{"id":"https://openalex.org/W2163498423","doi":"https://doi.org/10.1016/s0021-9258(18)42569-0","title":"Glycophorin A dimerization is driven by specific interactions between transmembrane alpha-helices.","display_name":"Glycophorin A dimerization is driven by specific interactions between transmembrane alpha-helices.","publication_year":1992,"publication_date":"1992-04-01","ids":{"openalex":"https://openalex.org/W2163498423","doi":"https://doi.org/10.1016/s0021-9258(18)42569-0","mag":"2163498423","pmid":"https://pubmed.ncbi.nlm.nih.gov/1560003"},"language":"en","primary_location":{"id":"doi:10.1016/s0021-9258(18)42569-0","doi":"https://doi.org/10.1016/s0021-9258(18)42569-0","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(18)42569-0","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0021-9258(18)42569-0","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073959537","display_name":"Mark A. Lemmon","orcid":"https://orcid.org/0000-0002-3379-5319","observed_orcids":["https://orcid.org/0000-0002-3379-5319"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M.A. Lemmon","raw_affiliation_strings":["Department of Molecular Biophysics and Biochemistry Yale University New Haven, Connecticut 06511"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biophysics and Biochemistry Yale University New Haven, Connecticut 06511","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088323138","display_name":"John M. Flanagan","orcid":"https://orcid.org/0000-0002-1007-659X","observed_orcids":["https://orcid.org/0000-0002-1007-659X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J.M. Flanagan","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041462222","display_name":"John Francis Hunt","orcid":"https://orcid.org/0000-0003-0034-5167","observed_orcids":["https://orcid.org/0000-0003-0034-5167"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J.F. Hunt","raw_affiliation_strings":["Department of Molecular Biophysics and Biochemistry Yale University New Haven, Connecticut 06511"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biophysics and Biochemistry Yale University New Haven, Connecticut 06511","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075352526","display_name":"Brian D. Adair","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B.D. Adair","raw_affiliation_strings":["Department of Molecular Biophysics and Biochemistry Yale University New Haven, Connecticut 06511"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biophysics and Biochemistry Yale University New Haven, Connecticut 06511","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030481035","display_name":"Barbara J. Bormann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B.J. Bormann","raw_affiliation_strings":["Department of Molecular Biophysics and Biochemistry Yale University New Haven, Connecticut 06511"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biophysics and Biochemistry Yale University New Haven, Connecticut 06511","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043170950","display_name":"Christopher E. Dempsey","orcid":"https://orcid.org/0000-0002-1933-7805","observed_orcids":["https://orcid.org/0000-0002-1933-7805"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C.E. Dempsey","raw_affiliation_strings":["Department of Molecular Biophysics and Biochemistry Yale University New Haven, Connecticut 06511"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biophysics and Biochemistry Yale University New Haven, Connecticut 06511","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002753770","display_name":"Donald M. Engelman","orcid":"https://orcid.org/0000-0002-6312-4583","observed_orcids":["https://orcid.org/0000-0002-6312-4583"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D.M. Engelman","raw_affiliation_strings":["Department of Molecular Biophysics and Biochemistry Yale University New Haven, Connecticut 06511"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biophysics and Biochemistry Yale University New Haven, Connecticut 06511","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":6.854,"has_fulltext":false,"cited_by_count":466,"citation_normalized_percentile":{"value":0.9786121,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"267","issue":"11","first_page":"7683","last_page":"7689"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.7294999957084656,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.7294999957084656,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.23170000314712524,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.013199999928474426,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glycophorin-a","display_name":"glycophorin