{"id":"https://openalex.org/W2163109682","doi":"https://doi.org/10.1084/jem.20040845","title":"Bone Marrow Microenvironmental Changes Underlie Reduced RAG-mediated Recombination and B Cell Generation in Aged Mice","display_name":"Bone Marrow Microenvironmental Changes Underlie Reduced RAG-mediated Recombination and B Cell Generation in Aged Mice","publication_year":2004,"publication_date":"2004-08-16","ids":{"openalex":"https://openalex.org/W2163109682","doi":"https://doi.org/10.1084/jem.20040845","mag":"2163109682","pmid":"https://pubmed.ncbi.nlm.nih.gov/15314072","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2211932"},"language":"en","primary_location":{"id":"doi:10.1084/jem.20040845","doi":"https://doi.org/10.1084/jem.20040845","is_oa":true,"landing_page_url":"https://doi.org/10.1084/jem.20040845","pdf_url":"https://rupress.org/jem/article-pdf/200/4/411/1151749/jem2004411.pdf","source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Experimental Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://rupress.org/jem/article-pdf/200/4/411/1151749/jem2004411.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054838398","display_name":"Joseph E. Labrie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph E. Labrie","raw_affiliation_strings":["1Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01655"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01655","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003014282","display_name":"Alex P. Sah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alex P. Sah","raw_affiliation_strings":["2Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066485275","display_name":"David Allman","orcid":"https://orcid.org/0000-0001-9345-1502","observed_orcids":["https://orcid.org/0000-0001-9345-1502"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David M. Allman","raw_affiliation_strings":["2Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087129282","display_name":"Michael P. Cancro","orcid":"https://orcid.org/0000-0002-8659-3227","observed_orcids":["https://orcid.org/0000-0002-8659-3227"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael P. Cancro","raw_affiliation_strings":["2Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057150258","display_name":"Rachel M. Gerstein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachel M. Gerstein","raw_affiliation_strings":["1Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01655"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01655","institution_ids":["https://openalex.org/I166722992"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.9908,"has_fulltext":true,"cited_by_count":148,"citation_normalized_percentile":{"value":0.91779348,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"200","issue":"4","first_page":"411","last_page":"423"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.007400000002235174,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bone-marrow-microenvironment","display_name":"bone marrow microenvironment","score":0.8410000205039978},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.722000002861023},{"id":"https://openalex.org/keywords/b-cell-development","display_name":"B cell development","score":0.7049999833106995},{"id":"https://openalex.org/keywords/v-d-j-recombination","display_name":"V(D)J recombination","score":0.9160000085830688},{"id":"https://openalex.org/keywords/rag2","display_name":"RAG2","score":0.7490000128746033},{"id":"https://openalex.org/keywords/pro-b-cells","display_name":"pro-B cells","score":0.8140000104904175},{"id":"https://openalex.org/keywords/pre-b-cells","display_name":"pre-B cells","score":0.9829999804496765},{"id":"https://openalex.org/keywords/immunosenescence","display_name":"immunosenescence","score":0.8759999871253967},{"id":"https://openalex.org/keywords/immunoglobulin-diversity","display_name":"immunoglobulin diversity","score":0.7730000019073486},{"id":"https://openalex.org/keywords/bone-marrow-chimeras","display_name":"bone marrow chimeras","score":0.8569999933242798}],"concepts":[{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.7673799991607666},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.6703988313674927},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6694294214248657},{"id":"https://openalex.org/C113646796","wikidata":"https://www.wikidata.org/wiki/Q50263283","display_name":"Recombination-activating