{"id":"https://openalex.org/W2163321855","doi":"https://doi.org/10.1677/joe.1.06150","title":"Adipose tissue transplantation protects ob/ob mice from obesity, normalizes insulin sensitivity and restores fertility","display_name":"Adipose tissue transplantation protects ob/ob mice from obesity, normalizes insulin sensitivity and restores fertility","publication_year":2005,"publication_date":"2005-07-01","ids":{"openalex":"https://openalex.org/W2163321855","doi":"https://doi.org/10.1677/joe.1.06150","mag":"2163321855","pmid":"https://pubmed.ncbi.nlm.nih.gov/16002549"},"language":"en","primary_location":{"id":"doi:10.1677/joe.1.06150","doi":"https://doi.org/10.1677/joe.1.06150","is_oa":true,"landing_page_url":"https://doi.org/10.1677/joe.1.06150","pdf_url":"https://joe.bioscientifica.com/downloadpdf/journals/joe/186/1/1860203.pdf","source":{"id":"https://openalex.org/S34842069","display_name":"Journal of Endocrinology","issn_l":"0022-0795","issn":["0022-0795","1479-6805"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://joe.bioscientifica.com/downloadpdf/journals/joe/186/1/1860203.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083049708","display_name":"Simon Klebanov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1321572752","display_name":"St. Luke's-Roosevelt Hospital Center","ror":"https://ror.org/011t2cn48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1321572752"]},{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Simon Klebanov","raw_affiliation_strings":["The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA. seklebanov@hotmail.com","New York Obesity Research Center, St Luke's-Roosevelt Hospital Center, 1111 Amsterdam Avenue WH 1020, New York, New York 10025, USA","The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA. seklebanov@hotmail.com","institution_ids":["https://openalex.org/I4210115256"]},{"raw_affiliation_string":"New York Obesity Research Center, St Luke's-Roosevelt Hospital Center, 1111 Amsterdam Avenue WH 1020, New York, New York 10025, USA","institution_ids":["https://openalex.org/I1321572752"]},{"raw_affiliation_string":"The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071661526","display_name":"Clinton M. Astle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Clinton M Astle","raw_affiliation_strings":["The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5098258753","display_name":"Olga DeSimone","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Olga DeSimone","raw_affiliation_strings":["The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081775730","display_name":"Vitaly G. Ablamunits","orcid":"https://orcid.org/0000-0002-0769-1559","observed_orcids":["https://orcid.org/0000-0002-0769-1559"]},"institutions":[{"id":"https://openalex.org/I1321572752","display_name":"St. Luke's-Roosevelt Hospital Center","ror":"https://ror.org/011t2cn48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1321572752"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vitaly Ablamunits","raw_affiliation_strings":["New York Obesity Research Center, St Luke's-Roosevelt Hospital Center, 1111 Amsterdam Avenue WH 1020, New York, New York 10025, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York Obesity Research Center, St Luke's-Roosevelt Hospital Center, 1111 Amsterdam Avenue WH 1020, New York, New York 10025, USA","institution_ids":["https://openalex.org/I1321572752"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064981080","display_name":"David E. Harrison","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David E Harrison","raw_affiliation_strings":["The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA","institution_ids":["https://openalex.org/I4210115256"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5083049708"],"corresponding_institution_ids":["https://openalex.org/I1321572752","https://openalex.org/I4210115256"],"apc_list":null,"apc_paid":null,"fwci":0.9998,"has_fulltext":true,"cited_by_count":66,"citation_normalized_percentile":{"value":0.77684564,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"186","issue":"1","first_page":"203","last_page":"211"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.8798999786376953,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.8798999786376953,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.062300000339746475,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.03840000182390213,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adipose-tissue-transplantation","display_name":"adipose tissue transplantation","score":0.9629999995231628},{"id":"https://openalex.org/keywords/white-adipose-tissue","display_name":"white adipose tissue","score":0.9179999828338623},{"id":"https://openalex.org/keywords/ob-ob-mice","display_name":"ob/ob mice","score":0.9480000138282776},{"id":"https://openalex.org/keywords/leptin-deficiency","display_name":"leptin