{"id":"https://openalex.org/W2163393645","doi":"https://doi.org/10.1016/j.str.2009.07.018","title":"Structural Plasticity of Eph Receptor A4 Facilitates Cross-Class Ephrin Signaling","display_name":"Structural Plasticity of Eph Receptor A4 Facilitates Cross-Class Ephrin Signaling","publication_year":2009,"publication_date":"2009-10-01","ids":{"openalex":"https://openalex.org/W2163393645","doi":"https://doi.org/10.1016/j.str.2009.07.018","mag":"2163393645","pmid":"https://pubmed.ncbi.nlm.nih.gov/19836338","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2832735"},"language":"en","primary_location":{"id":"doi:10.1016/j.str.2009.07.018","doi":"https://doi.org/10.1016/j.str.2009.07.018","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.str.2009.07.018","pdf_url":"http://www.cell.com/article/S0969212609003396/pdf","source":{"id":"https://openalex.org/S7112016","display_name":"Structure","issn_l":"0969-2126","issn":["0969-2126","1878-4186"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Structure","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.cell.com/article/S0969212609003396/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078622476","display_name":"Thomas A. Bowden","orcid":"https://orcid.org/0000-0002-8066-8785","observed_orcids":["https://orcid.org/0000-0002-8066-8785"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Thomas A. Bowden","raw_affiliation_strings":["Division of Structural Biology, University of Oxford, Henry Wellcome Building of Genomic Medicine, Roosevelt Drive, Oxford, UK","Division of Structural Biology, University of Oxford, Henry Wellcome Building of Genomic Medicine, Roosevelt Drive, Oxford OX3 7BN, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Structural Biology, University of Oxford, Henry Wellcome Building of Genomic Medicine, Roosevelt Drive, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]},{"raw_affiliation_string":"Division of Structural Biology, University of Oxford, Henry Wellcome Building of Genomic Medicine, Roosevelt Drive, Oxford OX3 7BN, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035024575","display_name":"Alexandru Radu Aricescu","orcid":"https://orcid.org/0000-0003-3783-1388","observed_orcids":["https://orcid.org/0000-0003-3783-1388"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A. Radu Aricescu","raw_affiliation_strings":["Division of Structural Biology, University of Oxford, Henry Wellcome Building of Genomic Medicine, Roosevelt Drive, Oxford OX3 7BN, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Structural Biology, University of Oxford, Henry Wellcome Building of Genomic Medicine, Roosevelt Drive, Oxford OX3 7BN, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036384350","display_name":"Joanne E. Nettleship","orcid":"https://orcid.org/0000-0002-1258-1733","observed_orcids":["https://orcid.org/0000-0002-1258-1733"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Joanne E. Nettleship","raw_affiliation_strings":["Oxford Protein Production Facility, University of Oxford, Henry Wellcome Building of Genomic Medicine, Roosevelt Drive, Oxford OX3 7BN, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oxford Protein Production Facility, University of Oxford, Henry Wellcome Building of Genomic Medicine, Roosevelt Drive, Oxford OX3 7BN, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037626610","display_name":"Christian Siebold","orcid":"https://orcid.org/0000-0002-6635-3621","observed_orcids":["https://orcid.org/0000-0002-6635-3621"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Christian Siebold","raw_affiliation_strings":["Division of Structural Biology, University of Oxford, Henry Wellcome Building of Genomic Medicine, Roosevelt Drive, Oxford OX3 7BN, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Structural Biology, University of Oxford, Henry Wellcome Building of Genomic Medicine, Roosevelt Drive, Oxford OX3 7BN, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087006448","display_name":"Nahid Rahman-Huq","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nahid Rahman-Huq","raw_affiliation_strings":["Oxford Protein Production Facility, University of Oxford, Henry Wellcome Building of Genomic Medicine, Roosevelt Drive, Oxford OX3 7BN, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oxford