{"id":"https://openalex.org/W2163572014","doi":"https://doi.org/10.1111/j.1751-1097.1997.tb03208.x","title":"Mutagenicity of Photodynamic Therapy as Compared to UVC and Ionizing Radiation in Human and Murine Lymphoblast Cell Lines","display_name":"Mutagenicity of Photodynamic Therapy as Compared to UVC and Ionizing Radiation in Human and Murine Lymphoblast Cell Lines","publication_year":1997,"publication_date":"1997-11-01","ids":{"openalex":"https://openalex.org/W2163572014","doi":"https://doi.org/10.1111/j.1751-1097.1997.tb03208.x","mag":"2163572014","pmid":"https://pubmed.ncbi.nlm.nih.gov/9383992"},"language":"en","primary_location":{"id":"doi:10.1111/j.1751-1097.1997.tb03208.x","doi":"https://doi.org/10.1111/j.1751-1097.1997.tb03208.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1751-1097.1997.tb03208.x","pdf_url":null,"source":{"id":"https://openalex.org/S61245073","display_name":"Photochemistry and Photobiology","issn_l":"0031-8655","issn":["0031-8655","1751-1097"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Photochemistry and Photobiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111830441","display_name":"Helen H. Evans","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Helen H. Evans","raw_affiliation_strings":["Department of Radiology, Case Western Reserve University, Cleveland, OH 44106-4942, USA","Department of Radiology; Case Western Reserve University; Cleveland OH USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Case Western Reserve University, Cleveland, OH 44106-4942, USA","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Department of Radiology; Case Western Reserve University; Cleveland OH USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108563685","display_name":"Min\u2010Fen Horng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Min\u2010Fen Horng","raw_affiliation_strings":["Department of Radiology, Case Western Reserve University, Cleveland, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Case Western Reserve University, Cleveland, OH, USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088009464","display_name":"Marlene Ricanati","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marlene Ricanati","raw_affiliation_strings":["Department of Radiology, Case Western Reserve University, Cleveland, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Case Western Reserve University, Cleveland, OH, USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001888622","display_name":"J. Thom Deahl","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Thorn Deahl","raw_affiliation_strings":["\u2020Lilly Greenfield Research Laboratories, P.O. Box 708, Greenfield, IN 46140, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2020Lilly Greenfield Research Laboratories, P.O. Box 708, Greenfield, IN 46140, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043087658","display_name":"Nancy L. Oleinick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nancy L. Oleinick","raw_affiliation_strings":["Department of Radiology, Case Western Reserve University, Cleveland, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Case Western Reserve University, Cleveland, OH, USA","institution_ids":["https://openalex.org/I58956616"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111830441"],"corresponding_institution_ids":["https://openalex.org/I58956616"],"apc_list":{"value":4330,"currency":"USD","value_usd":4330},"apc_paid":null,"fwci":2.5085,"has_fulltext":false,"cited_by_count":46,"citation_normalized_percentile":{"value":0.89252531,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"66","issue":"5","first_page":"690","last_page":"696"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/photodynamic-therapy","display_name":"photodynamic therapy","score":0.9670000076293945},{"id":"https://openalex.org/keywords/mutagenicity","display_name":"mutagenicity","score":0.9900000095367432},{"id":"https://openalex.org/keywords/thymidine-kinase-locus","display_name":"thymidine kinase locus","score":0.8299999833106995},{"id":"https://openalex.org/keywords/tp53-status","display_name":"p53 status","score":0.6779999732971191},{"id":"https://openalex.org/keywords/porfimer-sodium","display_name":"porfimer