{"id":"https://openalex.org/W2163388674","doi":"https://doi.org/10.1016/s0014-2999(99)00166-1","title":"Evidence for the differential sensitivity to hypoxia of basal and agonist-induced nitric oxide release","display_name":"Evidence for the differential sensitivity to hypoxia of basal and agonist-induced nitric oxide release","publication_year":1999,"publication_date":"1999-04-01","ids":{"openalex":"https://openalex.org/W2163388674","doi":"https://doi.org/10.1016/s0014-2999(99)00166-1","mag":"2163388674","pmid":"https://pubmed.ncbi.nlm.nih.gov/10334513"},"language":"en","primary_location":{"id":"doi:10.1016/s0014-2999(99)00166-1","doi":"https://doi.org/10.1016/s0014-2999(99)00166-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0014-2999(99)00166-1","pdf_url":null,"source":{"id":"https://openalex.org/S187816532","display_name":"European Journal of Pharmacology","issn_l":"0014-2999","issn":["0014-2999","1879-0712"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037915418","display_name":"Yagna P. R. Jarajapu","orcid":"https://orcid.org/0000-0002-7186-3693","observed_orcids":["https://orcid.org/0000-0002-7186-3693"]},"institutions":[{"id":"https://openalex.org/I181647926","display_name":"University of Strathclyde","ror":"https://ror.org/00n3w3b69","country_code":"GB","type":"education","lineage":["https://openalex.org/I181647926"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Yagna P.R Jarajapu","raw_affiliation_strings":["Department of Physiology and Pharmacology, University of Strathclyde, Glasgow, Scotland, UK","Department of Physiology and Pharmacology, University of Strathclyde, Glasgow, G4 0NR, Scotland, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Pharmacology, University of Strathclyde, Glasgow, Scotland, UK","institution_ids":["https://openalex.org/I181647926"]},{"raw_affiliation_string":"Department of Physiology and Pharmacology, University of Strathclyde, Glasgow, G4 0NR, Scotland, UK","institution_ids":["https://openalex.org/I181647926"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108468427","display_name":"Roger M. Wadsworth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181647926","display_name":"University of Strathclyde","ror":"https://ror.org/00n3w3b69","country_code":"GB","type":"education","lineage":["https://openalex.org/I181647926"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Roger M Wadsworth","raw_affiliation_strings":["Department of Physiology and Pharmacology, University of Strathclyde, Glasgow, G4 0NR, Scotland, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Pharmacology, University of Strathclyde, Glasgow, G4 0NR, Scotland, UK","institution_ids":["https://openalex.org/I181647926"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I181647926"],"apc_list":{"value":3230,"currency":"USD","value_usd":3230},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.21158295,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"370","issue":"3","first_page":"R1","last_page":"R3"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.8920000195503235},{"id":"https://openalex.org/keywords/nitric-oxide-release","display_name":"nitric oxide release","score":0.9459999799728394},{"id":"https://openalex.org/keywords/nitric-oxide-synthase","display_name":"nitric oxide synthase","score":0.9879999756813049},{"id":"https://openalex.org/keywords/pulmonary-artery","display_name":"pulmonary artery","score":0.5669999718666077},{"id":"https://openalex.org/keywords/thapsigargin","display_name":"thapsigargin","score":0.9670000076293945},{"id":"https://openalex.org/keywords/l-name","display_name":"L-NAME","score":0.9769999980926514},{"id":"https://openalex.org/keywords/oxygen-deprivation","display_name":"oxygen deprivation","score":0.5099999904632568},{"id":"https://openalex.org/keywords/smooth-muscle-contraction","display_name":"smooth muscle contraction","score":0.47999998927116394}],"concepts":[{"id":"https://openalex.org/C2778988552","wikidata":"https://www.wikidata.org/wiki/Q419401","display_name":"Carbachol","level":3,"score":0.9494702816009521},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.7171788215637207},{"id":"https://openalex.org/C2777952589","wikidata":"https://www.wikidata.org/wiki/Q421910","display_name":"Phenylephrine","level":3,"score":0.6997723579406738},{"id":"https://openalex.org/C2777146706","wikidata":"https://www.wikidata.org/wiki/Q3981006","display_name":"Thapsigargin","level":3,"score":0.6686001420021057},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.65498286485672},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5978752374649048},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5808966159820557},{"id":"https://openalex.org/C163415756","wikidata":"https://www.wikidata.org/wiki/Q126473","display_name":"Contraction (grammar)","level":2,"score":0.5502434372901917},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.5471181273460388},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.49569809436798096},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.483275443315506},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.2596844434738159},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21369394659996033},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.21324467658996582},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.21042004227638245},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20040252804756165},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07285141944885254},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.05818551778793335},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002217","descriptor_name":"Carbachol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009126","descriptor_name":"Muscle Relaxation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009130","descriptor_name":"Muscle, Smooth","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010656","descriptor_name":"Phenylephrine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011651","descriptor_name":"Pulmonary Artery","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019001","descriptor_name":"Nitric Oxide Synthase","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019001","descriptor_name":"Nitric Oxide Synthase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019284","descriptor_name":"Thapsigargin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019331","descriptor_name":"NG-Nitroarginine Methyl Ester","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0014-2999(99)00166-1","doi":"https://doi.org/10.1016/s0014-2999(99)00166-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0014-2999(99)00166-1","pdf_url":null,"source":{"id":"https://openalex.org/S187816532","display_name":"European Journal of Pharmacology","issn_l":"0014-2999","issn":["0014-2999","1879-0712"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pharmacology","raw_type":"journal-article"},{"id":"pmid:10334513","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10334513","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":7,"referenced_works":["https://openalex.org/W1965570074","https://openalex.org/W1975853356","https://openalex.org/W2009151731","https://openalex.org/W2011995481","https://openalex.org/W2169182236","https://openalex.org/W2308198663","https://openalex.org/W2398499060"],"related_works":["https://openalex.org/W2009388283","https://openalex.org/W2413547941","https://openalex.org/W2612288734","https://openalex.org/W1976279752","https://openalex.org/W1999033302","https://openalex.org/W2400993857","https://openalex.org/W1976652573","https://openalex.org/W1971900951","https://openalex.org/W2433793390","https://openalex.org/W2072150226"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}