{"id":"https://openalex.org/W2163670032","doi":"https://doi.org/10.1186/1745-6673-6-3","title":"Defined plant extracts can protect human cells against combined xenobiotic effects","display_name":"Defined plant extracts can protect human cells against combined xenobiotic effects","publication_year":2011,"publication_date":"2011-01-20","ids":{"openalex":"https://openalex.org/W2163670032","doi":"https://doi.org/10.1186/1745-6673-6-3","mag":"2163670032","pmid":"https://pubmed.ncbi.nlm.nih.gov/21251308","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3041787"},"language":"en","primary_location":{"id":"doi:10.1186/1745-6673-6-3","doi":"https://doi.org/10.1186/1745-6673-6-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1745-6673-6-3","pdf_url":"https://occup-med.biomedcentral.com/counter/pdf/10.1186/1745-6673-6-3","source":{"id":"https://openalex.org/S61677374","display_name":"Journal of Occupational Medicine and Toxicology","issn_l":"1745-6673","issn":["1745-6673"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Occupational Medicine and Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://occup-med.biomedcentral.com/counter/pdf/10.1186/1745-6673-6-3","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016162562","display_name":"C\u00e9line Gasnier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98702875","display_name":"Universit\u00e9 de Caen Normandie","ror":"https://ror.org/051kpcy16","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210105918","https://openalex.org/I98702875"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"C\u00e9line Gasnier","raw_affiliation_strings":["Laboratory of Biochemistry EA2608, Institute of Biology, University of Caen, France. criigen@unicaen.fr","Laboratory of Biochemistry EA2608, Institute of Biology, University of Caen, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Biochemistry EA2608, Institute of Biology, University of Caen, France. criigen@unicaen.fr","institution_ids":["https://openalex.org/I98702875"]},{"raw_affiliation_string":"Laboratory of Biochemistry EA2608, Institute of Biology, University of Caen, France","institution_ids":["https://openalex.org/I98702875"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108522923","display_name":"Claire Laurant","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Claire Laurant","raw_affiliation_strings":["Sevene Pharma, 30170, Monoblet, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sevene Pharma, 30170, Monoblet, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031882018","display_name":"C\u00e9cile Decroix-Laporte","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C\u00e9cile Decroix-Laporte","raw_affiliation_strings":["Sevene Pharma, 30170, Monoblet, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sevene Pharma, 30170, Monoblet, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048102530","display_name":"Robin Mesnage","orcid":"https://orcid.org/0000-0003-1732-4741","observed_orcids":["https://orcid.org/0000-0003-1732-4741"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I98702875","display_name":"Universit\u00e9 de Caen Normandie","ror":"https://ror.org/051kpcy16","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210105918","https://openalex.org/I98702875"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Robin Mesnage","raw_affiliation_strings":["CRIIGEN and Risk P\u00f4le MRSH, CNRS, University of Caen, 14032, France","Laboratory of Biochemistry EA2608, Institute of Biology, University of Caen, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CRIIGEN and Risk P\u00f4le MRSH, CNRS, University of Caen, 14032, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I98702875"]},{"raw_affiliation_string":"Laboratory of Biochemistry EA2608, Institute of Biology, University of Caen, France","institution_ids":["https://openalex.org/I98702875"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091786713","display_name":"Emilie Clair A","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I98702875","display_name":"Universit\u00e9 de Caen Normandie","ror":"https://ror.org/051kpcy16","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210105918","https://openalex.org/I98702875"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Emilie Clair","raw_affiliation_strings":["CRIIGEN and Risk P\u00f4le MRSH, CNRS, University of Caen, 14032, France","Laboratory of Biochemistry EA2608, Institute of Biology, University of Caen, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CRIIGEN and Risk P\u00f4le MRSH, CNRS, University of Caen, 14032, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I98702875"]},{"raw_affiliation_string":"Laboratory of Biochemistry EA2608, Institute of Biology, University of Caen, France","institution_ids":["https://openalex.org/I98702875"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019732154","display_name":"Carine Travert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98702875","display_name":"Universit\u00e9 