{"id":"https://openalex.org/W2163708910","doi":"https://doi.org/10.1158/0008-5472.can-04-1150","title":"Signaling and Transcriptional Changes Critical for Transformation of Human Cells by Simian Virus 40 Small Tumor Antigen or Protein Phosphatase 2A B56\u03b3 Knockdown","display_name":"Signaling and Transcriptional Changes Critical for Transformation of Human Cells by Simian Virus 40 Small Tumor Antigen or Protein Phosphatase 2A B56\u03b3 Knockdown","publication_year":2004,"publication_date":"2004-10-01","ids":{"openalex":"https://openalex.org/W2163708910","doi":"https://doi.org/10.1158/0008-5472.can-04-1150","mag":"2163708910","pmid":"https://pubmed.ncbi.nlm.nih.gov/15466190"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.can-04-1150","doi":"https://doi.org/10.1158/0008-5472.can-04-1150","is_oa":false,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-04-1150","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056719621","display_name":"Carlos S. Moreno","orcid":"https://orcid.org/0000-0002-5582-0028","observed_orcids":["https://orcid.org/0000-0002-5582-0028"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I4390039307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carlos S. Moreno","raw_affiliation_strings":["1Department of Pathology and Laboratory Medicine, Emory University School of Medicine,","2Winship Cancer Institute, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Pathology and Laboratory Medicine, Emory University School of Medicine,","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"2Winship Cancer Institute, and","institution_ids":["https://openalex.org/I4390039307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072332372","display_name":"Sumathi Ramachandran","orcid":"https://orcid.org/0000-0001-6359-5003","observed_orcids":["https://orcid.org/0000-0001-6359-5003"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I4390039307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sumathi Ramachandran","raw_affiliation_strings":["1Department of Pathology and Laboratory Medicine, Emory University School of Medicine,","2Winship Cancer Institute, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Pathology and Laboratory Medicine, Emory University School of Medicine,","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"2Winship Cancer Institute, and","institution_ids":["https://openalex.org/I4390039307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030571646","display_name":"Danita G. Ashby","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I4390039307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Danita G. Ashby","raw_affiliation_strings":["2Winship Cancer Institute, and","3Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Winship Cancer Institute, and","institution_ids":["https://openalex.org/I4390039307"]},{"raw_affiliation_string":"3Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia;","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071074474","display_name":"Noelani Laycock","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I4390039307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Noelani Laycock","raw_affiliation_strings":["1Department of Pathology and Laboratory Medicine, Emory University School of Medicine,","2Winship Cancer Institute, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Pathology and Laboratory Medicine, Emory University School of Medicine,","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"2Winship Cancer Institute, and","institution_ids":["https://openalex.org/I4390039307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026635290","display_name":"Courtney A. Plattner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I4390039307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Courtney A. Plattner","raw_affiliation_strings":["2Winship Cancer Institute, and","3Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Winship Cancer Institute, and","institution_ids":["https://openalex.org/I4390039307"]},{"raw_affiliation_string":"3Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia;","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075176211","display_name":"Wen Chen","orcid":"https://orcid.org/0000-0001-8493-0157","observed_orcids":["https://orcid.org/0000-0001-8493-0157"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210161994","display_name":"Dana-Farber Brigham Cancer Center","ror":"https://ror.org/05rgrbr06","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I4210117453","https://openalex.org/I4210161994","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wen Chen","raw_affiliation_strings":["4Department of Medical Oncology, Dana-Farber Cancer Institute, Department of Medicine, Brigham and Women\u2019s Hospital, and Harvard Medical School, Boston, Massachusetts; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Department of Medical Oncology, Dana-Farber Cancer Institute, Department of Medicine, Brigham and Women\u2019s Hospital, and Harvard Medical School, Boston, Massachusetts; and","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210161994"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063875415","display_name":"William C. Hahn","orcid":"https://orcid.org/0000-0003-2840-9791","observed_orcids":["https://orcid.org/0000-0003-2840-9791"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210161994","display_name":"Dana-Farber Brigham Cancer Center","ror":"https://ror.org/05rgrbr06","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I4210117453","https://openalex.org/I4210161994","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William C. Hahn","raw_affiliation_strings":["4Department of Medical Oncology, Dana-Farber Cancer Institute, Department of Medicine, Brigham and Women\u2019s Hospital, and Harvard Medical School, Boston, Massachusetts; and","5Broad Institute, Cambridge, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Department of Medical Oncology, Dana-Farber