gene","level":4,"score":0.49460551142692566},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.44811728596687317},{"id":"https://openalex.org/C79904392","wikidata":"https://www.wikidata.org/wiki/Q5976738","display_name":"Lymphopoiesis","level":4,"score":0.44700291752815247},{"id":"https://openalex.org/C102414288","wikidata":"https://www.wikidata.org/wiki/Q1172461","display_name":"Recombinase","level":4,"score":0.44343870878219604},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4392537772655487},{"id":"https://openalex.org/C125929170","wikidata":"https://www.wikidata.org/wiki/Q908966","display_name":"Cre recombinase","level":5,"score":0.41679665446281433},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.39727145433425903},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.3617205023765564},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3251872956752777},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.30257558822631836},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.2299557626247406},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1641327440738678},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.14500552415847778},{"id":"https://openalex.org/C156695909","wikidata":"https://www.wikidata.org/wiki/Q3373825","display_name":"Recombination","level":3,"score":0.14062201976776123},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06272462010383606}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001853","descriptor_name":"Bone Marrow","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001973","descriptor_name":"Bromodeoxyuridine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007111","descriptor_name":"Immunity, Cellular","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045567","descriptor_name":"VDJ Recombinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1084/jem.20040845","doi":"https://doi.org/10.1084/jem.20040845","is_oa":true,"landing_page_url":"https://doi.org/10.1084/jem.20040845","pdf_url":"https://rupress.org/jem/article-pdf/200/4/411/1151749/jem2004411.pdf","source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Experimental Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2211932","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2211932","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Exp Med","raw_type":"Text"},{"id":"pmid:15314072","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15314072","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of experimental medicine","raw_type":"Comparative Study"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.282.2222","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.282.2222","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/63/f8/J_Exp_Med_2004_Aug_16_200(4)_411-423.tar.gz","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.456.5728","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.456.5728","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://classes.biology.ucsd.edu/old.web.classes/bggn225.FA04/Gerstein JEM.pdf","raw_type":"text"},{"id":"pmh:oai:escholarship.umassmed.edu:oapubs-2032","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.umassmed.edu/oapubs/1033","pdf_url":null,"source":{"id":"https://openalex.org/S7407064370","display_name":"eScholarship@UMassChan","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Open Access Publications by UMass Chan Authors","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1084/jem.20040845","doi":"https://doi.org/10.1084/jem.20040845","is_oa":true,"landing_page_url":"https://doi.org/10.1084/jem.20040845","pdf_url":"https://rupress.org/jem/article-pdf/200/4/411/1151749/jem2004411.pdf","source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Experimental Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2483587869","display_name":"Regulation of V(D)J recombination in B cell development","funder_award_id":"R01AI043534","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G3739778505","display_name":"DIMINISHED V(D)J RECOMBINATION DURING B CELL DEVELOPMENT","funder_award_id":"R03AG019042","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5864376598","display_name":"Diabetes Endocrinology Research Center (DERC)","funder_award_id":"P30DK032520","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G6152931427","display_name":"B LYMPHOCYTE PRODUCTION AND TURNOVER IN AGED MICE","funder_award_id":"R03AG015623","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G66444717","display_name":null,"funder_award_id":"AI043534","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8716962420","display_name":"Regulation of V(D)J recombination in B cell development","funder_award_id":"R56AI043534","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2163109682.pdf","grobid_xml":"https://content.openalex.org/works/W2163109682.