{"id":"https://openalex.org/W2163479012","doi":null,"title":"STEM CELL SIGNATURES IN GLIOMA","display_name":"STEM CELL SIGNATURES IN GLIOMA","publication_year":2012,"publication_date":"2012-08-30","ids":{"openalex":"https://openalex.org/W2163479012","mag":"2163479012"},"language":"en","primary_location":{"id":"pmh:oai:figshare.com:article/26917282","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/Stem_cell_signatures_in_glioma/26917282","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10616/41143","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100945083","display_name":"Xiaobing He","orcid":"https://orcid.org/0009-0004-9907-7995","observed_orcids":["https://orcid.org/0009-0004-9907-7995"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Xiaobing He","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5100945083"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.01730000041425228,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9909999966621399},{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":0.9190000295639038},{"id":"https://openalex.org/keywords/gene-expression-signatures","display_name":"gene expression signatures","score":0.8529999852180481},{"id":"https://openalex.org/keywords/sox2","display_name":"SOX2","score":0.7379999756813049},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitor-resistance","display_name":"tyrosine kinase inhibitor resistance","score":0.8429999947547913},{"id":"https://openalex.org/keywords/pdgfr-inhibitors","display_name":"PDGFR inhibitors","score":0.8529999852180481},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.7049999833106995},{"id":"https://openalex.org/keywords/epigenetic-modifications","display_name":"epigenetic modifications","score":0.6589999794960022},{"id":"https://openalex.org/keywords/dna-hypomethylation","display_name":"DNA hypomethylation","score":0.9909999966621399},{"id":"https://openalex.org/keywords/h3k9me2","display_name":"H3K9me2","score":0.949999988079071},{"id":"https://openalex.org/keywords/neural-stem-cells","display_name":"neural stem cells","score":0.5910000205039978},{"id":"https://openalex.org/keywords/stem-cell-markers","display_name":"stem cell markers","score":0.7879999876022339},{"id":"https://openalex.org/keywords/p53-null-mice","display_name":"p53-null mice","score":0.7120000123977661}],"concepts":[{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.758084774017334},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6745325922966003},{"id":"https://openalex.org/C2777389519","wikidata":"https://www.wikidata.org/wiki/Q425088","display_name":"Temozolomide","level":3,"score":0.6675426959991455},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6608778238296509},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.6401360034942627},{"id":"https://openalex.org/C136834591","wikidata":"https://www.wikidata.org/wiki/Q2944097","display_name":"Neural stem cell","level":3,"score":0.588354766368866},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.5634361505508423},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.5226438045501709},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.5184042453765869},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.19773715734481812},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17650187015533447},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12145951390266418}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:figshare.com:article/26917282","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/Stem_cell_signatures_in_glioma/26917282","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"pmh:oai:openarchive.ki.se:10616/41143","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/41143","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:2163479012","doi":null,"is_oa":false,"landing_page_url":"http://publications.ki.se/xmlui/bitstream/handle/10616/41143/Thesis_He_Xiaobing.pdf?sequence=1","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:openarchive.ki.se:10616/41143","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/41143","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":214,"referenced_works":["https://openalex.org/W197014098","https://openalex.org/W1492600479","https://openalex.org/W1495551511","https://openalex.org/W1531180106","https://openalex.org/W1534734027","https://openalex.org/W1560814177","https://openalex.org/W1579447084","https://openalex.org/W1595064915","https://openalex.org/W1608762