{"id":"https://openalex.org/W2163186170","doi":"https://doi.org/10.1128/.20.17.6201-6211.2000","title":"BF-1 Interferes with Transforming Growth Factor \u03b2 Signaling by Associating with Smad Partners","display_name":"BF-1 Interferes with Transforming Growth Factor \u03b2 Signaling by Associating with Smad Partners","publication_year":2000,"publication_date":"2000-01-01","ids":{"openalex":"https://openalex.org/W2163186170","doi":"https://doi.org/10.1128/.20.17.6201-6211.2000","mag":"2163186170","pmid":"https://pubmed.ncbi.nlm.nih.gov/10938097","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/86095"},"language":"en","primary_location":{"id":"doi:10.1128/.20.17.6201-6211.2000","doi":"https://doi.org/10.1128/.20.17.6201-6211.2000","is_oa":false,"landing_page_url":"https://doi.org/10.1128/.20.17.6201-6211.2000","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/86095","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069077706","display_name":"Changlin Dou","orcid":"https://orcid.org/0000-0001-8221-8086","observed_orcids":["https://orcid.org/0000-0001-8221-8086"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Changlin Dou","raw_affiliation_strings":["Cell Biology Program, Memorial Sloan-Kettering Cancer Center,1 and","Cell Biology Program, Memorial Sloan-Kettering Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Biology Program, Memorial Sloan-Kettering Cancer Center,1 and","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Cell Biology Program, Memorial Sloan-Kettering Cancer Center","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100442887","display_name":"Jun Hyung Lee","orcid":"https://orcid.org/0000-0002-5756-5470","observed_orcids":["https://orcid.org/0000-0002-5756-5470"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jun Lee","raw_affiliation_strings":["Cell Biology Program, Memorial Sloan-Kettering Cancer Center,1 and","Cell Biology Program, Memorial Sloan-Kettering Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Biology Program, Memorial Sloan-Kettering Cancer Center,1 and","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Cell Biology Program, Memorial Sloan-Kettering Cancer Center","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100461614","display_name":"Bo Liu","orcid":"https://orcid.org/0000-0002-0459-9132","observed_orcids":["https://orcid.org/0000-0002-0459-9132"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bo Liu","raw_affiliation_strings":["Cell Biology Program, Memorial Sloan-Kettering Cancer Center,1 and","Cell Biology Program, Memorial Sloan-Kettering Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Biology Program, Memorial Sloan-Kettering Cancer Center,1 and","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Cell Biology Program, Memorial Sloan-Kettering Cancer Center","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108005687","display_name":"Fang Liu","orcid":"https://orcid.org/0000-0003-0972-9968","observed_orcids":["https://orcid.org/0000-0003-0972-9968"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fang Liu","raw_affiliation_strings":["Cell Biology Program, Memorial Sloan-Kettering Cancer Center,1 and","Cell Biology Program, Memorial Sloan-Kettering Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Biology Program, Memorial Sloan-Kettering Cancer Center,1 and","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Cell Biology Program, Memorial Sloan-Kettering Cancer Center","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055628562","display_name":"Joan Massagu\u00e9","orcid":"https://orcid.org/0000-0001-9324-8408","observed_orcids":["https://orcid.org/0000-0001-9324-8408"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joan Massague","raw_affiliation_strings":["Cell Biology Program, Memorial Sloan-Kettering Cancer Center,1 and","Howard Hughes Medical Institute,2 New York, New York 10021","2 Howard Hughes Medical Institute, New York, New York10021","Cell Biology Program, Memorial Sloan-Kettering Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Biology Program, Memorial Sloan-Kettering Cancer Center,1 and","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Howard Hughes Medical Institute,2 New York, New York 10021","institution_ids":["https://openalex.org/I1344073410"]},{"raw_affiliation_string":"2 Howard Hughes Medical Institute, New York, New York10021","institution_ids":["https://openalex.org/I1344073410"]},{"raw_affiliation_string":"Cell Biology Program, Memorial Sloan-Kettering Cancer Center","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037520367","display_name":"Shouhong Xuan","orcid":"https://orcid.org/0000-0003-0571-7855","observed_orcids":["https://orcid.org/0000-0003-0571-7855"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shouhong Xuan","raw_affiliation_strings":["Cell Biology Program, Memorial Sloan-Kettering Cancer Center,1 and","Cell Biology Program, Memorial Sloan-Kettering Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Biology Program, Memorial Sloan-Kettering Cancer Center,1 and","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Cell Biology Program, Memorial Sloan-Kettering Cancer Center","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048221931","display_name":"Eseng