A","score":1.0},{"id":"https://openalex.org/keywords/transmembrane-helices","display_name":"transmembrane helices","score":0.7950000166893005},{"id":"https://openalex.org/keywords/helix-helix-interactions","display_name":"helix-helix interactions","score":0.9670000076293945},{"id":"https://openalex.org/keywords/protein-dimerization","display_name":"protein dimerization","score":0.8930000066757202},{"id":"https://openalex.org/keywords/transmembrane-domain","display_name":"transmembrane domain","score":0.675000011920929},{"id":"https://openalex.org/keywords/site-directed-mutagenesis","display_name":"site-directed mutagenesis","score":0.6909999847412109},{"id":"https://openalex.org/keywords/hydrophobic-residues","display_name":"hydrophobic residues","score":0.5419999957084656},{"id":"https://openalex.org/keywords/integral-membrane-proteins","display_name":"integral membrane proteins","score":0.7059999704360962}],"concepts":[{"id":"https://openalex.org/C67982717","wikidata":"https://www.wikidata.org/wiki/Q24724397","display_name":"Glycophorin","level":3,"score":0.9466552138328552},{"id":"https://openalex.org/C64943373","wikidata":"https://www.wikidata.org/wiki/Q2651003","display_name":"Alpha (finance)","level":4,"score":0.6124966144561768},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5995279550552368},{"id":"https://openalex.org/C24530287","wikidata":"https://www.wikidata.org/wiki/Q424204","display_name":"Transmembrane protein","level":3,"score":0.5906044244766235},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4663699269294739},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4048139452934265},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3347555100917816},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2441609501838684},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.23384389281272888},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.132697194814682},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.10266083478927612},{"id":"https://openalex.org/C2775944032","wikidata":"https://www.wikidata.org/wiki/Q22907659","display_name":"Patient satisfaction","level":2,"score":0.0},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0},{"id":"https://openalex.org/C49453240","wikidata":"https://www.wikidata.org/wiki/Q1592163","display_name":"Construct validity","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002942","descriptor_name":"Circular Dichroism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004591","descriptor_name":"Electrophoresis, Polyacrylamide Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006021","descriptor_name":"Glycophorins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006021","descriptor_name":"Glycophorins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008836","descriptor_name":"Micrococcal Nuclease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008836","descriptor_name":"Micrococcal Nuclease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/s0021-9258(18)42569-0","doi":"https://doi.org/10.1016/s0021-9258(18)42569-0","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(18)42569-0","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:1560003","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1560003","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.555.2774","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.555.2774","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.yale.edu/engelman/PDF/Lemmon-1992-2.pdf","raw_type":"text"},{"id":"pmh:oai:research-information.bris.ac.uk:openaire_cris_publications/1a8f0945-fa8c-40d0-a757-4d442d23aa78","doi":null,"is_oa":false,"landing_page_url":"https://research-information.bris.ac.uk/en/publications/1a8f0945-fa8c-40d0-a757-4d442d23aa78","pdf_url":null,"source":{"id":"https://openalex.org/S4306400895","display_name":"Bristol Research (University of Bristol)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I36234482","host_organization_name":"University of Bristol","host_organization_lineage":["https://openalex.org/I36234482"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Lemmon, MA, Flanagan, BM, Hunt, SH, Adair, BD, Bormann, B-J, Dempsey, CE & Engelman, DM 1992, 'Glycophorin A dimerization is driven by specific interactions between transmembrane alpha helices', Journal of Biological Chemistry, vol. 267, pp. 7683 - 