deficiency","score":0.9900000095367432},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.5460000038146973},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.8289999961853027},{"id":"https://openalex.org/keywords/insulin-sensitivity","display_name":"insulin sensitivity","score":0.8289999961853027},{"id":"https://openalex.org/keywords/fertility-restoration","display_name":"fertility restoration","score":0.8080000281333923},{"id":"https://openalex.org/keywords/corticosterone","display_name":"corticosterone","score":0.9319999814033508},{"id":"https://openalex.org/keywords/lipodystrophy","display_name":"lipodystrophy","score":0.8069999814033508},{"id":"https://openalex.org/keywords/leptin-replacement-therapy","display_name":"leptin replacement therapy","score":0.7739999890327454},{"id":"https://openalex.org/keywords/obesity-prevention","display_name":"obesity prevention","score":0.4180000126361847},{"id":"https://openalex.org/keywords/obesity-treatment","display_name":"obesity treatment","score":0.5770000219345093}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8768966197967529},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8596543073654175},{"id":"https://openalex.org/C2780613262","wikidata":"https://www.wikidata.org/wiki/Q223739","display_name":"Leptin","level":3,"score":0.8005667328834534},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.7300010919570923},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.7000161409378052},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6137989163398743},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.5715692639350891},{"id":"https://openalex.org/C151955695","wikidata":"https://www.wikidata.org/wiki/Q654528","display_name":"White adipose tissue","level":3,"score":0.5324859023094177},{"id":"https://openalex.org/C194832188","wikidata":"https://www.wikidata.org/wiki/Q2638593","display_name":"Adipokine","level":4,"score":0.531258761882782},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.5302379131317139},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.4702381491661072},{"id":"https://openalex.org/C2780320433","wikidata":"https://www.wikidata.org/wiki/Q3403879","display_name":"Weight gain","level":3,"score":0.4285692274570465},{"id":"https://openalex.org/C147583825","wikidata":"https://www.wikidata.org/wiki/Q620876","display_name":"Body weight","level":2,"score":0.16792839765548706}],"mesh":[{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001323","descriptor_name":"Autoantibodies","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007247","descriptor_name":"Infertility, Female","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007247","descriptor_name":"Infertility, Female","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008820","descriptor_name":"Mice, Obese","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015431","descriptor_name":"Weight Loss","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1677/joe.1.06150","doi":"https://doi.org/10.1677/joe.1.06150","is_oa":true,"landing_page_url":"https://doi.org/10.1677/joe.1.06150","pdf_url":"https://joe.bioscientifica.com/downloadpdf/journals/joe/186/1/1860203.pdf","source":{"id":"https://openalex.org/S34842069","display_name":"Journal of Endocrinology","issn_l":"0022-0795","issn":["0022-0795","1479-6805"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Endocrinology","raw_type":"journal-article"},{"id":"pmid:16002549","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16002549","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of endocrinology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.486.6647","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.486.6647","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://joe.endocrinology-journals.org/content/186/1/203.full.pdf","raw_type":"text"},{"id":"pmh:oai:mouseion.jax.org:stfb2000_2009-2103","doi":null,"is_oa":false,"landing_page_url":"https://mouseion.jax.org/stfb2000_2009/1104","pdf_url":null,"source":{"id":"https://openalex.org/S4377196421","display_name":"The Mouseion at the JAXlibrary (Jackson Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210115256","host_organization_name":"Jackson Laboratory","host_organization_lineage":["https://openalex.org/I4210115256"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty Research 2000 - 2009","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1677/joe.1.06150","doi":"https://doi.org/10.1677/joe.1.06150","is_oa":true,"landing_page_url":"https://doi.org/10.1677/joe.1.06150","pdf_url":"https://joe.bioscientifica.com/downloadpdf/journals/joe/186/1/1860203.pdf","source":{"id":"https://openalex.org/S34842069","display_name":"Journal of Endocrinology","issn_l":"0022-0795","issn":["0022-0795","1479-6805"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Endocrinology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4468343291","display_name":"GENETIC LOCUS EXTENDING LIFE AND REDUCING INSULIN","funder_award_id":"R01AG018003","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G7154776755","display_name":"Life Extension by Caloric Restriction: Role of Leptin","funder_award_id":"R01AG019894","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G960562506","display_name":"MOUSE MODELS WITH DELAYED PATHOLOGIES","funder_award_id":"R24RR014455","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2163321855.pdf","grobid_xml":"https://content.openalex.org/works/W2163321855.