Protein Production Facility, University of Oxford, Henry Wellcome Building of Genomic Medicine, Roosevelt Drive, Oxford OX3 7BN, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006045347","display_name":"Raymond J. Owens","orcid":"https://orcid.org/0000-0002-3705-2993","observed_orcids":["https://orcid.org/0000-0002-3705-2993"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Raymond J. Owens","raw_affiliation_strings":["Oxford Protein Production Facility, University of Oxford, Henry Wellcome Building of Genomic Medicine, Roosevelt Drive, Oxford OX3 7BN, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oxford Protein Production Facility, University of Oxford, Henry Wellcome Building of Genomic Medicine, Roosevelt Drive, Oxford OX3 7BN, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056016799","display_name":"David Ian Stuart","orcid":"https://orcid.org/0000-0002-3426-4210","observed_orcids":["https://orcid.org/0000-0002-3426-4210"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David I. Stuart","raw_affiliation_strings":["Division of Structural Biology, University of Oxford, Henry Wellcome Building of Genomic Medicine, Roosevelt Drive, Oxford OX3 7BN, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Structural Biology, University of Oxford, Henry Wellcome Building of Genomic Medicine, Roosevelt Drive, Oxford OX3 7BN, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016293875","display_name":"E. Yvonne Jones","orcid":"https://orcid.org/0000-0002-3834-1893","observed_orcids":["https://orcid.org/0000-0002-3834-1893"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"E. Yvonne Jones","raw_affiliation_strings":["Division of Structural Biology, University of Oxford, Henry Wellcome Building of Genomic Medicine, Roosevelt Drive, Oxford OX3 7BN, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Structural Biology, University of Oxford, Henry Wellcome Building of Genomic Medicine, Roosevelt Drive, Oxford OX3 7BN, UK","institution_ids":["https://openalex.org/I40120149"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5016293875"],"corresponding_institution_ids":["https://openalex.org/I40120149"],"apc_list":{"value":9350,"currency":"USD","value_usd":9350},"apc_paid":{"value":9350,"currency":"USD","value_usd":9350},"fwci":2.1087,"has_fulltext":true,"cited_by_count":98,"citation_normalized_percentile":{"value":0.8603226,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"17","issue":"10","first_page":"1386","last_page":"1397"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12061","display_name":"Axon Guidance and Neuronal Signaling","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12061","display_name":"Axon Guidance and Neuronal Signaling","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epha4","display_name":"EphA4","score":0.9890000224113464},{"id":"https://openalex.org/keywords/ephrin-b2","display_name":"ephrin-B2","score":0.7950000166893005},{"id":"https://openalex.org/keywords/eph-receptor-signaling","display_name":"Eph receptor signaling","score":0.5910000205039978},{"id":"https://openalex.org/keywords/ligand-binding-domain","display_name":"ligand-binding domain","score":0.8199999928474426},{"id":"https://openalex.org/keywords/conformational-plasticity","display_name":"conformational plasticity","score":0.8899999856948853},{"id":"https://openalex.org/keywords/receptor-tyrosine-kinases","display_name":"receptor tyrosine kinase","score":0.7710000276565552},{"id":"https://openalex.org/keywords/receptor-ligand-complex-structure","display_name":"receptor-ligand complex structure","score":0.6389999985694885}],"concepts":[{"id":"https://openalex.org/C19331615","wikidata":"https://www.wikidata.org/wiki/Q423602","display_name":"Erythropoietin-producing hepatocellular (Eph) receptor","level":4,"score":0.9677358269691467},{"id":"https://openalex.org/C170286479","wikidata":"https://www.wikidata.org/wiki/Q24787399","display_name":"Ephrin","level":3,"score":0.8930152654647827},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5880080461502075},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5103055834770203},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.46326521039009094},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4264788031578064},{"id":"https://openalex.org/C101544691","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor