{"id":"https://openalex.org/W2163421171","doi":"https://doi.org/10.3390/ijms9020181","title":"Some QSAR Studies for a Group of Sulfonamide Schiff Base as Carbonic Anhydrase CA II Inhibitors","display_name":"Some QSAR Studies for a Group of Sulfonamide Schiff Base as Carbonic Anhydrase CA II Inhibitors","publication_year":2008,"publication_date":"2008-02-26","ids":{"openalex":"https://openalex.org/W2163421171","doi":"https://doi.org/10.3390/ijms9020181","mag":"2163421171","pmid":"https://pubmed.ncbi.nlm.nih.gov/19325742","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2635660"},"language":"en","primary_location":{"id":"doi:10.3390/ijms9020181","doi":"https://doi.org/10.3390/ijms9020181","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms9020181","pdf_url":"https://www.mdpi.com/1422-0067/9/2/181/pdf?version=1403130464","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/9/2/181/pdf?version=1403130464","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082995136","display_name":"Erol Ero\u011flu","orcid":"https://orcid.org/0000-0002-5401-987X","observed_orcids":["https://orcid.org/0000-0002-5401-987X"]},"institutions":[{"id":"https://openalex.org/I80538482","display_name":"Harran University","ror":"https://ror.org/057qfs197","country_code":"TR","type":"education","lineage":["https://openalex.org/I80538482"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Erol Eroglu","raw_affiliation_strings":["Department of Physics, Faculty of Sciences and Arts, Harran University, Osmanbey Campus, Sanliurfa 63300, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physics, Faculty of Sciences and Arts, Harran University, Osmanbey Campus, Sanliurfa 63300, Turkey","institution_ids":["https://openalex.org/I80538482"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5082995136"],"corresponding_institution_ids":["https://openalex.org/I80538482"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":0.784,"has_fulltext":true,"cited_by_count":35,"citation_normalized_percentile":{"value":0.68332917,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"9","issue":"2","first_page":"181","last_page":"197"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12412","display_name":"Enzyme function and inhibition","score":0.9125999808311462,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12412","display_name":"Enzyme function and inhibition","score":0.9125999808311462,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.0869000032544136,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/carbonic-anhydrase-ii-inhibitors","display_name":"carbonic anhydrase II inhibitors","score":0.8840000033378601},{"id":"https://openalex.org/keywords/qsar","display_name":"QSAR","score":0.7440000176429749},{"id":"https://openalex.org/keywords/molecular-descriptors","display_name":"molecular descriptors","score":0.6669999957084656},{"id":"https://openalex.org/keywords/enzyme-inhibition","display_name":"enzyme inhibition","score":0.4880000054836273},{"id":"https://openalex.org/keywords/ki-values","display_name":"Ki values","score":0.6129999756813049},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.753000020980835},{"id":"https://openalex.org/keywords/physicochemical-factors","display_name":"physicochemical factors","score":0.5090000033378601}],"concepts":[{"id":"https://openalex.org/C2775914622","wikidata":"https://www.wikidata.org/wiki/Q284089","display_name":"Carbonic anhydrase","level":3,"score":0.9393180012702942},{"id":"https://openalex.org/C164126121","wikidata":"https://www.wikidata.org/wiki/Q766383","display_name":"Quantitative structure\u2013activity relationship","level":2,"score":0.8621960878372192},{"id":"https://openalex.org/C2781039511","wikidata":"https://www.wikidata.org/wiki/Q3208529","display_name":"Sulfonamide","level":2,"score":0.7302883863449097},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6789571046829224},{"id":"https://openalex.org/C2776428424","wikidata":"https://www.wikidata.org/wiki/Q2602701","display_name":"Schiff base","level":2,"score":0.6209563612937927},{"id":"https://openalex.org/C48921125","wikidata":"https://www.wikidata.org/wiki/Q10861030","display_name":"Linear regression","level":2,"score":0.47025051712989807},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.4617460370063782},{"id":"https://openalex.org/C2780092901","wikidata":"https://www.wikidata.org/wiki/Q3433612","display_name":"Correlation coefficient","level":2,"score":0.4527781307697296},{"id":"https://openalex.org/C2989041947","wikidata":"https://www.wikidata.org/wiki/Q186290","display_name":"Linear correlation","level":2,"score":0.43012210726737976},{"id":"https://openalex.org/C2991951333","wikidata":"https://www.wikidata.org/wiki/Q188403","display_name":"Quantum