Cancer Institute, Department of Medicine, Brigham and Women\u2019s Hospital, and Harvard Medical School, Boston, Massachusetts; and","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210161994"]},{"raw_affiliation_string":"5Broad Institute, Cambridge, Massachusetts","institution_ids":["https://openalex.org/I107606265"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109602306","display_name":"David C. Pallas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I4390039307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David C. Pallas","raw_affiliation_strings":["2Winship Cancer Institute, and","3Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Winship Cancer Institute, and","institution_ids":["https://openalex.org/I4390039307"]},{"raw_affiliation_string":"3Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia;","institution_ids":["https://openalex.org/I150468666"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.9406,"has_fulltext":false,"cited_by_count":59,"citation_normalized_percentile":{"value":0.90819938,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"64","issue":"19","first_page":"6978","last_page":"6988"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11827","display_name":"Polyomavirus and related diseases","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11827","display_name":"Polyomavirus and related diseases","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-phosphatase-2a","display_name":"protein phosphatase 2A","score":0.9129999876022339},{"id":"https://openalex.org/keywords/cell-transformation","display_name":"cell transformation","score":0.6629999876022339},{"id":"https://openalex.org/keywords/htert","display_name":"hTERT","score":0.8669999837875366},{"id":"https://openalex.org/keywords/gene-expression-changes","display_name":"gene expression changes","score":0.7129999995231628},{"id":"https://openalex.org/keywords/integrin-signaling","display_name":"integrin signaling","score":0.8999999761581421},{"id":"https://openalex.org/keywords/src-phosphorylation","display_name":"Src phosphorylation","score":0.8999999761581421},{"id":"https://openalex.org/keywords/nf-kappab-activation","display_name":"NF-\u03baB activation","score":0.9010000228881836},{"id":"https://openalex.org/keywords/mhc-class-i-downregulation","display_name":"MHC class I downregulation","score":0.8799999952316284},{"id":"https://openalex.org/keywords/anchorage-independent-growth","display_name":"anchorage-independent growth","score":0.9660000205039978},{"id":"https://openalex.org/keywords/cell-cell-adhesion","display_name":"cell-cell adhesion","score":0.7089999914169312},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.6069999933242798},{"id":"https://openalex.org/keywords/immune-evasion","display_name":"immune evasion","score":0.38100001215934753}],"concepts":[{"id":"https://openalex.org/C389152","wikidata":"https://www.wikidata.org/wiki/Q6593007","display_name":"Protein phosphatase 2","level":4,"score":0.7667757868766785},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.6961193084716797},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6691492795944214},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5089993476867676},{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.4695751368999481},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.43975040316581726},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.42381617426872253},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3596112132072449},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.3570382297039032},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.33905312418937683},{"id":"https://openalex.org/C178666793","wikidata":"https://www.wikidata.org/wiki/Q422476","display_name":"Phosphatase","level":3,"score":0.3232518136501312},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.21459320187568665},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0826704204082489}],"mesh":[{"descriptor_ui":"D000952","descriptor_name":"Antigens, Polyomavirus Transforming","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010749","descriptor_name":"Phosphoprotein Phosphatases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D010749","descriptor_name":"Phosphoprotein Phosphatases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010749","descriptor_name":"Phosphoprotein Phosphatases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013539","descriptor_name":"Simian virus 40","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016023","descriptor_name":"Integrins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016023","descriptor_name":"Integrins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018816","descriptor_name":"Genes, cdc","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019061","descriptor_name":"src-Family Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019061","descriptor_name":"src-Family Kinases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054648","descriptor_name":"Protein Phosphatase 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1158/0008-5472.can-04-1150","doi":"https://doi.org/10.1158/0008-5472.can-04-1150","is_oa":false,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-04-1150","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},{"id":"pmid:15466190","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15466190","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.514.4081","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.514.4081","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://confac.emory.edu/SV40-ST.