{"id":"https://openalex.org/W2163105178","doi":null,"title":"Cyclic antibiotic therapy for diverticular disease: a critical reappraisal.","display_name":"Cyclic antibiotic therapy for diverticular disease: a critical reappraisal.","publication_year":2010,"publication_date":"2010-09-01","ids":{"openalex":"https://openalex.org/W2163105178","mag":"2163105178","pmid":"https://pubmed.ncbi.nlm.nih.gov/20922195"},"language":"en","primary_location":{"id":"pmid:20922195","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20922195","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of gastrointestinal and liver diseases : JGLD","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062032345","display_name":"Angelo Zullo","orcid":"https://orcid.org/0000-0003-2329-8105","observed_orcids":["https://orcid.org/0000-0003-2329-8105"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Angelo Zullo","raw_affiliation_strings":["Gastroenterology Unit, Nuovo Regina Margherita Hospital, Rome, Italy. zullo66@yahoo.it","Gastroenterology Unit, Nuovo Regina Margherita Hospital, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastroenterology Unit, Nuovo Regina Margherita Hospital, Rome, Italy. zullo66@yahoo.it","institution_ids":[]},{"raw_affiliation_string":"Gastroenterology Unit, Nuovo Regina Margherita Hospital, Rome, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010158984","display_name":"Cesare Hassan","orcid":"https://orcid.org/0000-0001-7167-1459","observed_orcids":["https://orcid.org/0000-0001-7167-1459"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cesare Hassan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027528495","display_name":"Giovanni Maconi","orcid":"https://orcid.org/0000-0003-0810-4026","observed_orcids":["https://orcid.org/0000-0003-0810-4026"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Giovanni Maconi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Gianpiero Manes","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gianpiero Manes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023932706","display_name":"Gianfranco Tammaro","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gianfranco Tammaro","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111962721","display_name":"Vincenzo De Francesco","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vincenzo De Francesco","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035332783","display_name":"Bruno Annibale","orcid":"https://orcid.org/0000-0001-9120-5957","observed_orcids":["https://orcid.org/0000-0001-9120-5957"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bruno Annibale","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070410976","display_name":"Leonardo Ficano","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Leonardo Ficano","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068823776","display_name":"Luigi Buri","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Luigi Buri","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067089346","display_name":"Giovanni Gatto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Giovanni Gatto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Roberto Lorenzetti","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roberto Lorenzetti","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073798414","display_name":"Salvatore Maria Antonio Campo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Salvatore M Campo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009028394","display_name":"Enzo Ierardi","orcid":"https://orcid.org/0000-0001-7275-5080","observed_orcids":["https://orcid.org/0000-0001-7275-5080"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Enzo Ierardi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031330585","display_name":"F\u00e1bio Pace","orcid":"https://orcid.org/0000-0002-8727-5757","observed_orcids":["https://orcid.org/0000-0002-8727-5757"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fabio Pace","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5066072593","display_name":"Sergio Morini","orcid":"https://orcid.org/0000-0001-6137-2404","observed_orcids":["https://orcid.org/0000-0001-6137-2404"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sergio Morini","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.4303,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.94211728,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"19","issue":"3","first_page":"295","last_page":"302"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12518","display_name":"Diverticular Disease and Complications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12518","display_name":"Diverticular Disease and Complications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11855","display_name":"Gastrointestinal disorders and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rifaximin","display_name":"rifaximin","score":0.8849999904632568},{"id":"https://openalex.org/keywords/uncomplicated-diverticular-disease","display_name":"uncomplicated diverticular disease","score":0.9599999785423279},{"id":"https://openalex.org/keywords/high-fiber-diet","display_name":"high-fiber diet","score":0.8619999885559082},{"id":"https://openalex.org/keywords/dietary-fiber","display_name":"dietary fiber","score":0.49799999594688416},{"id":"https://openalex.org/keywords/long-term-antibiotic-therapy","display_name":"long-term antibiotic therapy","score":0.5410000085830688}],"concepts":[{"id":"https://openalex.org/C2778889925","wikidata":"https://www.wikidata.org/wiki/Q416073","display_name":"Rifaximin","level":3,"score":0.9752145409584045},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9514094591140747},{"id":"https://openalex.org/C2776867784","wikidata":"https://www.wikidata.org/wiki/Q25324086","display_name":"Diverticular