409","https://openalex.org/W1755052449","https://openalex.org/W1843891279","https://openalex.org/W1894124425","https://openalex.org/W1964116579","https://openalex.org/W1964150693","https://openalex.org/W1966135244","https://openalex.org/W1966504370","https://openalex.org/W1967467247","https://openalex.org/W1969436259","https://openalex.org/W1971496676","https://openalex.org/W1973829016","https://openalex.org/W1974365957","https://openalex.org/W1978956991","https://openalex.org/W1980499453","https://openalex.org/W1981088384","https://openalex.org/W1981809048","https://openalex.org/W1982102668","https://openalex.org/W1984885474","https://openalex.org/W1985115576","https://openalex.org/W1986034385","https://openalex.org/W1987464002","https://openalex.org/W1988044590","https://openalex.org/W1988986134","https://openalex.org/W1989958716","https://openalex.org/W1991924455","https://openalex.org/W1992160731","https://openalex.org/W1992514491","https://openalex.org/W1992949513","https://openalex.org/W1993238204","https://openalex.org/W1993967951","https://openalex.org/W1994599132","https://openalex.org/W1994756194","https://openalex.org/W1994901446","https://openalex.org/W1995140011","https://openalex.org/W1995507229","https://openalex.org/W1996588332","https://openalex.org/W1999553354","https://openalex.org/W2000078674","https://openalex.org/W2001493754","https://openalex.org/W2001544973","https://openalex.org/W2002281319","https://openalex.org/W2008758335","https://openalex.org/W2009886857","https://openalex.org/W2010677999","https://openalex.org/W2014006702","https://openalex.org/W2015831734","https://openalex.org/W2017050785","https://openalex.org/W2017308570","https://openalex.org/W2017968214","https://openalex.org/W2018671779","https://openalex.org/W2018855387","https://openalex.org/W2019264784","https://openalex.org/W2020151184","https://openalex.org/W2020231800","https://openalex.org/W2023116564","https://openalex.org/W2023427658","https://openalex.org/W2024791894","https://openalex.org/W2024819383","https://openalex.org/W2025183726","https://openalex.org/W2026189661","https://openalex.org/W2029231546","https://openalex.org/W2029470215","https://openalex.org/W2030643073","https://openalex.org/W2031482209","https://openalex.org/W2031683488","https://openalex.org/W2031968704","https://openalex.org/W2032039673","https://openalex.org/W2035021866","https://openalex.org/W2035086650","https://openalex.org/W2035222904","https://openalex.org/W2036044314","https://openalex.org/W2036193202","https://openalex.org/W2037044453","https://openalex.org/W2037173620","https://openalex.org/W2037177143","https://openalex.org/W2038916652","https://openalex.org/W2039075677","https://openalex.org/W2039199416","https://openalex.org/W2040827479","https://openalex.org/W2041617965","https://openalex.org/W2041686632","https://openalex.org/W2042316019","https://openalex.org/W2043033879","https://openalex.org/W2045899482","https://openalex.org/W2048160969","https://openalex.org/W2049884365","https://openalex.org/W2051055358","https://openalex.org/W2051531582","https://openalex.org/W2052726917","https://openalex.org/W2053911973","https://openalex.org/W2057159461","https://openalex.org/W2060080437","https://openalex.org/W2061738719","https://openalex.org/W2062062519","https://openalex.org/W2062093164","https://openalex.org/W2064012961","https://openalex.org/W2064578746","https://openalex.org/W2064876412","https://openalex.org/W2065754676","https://openalex.org/W2067856703","https://openalex.org/W2068087430","https://openalex.org/W2069642304","https://openalex.org/W2069845109","https://openalex.org/W2070412580","https://openalex.org/W2071584884","https://openalex.org/W2073302269","https://openalex.org/W2073641341","https://openalex.org/W2073759231","https://openalex.org/W2079356804","https://openalex.org/W2080838269","https://openalex.org/W2081184407","https://openalex.org/W2082210456","https://openalex.org/W2082475821","https://openalex.org/W2083274861","https://openalex.org/W2084037323","https://openalex.org/W2084481314","https://openalex.org/W2086693994","https://openalex.org/W2086943348","https://openalex.org/W2090982381","https://openalex.org/W2091315047","https://openalex.org/W2093923075","https://openalex.org/W2095999479","https://openalex.org/W2096287682","https://openalex.org/W2096670842","https://openalex.org/W2098341282","https://openalex.org/W2098588666","https://openalex.org/W2099496555","https://openalex.org/W2