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W14179591","https://openalex.org/W1972275518","https://openalex.org/W1976860473","https://openalex.org/W1978819779","https://openalex.org/W1986131332","https://openalex.org/W1996713062","https://openalex.org/W1998916517","https://openalex.org/W2008667256","https://openalex.org/W2022589777","https://openalex.org/W2027457368","https://openalex.org/W2039382168","https://openalex.org/W2041553669","https://openalex.org/W2047734767","https://openalex.org/W2055956383","https://openalex.org/W2058073773","https://openalex.org/W2058648562","https://openalex.org/W2060682066","https://openalex.org/W2076823992","https://openalex.org/W2078769875","https://openalex.org/W2084310603","https://openalex.org/W2087394811","https://openalex.org/W2089779965","https://openalex.org/W2091085717","https://openalex.org/W2098025594","https://openalex.org/W2106173399","https://openalex.org/W2114589445","https://openalex.org/W2145387506","https://openalex.org/W2169731368","https://openalex.org/W2182306574","https://openalex.org/W2413258340","https://openalex.org/W2470986157","https://openalex.org/W4238663920","https://openalex.org/W4251240516"],"related_works":["https://openalex.org/W7097563693","https://openalex.org/W1997820019","https://openalex.org/W2907442140","https://openalex.org/W2053727415","https://openalex.org/W2040061700","https://openalex.org/W2066082147","https://openalex.org/W2140896805","https://openalex.org/W2075530034","https://openalex.org/W2124935940","https://openalex.org/W3216826245"],"abstract_inverted_index":{"Adipose":[0],"tissue":[1,51],"affects":[2],"metabolism":[3],"by":[4,45,220],"secreting":[5],"various":[6],"adipokines.":[7],"Lipodystropic":[8],"mice":[9,25,44,108,206],"benefit":[10],"both":[11,249],"from":[12,17,116,138,147,173,227],"leptin":[13,128,212],"replacement":[14,265],"therapy":[15],"and":[16,62,93,145,160,251],"transplantation":[18,46,55,90,185,234,245,257],"of":[19,38,41,47,98,132,183,211,275],"normal":[20,48,117],"fat.":[21],"Leptin-deficient":[22],"Lep(ob)/Lep(ob)":[23],"(ob/ob)":[24],"can":[26],"also":[27,169,272],"be":[28,70],"treated":[29],"with":[30,80,112,188,207,225],"leptin.":[31],"Surprisingly,":[32],"there":[33],"have":[34],"been":[35],"no":[36],"reports":[37],"successful":[39],"treatment":[40],"obese":[42,65,203],"ob/ob":[43,99,107,155,179,205],"white":[49],"adipose":[50],"(WAT).":[52],"If":[53],"WAT":[54,89,137,146,172,184,226,244,256],"is":[56],"ineffective":[57],"in":[58,64,72,134,154,178,231,266],"treating":[59,267],"insulin":[60,158,161,241],"resistance":[61],"diabetes":[63],"individuals,":[66],"its":[67],"applicability":[68],"may":[69,258],"limited":[71],"humans":[73],"as":[74],"such":[75],"abnormalities":[76,96],"are":[77],"usually":[78],"associated":[79],"obesity.":[81,276],"In":[82,253],"the":[83,103,200,254],"current":[84],"study,":[85],"we":[86],"tested":[87],"whether":[88],"might":[91],"prevent,":[92],"even":[94],"reverse,":[95],"characteristic":[97],"mice.":[100,118,136,156],"To":[101,198],"assess":[102,199],"preventive":[104],"potential,":[105,202],"6-week-old":[106],"were":[109,125,164,186,214],"transplanted,":[110],"subcutaneously,":[111],"gonadal":[113],"fat":[114],"pads":[115],"Profound":[119],"effects":[120,182],"on":[121],"multiple":[122],"physiological":[123],"phenotypes":[124],"achieved":[126],"despite":[127],"levels":[129,159],"below":[130],"25%":[131],"those":[133],"control":[135],"one":[139],"donor":[140],"reduced":[141,236],"body":[142,189,217],"weight":[143,190,218],"gain,":[144],"4":[148,174],"or":[149],"8":[150,228],"donors":[151,175],"prevented":[152],"obesity":[153],"Nonfasting":[157],"tolerance":[162],"test":[163],"normalized.":[165],"Corticosterone":[166],"elevation":[167],"was":[168,246],"prevented.":[170],"Finally,":[171],"restored":[176],"fertility":[177],"females.":[180],"The":[181],"long-lasting,":[187],"gain":[191],"suppressed":[192],"for":[193,248],"at":[194],"least":[195],"40":[196],"weeks.":[197],"therapeutic":[201],"13-month-old":[204],"a":[208,260],"long":[209],"history":[210],"deficiency":[213],"used.":[215],"Their":[216],"decreased":[219],"approximately":[221],"50%":[222],"when":[223],"transplanted":[224],"donors.":[229],"As":[230],"young":[232],"recipients,":[233],"greatly":[235],"nonfasting":[237],"insulin,":[238],"suggesting":[239],"normalized":[240],"sensitivity.":[242],"Thus,":[243],"effective":[247],"prevention":[250],"therapy.":[252],"future,":[255],"become":[259],"useful":[261],"alternative":[262],"to":[263],"hormone":[264],"not":[268],"only":[269],"lipodystropy,":[270],"but":[271],"certain":[273],"types":[274]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}