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W1502302398","https://openalex.org/W1531134742","https://openalex.org/W1539227874","https://openalex.org/W1556978242","https://openalex.org/W1595031127","https://openalex.org/W1597652136","https://openalex.org/W1598444116","https://openalex.org/W1626251921","https://openalex.org/W1780759219","https://openalex.org/W1973874010","https://openalex.org/W1976073214","https://openalex.org/W1978408586","https://openalex.org/W1979502907","https://openalex.org/W1990145497","https://openalex.org/W1991417672","https://openalex.org/W1993024789","https://openalex.org/W1995171968","https://openalex.org/W1999675354","https://openalex.org/W2004740571","https://openalex.org/W2009791555","https://openalex.org/W2013050058","https://openalex.org/W2041884957","https://openalex.org/W2043464691","https://openalex.org/W2049470832","https://openalex.org/W2062520378","https://openalex.org/W2068012172","https://openalex.org/W2068778527","https://openalex.org/W2069501059","https://openalex.org/W2069772361","https://openalex.org/W2083612972","https://openalex.org/W2086381184","https://openalex.org/W2089365752","https://openalex.org/W2098977954","https://openalex.org/W2103752453","https://openalex.org/W2107543871","https://openalex.org/W2112721427","https://openalex.org/W2116447401","https://openalex.org/W2117707303","https://openalex.org/W2118064524","https://openalex.org/W2122161903","https://openalex.org/W2138596251","https://openalex.org/W2142925276","https://openalex.org/W2156242308","https://openalex.org/W2158427884","https://openalex.org/W2159181151","https://openalex.org/W2161466962","https://openalex.org/W2166200442","https://openalex.org/W2168380125","https://openalex.org/W2415706144","https://openalex.org/W4313331746"],"related_works":["https://openalex.org/W7099970170","https://openalex.org/W2005771733","https://openalex.org/W7028529798","https://openalex.org/W2004740571","https://openalex.org/W1991417672","https://openalex.org/W2007499810","https://openalex.org/W2018216094","https://openalex.org/W1979502907","https://openalex.org/W1503053168","https://openalex.org/W1661490892"],"abstract_inverted_index":{"During":[0],"aging,":[1],"adaptive":[2],"immunity":[3],"is":[4,123,129],"severely":[5],"compromised,":[6],"due":[7],"in":[8,36,44,89,107,125,139,164,174,190],"part":[9],"to":[10,56,196],"decreased":[11],"production":[12,32,71,95],"of":[13,18,61,73,96,117,135,145],"B":[14,30],"lymphocytes":[15],"and":[16,70,103,128,142,161,193],"loss":[17,134],"immunoglobulin":[19],"(Ig)":[20],"diversity.":[21],"However,":[22],"the":[23,54,68,111,154,175,197],"molecular":[24],"mechanisms":[25],"that":[26,41,67,92,120,153,171,178],"underlie":[27],"age-associated":[28],"diminished":[29,194],"cell":[31,58,113,199],"remain":[33],"unclear.":[34],"Using":[35],"vivo":[37],"labeling,":[38],"we":[39,99],"find":[40],"this":[42],"reduction":[43],"marrow":[45,64,150,177],"pre-B":[46,57,74,97,146,198],"cells":[47,75,91,109,119,141,192],"reflects":[48],"increased":[49],"attrition":[50],"during":[51],"passage":[52],"from":[53],"pro-B":[55,90,108,118,140,165,191],"pool.":[59],"Analyses":[60],"reciprocal":[62],"bone":[63,149,176],"chimeras":[65,151],"reveal":[66],"magnitude":[69],"rates":[72],"are":[76,182],"controlled":[77],"primarily":[78],"by":[79],"microenvironmental":[80],"factors,":[81],"rather":[82],"than":[83],"intrinsic":[84],"events.":[85],"To":[86],"understand":[87],"changes":[88],"could":[93],"diminish":[94],"cells,":[98],"evaluated":[100],"rag2":[101,122,159],"expression":[102,160],"V(D)J":[104,136,188],"recombinase":[105,137,162],"activity":[106,138,163],"at":[110],"single":[112],"level.":[114],"The":[115],"percentage":[116],"express":[121],"reduced":[124,143],"aged":[126,155],"mice":[127],"correlated":[130],"with":[131,180],"both":[132],"a":[133],"numbers":[144],"cells.":[147,166],"Reciprocal":[148],"revealed":[152],"microenvironment":[156],"also":[157],"determines":[158],"Together,":[167],"these":[168],"observations":[169],"suggest":[170],"extrinsic":[172],"factors":[173],"decline":[179],"age":[181],"largely":[183],"responsible":[184],"for":[185],"less":[186],"efficient":[187],"recombination":[189],"progression":[195],"stage.":[200]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}