101332957","https://openalex.org/W2101357976","https://openalex.org/W2102626211","https://openalex.org/W2104978512","https://openalex.org/W2105100844","https://openalex.org/W2105528101","https://openalex.org/W2106816824","https://openalex.org/W2107575419","https://openalex.org/W2108340830","https://openalex.org/W2109610561","https://openalex.org/W2110015307","https://openalex.org/W2110301828","https://openalex.org/W2112050795","https://openalex.org/W2112495947","https://openalex.org/W2112567075","https://openalex.org/W2112703519","https://openalex.org/W2113942802","https://openalex.org/W2114254430","https://openalex.org/W2114426388","https://openalex.org/W2115862526","https://openalex.org/W2117577687","https://openalex.org/W2119593356","https://openalex.org/W2120963683","https://openalex.org/W2123151929","https://openalex.org/W2123159500","https://openalex.org/W2123509170","https://openalex.org/W2124078079","https://openalex.org/W2124512686","https://openalex.org/W2125987139","https://openalex.org/W2126817554","https://openalex.org/W2126851387","https://openalex.org/W2128146359","https://openalex.org/W2129172946","https://openalex.org/W2129866793","https://openalex.org/W2131170195","https://openalex.org/W2131799762","https://openalex.org/W2131860315","https://openalex.org/W2135046848","https://openalex.org/W2137586969","https://openalex.org/W2138472595","https://openalex.org/W2138977668","https://openalex.org/W2139990120","https://openalex.org/W2141410747","https://openalex.org/W2141431050","https://openalex.org/W2142046859","https://openalex.org/W2142079389","https://openalex.org/W2145925994","https://openalex.org/W2147511945","https://openalex.org/W2147518722","https://openalex.org/W2148521032","https://openalex.org/W2148977460","https://openalex.org/W2149254097","https://openalex.org/W2150056436","https://openalex.org/W2150163104","https://openalex.org/W2150197150","https://openalex.org/W2150268629","https://openalex.org/W2150638747","https://openalex.org/W2150696320","https://openalex.org/W2152387543","https://openalex.org/W2153382986","https://openalex.org/W2154313451","https://openalex.org/W2158233796","https://openalex.org/W2158619723","https://openalex.org/W2158681922","https://openalex.org/W2160266371","https://openalex.org/W2161289668","https://openalex.org/W2165057712","https://openalex.org/W2165582566","https://openalex.org/W2166556978","https://openalex.org/W2166798417","https://openalex.org/W2167650288","https://openalex.org/W2168298750","https://openalex.org/W2168414172","https://openalex.org/W2168990206","https://openalex.org/W2169529166","https://openalex.org/W2170429308","https://openalex.org/W2290452071","https://openalex.org/W2316741044"],"related_works":["https://openalex.org/W2114426388","https://openalex.org/W1991924455","https://openalex.org/W58669479","https://openalex.org/W2344708222","https://openalex.org/W4321463061","https://openalex.org/W7028347451","https://openalex.org/W2072622278","https://openalex.org/W2182194168","https://openalex.org/W2051462508","https://openalex.org/W4245698349"],"abstract_inverted_index":{"Gliomas":[0],"are":[1,60],"the":[2,7,14,27,52,113,119,149,242,252,291,307,314,328,334,351,507],"most":[3,15],"common":[4],"tumors":[5,59,284,308],"of":[6,22,26,102,126,133,151,169,187,203,213,226,244,313,348,353,389,410,414,463,510],"central":[8],"nervous":[9],"system":[10],"in":[11,57,89,131,264,281,286,306,311,323,350,369,474],"adults.":[12],"Glioblastoma,":[13],"aggressive":[16],"form,":[17],"has":[18,48],"a":[19,75,167,177,201,271,379,411,421],"median":[20],"survival":[21],"15":[23],"months":[24],"regardless":[25],"standard":[28],"treatment":[29,41],"with":[30,45,107,171,233,260,420,471],"surgery":[31],"and":[32,66,71,99,118,139,162,173,193,215,228,266,285,296,322,381,406,416,459,465,497,503],"temozolomide-based":[33],"radiochemotherapy.":[34],"Therefore,":[35,372],"it":[36],"is":[37,160,247],"imperative":[38],"to":[39,68,112,155],"improve":[40],"options":[42],"for":[43,62,78,83,180,277,386],"patients":[44],"glioblastoma.":[46,354],"It":[47],"been":[49],"suggested":[50],"that":[51,148,209,241],"putative":[53],"tumor":[54,181,253],"stem":[55,84,182,191,196,217,364,376,467],"cells":[56,192,197,269,289,343,377,419],"brain":[58,283,317,332,374],"responsible":[61],"glioma":[63,92,205,258,370],"initiation,":[64],"development":[65,352],"resistance":[67,150],"conventional":[69],"therapy":[70,385],"therefore":[72],"may":[73],"be":[74,164,345],"potential":