de Caen Normandie","ror":"https://ror.org/051kpcy16","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210105918","https://openalex.org/I98702875"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Carine Travert","raw_affiliation_strings":["Laboratory of Biochemistry EA2608, Institute of Biology, University of Caen, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Biochemistry EA2608, Institute of Biology, University of Caen, France","institution_ids":["https://openalex.org/I98702875"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091150707","display_name":"Gilles\u2010\u00c9ric S\u00e9ralini","orcid":"https://orcid.org/0000-0002-1673-1006","observed_orcids":["https://orcid.org/0000-0002-1673-1006","https://orcid.org/0000-0002-4428-5592"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I98702875","display_name":"Universit\u00e9 de Caen Normandie","ror":"https://ror.org/051kpcy16","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210105918","https://openalex.org/I98702875"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Gilles-Eric S\u00e9ralini","raw_affiliation_strings":["CRIIGEN and Risk P\u00f4le MRSH, CNRS, University of Caen, 14032, France","Laboratory of Biochemistry EA2608, Institute of Biology, University of Caen, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CRIIGEN and Risk P\u00f4le MRSH, CNRS, University of Caen, 14032, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I98702875"]},{"raw_affiliation_string":"Laboratory of Biochemistry EA2608, Institute of Biology, University of Caen, France","institution_ids":["https://openalex.org/I98702875"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5091150707"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I98702875"],"apc_list":{"value":3090,"currency":"USD","value_usd":3090},"apc_paid":{"value":3090,"currency":"USD","value_usd":3090},"fwci":2.0921,"has_fulltext":true,"cited_by_count":31,"citation_normalized_percentile":{"value":0.84115213,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"6","issue":"1","first_page":"3","last_page":"3"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10447","display_name":"Environmental Toxicology and Ecotoxicology","score":0.4611999988555908,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10447","display_name":"Environmental Toxicology and Ecotoxicology","score":0.4611999988555908,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10875","display_name":"Pesticide Exposure and Toxicity","score":0.3991999924182892,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.013000000268220901,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/medicinal-plant-extracts","display_name":"medicinal plant extracts","score":0.9380000233650208},{"id":"https://openalex.org/keywords/xenobiotic-toxicity","display_name":"xenobiotic toxicity","score":0.7730000019073486},{"id":"https://openalex.org/keywords/glyphosate","display_name":"glyphosate","score":0.996999979019165},{"id":"https://openalex.org/keywords/bisphenol-a","display_name":"bisphenol A","score":0.902999997138977},{"id":"https://openalex.org/keywords/atrazine","display_name":"atrazine","score":0.9779999852180481},{"id":"https://openalex.org/keywords/cyp1a2","display_name":"CYP1A2","score":0.8820000290870667},{"id":"https://openalex.org/keywords/cyp3a4","display_name":"CYP3A4","score":0.9980000257492065},{"id":"https://openalex.org/keywords/glutathione-s-transferase","display_name":"glutathione S-transferase","score":0.9850000143051147},{"id":"https://openalex.org/keywords/mitochondrial-succinate-dehydrogenase","display_name":"mitochondrial succinate dehydrogenase","score":0.9160000085830688},{"id":"https://openalex.org/keywords/detoxification","display_name":"detoxification","score":0.5590000152587891},{"id":"https://openalex.org/keywords/hepatotoxicity","display_name":"hepatotoxicity","score":0.6620000004768372},{"id":"https://openalex.org/keywords/nephrotoxicity","display_name":"nephrotoxicity","score":0.9750000238418579},{"id":"https://openalex.org/keywords/hepg2-cells","display_name":"HepG2 cells","score":0.7680000066757202},{"id":"https://openalex.org/keywords/contaminant-mixtures","display_name":"contaminant mixtures","score":0.6449999809265137}],"concepts":[{"id":"https://openalex.org/C82685317","wikidata":"https://www.wikidata.org/wiki/Q19829510","display_name":"Pollutant","level":2,"score":0.5887117981910706},{"id":"https://openalex.org/C2780497538","wikidata":"https://www.wikidata.org/wiki/Q1192006","display_name":"Detoxification (alternative