sodium","score":0.7599999904632568},{"id":"https://openalex.org/keywords/aluminum-phthalocyanine","display_name":"aluminum phthalocyanine","score":0.9399999976158142},{"id":"https://openalex.org/keywords/uv-c-radiation","display_name":"UV-C radiation","score":0.7760000228881836},{"id":"https://openalex.org/keywords/x-rays","display_name":"X-rays","score":0.9819999933242798},{"id":"https://openalex.org/keywords/lymphoblastoid-cell-lines","display_name":"lymphoblastoid cell lines","score":0.7960000038146973},{"id":"https://openalex.org/keywords/tk6-cells","display_name":"TK6 cells","score":0.9359999895095825},{"id":"https://openalex.org/keywords/l5178y-mouse-lymphoma-cells","display_name":"L5178Y cells","score":0.9800000190734863},{"id":"https://openalex.org/keywords/double-strand-break-repair","display_name":"DNA double-strand break repair","score":0.9480000138282776},{"id":"https://openalex.org/keywords/recombination","display_name":"recombination","score":0.6389999985694885},{"id":"https://openalex.org/keywords/mutant-frequency","display_name":"mutant frequency","score":0.7170000076293945},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7799999713897705},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.6980000138282776}],"concepts":[{"id":"https://openalex.org/C2781469039","wikidata":"https://www.wikidata.org/wiki/Q18388377","display_name":"Photosensitizer","level":2,"score":0.8415172100067139},{"id":"https://openalex.org/C113842279","wikidata":"https://www.wikidata.org/wiki/Q1873857","display_name":"Lymphoblast","level":3,"score":0.7647049427032471},{"id":"https://openalex.org/C2781323092","wikidata":"https://www.wikidata.org/wiki/Q1428072","display_name":"Photodynamic therapy","level":2,"score":0.7300093173980713},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5844194293022156},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.5821762681007385},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.5701361894607544},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5611424446105957},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5102214813232422},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4830077886581421},{"id":"https://openalex.org/C2776147627","wikidata":"https://www.wikidata.org/wiki/Q24783855","display_name":"Thymidine kinase","level":4,"score":0.4790319502353668},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.46374234557151794},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4570900797843933},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.41125980019569397},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.3866730034351349},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.38126659393310547},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2981525957584381},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23766526579856873},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.23095703125},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19376999139785767},{"id":"https://openalex.org/C75473681","wikidata":"https://www.wikidata.org/wiki/Q188651","display_name":"Photochemistry","level":1,"score":0.18186789751052856},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C2781196997","wikidata":"https://www.wikidata.org/wiki/Q655331","display_name":"Herpes simplex virus","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010778","descriptor_name":"Photochemotherapy","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D014466","descriptor_name":"Ultraviolet Rays","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D014965","descriptor_name":"X-Rays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D018462","descriptor_name":"Photobiology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1751-1097.1997.tb03208.x","doi":"https://doi.org/10.1111/j.1751-1097.1997.tb03208.