","country_code":"NG","type":"government","lineage":["https://openalex.org/I4210104694"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Idris Usman M","raw_affiliation_strings":["Depatment of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development (NIPRD), P.M.B. 21, Garki, Abuja, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Depatment of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development (NIPRD), P.M.B. 21, Garki, Abuja, Nigeria","institution_ids":["https://openalex.org/I4210104694"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113696052","display_name":"A Ibrahim J","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104694","display_name":"National Institute for Pharmaceutical Research and Development","ror":"https://ror.org/01c7jsk34","country_code":"NG","type":"government","lineage":["https://openalex.org/I4210104694"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"A Ibrahim J","raw_affiliation_strings":["Department of Medicinal Plant Research and Traditional Medicine, National Institute for Pharmaceutical Research and Development (NIPRD), P.M.B. 21, Garki, Abuja, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Plant Research and Traditional Medicine, National Institute for Pharmaceutical Research and Development (NIPRD), P.M.B. 21, Garki, Abuja, Nigeria","institution_ids":["https://openalex.org/I4210104694"]}]},{"author_position":"middle","author":{"id":null,"display_name":"C Chilaka K","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I207227095","display_name":"Nnamdi Azikiwe University","ror":"https://ror.org/02r6pfc06","country_code":"NG","type":"education","lineage":["https://openalex.org/I207227095"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"C Chilaka K","raw_affiliation_strings":["Department of Pharmacology and Therapeutics, Faculty of Medicine, Nnamdi Azikiwe University, Awka, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, Faculty of Medicine, Nnamdi Azikiwe University, Awka, Nigeria","institution_ids":["https://openalex.org/I207227095"]}]},{"author_position":"middle","author":{"id":null,"display_name":"L Akpan J","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I96009557","display_name":"Ebonyi State University","ror":"https://ror.org/01jhpwy79","country_code":"NG","type":"education","lineage":["https://openalex.org/I96009557"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"L Akpan J","raw_affiliation_strings":["Department of Pharmacology and Therapeutics, Faculty of Clinical Medicine, Ebonyi State University, Abakiliki, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, Faculty of Clinical Medicine, Ebonyi State University, Abakiliki, Nigeria","institution_ids":["https://openalex.org/I96009557"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024155292","display_name":"Sunday Dzarma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104694","display_name":"National Institute for Pharmaceutical Research and Development","ror":"https://ror.org/01c7jsk34","country_code":"NG","type":"government","lineage":["https://openalex.org/I4210104694"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Dzarma S","raw_affiliation_strings":["Depatment of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development (NIPRD), P.M.B. 21, Garki, Abuja, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Depatment of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development (NIPRD), P.M.B. 21, Garki, Abuja, Nigeria","institution_ids":["https://openalex.org/I4210104694"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045665852","display_name":"I Muazzam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104694","display_name":"National Institute for Pharmaceutical Research and Development","ror":"https://ror.org/01c7jsk34","country_code":"NG","type":"government","lineage":["https://openalex.org/I4210104694"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Muazzam I","raw_affiliation_strings":["Department of Medicinal Plant Research and Traditional Medicine, National Institute for Pharmaceutical Research and Development (NIPRD), P.M.B. 21, Garki, Abuja, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Plant Research and Traditional Medicine, National Institute for Pharmaceutical Research and Development (NIPRD), P.M.B. 21, Garki, Abuja, Nigeria","institution_ids":["https://openalex.org/I4210104694"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111983274","display_name":"A Osunkwo U","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104694","display_name":"National Institute for Pharmaceutical Research and Development","ror":"https://ror.org/01c7jsk34","country_code":"NG","type":"government","lineage":["https://openalex.org/I4210104694"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"A Osunkwo U","raw_affiliation_strings":["Depatment of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development (NIPRD), P.M.B. 21, Garki, Abuja, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Depatment of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development (NIPRD), P.M.B. 21, Garki, Abuja, Nigeria","institution_ids":["https://openalex.org/I4210104694"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210104694"],"apc_list":null,"apc_paid":null,"fwci":3.4,"has_fulltext":true,"cited_by_count":23,"citation_normalized_percentile":{"value":0.91854107,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"10","issue":"16","first_page":"3191","last_page":"3196"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.9696999788284302,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.9696999788284302,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12657","display_name":"Phytochemistry Medicinal Plant Applications","score":0.011699999682605267,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11613","display_name":"Phytochemistry and Biological Activities","score":0.00800000037997961,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bombax-buonopozense","display_name":"Bombax buonopozense","score":0.9990000128746033},{"id":"https://openalex.org/keywords/methanolic-leaf-extract","display_name":"methanolic leaf extract","score":0.8960000276565552},{"id":"https://openalex.org/keywords/antinociceptive-activity","display_name":"antinociceptive