medicine)","level":3,"score":0.5774327516555786},{"id":"https://openalex.org/C115448650","wikidata":"https://www.wikidata.org/wiki/Q409205","display_name":"Xenobiotic","level":3,"score":0.5363819003105164},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.5076988935470581},{"id":"https://openalex.org/C33070731","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Toxicology","level":1,"score":0.5021333694458008},{"id":"https://openalex.org/C2779595939","wikidata":"https://www.wikidata.org/wiki/Q408652","display_name":"Atrazine","level":3,"score":0.49415281414985657},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4703127443790436},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.45478594303131104},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.45432156324386597},{"id":"https://openalex.org/C161176658","wikidata":"https://www.wikidata.org/wiki/Q131656","display_name":"Pesticide","level":2,"score":0.3730829954147339},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35038208961486816},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.275373637676239},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.18350845575332642},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10692903399467468},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.09248420596122742},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.08022454380989075},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.1186/1745-6673-6-3","doi":"https://doi.org/10.1186/1745-6673-6-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1745-6673-6-3","pdf_url":"https://occup-med.biomedcentral.com/counter/pdf/10.1186/1745-6673-6-3","source":{"id":"https://openalex.org/S61677374","display_name":"Journal of Occupational Medicine and Toxicology","issn_l":"1745-6673","issn":["1745-6673"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Occupational Medicine and Toxicology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3041787","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3041787","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Occup Med Toxicol","raw_type":"Text"},{"id":"pmid:21251308","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21251308","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of occupational medicine and toxicology (London, England)","raw_type":"Journal Article"},{"id":"pmh:oai:kclpure.kcl.ac.uk:openaire/4cb958e0-b407-4ed6-a8e8-1e1c5b110a76","doi":null,"is_oa":true,"landing_page_url":"https://kclpure.kcl.ac.uk/portal/en/publications/4cb958e0-b407-4ed6-a8e8-1e1c5b110a76","pdf_url":null,"source":{"id":"https://openalex.org/S4306400216","display_name":"Research Portal (King's College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I183935753","host_organization_name":"King's College London","host_organization_lineage":["https://openalex.org/I183935753"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gasnier, C, Laurant, C, Decroix-Laporte, C, Mesnage, R, Clair, E, Travert, C & S\u00e9ralini, G-E 2011, 'Defined plant extracts can protect human cells against combined xenobiotic effects', Journal of occupational medicine and toxicology (London, England), vol. 6, no. 1, 3. https://doi.org/10.1186/1745-6673-6-3","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.293.7632","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.293.7632","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/c7/92/J_Occup_Med_Toxicol_2011_Jan_20_6_3.tar.gz","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:32c9d63844024ab985747afca7b3f3ac","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/32c9d63844024ab985747afca7b3f3ac","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Occupational Medicine and Toxicology, Vol 6, Iss 1, p 3 (2011)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/1745-6673-6-3","doi":"https://doi.org/10.1186/1745-6673-6-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1745-6673-6-3","pdf_url":"https://occup-med.biomedcentral.com/counter/pdf/10.1186/1745-6673-6-3","source":{"id":"https://openalex.org/S61677374","display_name":"Journal of Occupational Medicine and Toxicology","issn_l":"1745-6673","issn":["1745-6673"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Occupational Medicine and Toxicology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8199999928474426,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320329938","display_name":"R\u00e9gion Normandie","ror":"https://ror.org/03cq89j92"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2163670032.pdf","grobid_xml":"https://content.openalex.org/works/W2163670032.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W1491040078","https://openalex.org/W1581414347","https://openalex.org/W1629179716","https://openalex.org/W1964472878","https://openalex.org/W1978514924","https://openalex.org/W1980609495","https://openalex.org/W1983548077","https://openalex.org/W1985667691","https://openalex.org/W1987554735","https://openalex.org/W1988012394","https://openalex.org/W2008902243","https://openalex.org/W2015012586","https://openalex.org/W2018227341","https://openalex.org/W2024611583","https://openalex.org/W2027299002","https://openalex.org/W2033328351","https://openalex.org/W2035217224","https://openalex.org/W2036819659","https://openalex.org/W2038875676","https://openalex.org/W2049881395","https://openalex.org/W2057744227","