7689.","raw_type":"info:eu-repo/semantics/publishedVersion"}],"best_oa_location":{"id":"doi:10.1016/s0021-9258(18)42569-0","doi":"https://doi.org/10.1016/s0021-9258(18)42569-0","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(18)42569-0","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4292621878","display_name":"STRUCTURE AND FUNCTION OF HIV PROTEINS","funder_award_id":"P01GM039546","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5620470301","display_name":null,"funder_award_id":"5PO1GM39546","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1530737864","https://openalex.org/W1540419168","https://openalex.org/W1781531090","https://openalex.org/W1873199501","https://openalex.org/W1963570264","https://openalex.org/W1967507598","https://openalex.org/W1975304761","https://openalex.org/W1979537410","https://openalex.org/W1983673751","https://openalex.org/W2002682015","https://openalex.org/W2002830266","https://openalex.org/W2006174930","https://openalex.org/W2020988380","https://openalex.org/W2024363942","https://openalex.org/W2027711565","https://openalex.org/W2028387622","https://openalex.org/W2032359283","https://openalex.org/W2037926081","https://openalex.org/W2046521417","https://openalex.org/W2048481017","https://openalex.org/W2058723245","https://openalex.org/W2065510140","https://openalex.org/W2073443732","https://openalex.org/W2074756868","https://openalex.org/W2081569845","https://openalex.org/W2082836578","https://openalex.org/W2100837269","https://openalex.org/W2110810808","https://openalex.org/W2115196876","https://openalex.org/W2138270253","https://openalex.org/W2144112248","https://openalex.org/W2144634347","https://openalex.org/W2314225431","https://openalex.org/W2888511473","https://openalex.org/W7098124190"],"related_works":["https://openalex.org/W7096031975","https://openalex.org/W2035873802","https://openalex.org/W7097851359","https://openalex.org/W60395508","https://openalex.org/W2118259597","https://openalex.org/W1997677265","https://openalex.org/W2081030911","https://openalex.org/W2119221408","https://openalex.org/W2058313971","https://openalex.org/W1991442277"],"abstract_inverted_index":{"Specific":[0],"side-by-side":[1],"interactions":[2],"between":[3,179],"transmembrane":[4,32,69,104,117],"alpha-helices":[5],"may":[6],"be":[7,49,138,183],"important":[8],"in":[9,54,91,170],"the":[10,23,40,67,79,103,115,160,171,177],"assembly":[11],"and":[12,25,57],"function":[13],"of":[14,28,35,42,71,82,98,106,159,168],"integral":[15],"membrane":[16],"proteins.":[17],"We":[18],"describe":[19],"a":[20,89,99,127,133,153,156,165],"system":[21],"for":[22,120],"genetic":[24],"biophysical":[26],"analysis":[27],"these":[29],"interactions.":[30,173],"The":[31,45,85],"alpha-helical":[33],"domain":[34,105,118],"interest":[36],"is":[37,58,94],"fused":[38],"to":[39,77,102,113,182],"C-terminus":[41],"staphylococcal":[43],"nuclease.":[44],"resulting":[46,86],"chimera":[47,87],"can":[48,137],"expressed":[50],"at":[51,152],"high":[52,166],"levels":[53],"Escherichia":[55],"coli":[56],"readily":[59],"purified.":[60],"In":[61],"our":[62],"initial":[63],"application":[64],"we":[65],"study":[66],"single":[68],"alpha-helix":[70,161],"human":[72],"glycophorin":[73],"A":[74],"(GpA),":[75],"thought":[76],"mediate":[78],"SDS-stable":[80],"dimerization":[81],"this":[83,121],"protein.":[84],"forms":[88],"dimer":[90],"SDS,":[92],"which":[93],"disrupted":[95],"upon":[96],"addition":[97],"peptide":[100],"corresponding":[101],"GpA.":[107],"Deletion":[108],"mutagenesis":[109,124],"has":[110],"been":[111],"used":[112],"delineate":[114],"minimum":[116],"sufficient":[119],"behavior.":[122],"Site-specific":[123],"shows":[125],"that":[126],"methionine":[128],"residue,":[129,136],"previously":[130],"implicated":[131],"as":[132],"potential":[134],"interfacial":[135],"replaced":[139],"with":[140],"other":[141],"hydrophobic":[142],"residues":[143],"without":[144],"disrupting":[145],"dimerization.":[146],"By":[147],"contrast,":[148],"rather":[149],"conservative":[150],"substitutions":[151],"valine":[154],"on":[155],"different":[157],"face":[158],"disrupt":[162],"dimerization,":[163],"suggesting":[164],"degree":[167],"specificity":[169],"helix-helix":[172],"This":[174],"approach":[175],"allows":[176],"interface":[178],"interacting":[180],"helices":[181],"defined.":[184]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":18},{"year":2015,"cited_by_count":14},{"year":2014,"cited_by_count":17},{"year":2013,"cited_by_count":14},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}