{"id":"https://openalex.org/W2163481415","doi":null,"title":"Kinetic sensitivity of a receptor-binding radiopharmaceutical: technetium-99m galactosyl-neoglycoalbumin.","display_name":"Kinetic sensitivity of a receptor-binding radiopharmaceutical: technetium-99m galactosyl-neoglycoalbumin.","publication_year":1989,"publication_date":"1989-09-01","ids":{"openalex":"https://openalex.org/W2163481415","mag":"2163481415","pmid":"https://pubmed.ncbi.nlm.nih.gov/2549225"},"language":"en","primary_location":{"id":"pmid:2549225","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2549225","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043166346","display_name":"David R. Vera","orcid":"https://orcid.org/0000-0001-8253-1099","observed_orcids":["https://orcid.org/0000-0001-8253-1099"]},"institutions":[{"id":"https://openalex.org/I4210160527","display_name":"University of California Davis Medical Center","ror":"https://ror.org/05t6gpm70","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160527","https://openalex.org/I4210160856"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D R Vera","raw_affiliation_strings":["Department of Radiology, University of California, Davis, Medical Center, Sacramento 95817"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, University of California, Davis, Medical Center, Sacramento 95817","institution_ids":["https://openalex.org/I4210160527","https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027751857","display_name":"E. Steve Woodle","orcid":"https://orcid.org/0000-0003-4280-0842","observed_orcids":["https://orcid.org/0000-0003-4280-0842"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E S Woodle","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109899834","display_name":"Robert C. Stadalnik","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R C Stadalnik","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.2565,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.87457627,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"30","issue":"9","first_page":"1519","last_page":"30"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.008200000040233135,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatic-plasma-flow","display_name":"hepatic plasma flow","score":0.8489999771118164},{"id":"https://openalex.org/keywords/ligand-binding-affinity","display_name":"ligand binding affinity","score":0.9890000224113464},{"id":"https://openalex.org/keywords/receptor-concentration","display_name":"receptor concentration","score":0.9750000238418579},{"id":"https://openalex.org/keywords/time-activity-curves","display_name":"time-activity curves","score":0.8450000286102295},{"id":"https://openalex.org/keywords/tissue-distribution","display_name":"tissue distribution","score":0.7250000238418579},{"id":"https://openalex.org/keywords/liver","display_name":"liver","score":0.35100001096725464},{"id":"https://openalex.org/keywords/blood","display_name":"blood","score":0.7839999794960022},{"id":"https://openalex.org/keywords/kinetic-modeling","display_name":"kinetic modeling","score":0.7699999809265137}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7386456727981567},{"id":"https://openalex.org/C2777807558","wikidata":"https://www.wikidata.org/wiki/Q4914764","display_name":"Biodistribution","level":3,"score":0.5992920994758606},{"id":"https://openalex.org/C2781065829","wikidata":"https://www.wikidata.org/wiki/Q905662","display_name":"Indocyanine green","level":2,"score":0.5768818855285645},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.49708250164985657},{"id":"https://openalex.org/C43376680","wikidata":"https://www.wikidata.org/wiki/Q6580786","display_name":"Bolus (digestion)","level":2,"score":0.47262975573539734},{"id":"https://openalex.org/C4375535","wikidata":"https://www.wikidata.org/wiki/Q2373354","display_name":"Technetium-99m","level":3,"score":0.4661394953727722},{"id":"https://openalex.org/C2778597219","wikidata":"https://www.wikidata.org/wiki/Q11721976","display_name":"Human serum albumin","level":2,"score":0.44490861892700195},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.44338130950927734},{"id":"https://openalex.org/C522557706","wikidata":"https://www.wikidata.org/wiki/Q1054","display_name":"Technetium","level":2,"score":0.4384183883666992},{"id":"https://openalex.org/C158846371","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Blood flow","level":2,"score":0.43450677394866943},{"id":"https://openalex.org/C2780723685","wikidata":"https://www.wikidata.org/wiki/Q1961418","display_name":"Technetium-99","level":2,"score":0.4261499345302582},{"id":"https://openalex.org/C2780367336","wikidata":"https://www.wikidata.org/wiki/Q4808618","display_name":"Assay sensitivity","level":3,"score":0.4168587923049927},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.3662383556365967},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.35449156165122986},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2859528660774231},{"id":"https://openalex.org/C2779902710","wikidata":"https://www.wikidata.org/wiki/Q1130465","display_name":"Scintigraphy","level":2,"score":0.1894434690475464},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1675751507282257},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.16220474243164062},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.12385523319244385},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12156054377555847},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07630011439323425},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C13965031","wikidata":"https://www.wikidata.org/wiki/Q243545","display_name":"Nuclear chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000418","descriptor_name":"Albumins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000418","descriptor_name":"Albumins","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008102","descriptor_name":"Liver Circulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009942","descriptor_name":"Organometallic Compounds","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009942","descriptor_name":"Organometallic Compounds","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009942","descriptor_name":"Organometallic Compounds","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D010953","descriptor_name":"Plasma Volume","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012709","descriptor_name":"Serum Albumin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013667","descriptor_name":"Technetium","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013667","descriptor_name":"Technetium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015609","descriptor_name":"Organotechnetium Compounds","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:2549225","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2549225","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","raw_type":"Journal Article"},{"id":"mag:2163481415","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2549225","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.428600013256073,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G153426115","display_name":"TRAUMA ACADEMIC TRAINING PROGRAM","funder_award_id":"T32GM007860","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3646098654","display_name":"TC99M-NEOGALACTOALBUMIN EVALUATION OF LIVER DISEASE","funder_award_id":"1r01am034706-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W98090258","https://openalex.org/W1606147438","https://openalex.org/W1814487004","https://openalex.org/W1893058155","https://openalex.org/W1966837555","https://openalex.org/W1976630512","https://openalex.org/W2017016134","https://openalex.org/W2022889438","https://openalex.org/W2047922146","https://openalex.org/W2053891432","https://openalex.org/W2066735646","https://openalex.org/W2067722023","https://openalex.org/W2080549100","https://openalex.org/W2341283081","https://openalex.org/W2399287373","https://openalex.org/W2439039152"],"related_works":["https://openalex.org/W2184616672","https://openalex.org/W1995343285","https://openalex.org/W2077946552","https://openalex.org/W322337358","https://openalex.org/W2159420827","https://openalex.org/W1893058155","https://openalex.org/W2181443686","https://openalex.org/W2082909699","https://openalex.org/W1764649939","https://openalex.org/W973104974"],"abstract_inverted_index":{"Kinetic":[0],"sensitivity":[1,19,142],"is":[2,125,158],"the":[3,11,115,121,146,151],"ability":[4],"of":[5,14,20,32,63,71,114,140,145,153,166],"a":[6,15,28,154,159,162],"physiochemical":[7],"parameter":[8],"to":[9,110,128,161],"alter":[10],"time-activity":[12,24,106],"curve":[13],"radiotracer.":[16],"The":[17],"kinetic":[18,141,170],"liver":[21,103],"and":[22,54,67,79,104,134],"blood":[23,105],"data":[25,93],"resulting":[26],"from":[27],"single":[29],"bolus":[30],"injection":[31],"[99mTc]galactosyl-neoglycoalbumin":[33],"[(":[34],"Tc]NGA)":[35],"into":[36],"healthy":[37],"pigs":[38],"was":[39],"examined.":[40],"Three":[41],"parameters,":[42],"hepatic":[43,80,129],"plasma":[44,50,72,81,130],"flow":[45,48,82],"scaled":[46],"as":[47],"per":[49],"volume,":[51],"ligand-receptor":[52,132],"affinity,":[53,133],"total":[55],"receptor":[56,135,167],"concentration,":[57],"were":[58,86],"tested":[59,116],"using":[60],"[Tc]NGA":[61,90,122],"injections":[62],"various":[64],"molar":[65],"doses":[66],"affinities.":[68],"Simultaneous":[69],"measurements":[70],"volume":[73],"(iodine-125":[74],"human":[75],"serum":[76],"albumin":[77],"dilution),":[78],"(indocyanine":[83],"green":[84],"extraction)":[85],"performed":[87],"during":[88],"12":[89],"studies.":[91],"Paired":[92],"sets":[94],"demonstrated":[95],"differences":[96],"(P(chi":[97],"v2)":[98],"less":[99],"than":[100],"0.01)":[101],"in":[102,108,112],"curves":[107],"response":[109],"changes":[111],"each":[113],"parameters.":[117],"We":[118],"conclude":[119],"that":[120,149],"radiopharmacokinetic":[123],"system":[124],"therefore":[126],"sensitive":[127],"flow,":[131],"concentration.":[136],"In":[137],"vivo":[138],"demonstration":[139],"permits":[143],"delineation":[144,157],"physiologic":[147],"parameters":[148],"determine":[150],"biodistribution":[152],"radiopharmaceutical.":[155],"This":[156],"prerequisite":[160],"valid":[163],"analytic":[164],"assessment":[165],"biochemistry":[168],"via":[169],"modeling.":[171]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}