tyrosine kinase","level":3,"score":0.42394915223121643},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.41198575496673584},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39141911268234253},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.35367757081985474},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2747647166252136}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D036122","descriptor_name":"Receptor, EphA4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D036122","descriptor_name":"Receptor, EphA4","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D036342","descriptor_name":"Ephrins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D036342","descriptor_name":"Ephrins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1016/j.str.2009.07.018","doi":"https://doi.org/10.1016/j.str.2009.07.018","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.str.2009.07.018","pdf_url":"http://www.cell.com/article/S0969212609003396/pdf","source":{"id":"https://openalex.org/S7112016","display_name":"Structure","issn_l":"0969-2126","issn":["0969-2126","1878-4186"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Structure","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2832735","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2832735","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Structure","raw_type":"Text"},{"id":"pmid:19836338","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19836338","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Structure (London, England : 1993)","raw_type":"Journal Article"},{"id":"pmid:28903018","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28903018","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Structure (London, England : 1993)","raw_type":"Published Erratum"},{"id":"pmh:oai:pure.ed.ac.uk:openaire/f6e23393-8c3a-4fa0-809c-2b0415d4d478","doi":null,"is_oa":true,"landing_page_url":"https://www.research.ed.ac.uk/en/publications/f6e23393-8c3a-4fa0-809c-2b0415d4d478","pdf_url":"https://www.research.ed.ac.uk/files/15284933/Structural_plasticity_of_eph_receptor_A4_facilitates_cross_class_ephrin_signaling.pdf","source":{"id":"https://openalex.org/S4306400321","display_name":"Edinburgh Research Explorer (University of Edinburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I98677209","host_organization_name":"University of Edinburgh","host_organization_lineage":["https://openalex.org/I98677209"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bowden, T A, Aricescu, A R, Nettleship, J E, Siebold, C, Rahman-Huq, N, Owens, R J, Stuart, D I & Jones, E Y 2009, 'Structural plasticity of eph receptor A4 facilitates cross-class ephrin signaling', Structure, vol. 17, no. 10, pp. 1386-97. https://doi.org/10.1016/j.str.2009.07.018","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:3024421147","doi":null,"is_oa":false,"landing_page_url":"https://www.camsoxford.ox.ac.uk/coi-publications/publications/94578","pdf_url":null,"source":{"id":"https://openalex.org/S7112016","display_name":"Structure","issn_l":"0969-2126","issn":["0969-2126","1878-4186"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Structure","raw_type":null}],"best_oa_location":{"id":"doi:10.1016/j.str.2009.07.018","doi":"https://doi.org/10.1016/j.str.2009.07.018","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.str.2009.07.018","pdf_url":"http://www.cell.com/article/S0969212609003396/pdf","source":{"id":"https://openalex.org/S7112016","display_name":"Structure","issn_l":"0969-2126","issn":["0969-2126","1878-4186"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Structure","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2519939593","display_name":null,"funder_award_id":"031220","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G5134986304","display_name":null,"funder_award_id":"031220","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G5629465105","display_name":null,"funder_award_id":"C375/A3964","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G786558585","display_name":null,"funder_award_id":"A3964","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G8057470512","display_name":null,"funder_award_id":"10976","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320313096","display_name":"Diamond Light Source","ror":"https://ror.org/05etxs293"},{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320320887","display_name":"European Synchrotron Radiation Facility","ror":"https://ror.org/02550n020"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2163393645.pdf","grobid_xml":"https://content.openalex.org/works/W2163393645.