disease","level":2,"score":0.8137773871421814},{"id":"https://openalex.org/C2777929615","wikidata":"https://www.wikidata.org/wiki/Q1066061","display_name":"Diverticulitis","level":2,"score":0.6861032843589783},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6449452042579651},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.6105062961578369},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.6032324433326721},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.5133858919143677},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4441489279270172},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3524148464202881},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000078262","descriptor_name":"Rifaximin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D004043","descriptor_name":"Dietary Fiber","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004238","descriptor_name":"Diverticulitis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D004238","descriptor_name":"Diverticulitis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D004240","descriptor_name":"Diverticulum","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D004240","descriptor_name":"Diverticulum","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012294","descriptor_name":"Rifamycins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018579","descriptor_name":"Patient Selection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019317","descriptor_name":"Evidence-Based Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmid:20922195","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20922195","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of gastrointestinal and liver diseases : JGLD","raw_type":"Journal Article"},{"id":"pmh:oai:iris.unipa.it:10447/56086","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10447/56086","pdf_url":null,"source":{"id":"https://openalex.org/S4306401065","display_name":"Nova Science Publishers (Nova Science Publishers, Inc.)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.uniroma1.it:11573/481212","doi":null,"is_oa":false,"landing_page_url":"http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=000282863600013&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=0c7ff228ccbaaa74236f48834a34396a","pdf_url":null,"source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2163105178","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20922195","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W117820052","https://openalex.org/W181830242","https://openalex.org/W1524371560","https://openalex.org/W1591609573","https://openalex.org/W1598780961","https://openalex.org/W1832365029","https://openalex.org/W1966420230","https://openalex.org/W1968464707","https://openalex.org/W1971184332","https://openalex.org/W1998436078","https://openalex.org/W2003111718","https://openalex.org/W2010971619","https://openalex.org/W2021669809","https://openalex.org/W2022186535","https://openalex.org/W2025328864","https://openalex.org/W2028093640","https://openalex.org/W2036426721","https://openalex.org/W2050096359","https://openalex.org/W2052689271","https://openalex.org/W2054034465","https://openalex.org/W2060058442","https://openalex.org/W2066343255","https://openalex.org/W2078254564","https://openalex.org/W2082973495","https://openalex.org/W2093040712","https://openalex.org/W2099514529","https://openalex.org/W2103771013","https://openalex.org/W2121076704","https://openalex.org/W2134329281","https://openalex.org/W2137160419","https://openalex.org/W2150693489","https://openalex.org/W2153953068","https://openalex.org/W2154766798","https://openalex.org/W2165658880","https://openalex.org/W2188792855","https://openalex.org/W2319710449","https://openalex.org/W2337049293","https://openalex.org/W2427207750"],"related_works":["https://openalex.org/W1968464707","https://openalex.org/W2044873954","https://openalex.org/W6990798683","https://openalex.org/W2066343255","https://openalex.org/W2153827137","https://openalex.org/W4321598378","https://openalex.org/W185689844","https://openalex.org/W2626388815","https://openalex.org/W1557515811","https://openalex.org/W2921531917"],"abstract_inverted_index":{"Different":[0],"symptoms":[1,64],"have":[2,162],"been":[3,163],"attributed":[4],"to":[5,74,81,95,107,140,184],"uncomplicated":[6,17],"diverticular":[7],"disease":[8],"(DD).":[9],"Poor":[10],"absorbable":[11],"antibiotics":[12],"are":[13],"largely":[14],"used":[15],"for":[16,20],"DD,":[18],"mainly":[19],"symptom":[21,102],"treatment":[22,154],"and":[23,45,76,168],"prevention":[24],"of":[25,33,88,131,135,177],"diverticulitis":[26,137],"onset.":[27],"Controlled":[28],"trials":[29],"on":[30],"cyclic":[31,55,123,180],"administration":[32],"rifaximin":[34,69,124,181],"in":[35,61],"DD":[36,187],"patients":[37,188],"were":[38,50],"evaluated.":[39],"Four":[40],"controlled,":[41],"including":[42],"1":[43],"double-blind":[44],"3":[46],"open-label,":[47],"randomized":[48],"studies":[49,161],"available.":[51],"Following":[52],"a":[53,57,90,99,147,178],"long-term":[54],"therapy,":[56],"significant":[58],"difference":[59,93],"emerged":[60],"the":[62,84,129,132],"global":[63,101],"score":[65,103],"(range:":[66],"0-18)":[67],"between":[68],"plus":[70,125],"fibers":[71,77,126,141],"(from":[72,79,105],"6-6.5":[73],"1-2)":[75],"alone":[78,142],"6.7":[80],"2-3.8),":[82],"although":[83],"actual":[85],"clinically":[86],"relevance":[87],"such":[89],"very":[91],"small":[92],"remains":[94],"be":[96,110,156,173],"ascertained.":[97],"Moreover,":[98],"similar":[100],"reduction":[104],"6":[106],"2.4)":[108],"can":[109,155],"achieved":[111],"by":[112,165],"simply":[113],"recommending":[114],"an":[115],"inexpensive":[116],"high-fiber":[117],"diet.":[118],"Current":[119],"data":[120],"suggest":[121],"that":[122],"significantly":[127],"reduce":[128],"incidence":[130],"first":[133],"episode":[134],"acute":[136],"as":[138],"compared":[139],"(1.03%":[143],"vs":[144],"2.75%),":[145],"but":[146],"cost-efficacy":[148],"analysis":[149],"is":[150],"needed":[151],"before":[152],"this":[153],"routinely":[157],"recommended.":[158],"The":[159,175],"available":[160],"hampered":[164],"some":[166],"limitations,":[167],"definite":[169],"conclusions":[170],"could":[171],"not":[172],"drawn.":[174],"cost":[176],"long-life,":[179],"therapy":[182],"administered":[183],"all":[185],"symptomatic":[186],"would":[189],"appear":[190],"prohibitive.":[191]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}