Lai","orcid":"https://orcid.org/0000-0001-5141-3452","observed_orcids":["https://orcid.org/0000-0001-5141-3452"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Eseng Lai","raw_affiliation_strings":["Cell Biology Program, Memorial Sloan-Kettering Cancer Center,1 and","Cell Biology Program, Memorial Sloan-Kettering Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Biology Program, Memorial Sloan-Kettering Cancer Center,1 and","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Cell Biology Program, Memorial Sloan-Kettering Cancer Center","institution_ids":["https://openalex.org/I1334819555"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5048221931"],"corresponding_institution_ids":["https://openalex.org/I1334819555"],"apc_list":null,"apc_paid":null,"fwci":2.0396,"has_fulltext":false,"cited_by_count":107,"citation_normalized_percentile":{"value":0.86866553,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"20","issue":"17","first_page":"6201","last_page":"6211"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.008999999612569809,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12835","display_name":"FOXO transcription factor regulation","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/foxg1","display_name":"FOXG1","score":0.9409999847412109},{"id":"https://openalex.org/keywords/winged-helix-transcription-factor","display_name":"winged helix transcription factor","score":0.8059999942779541},{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.8479999899864197},{"id":"https://openalex.org/keywords/smad2","display_name":"Smad2","score":0.8119999766349792},{"id":"https://openalex.org/keywords/activin","display_name":"activin","score":0.7699999809265137},{"id":"https://openalex.org/keywords/cell-cycle-exit","display_name":"cell cycle exit","score":0.7300000190734863},{"id":"https://openalex.org/keywords/transcriptional-activation","display_name":"transcriptional activation","score":0.6869999766349792},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.753000020980835},{"id":"https://openalex.org/keywords/tgf-beta-antagonists","display_name":"TGF-beta antagonists","score":0.7540000081062317}],"concepts":[{"id":"https://openalex.org/C2781080636","wikidata":"https://www.wikidata.org/wiki/Q700000","display_name":"SMAD","level":3,"score":0.8596149682998657},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.7192378640174866},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7188845276832581},{"id":"https://openalex.org/C2909521502","wikidata":"https://www.wikidata.org/wiki/Q14903945","display_name":"Smad2 Protein","level":4,"score":0.6073766350746155},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5527815818786621},{"id":"https://openalex.org/C73568257","wikidata":"https://www.wikidata.org/wiki/Q7273271","display_name":"R-SMAD","level":5,"score":0.4831109046936035},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.46868351101875305},{"id":"https://openalex.org/C97037327","wikidata":"https://www.wikidata.org/wiki/Q5334291","display_name":"Ectopic expression","level":3,"score":0.467505544424057},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.457681804895401},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.4511626362800598},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3351115584373474},{"id":"https://openalex.org/C125555471","wikidata":"https://www.wikidata.org/wiki/Q14908037","display_name":"TGF alpha","level":4,"score":0.29630517959594727},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.29439443349838257},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.227524995803833},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.22280120849609375},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17696157097816467},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.1528725028038025}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001616","descriptor_name":"beta-Galactosidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007265","descriptor_name":"Inhibins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008156","descriptor_name":"Luciferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008907","descriptor_name":"Mink","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011233","descriptor_name":"Precipitin Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015151","descriptor_name":"Immunoblotting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015533","descriptor_name":"Transcriptional Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019556","descriptor_name":"COS Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D028341","descriptor_name":"Activins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051858","descriptor_name":"Forkhead Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051899","descriptor_name":"Smad2 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1128/.20.17.6201-6211.2000","doi":"https://doi.org/10.1128/.20.17.6201-6211.2000","is_oa":false,"landing_page_url":"https://doi.org/10.1128/.20.17.6201-6211.2000","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},{"id":"doi:10.1128/mcb.20.17.6201-6211.2000","doi":"https://doi.org/10.1128/mcb.20.17.6201-6211.2000","is_oa":false,"landing_page_url":"https://doi.org/10.1128/mcb.20.17.6201-6211.2000","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:86095","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/86095","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Cell