[76],"target":[77],"novel":[79,95,178],"therapy.":[80,184],"By":[81],"searching":[82],"cell":[85,218,365,468],"gene":[86,108],"expression":[87,109,212,225],"signatures":[88,469],"human":[90,204,261,475],"high-grade":[91,221],"cultures,":[93],"two":[94,124],"subsets":[96,125],"(type":[97],"A":[98,153,185],"type":[100,152],"B)":[101],"glioblastoma":[103,418],"cultures":[104,127,154,325],"were":[105,198,302],"identified":[106],"profiles":[110],"similar":[111],"recently":[114],"described":[115],"TCGA":[116],"proneural/classical/neural":[117],"mesenchymal":[120],"subsets,":[121],"respectively.":[122],"The":[123,146],"have":[128],"different":[129],"capacities":[130],"terms":[132],"tumorigenic":[134],"potential,":[135],"sphere":[136],"forming":[137],"ability":[138],"distinct":[140,422],"tyrosine":[141,156,423],"kinase":[142,157,424],"inhibitor":[143,158,425],"sensitivity":[144,426],"profiles.":[145],"findings":[147],"mono-treatment":[159],"SOX2-dependent":[161,412],"can":[163],"overcome":[165],"by":[166],"combination":[168],"treatments":[170],"PDGFR":[172],"IGF1-R":[174],"inhibitors":[175],"provide":[176],"strategy":[179],"cell-targeting":[183],"set":[186],"markers":[188,246],"defining":[189],"neural":[190,214,234,287,464],"pluripotent":[194,216,466],"embryonic":[195],"tested":[199],"on":[200,249,270],"series":[202],"tissues.":[206],"Results":[207],"demonstrated":[208],"besides":[210],"deregulated":[211],"regulatory":[219],"proteins,":[220],"gliomas":[222],"also":[223,310],"show":[224],"mesodermal-":[227],"endodermal-specific":[229],"transcription":[230],"factors":[231],"together":[232],"proteins.":[235],"In":[236],"vivo":[237],"xenograft":[238],"experiments":[239],"indicated":[240],"presence":[243],"pluripotency":[245],"dependent":[248],"signals":[250],"from":[251,327],"microenvironment.":[254],"An":[255],"experimental":[256,511],"mouse":[257,282,512],"model":[259],"PDGFB":[262],"overexpressed":[263],"astrocyte":[265,267],"progenitor":[268],"p53":[272],"null":[273,330],"background":[274],"was":[275],"used":[276],"studying":[278],"epigenetic":[279],"changes":[280],"stem/progenitor":[288],"during":[290,333,506],"pre-neoplastic":[292,335],"stage.":[293,336],"DNA":[294,504],"hypomethylation":[295,505],"elevated":[297],"Histone3":[298,500],"Lysine9":[299],"di-methylation":[300],"(H3K9Me2)":[301],"detected":[303],"not":[304],"only":[305],"but":[309,339],"samples":[312],"adult":[315],"frontal":[316],"lateral":[318],"ventricular":[319],"wall":[320],"(LVW)":[321],"neurosphere":[324],"respectively,":[326],"hGFAPpPDGFB/Trp53":[329],"(B+p53-/-)":[331],"Thus,":[337],"non-neoplastic":[338],"epigenetically":[340],"disturbed":[341],"LVW":[342],"might":[344],"early":[346],"targets":[347],"transformation":[349],"Taken":[355],"together,":[356],"this":[357],"work":[358],"provides":[359],"some":[360],"new":[361,380],"insights":[362],"into":[363],"related":[366],"mechanisms":[367],"involved":[368],"development.":[371],"targeting":[373],"cancer":[375],"presents":[378],"potentially":[382],"more":[383],"effective":[384],"glioma.":[387,476,513],"List":[388],"scientific":[390],"papers":[391],"I.":[392],"Daniel":[393],"H\u00e4gerstrand,":[394],"Xiaobing":[395,438,486],"He,":[396,439,487],"Maja":[397],"Bradic":[398],"Lindh,":[399],"Saskia":[400],"Hoefs,":[401],"G\u00f6ran":[402,444],"Hesselager,":[403,445],"Arne":[404],"\u00d6stman":[405],"Monica":[407,457,498],"Nist\u00e9r.":[408,499],"Identification":[409],"subset":[413],"tumor-":[415],"sphere-forming":[417],"profile.":[427],"Neuro":[428],"Oncol.":[429],"2011":[430,479],"Nov;":[431],"13(11):":[432],"1178-91.":[433],"https://doi.org/10.1093/neuonc/nor113":[434],"II.":[435],"Johan":[436],"Holmberg,":[437],"Inti":[440],"Peredo,":[441],"Abiel":[442],"Orrego,":[443],"Christer":[446],"Ericsson,":[447],"Outi":[448],"Hovatta,":[449],"Sueli":[450],"Mieko":[451],"Oba-Shinjo,":[452],"Suely":[453],"Kazue":[454],"Nagahashi":[455],"Marie,":[456],"Nist\u00e9r":[458],"Jonas":[460],"Muhr.":[461],"Activation":[462],"correlates":[470],"increased":[472],"malignancy":[473],"PLoS":[477],"One.":[478],"Mar":[480],"31;":[481],"6(3):":[482],"e18454.":[483],"https://doi.org/10.1371/journal.pone.0018454":[484],"III.":[485],"Mohsen":[488],"Karimi,":[489],"Mingqi":[490],"Qu,":[491],"Anna":[492],"Hedr\u00e9n,":[493],"Tomas":[494],"J":[495],"Ekstr\u00f6m":[496],"lysine9":[501],"methylation":[502],"preneoplastic":[508],"stage":[509],"[Manuscript]":[514]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
