{"id":"https://openalex.org/W2163366353","doi":"https://doi.org/10.1345/aph.1e061","title":"Aralast: A New \u03b1 1 -Protease Inhibitor for Treatment of \u03b1-Antitrypsin Deficiency","display_name":"Aralast: A New \u03b1 1 -Protease Inhibitor for Treatment of \u03b1-Antitrypsin Deficiency","publication_year":2005,"publication_date":"2005-10-11","ids":{"openalex":"https://openalex.org/W2163366353","doi":"https://doi.org/10.1345/aph.1e061","mag":"2163366353","pmid":"https://pubmed.ncbi.nlm.nih.gov/16219903"},"language":"en","primary_location":{"id":"doi:10.1345/aph.1e061","doi":"https://doi.org/10.1345/aph.1e061","is_oa":false,"landing_page_url":"https://doi.org/10.1345/aph.1e061","pdf_url":null,"source":{"id":"https://openalex.org/S113426163","display_name":"Annals of Pharmacotherapy","issn_l":"0012-6578","issn":["0012-6578","1060-0280","1542-6270"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Pharmacotherapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002462952","display_name":"Stan G. Louie","orcid":"https://orcid.org/0000-0001-5941-6690","observed_orcids":["https://orcid.org/0000-0001-5941-6690"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stan Gee Louie","raw_affiliation_strings":["Stan Gee Louie PharmD, Associate Professor, Department of Pharmacy, University of Southern California, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stan Gee Louie PharmD, Associate Professor, Department of Pharmacy, University of Southern California, Los Angeles, CA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026568748","display_name":"David Alexander Sclar","orcid":"https://orcid.org/0000-0002-0983-4293","observed_orcids":["https://orcid.org/0000-0002-0983-4293"]},"institutions":[{"id":"https://openalex.org/I72951846","display_name":"Washington State University","ror":"https://ror.org/05dk0ce17","country_code":"US","type":"education","lineage":["https://openalex.org/I72951846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Alexander Sclar","raw_affiliation_strings":["David Alexander Sclar PhD, Boeing Distinguished Professor, Health Policy & Administration, Washington State University, Pullman, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"David Alexander Sclar PhD, Boeing Distinguished Professor, Health Policy & Administration, Washington State University, Pullman, WA","institution_ids":["https://openalex.org/I72951846"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111691452","display_name":"Mark Anthony Gill","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark Anthony Gill","raw_affiliation_strings":["Mark Anthony Gill PharmD, Professor, Department of Pharmacy, University of Southern California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mark Anthony Gill PharmD, Professor, Department of Pharmacy, University of Southern California","institution_ids":["https://openalex.org/I1174212"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4400,"currency":"USD","value_usd":4400},"apc_paid":null,"fwci":1.3771,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.83678077,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"39","issue":"11","first_page":"1861","last_page":"1869"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.7753999829292297,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.7753999829292297,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.12240000069141388,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.010900000110268593,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-1-antitrypsin-deficiency","display_name":"alpha-1 antitrypsin deficiency","score":0.8579999804496765},{"id":"https://openalex.org/keywords/alpha-1-antitrypsin-augmentation-therapy","display_name":"alpha-1 antitrypsin augmentation therapy","score":0.9210000038146973},{"id":"https://openalex.org/keywords/alpha-1-antitrypsin","display_name":"alpha-1-antitrypsin","score":0.7730000019073486},{"id":"https://openalex.org/keywords/emphysema","display_name":"emphysema","score":0.8859999775886536},{"id":"https://openalex.org/keywords/pharmacoeconomics","display_name":"pharmacoeconomics","score":0.7730000019073486},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.6779999732971191},{"id":"https://openalex.org/keywords/formulary-inclusion","display_name":"formulary inclusion","score":0.550000011920929}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8661656379699707},{"id":"https://openalex.org/C2781143361","wikidata":"https://www.wikidata.org/wiki/Q55761529","display_name":"Protease inhibitor (pharmacology)","level":5,"score":0.6605240106582642},{"id":"https://openalex.org/C2776714187","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Protease","level":3,"score":0.4476187527179718},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.33475613594055176},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.31705963611602783},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.09789898991584778},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.09263491630554199},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08723405003547668},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000515","descriptor_name":"alpha 1-Antitrypsin","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":false},{"descriptor_ui":"D000515","descriptor_name":"alpha 1-Antitrypsin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019896","descriptor_name":"alpha 1-Antitrypsin Deficiency","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1345/aph.1e061","doi":"https://doi.org/10.1345/aph.1e061","is_oa":false,"landing_page_url":"https://doi.org/10.1345/aph.1e061","pdf_url":null,"source":{"id":"https://openalex.org/S113426163","display_name":"Annals of Pharmacotherapy","issn_l":"0012-6578","issn":["0012-6578","1060-0280","1542-6270"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Pharmacotherapy","raw_type":"journal-article"},{"id":"pmid:16219903","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16219903","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Annals of pharmacotherapy","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W22038449","https://openalex.org/W250182197","https://openalex.org/W1598347620","https://openalex.org/W1866342749","https://openalex.org/W1921725433","https://openalex.org/W1963723016","https://openalex.org/W1968325722","https://openalex.org/W1969397352","https://openalex.org/W1995832270","https://openalex.org/W1997541030","https://openalex.org/W2004406029","https://openalex.org/W2025560515","https://openalex.org/W2037783065","https://openalex.org/W2039889139","https://openalex.org/W2045616259","https://openalex.org/W2059220887","https://openalex.org/W2069535685","https://openalex.org/W2076261669","https://openalex.org/W2079330967","https://openalex.org/W2089695818","https://openalex.org/W2090378276","https://openalex.org/W2098777305","https://openalex.org/W2107111755","https://openalex.org/W2119128997","https://openalex.org/W2127951128","https://openalex.org/W2130915430","https://openalex.org/W2137240228","https://openalex.org/W2232316807","https://openalex.org/W2323886210","https://openalex.org/W2432739756","https://openalex.org/W2601839973"],"related_works":["https://openalex.org/W1526753735","https://openalex.org/W2064272773","https://openalex.org/W3129743100","https://openalex.org/W349410514","https://openalex.org/W2081104353","https://openalex.org/W4292423128","https://openalex.org/W2155443041","https://openalex.org/W2065645980","https://openalex.org/W2044661074","https://openalex.org/W2011812800"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"review":[2],"the":[3,22,59,128],"epidemiology,":[4],"pathogenesis,":[5],"and":[6,15,46,92,97,108,146],"management":[7],"of":[8,21,64,89,115,123,130,143],"patients":[9,71],"with":[10,18,40,72,100,111,151],"alpha-antitrypsin":[11,45],"(AAT)":[12],"deficiency":[13],"syndrome":[14],"compare":[16],"Aralast":[17,101,131,153],"Prolastin,":[19,68,152],"2":[20],"3":[23],"available":[24],"human":[25],"plasma-derived":[26,65],"AAT":[27,66,85,124],"agents.":[28],"DATA":[29,51,79],"SOURCES:":[30],"Articles":[31],"were":[32,77],"identified":[33],"using":[34],"a":[35,112],"MEDLINE":[36],"(1966-September":[37],"2005)":[38],"search":[39],"MESH":[41],"headings":[42],"that":[43,84,127],"included":[44],"emphysema.":[47,140],"STUDY":[48],"SELECTION":[49],"AND":[50],"EXTRACTION:":[52],"All":[53],"papers":[54],"from":[55],"peer-reviewed":[56],"journals":[57],"on":[58],"laboratory":[60],"or":[61],"clinical":[62],"efficacy":[63],"(eg,":[67],"Aralast)":[69],"for":[70,138,157],"this":[73],"autosomal":[74],"recessive":[75],"disorder":[76],"reviewed.":[78],"SYNTHESIS:":[80],"Clinical":[81],"trials":[82],"found":[83],"augmentation":[86,125,136],"prevents":[87],"progression":[88],"AAT-deficient":[90,139],"emphysema":[91],"thus":[93],"its":[94,144],"associated":[95],"morbidity":[96],"mortality.":[98],"Treatment":[99],"has":[102],"been":[103],"shown":[104],"to":[105,117],"be":[106,155],"safe":[107],"well":[109],"tolerated,":[110],"low":[113],"incidence":[114],"mild":[116],"moderate":[118],"adverse":[119],"events.":[120],"Pharmacoeconomics":[121],"studies":[122],"demonstrated":[126],"use":[129],"was":[132],"cost-effective":[133],"as":[134],"lifelong":[135],"therapy":[137],"CONCLUSIONS:":[141],"Because":[142],"effectiveness":[145],"extra":[147],"safety":[148],"measure":[149],"compared":[150],"should":[154],"recommended":[156],"formulary":[158],"inclusion.":[159]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