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W97833451","https://openalex.org/W1539796472","https://openalex.org/W1546639740","https://openalex.org/W1584018958","https://openalex.org/W1968656665","https://openalex.org/W1969417879","https://openalex.org/W1980221962","https://openalex.org/W1983097317","https://openalex.org/W1985629904","https://openalex.org/W1993442892","https://openalex.org/W1995392323","https://openalex.org/W1998255137","https://openalex.org/W1999591105","https://openalex.org/W2003166050","https://openalex.org/W2008807736","https://openalex.org/W2015869998","https://openalex.org/W2016765195","https://openalex.org/W2029487310","https://openalex.org/W2033114158","https://openalex.org/W2034767282","https://openalex.org/W2035503835","https://openalex.org/W2038840577","https://openalex.org/W2038894508","https://openalex.org/W2039665187","https://openalex.org/W2050032878","https://openalex.org/W2056034415","https://openalex.org/W2071704671","https://openalex.org/W2084137696","https://openalex.org/W2085761836","https://openalex.org/W2087546428","https://openalex.org/W2088023367","https://openalex.org/W2089542817","https://openalex.org/W2091073822","https://openalex.org/W2093238184","https://openalex.org/W2093467487","https://openalex.org/W2093842873","https://openalex.org/W2103747393","https://openalex.org/W2105912939","https://openalex.org/W2118455767","https://openalex.org/W2120376007","https://openalex.org/W2122339645","https://openalex.org/W2122500867","https://openalex.org/W2142265558","https://openalex.org/W2143730384","https://openalex.org/W2144081223","https://openalex.org/W2145381994","https://openalex.org/W2147957869","https://openalex.org/W2148468292","https://openalex.org/W2164027317","https://openalex.org/W3199943451","https://openalex.org/W4229680502","https://openalex.org/W6800717233"],"related_works":["https://openalex.org/W1995716366","https://openalex.org/W1966371815","https://openalex.org/W3024421147","https://openalex.org/W2100369062","https://openalex.org/W2064974190","https://openalex.org/W1969417879","https://openalex.org/W2087546428","https://openalex.org/W7097891379","https://openalex.org/W1966357275","https://openalex.org/W3177206852"],"abstract_inverted_index":{"The":[0],"EphA4":[1,42,62,101,132],"tyrosine":[2],"kinase":[3],"cell":[4],"surface":[5],"receptor":[6,22,97,146],"regulates":[7],"an":[8],"array":[9],"of":[10,40,58,122],"physiological":[11],"processes":[12],"and":[13,27,47,53,104,142,148],"is":[14],"the":[15,37,41,123],"only":[16],"currently":[17],"known":[18],"class":[19,29,84,87,111,124,144],"A":[20,26,85,112,141],"Eph":[21,96,113,126,145],"that":[23,61,77,100],"binds":[24],"both":[25,140],"B":[28,88,125,143],"ephrins":[30],"with":[31,50,107],"high":[32],"affinity.":[33],"We":[34],"have":[35],"solved":[36],"crystal":[38],"structure":[39],"ligand":[43,69],"binding":[44,70,74,117],"domain":[45],"alone":[46],"in":[48,67,102,105],"complex":[49,106],"(1)":[51],"ephrinB2":[52,118],"(2)":[54],"ephrinA2.":[55],"This":[56,128],"set":[57],"structures":[59],"shows":[60],"has":[63,79],"significant":[64],"conformational":[65],"plasticity":[66,130],"its":[68],"face.":[71],"In":[72],"vitro":[73],"data":[75],"demonstrate":[76],"it":[78],"a":[80,134,151],"higher":[81],"affinity":[82],"for":[83,154],"than":[86],"ligands.":[89],"Structural":[90],"analyses,":[91],"drawing":[92],"on":[93,116],"previously":[94],"reported":[95],"structures,":[98],"show":[99],"isolation":[103],"ephrinA2":[108],"resembles":[109],"other":[110],"receptors":[114],"but":[115],"assumes":[119],"structural":[120,135],"hallmarks":[121],"receptors.":[127],"interactive":[129],"reveals":[131],"as":[133],"chameleon,":[136],"able":[137],"to":[138],"adopt":[139],"conformations,":[147],"thus":[149],"provides":[150],"molecular":[152],"basis":[153],"EphA-type":[155],"cross-class":[156],"reactivity.":[157]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}