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1751-1097.1997.tb03208.x","pdf_url":null,"source":{"id":"https://openalex.org/S61245073","display_name":"Photochemistry and Photobiology","issn_l":"0031-8655","issn":["0031-8655","1751-1097"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Photochemistry and Photobiology","raw_type":"journal-article"},{"id":"pmid:9383992","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9383992","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Photochemistry and photobiology","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4323490007","display_name":"PHTHALOCYANINE PHOTODYNAMIC THERAPY--MECHANISTIC STUDIES","funder_award_id":"P01CA048735","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000862237","display_name":"Case Comprehensive Cancer Center Support Grant","funder_award_id":"P30CA043703","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W15788196","https://openalex.org/W611347588","https://openalex.org/W1864127169","https://openalex.org/W1875016115","https://openalex.org/W1973023456","https://openalex.org/W1973722543","https://openalex.org/W1978525144","https://openalex.org/W1980655006","https://openalex.org/W1981951234","https://openalex.org/W1986408941","https://openalex.org/W1993634675","https://openalex.org/W1996720127","https://openalex.org/W2011002646","https://openalex.org/W2019653311","https://openalex.org/W2020391615","https://openalex.org/W2027732005","https://openalex.org/W2046606219","https://openalex.org/W2047333711","https://openalex.org/W2048560591","https://openalex.org/W2050999776","https://openalex.org/W2051318514","https://openalex.org/W2056605440","https://openalex.org/W2063194457","https://openalex.org/W2069288310","https://openalex.org/W2077757406","https://openalex.org/W2083741621","https://openalex.org/W2095190275","https://openalex.org/W2112215648","https://openalex.org/W2130477771","https://openalex.org/W2168643927","https://openalex.org/W2202253706","https://openalex.org/W2334260109","https://openalex.org/W2413881990"],"related_works":["https://openalex.org/W2051318514","https://openalex.org/W2095190275","https://openalex.org/W2078929969","https://openalex.org/W1970451833","https://openalex.org/W1963973740","https://openalex.org/W2145682522","https://openalex.org/W2033895480","https://openalex.org/W2090288682","https://openalex.org/W2084284823","https://openalex.org/W2168643927"],"abstract_inverted_index":{"The":[0,131,161,185],"mutagenicity":[1,44,56,221],"of":[2,45,57,91,200,205,222,228,244],"photodynamic":[3],"therapy":[4,66],"(PDT)":[5],"using":[6],"red":[7],"light":[8],"and":[9,37,39,47,82,89,116,122,187,230],"either":[10,99,171],"Photofrin":[11],"(porfimer":[12],"sodium)":[13],"(PF)":[14],"or":[15],"aluminum":[16],"phthalocyanine":[17],"(AlPc)":[18],"as":[19,52,54,126,140,238,240],"the":[20,25,31,43,55,113,141,197,203,220,235,241,245],"photosensitizer":[21,142,172],"was":[22,40,67,101,143,173,208],"determined":[23],"at":[24,158,182],"thymidine":[26],"kinase":[27],"(TK)":[28],"locus":[29],"in":[30,49,59,73,87,104,112,120,135,167,179,193,210,213,225],"human":[32],"lymphoblastic":[33,62],"cell":[34,63],"lines,":[35],"TK6":[36,74,129,186,211],"WTK1,":[38],"compared":[41,127],"to":[42,70,128,145,196,234],"UVC":[46,149],"X-radiation":[48,157],"these":[50],"cells":[51,137,169,189,229],"well":[53,239],"PDT":[58,97,166,223],"murine":[60,180],"L5178Y":[61],"lines.":[64],"Photodynamic":[65],"found":[68],"not":[69,191],"be":[71,232],"mutagenic":[72,103],"cells,":[75,106],"which":[76,83,107],"possess":[77],"an":[78,109],"active":[79],"p53":[80,114,242],"gene":[81,115],"are":[84,117],"relatively":[85,118],"deficient":[86],"recombination":[88,121],"repair":[90,125,236],"DNA":[92],"double-strand":[93,123],"breaks.":[94],"In":[95],"contrast,":[96],"with":[98,138,170],"sensitizer":[100],"significantly":[102],"WTK1":[105,136,168,188,214],"harbor":[108],"inactivating":[110],"mutation":[111],"efficient":[119],"break":[124],"cells.":[130,215,246],"induced":[132,147,155,164,178],"mutant":[133,162],"frequency":[134,163],"PF":[139],"similar":[144],"that":[146,154,177,219],"by":[148,156,165],"radiation":[150],"but":[151,202],"lower":[152,175],"than":[153,176,212],"equitoxic":[159,183],"fluences/doses.":[160],"much":[174],"lymphoblasts":[181],"fluences.":[184],"did":[190],"differ":[192],"their":[194],"sensitivity":[195],"cytotoxic":[198],"effects":[199],"PDT,":[201],"level":[204],"PDT-induced":[206],"apoptosis":[207],"greater":[209],"These":[216],"results":[217],"indicate":[218],"varies":[224],"different":[226],"types":[227],"may":[231],"related":[233],"capabilities":[237],"status":[243]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}