activity","score":0.9800000190734863},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.9769999980926514},{"id":"https://openalex.org/keywords/antipyretic-activity","display_name":"antipyretic activity","score":0.9940000176429749},{"id":"https://openalex.org/keywords/acetic-acid-writhing-test","display_name":"acetic acid-induced writhing","score":0.847000002861023},{"id":"https://openalex.org/keywords/formalin-test","display_name":"formalin test","score":0.9940000176429749},{"id":"https://openalex.org/keywords/yeast-induced-pyrexia","display_name":"yeast-induced pyrexia","score":0.9409999847412109},{"id":"https://openalex.org/keywords/medicinal-plants","display_name":"medicinal plants","score":0.6050000190734863}],"concepts":[{"id":"https://openalex.org/C2779703632","wikidata":"https://www.wikidata.org/wiki/Q581996","display_name":"Anti-inflammatory","level":2,"score":0.7664068341255188},{"id":"https://openalex.org/C2779252780","wikidata":"https://www.wikidata.org/wiki/Q582687","display_name":"Antipyretic","level":3,"score":0.7232832908630371},{"id":"https://openalex.org/C2780820201","wikidata":"https://www.wikidata.org/wiki/Q173235","display_name":"Analgesic","level":2,"score":0.7108259201049805},{"id":"https://openalex.org/C15490471","wikidata":"https://www.wikidata.org/wiki/Q2734305","display_name":"Nociception","level":3,"score":0.6525225639343262},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5824812650680542},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5815541744232178},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.5776808261871338},{"id":"https://openalex.org/C2776673659","wikidata":"https://www.wikidata.org/wiki/Q47512","display_name":"Acetic acid","level":2,"score":0.48661455512046814},{"id":"https://openalex.org/C197711040","wikidata":"https://www.wikidata.org/wiki/Q5910791","display_name":"Hot plate test","level":4,"score":0.4760417938232422},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.25853270292282104},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1693134307861328},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.09314438700675964}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.5897/ajb09.1896","doi":"https://doi.org/10.5897/ajb09.1896","is_oa":true,"landing_page_url":"https://doi.org/10.5897/ajb09.1896","pdf_url":"https://academicjournals.org/journal/AJB/article-full-text-pdf/D27695327550.pdf","source":{"id":"https://openalex.org/S118568332","display_name":"AFRICAN JOURNAL OF BIOTECHNOLOGY","issn_l":"1684-5315","issn":["1684-5315"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310321074","host_organization_name":"Academic Journals","host_organization_lineage":["https://openalex.org/P4310321074"],"host_organization_lineage_names":["Academic Journals"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"African Journal of Biotechnology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.5897/ajb09.1896","doi":"https://doi.org/10.5897/ajb09.1896","is_oa":true,"landing_page_url":"https://doi.org/10.5897/ajb09.1896","pdf_url":"https://academicjournals.org/journal/AJB/article-full-text-pdf/D27695327550.pdf","source":{"id":"https://openalex.org/S118568332","display_name":"AFRICAN JOURNAL OF BIOTECHNOLOGY","issn_l":"1684-5315","issn":["1684-5315"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310321074","host_organization_name":"Academic Journals","host_organization_lineage":["https://openalex.org/P4310321074"],"host_organization_lineage_names":["Academic Journals"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"African Journal of Biotechnology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2163840402.pdf","grobid_xml":"https://content.openalex.org/works/W2163840402.grobid-xml"},"referenced_works_count":16,"referenced_works":["https://openalex.org/W11380603","https://openalex.org/W20133550","https://openalex.org/W1834905825","https://openalex.org/W1986942777","https://openalex.org/W1987464387","https://openalex.org/W2001933690","https://openalex.org/W2009345240","https://openalex.org/W2010248759","https://openalex.org/W2020595768","https://openalex.org/W2027127607","https://openalex.org/W2051690250","https://openalex.org/W2078376298","https://openalex.org/W2278365557","https://openalex.org/W2788835785","https://openalex.org/W4293052548","https://openalex.org/W4300718923"],"related_works":["https://openalex.org/W2693596435","https://openalex.org/W1982609403","https://openalex.org/W2087981942","https://openalex.org/W2122163111","https://openalex.org/W2524913947","https://openalex.org/W1937460089","https://openalex.org/W2076351052","https://openalex.org/W4401359697","https://openalex.org/W2405368192","https://openalex.org/W2096314018"],"abstract_inverted_index":{"Methanolic":[0],"extract":[1,55,80],"of":[2,37,68,71,81,94,117],"Bombax":[3,124],"buonopozense":[4,83,106],"was":[5],"evaluated":[6],"for":[7,114],"possible":[8],"anti-nociceptive,":[9],"anti-inflammatory":[10,50,97],"and":[11,16,25,47,66,91,120],"anti-pyretic":[12],"activities":[13],"in":[14,23,28,52,60,64,76,99],"mice":[15,24,65],"rats.":[17,53,77,100],"Acetic":[18],"acid-induced":[19,62],"abdominal":[20],"constriction":[21],"test":[22,27,75],"formalin":[26,73],"rats":[29],"were":[30,41],"used":[31],"to":[32],"investigate":[33],"the":[34,38,72,115],"antinociceptive":[35],"effect":[36,90],"extract.":[39],"Studies":[40],"carried":[42],"out":[43],"on":[44],"yeast-induced":[45],"pyrexia":[46],"egg":[48,95],"albumin-induced":[49,96],"activity":[51,98],"The":[54,78,101],"produced":[56,86],"a":[57,87],"significant":[58,92],"decrease":[59],"acetic":[61],"writhing":[63],"inhibition":[67,93],"late":[69],"phase":[70],"pain":[74],"methanolic":[79],"B.":[82,105],"leaf":[84],"also":[85],"potent":[88],"antipyretic":[89],"result":[102],"suggests":[103],"that":[104],"contains":[107],"biologically":[108],"active":[109],"substances":[110],"with":[111],"potential":[112],"values":[113],"treatment":[116],"fever,":[118],"painful":[119],"inflammatory":[121],"conditions.":[122],"Keywords:":[123],"buonopozense;":[125],"analgesic,":[126],"inflammation,":[127],"pyrexia.":[128]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}