https://openalex.org/W2070451131","https://openalex.org/W2072624946","https://openalex.org/W2077182680","https://openalex.org/W2078333674","https://openalex.org/W2080958300","https://openalex.org/W2081071734","https://openalex.org/W2082866365","https://openalex.org/W2089285493","https://openalex.org/W2089780996","https://openalex.org/W2093229118","https://openalex.org/W2093529099","https://openalex.org/W2094110446","https://openalex.org/W2096364120","https://openalex.org/W2103188354","https://openalex.org/W2107978933","https://openalex.org/W2111903453","https://openalex.org/W2112150009","https://openalex.org/W2114918609","https://openalex.org/W2115001759","https://openalex.org/W2120475447","https://openalex.org/W2134236053","https://openalex.org/W2139673280","https://openalex.org/W2147373429","https://openalex.org/W2163656090","https://openalex.org/W2168802892","https://openalex.org/W2384630944"],"related_works":["https://openalex.org/W7095452826","https://openalex.org/W2139673280","https://openalex.org/W2506222128","https://openalex.org/W366874168","https://openalex.org/W7067256206","https://openalex.org/W3116047440","https://openalex.org/W4407164058","https://openalex.org/W2014822208","https://openalex.org/W2556013707","https://openalex.org/W7113136763"],"abstract_inverted_index":{"BACKGROUND:":[0],"Pollutants":[1],"representative":[2],"of":[3,26,105,107,128,145,159,180,195,237,260,270],"common":[4,24,110],"environmental":[5],"contaminants":[6],"induce":[7],"intracellular":[8,308],"toxicity":[9],"in":[10,17,30,61,134,164,316,323,335],"human":[11,31,88,325],"cells,":[12,165],"which":[13],"is":[14],"generally":[15],"amplified":[16],"combinations.":[18],"We":[19,37,81],"wanted":[20],"to":[21,63,223,256,330],"test":[22],"the":[23,99,108,122,157,204,215,226,251,281,295,301,338],"pathways":[25],"intoxication":[27,95],"and":[28,33,46,48,59,75,86,92,117,120,130,138,142,166,171,220,287,297],"detoxification":[29,79],"embryonic":[32,84],"liver":[34,76],"cell":[35,89,186,326],"lines.":[36,327],"used":[38],"various":[39],"pollutants":[40,181,306],"such":[41,196],"as":[42,173,175],"Roundup":[43,113],"residues,":[44],"Bisphenol-A":[45,129],"Atrazine,":[47,131],"five":[49],"precise":[50,319],"medicinal":[51,246,320],"plant":[52,146,205,233,247,265,321],"extracts":[53,147,206,266,322],"called":[54],"Circ1,":[55],"Dig1,":[56],"Dig2,":[57],"Sp1,":[58],"Uro1":[60],"order":[62],"understand":[64],"whether":[65],"specific":[66,118],"molecular":[67],"actions":[68],"took":[69,198],"place":[70,199],"or":[71,314],"not.":[72],"METHODS:":[73],"Kidney":[74],"are":[77],"major":[78],"organs.":[80],"have":[82,307],"studied":[83],"kidney":[85],"hepatic":[87],"lines":[90,187],"E293":[91,216,239],"HepG2.":[93,227],"The":[94,140,193,258],"was":[96,235],"induced":[97],"on":[98,121,151,156,167,184,294,300],"one":[100,106],"hand":[101,124],"by":[102,125,218,285,318,337],"a":[103,126,290],"formulation":[104],"most":[109],"herbicides":[111],"worldwide,":[112],"450":[114],"GT+":[115],"(glyphosate":[116],"adjuvants),":[119],"other":[123],"mixture":[127],"all":[132],"found":[133],"surface":[135],"waters,":[136],"feed":[137],"food.":[139],"prevention":[141,194],"curative":[143],"effects":[144,309],"were":[148,182,267],"also":[149],"measured":[150],"mitochondrial":[152],"succinate":[153],"dehydrogenase":[154],"activity,":[155],"entry":[158],"radiolabelled":[160,272],"glyphosate":[161,273],"(in":[162],"Roundup)":[163],"cytochromes":[168,339],"P450":[169,340],"1A2":[170],"3A4":[172],"well":[174],"glutathione-S-transferase.":[176],"RESULTS:":[177],"Clear":[178],"toxicities":[179],"observed":[183],"both":[185],"at":[188,333],"very":[189],"low":[190],"sub-agricultural":[191],"dilutions.":[192],"phenomena":[197],"within":[200,241],"48":[201,242],"h":[202],"with":[203,208],"tested,":[207],"success":[209],"rates":[210],"ranging":[211],"between":[212],"25-34%":[213],"for":[214,225],"intoxicated":[217,253],"Roundup,":[219,286],"surprisingly":[221],"up":[222,255],"71%":[224],"By":[228],"contrast,":[229],"after":[230],"intoxication,":[231],"no":[232,298],"extract":[234],"capable":[236,269],"restoring":[238],"viability":[240],"h,":[243],"however,":[244],"two":[245,324],"combinations":[248],"did":[249,279],"restore":[250,280],"Bisphenol-A/Atrazine":[252],"HepG2":[254],"24-28%.":[257],"analysis":[259],"underlying":[261],"mechanisms":[262],"revealed":[263],"that":[264,310],"not":[268],"preventing":[271],"from":[274],"entering":[275],"cells;":[276],"however":[277],"Dig2":[278],"CYP1A2":[282],"activity":[283],"disrupted":[284],"had":[288],"only":[289],"mild":[291],"preventive":[292],"effect":[293,299],"CYP3A4,":[296],"glutathione":[302],"S-transferase.":[303],"CONCLUSIONS:":[304],"Environmental":[305],"can":[311],"be":[312,331],"prevented,":[313],"cured":[315],"part,":[317],"This":[328],"appears":[329],"mediated":[332],"least":[334],"part":[336],"modulation.":[341]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}