{"id":"https://openalex.org/W2163750159","doi":"https://doi.org/10.1097/00000542-196307000-00018","title":"Effects of Anesthetics on the Response ofthe Microcirculation to Circulating Humors","display_name":"Effects of Anesthetics on the Response ofthe Microcirculation to Circulating Humors","publication_year":1963,"publication_date":"1963-07-01","ids":{"openalex":"https://openalex.org/W2163750159","doi":"https://doi.org/10.1097/00000542-196307000-00018","mag":"2163750159","pmid":"https://pubmed.ncbi.nlm.nih.gov/14044787"},"language":"en","primary_location":{"id":"doi:10.1097/00000542-196307000-00018","doi":"https://doi.org/10.1097/00000542-196307000-00018","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00000542-196307000-00018","pdf_url":null,"source":{"id":"https://openalex.org/S124035732","display_name":"Anesthesiology","issn_l":"0003-3022","issn":["0003-3022","1528-1175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053409472","display_name":"Silvio Baez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I19772626","display_name":"Yeshiva University","ror":"https://ror.org/045x93337","country_code":"US","type":"education","lineage":["https://openalex.org/I19772626"]},{"id":"https://openalex.org/I2800364127","display_name":"Jacobi Medical Center","ror":"https://ror.org/05hcfns23","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800364127"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Silvio Baez","raw_affiliation_strings":["The authors are in the Department of Anesthesi-ology, The Albert Einstein College of Medicine, Yeshiva University and Bronx Municipal Hospital Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The authors are in the Department of Anesthesi-ology, The Albert Einstein College of Medicine, Yeshiva University and Bronx Municipal Hospital Center","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I19772626","https://openalex.org/I2800364127"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111850336","display_name":"Louis R. Orkin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I19772626","display_name":"Yeshiva University","ror":"https://ror.org/045x93337","country_code":"US","type":"education","lineage":["https://openalex.org/I19772626"]},{"id":"https://openalex.org/I2800364127","display_name":"Jacobi Medical Center","ror":"https://ror.org/05hcfns23","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800364127"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Louis\u00a0R. Orkin","raw_affiliation_strings":["The authors are in the Department of Anesthesi-ology, The Albert Einstein College of Medicine, Yeshiva University and Bronx Municipal Hospital Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The authors are in the Department of Anesthesi-ology, The Albert Einstein College of Medicine, Yeshiva University and Bronx Municipal Hospital Center","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I19772626","https://openalex.org/I2800364127"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.8235,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.9574124,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"24","issue":"4","first_page":"568","last_page":"579"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.6880000233650208,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.6880000233650208,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.042399998754262924,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.03440000116825104,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anesthetic-agents","display_name":"anesthetic agents","score":0.753000020980835},{"id":"https://openalex.org/keywords/microcirculation","display_name":"microcirculation","score":0.9940000176429749},{"id":"https://openalex.org/keywords/local-hormones","display_name":"local hormones","score":0.8379999995231628},{"id":"https://openalex.org/keywords/vascular-smooth-muscle","display_name":"vascular smooth muscle","score":0.7229999899864197},{"id":"https://openalex.org/keywords/capillary-bed","display_name":"capillary network","score":0.7580000162124634}],"concepts":[{"id":"https://openalex.org/C12722491","wikidata":"https://www.wikidata.org/wiki/Q1632335","display_name":"Microcirculation","level":2,"score":0.8855912089347839},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7487316131591797},{"id":"https://openalex.org/C133828647","wikidata":"https://www.wikidata.org/wiki/Q6159778","display_name":"Vasoactive","level":2,"score":0.5416131615638733},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5186466574668884},{"id":"https://openalex.org/C2778012447","wikidata":"https://www.wikidata.org/wiki/Q1034415","display_name":"Scope (computer science)","level":2,"score":0.43323877453804016},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.32823753356933594},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.322543740272522},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1913740336894989},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.10446837544441223},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000777","descriptor_name":"Anesthetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008833","descriptor_name":"Microcirculation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014666","descriptor_name":"Vasomotor System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/00000542-196307000-00018","doi":"https://doi.org/10.1097/00000542-196307000-00018","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00000542-196307000-00018","pdf_url":null,"source":{"id":"https://openalex.org/S124035732","display_name":"Anesthesiology","issn_l":"0003-3022","issn":["0003-3022","1528-1175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"journal-article"},{"id":"pmid:14044787","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14044787","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.7524999976158142,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2401197322","https://openalex.org/W2106420385","https://openalex.org/W116587905","https://openalex.org/W1258649231","https://openalex.org/W2474193220","https://openalex.org/W2418723608","https://openalex.org/W2023107735","https://openalex.org/W30320556","https://openalex.org/W2017844221","https://openalex.org/W2410308116"],"abstract_inverted_index":{"REPORTS":[0],"pertaining":[1],"to":[2,54,131,148,183],"the":[3,9,12,24,30,34,37,43,51,62,69,75,85,106,112,123,146,153,163,174,178,187],"effects":[4],"of":[5,11,29,36,74,96,114,125,142,145,156,165,177],"humoral":[6],"factors":[7,65],"on":[8,42,111,162],"reaction":[10,180],"microcirculation":[13,38,147],"during":[14],"anesthesia":[15,182],"are":[16,60,79,95],"few":[17],"and":[18,41,58,195],"not":[19,61],"without":[20],"unanswered":[21],"questions.":[22],"On":[23],"one":[25],"hand,":[26],"our":[27],"knowledge":[28],"mechanisms":[31,168],"participating":[32],"in":[33,99,186],"regulation":[35],"is":[39],"incom-plete,":[40],"other,":[44],"\u201chumors\u201d":[45],"or":[46,91],"chemical":[47,64],"messengers":[48],"carried":[49],"by":[50,169],"blood":[52],"stream":[53],"dis-tant":[55],"target":[56],"organs":[57],"tissues":[59],"only":[63],"which":[66,82],"may":[67,191],"affect":[68],"vascular":[70],"smooth":[71],"muscle":[72],"receptors":[73],"capillary":[76],"bed.":[77],"Data":[78],"being":[80],"accumulated":[81],"indicate":[83],"that":[84,189],"so-called":[86],"\u201clocal":[87],"hormones\u201d":[88],"1,":[89],"2":[90],"\u201ctissue":[92],"mediators\u201d":[93],"3":[94],"considerable":[97],"importance":[98],"modifying":[100],"microcirculatory":[101,166,179],"dynamics.":[102],"Dif-ficulties":[103],"arise":[104],"from":[105],"rather":[107],"scanty":[108],"systematic":[109],"studies":[110],"interplay":[113],"these":[115],"vasoactive":[116],"humors":[117,185],"with":[118],"various":[119],"anesthetic":[120,170],"agents.":[121],"Within":[122],"scope":[124],"this":[126,157,190],"symposium,":[127],"we":[128],"should":[129],"like":[130],"describe":[132],"certain":[133],"aspects":[134],"outlined":[135],"as":[136],"follows:":[137],"(1)":[138],"a":[139],"brief":[140],"description":[141],"current":[143],"concepts":[144],"bring":[149],"into":[150],"better":[151],"per-spective":[152],"main":[154],"subject":[155],"discussion,":[158],"(2)":[159],"present":[160],"information":[161],"modification":[164],"homeostatic":[167],"agents,":[171],"and,":[172],"(3)":[173],"possible":[175],"re-lationship":[176],"under":[181],"circulating":[184],"hope":[188],"stimulate":[192],"further":[193],"thought":[194],"study.":[196]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}