chemical","level":3,"score":0.42742496728897095},{"id":"https://openalex.org/C119795356","wikidata":"https://www.wikidata.org/wiki/Q407801","display_name":"Isozyme","level":3,"score":0.4265504479408264},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.409010112285614},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3659305274486542},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.29884636402130127},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.21893492341041565},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.08174887299537659},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3390/ijms9020181","doi":"https://doi.org/10.3390/ijms9020181","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms9020181","pdf_url":"https://www.mdpi.com/1422-0067/9/2/181/pdf?version=1403130464","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2635660","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2635660","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmid:19325742","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19325742","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.358.2931","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.358.2931","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/9c/a7/Int_J_Mol_Sci_2008_Feb_26_9(2)_181-197.tar.gz","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:7516e87f7e9949dda9cf69f1fe124190","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/7516e87f7e9949dda9cf69f1fe124190","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Molecular Sciences, Vol 9, Iss 2, Pp 181-197 (2008)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/ijms9020181","doi":"https://doi.org/10.3390/ijms9020181","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms9020181","pdf_url":"https://www.mdpi.com/1422-0067/9/2/181/pdf?version=1403130464","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2163421171.pdf","grobid_xml":"https://content.openalex.org/works/W2163421171.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W106879616","https://openalex.org/W127655495","https://openalex.org/W198054044","https://openalex.org/W596972278","https://openalex.org/W605004440","https://openalex.org/W1488799823","https://openalex.org/W1516720576","https://openalex.org/W1545231783","https://openalex.org/W1550061415","https://openalex.org/W1964374723","https://openalex.org/W1964944281","https://openalex.org/W1969420576","https://openalex.org/W1969804944","https://openalex.org/W1970803441","https://openalex.org/W1980019773","https://openalex.org/W1986503300","https://openalex.org/W1995025774","https://openalex.org/W1995669341","https://openalex.org/W2001039921","https://openalex.org/W2002315496","https://openalex.org/W2013501370","https://openalex.org/W2021229217","https://openalex.org/W2029000192","https://openalex.org/W2033043436","https://openalex.org/W2041986574","https://openalex.org/W2044200529","https://openalex.org/W2050411762","https://openalex.org/W2060284559","https://openalex.org/W2060586322","https://openalex.org/W2063261072","https://openalex.org/W2088350865","https://openalex.org/W2090437431","https://openalex.org/W2094680415","https://openalex.org/W2095277158","https://openalex.org/W2098366846","https://openalex.org/W2104545864","https://openalex.org/W2118794768","https://openalex.org/W2143981217","https://openalex.org/W2158203275","https://openalex.org/W2163572677","https://openalex.org/W2331211511","https://openalex.org/W2898519191","https://openalex.org/W2950915491","https://openalex.org/W3100743833","https://openalex.org/W3143749224","https://openalex.org/W4211118618","https://openalex.org/W4233746703","https://openalex.org/W4235704898"],"related_works":["https://openalex.org/W2034567232","https://openalex.org/W2095277158","https://openalex.org/W2144076882","https://openalex.org/W2098366846","https://openalex.org/W1964374723","https://openalex.org/W2091769732","https://openalex.org/W1880054620","https://openalex.org/W2019851525","https://openalex.org/W2612928452","https://openalex.org/W2154643983"],"abstract_inverted_index":{"In":[0],"the":[1,35,77,84,101,127,131],"present":[2],"study,":[3,82],"quantitative":[4],"structure-activity-relationship":[5],"(QSAR)":[6],"study":[7],"on":[8],"a":[9,89],"group":[10],"of":[11,15,34,39,42,61,68,97,107,130],"sulfonamide":[12],"Schiff-base":[13],"inhibitors":[14,41],"Carbonic":[16],"Anhydrase":[17],"(CA)":[18],"enzyme":[19],"has":[20],"been":[21],"carried":[22],"out":[23],"using":[24,72],"Codessa":[25,73],"Pro":[26,74],"methodology":[27],"and":[28,65,70,100,119],"software.":[29,75],"Linear":[30],"regression":[31],"QSAR":[32],"models":[33,78,112],"biological":[36,128],"activity":[37,129],"(Ki)":[38],"38":[40],"carbonic":[43],"anhydrase":[44],"CA-II":[45],"isozyme":[46],"were":[47,55],"established":[48],"with":[49,92,126],"12":[50],"different":[51],"molecular":[52],"descriptors":[53,69],"which":[54,122],"selected":[56],"from":[57],"more":[58],"than":[59],"hundreds":[60],"geometrical,":[62],"topological,":[63],"quantum-mechanical,":[64],"electronic":[66],"types":[67],"calculated":[71],"Among":[76],"presented":[79],"in":[80],"this":[81],"statistically":[83],"most":[85],"significant":[86],"one":[87],"is":[88],"five-parameter":[90],"equation":[91],"correlation":[93,103],"coefficient,":[94,104],"R(2)":[95,105],"values":[96,106],"ca.":[98,108],"0.840,":[99],"cross-validated":[102],"0.777.":[109],"The":[110],"obtained":[111],"allowed":[113],"us":[114],"to":[115],"reveal":[116],"some":[117],"physicochemical":[118],"structural":[120],"factors,":[121],"are":[123],"strongly":[124],"correlated":[125],"compounds.":[132]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}