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5421264245","display_name":"Quality Threshold Analysis of Prostate Cancers","funder_award_id":"K22CA096560","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5668053009","display_name":"New Models of Human Cancer","funder_award_id":"K01CA094223","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6018147714","display_name":"Papova Virus Transforming Mechanisms","funder_award_id":"P01CA050661","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000342998","display_name":"Cellular Targets of Polyomavirus Tumor Antigens","funder_award_id":"R01CA057327","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320309018","display_name":"University of California, Santa Cruz","ror":"https://ror.org/03s65by71"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":60,"referenced_works":["https://openalex.org/W1545398558","https://openalex.org/W1560152642","https://openalex.org/W1909462870","https://openalex.org/W1933725398","https://openalex.org/W1964595176","https://openalex.org/W1964596167","https://openalex.org/W1965319787","https://openalex.org/W1969219687","https://openalex.org/W1971212979","https://openalex.org/W1979520552","https://openalex.org/W1982244057","https://openalex.org/W1983475354","https://openalex.org/W1995209206","https://openalex.org/W2003600165","https://openalex.org/W2014623219","https://openalex.org/W2015379895","https://openalex.org/W2017959339","https://openalex.org/W2023217479","https://openalex.org/W2023418239","https://openalex.org/W2031193906","https://openalex.org/W2047718979","https://openalex.org/W2048544621","https://openalex.org/W2048566300","https://openalex.org/W2049824761","https://openalex.org/W2050428089","https://openalex.org/W2063742002","https://openalex.org/W2066893159","https://openalex.org/W2067445582","https://openalex.org/W2074451273","https://openalex.org/W2078167830","https://openalex.org/W2080657371","https://openalex.org/W2084649822","https://openalex.org/W2090895449","https://openalex.org/W2098453858","https://openalex.org/W2102992354","https://openalex.org/W2104214883","https://openalex.org/W2104986494","https://openalex.org/W2105015609","https://openalex.org/W2105214585","https://openalex.org/W2110003347","https://openalex.org/W2111038541","https://openalex.org/W2111600528","https://openalex.org/W2111657659","https://openalex.org/W2114160852","https://openalex.org/W2116221195","https://openalex.org/W2120865735","https://openalex.org/W2123830992","https://openalex.org/W2124176234","https://openalex.org/W2128157486","https://openalex.org/W2128321469","https://openalex.org/W2129727010","https://openalex.org/W2134771161","https://openalex.org/W2155009866","https://openalex.org/W2157795344","https://openalex.org/W2160042168","https://openalex.org/W2168168058","https://openalex.org/W2323589738","https://openalex.org/W2428830490","https://openalex.org/W2475105307","https://openalex.org/W4294107304"],"related_works":["https://openalex.org/W7096101941","https://openalex.org/W1971212979","https://openalex.org/W2028083348","https://openalex.org/W2149754768","https://openalex.org/W1987970190","https://openalex.org/W2060729720","https://openalex.org/W2129727010","https://openalex.org/W2055038535","https://openalex.org/W2023418239","https://openalex.org/W7095680692"],"abstract_inverted_index":{"One":[0],"set":[1],"of":[2,7,14,43,52,88,142,160,201,209],"genes":[3,110,143],"sufficient":[4],"for":[5,94,169,197],"transformation":[6],"primary":[8],"human":[9],"cells":[10,100],"uses":[11],"the":[12,16,36,41],"combination":[13],"Ha-Ras-V12,":[15],"telomerase":[17],"catalytic":[18],"subunit":[19,91,137],"hTERT,":[20,103],"SV40":[21,27,33,170],"large":[22],"tumor":[23,29],"antigen":[24,30],"(LT),":[25],"and":[26,39,74,84,104,153,184,203,215,240],"small":[28],"(ST).":[31],"Whereas":[32],"LT":[34],"inactivates":[35],"retinoblastoma":[37],"protein":[38,59],"p53,":[40],"contribution":[42],"ST":[44,53,73,77,95,132,139,156,175,231],"is":[45],"poorly":[46],"understood.":[47],"The":[48],"essential":[49],"helper":[50],"function":[51],"requires":[54],"a":[55,123,167,227],"functional":[56],"interaction":[57],"with":[58,166],"phosphatase":[60],"2A":[61],"(PP2A).":[62],"Here":[63],"we":[64],"have":[65,118],"identified":[66],"changes":[67,80],"in":[68,113,145,181,187,222,229],"gene":[69],"expression":[70,96,133,141,159,176],"induced":[71],"by":[72,127],"show":[75],"that":[76,117,213],"mediates":[78],"these":[79,198],"through":[81,234],"both":[82],"PP2A-dependent":[83],"PP2A-independent":[85],"mechanisms.":[86],"Knockdown":[87],"PP2A":[89,135],"B56gamma":[90,136,191],"can":[92],"substitute":[93],"to":[97,171],"fully":[98,120],"transform":[99],"expressing":[101],"LT,":[102],"Ras-V12.":[105],"We":[106],"also":[107],"identify":[108],"those":[109],"affected":[111],"similarly":[112],"two":[114,128],"cell":[115,178],"lines":[116],"been":[119],"transformed":[121,210],"from":[122],"common":[124],"parental":[125],"line":[126],"alternative":[129],"mechanisms,":[130],"namely":[131],"or":[134],"knockdown.":[138],"altered":[140],"involved":[144],"proliferation,":[146],"apoptosis,":[147],"integrin":[148,202,214,236],"signaling,":[149,237],"development,":[150],"immune":[151,173],"responses,":[152],"transcriptional":[154],"regulation.":[155],"reduced":[157,182],"surface":[158],"MHC":[161],"class":[162],"I":[163],"molecules,":[164],"consistent":[165],"need":[168],"evade":[172],"detection.":[174],"enabled":[177],"cycle":[179],"progression":[180],"serum":[183,195],"src":[185,204,216,238],"phosphorylation":[186],"anchorage-independent":[188,207],"media,":[189],"whereas":[190],"knockdown":[192],"required":[193],"normal":[194],"levels":[196],"phenotypes.":[199],"Inhibitors":[200],"signaling":[205],"prevented":[206],"growth":[208],"cells,":[211],"suggesting":[212],"activation":[217],"are":[218],"key":[219],"ST-mediated":[220],"events":[221],"transformation.":[223],"Our":[224],"data":[225],"support":[226],"model":[228],"which":[230],"promotes":[232],"survival":[233],"constitutive":[235],"phosphorylation,":[239],"nuclear":[241],"factor":[242],"kappaB":[243],"activation,":[244],"while":[245],"inhibiting":[246],"cell-cell":[247],"adhesion":[248],"pathways.":[249]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}