Biol","raw_type":"Text"},{"id":"pmid:10938097","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10938097","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and cellular biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:86095","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/86095","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Cell Biol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3004026129","display_name":null,"funder_award_id":"HD29584","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G6055119165","display_name":"TRANSCRIPTIONAL CONTROL OF BRAIN DEVELOPMENT","funder_award_id":"F32NS010313","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320309468","display_name":"Memorial Sloan-Kettering Cancer Center","ror":"https://ror.org/02yrq0923"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W157700276","https://openalex.org/W1515719112","https://openalex.org/W1532921008","https://openalex.org/W1553444759","https://openalex.org/W1559406855","https://openalex.org/W1589859980","https://openalex.org/W1641035883","https://openalex.org/W1749561766","https://openalex.org/W1902497723","https://openalex.org/W1923939500","https://openalex.org/W1969683835","https://openalex.org/W1971846249","https://openalex.org/W1997510672","https://openalex.org/W2003907692","https://openalex.org/W2005144583","https://openalex.org/W2021186319","https://openalex.org/W2023930954","https://openalex.org/W2034339135","https://openalex.org/W2059437327","https://openalex.org/W2059524152","https://openalex.org/W2060116181","https://openalex.org/W2070539534","https://openalex.org/W2081451346","https://openalex.org/W2081476887","https://openalex.org/W2090429649","https://openalex.org/W2093417867","https://openalex.org/W2093712120","https://openalex.org/W2099985524","https://openalex.org/W2109379227","https://openalex.org/W2113002082","https://openalex.org/W2115438940","https://openalex.org/W2129454448","https://openalex.org/W2132135263","https://openalex.org/W2138852914","https://openalex.org/W2139949950","https://openalex.org/W2145589640","https://openalex.org/W2255393028","https://openalex.org/W2290374156","https://openalex.org/W4296588288"],"related_works":["https://openalex.org/W2081336020","https://openalex.org/W1641035883","https://openalex.org/W2171078009","https://openalex.org/W2081835840","https://openalex.org/W2048303318","https://openalex.org/W2124207551","https://openalex.org/W2036149690","https://openalex.org/W287407903","https://openalex.org/W2067682523","https://openalex.org/W2058534588"],"abstract_inverted_index":{"The":[0],"winged-helix":[1],"(WH)":[2],"BF-1":[3,60,78,96,113,161,198,220],"gene,":[4],"which":[5,141,175,205,219,237,243],"encodes":[6],"brain":[7],"factor":[8,49,156],"1":[9],"(BF-1)":[10],"(also":[11],"known":[12,143],"as":[13,81,239],"foxg1),":[14],"is":[15,142,167,199,206],"essential":[16],"for":[17,208],"the":[18,21,25,41,75,120,123,154,170,182,193,202],"proliferation":[19],"of":[20,24,59,77,122,173,185,195,248],"progenitor":[22,34],"cells":[23,35],"cerebral":[26],"cortex.":[27],"Here":[28],"we":[29,72,93,135],"show":[30],"that":[31,56,74,112,160],"BF-1-deficient":[32],"telencephalic":[33],"are":[36,131],"more":[37],"apt":[38],"to":[39,46,79,144,179,210,225],"leave":[40],"cell":[42],"cycle":[43],"in":[44,61,218],"response":[45],"transforming":[47],"growth":[48,66,127],"beta":[50],"(TGF-beta)":[51],"and":[52,68,149,153,187,242],"activin.":[53],"We":[54,110,158,214],"found":[55,73,111],"ectopic":[57],"expression":[58],"vitro":[62],"inhibits":[63],"TGF-beta":[64,83,130,150,186,226],"mediated":[65,200],"inhibition":[67,128],"transcriptional":[69,100,190,223],"activation.":[70,191],"Surprisingly,":[71],"ability":[76,178],"function":[80,238],"a":[82,137,216,245],"antagonist":[84],"does":[85,114],"not":[86,115,132],"require":[87],"its":[88,177],"DNA":[89,234],"binding":[90,108,235],"activity.":[91],"Therefore,":[92],"investigated":[94],"whether":[95],"can":[97],"inhibit":[98],"Smad-dependent":[99],"responses":[101,224],"by":[102,129,147,201,227],"interacting":[103,228],"with":[104,117,163,181,188,197,212,222,229,232,250],"Smads":[105,152],"or":[106,231],"Smad":[107,124],"partners.":[109],"interact":[116,211],"Smads.":[118],"Because":[119],"identities":[121],"partners":[125,241],"mediating":[126],"clearly":[133],"established,":[134],"examined":[136],"model":[138,217],"reporter":[139],"system":[140],"be":[145],"activated":[146],"activin":[148],"through":[151],"WH":[155],"FAST-2.":[157,164],"demonstrate":[159],"associates":[162],"This":[165],"interaction":[166,194,249],"dependent":[168],"on":[169],"same":[171,203],"region":[172],"protein":[174],"mediates":[176],"interfere":[180],"antiproliferative":[183],"activity":[184],"TGF-beta-dependent":[189],"Furthermore,":[192],"FAST-2":[196,209,230],"domain":[204],"required":[207],"Smad2.":[213,251],"propose":[215],"interferes":[221],"other":[233],"proteins":[236],"Smad2":[240],"have":[244],"common":[246],"mode":[247]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}