{"id":"https://openalex.org/W2163032333","doi":"https://doi.org/10.1128/iai.64.12.5178-5186.1996","title":"Characterization of the Treponema denticola prtP gene encoding a prolyl-phenylalanine-specific protease (dentilisin)","display_name":"Characterization of the Treponema denticola prtP gene encoding a prolyl-phenylalanine-specific protease (dentilisin)","publication_year":1996,"publication_date":"1996-12-01","ids":{"openalex":"https://openalex.org/W2163032333","doi":"https://doi.org/10.1128/iai.64.12.5178-5186.1996","mag":"2163032333","pmid":"https://pubmed.ncbi.nlm.nih.gov/8945563","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/174505"},"language":"en","primary_location":{"id":"doi:10.1128/iai.64.12.5178-5186.1996","doi":"https://doi.org/10.1128/iai.64.12.5178-5186.1996","is_oa":false,"landing_page_url":"https://doi.org/10.1128/iai.64.12.5178-5186.1996","pdf_url":null,"source":{"id":"https://openalex.org/S128227336","display_name":"Infection and Immunity","issn_l":"0019-9567","issn":["0019-9567","1070-6313","1098-5522"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and Immunity","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC174505","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057302877","display_name":"Kazuyuki Ishihara","orcid":"https://orcid.org/0000-0002-6567-807X","observed_orcids":["https://orcid.org/0000-0002-6567-807X"]},"institutions":[{"id":"https://openalex.org/I149564915","display_name":"Tokyo Dental College","ror":"https://ror.org/0220f5b41","country_code":"JP","type":"education","lineage":["https://openalex.org/I149564915"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K Ishihara","raw_affiliation_strings":["Department of Microbiology, Tokyo Dental College, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Tokyo Dental College, Chiba, Japan","institution_ids":["https://openalex.org/I149564915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109248674","display_name":"Tomohiro Miura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149564915","display_name":"Tokyo Dental College","ror":"https://ror.org/0220f5b41","country_code":"JP","type":"education","lineage":["https://openalex.org/I149564915"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T Miura","raw_affiliation_strings":["Department of Microbiology, Tokyo Dental College, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Tokyo Dental College, Chiba, Japan","institution_ids":["https://openalex.org/I149564915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060471511","display_name":"Howard K. Kuramitsu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149564915","display_name":"Tokyo Dental College","ror":"https://ror.org/0220f5b41","country_code":"JP","type":"education","lineage":["https://openalex.org/I149564915"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H K Kuramitsu","raw_affiliation_strings":["Department of Microbiology, Tokyo Dental College, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Tokyo Dental College, Chiba, Japan","institution_ids":["https://openalex.org/I149564915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082628144","display_name":"Kensuke Okuda","orcid":"https://orcid.org/0000-0002-3768-0965","observed_orcids":["https://orcid.org/0000-0002-3768-0965"]},"institutions":[{"id":"https://openalex.org/I149564915","display_name":"Tokyo Dental College","ror":"https://ror.org/0220f5b41","country_code":"JP","type":"education","lineage":["https://openalex.org/I149564915"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K Okuda","raw_affiliation_strings":["Department of Microbiology, Tokyo Dental College, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Tokyo Dental College, Chiba, Japan","institution_ids":["https://openalex.org/I149564915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I149564915"],"apc_list":null,"apc_paid":null,"fwci":6.1775,"has_fulltext":false,"cited_by_count":109,"citation_normalized_percentile":{"value":0.96719116,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"64","issue":"12","first_page":"5178","last_page":"5186"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.009999999776482582,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11617","display_name":"Enzyme Production and Characterization","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/treponema-denticola","display_name":"Treponema denticola","score":1.0},{"id":"https://openalex.org/keywords/dentilisin","display_name":"dentilisin","score":0.9610000252723694},{"id":"https://openalex.org/keywords/chymotrypsin-like-protease","display_name":"chymotrypsin-like protease","score":0.953000009059906},{"id":"https://openalex.org/keywords/serine-protease","display_name":"serine protease","score":0.9879999756813049},{"id":"https://openalex.org/keywords/protease-specificity","display_name":"protease specificity","score":0.7440000176429749},{"id":"https://openalex.org/keywords/protease-inhibitors","display_name":"protease inhibitors","score":0.8100000023841858},{"id":"https://openalex.org/keywords/fibronectin-degradation","display_name":"fibronectin degradation","score":0.8119999766349792},{"id":"https://openalex.org/keywords/signal-peptide","display_name":"signal peptide","score":0.6959999799728394},{"id":"https://openalex.org/keywords/prosequence","display_name":"prosequence","score":0.753000020980835},{"id":"https://openalex.org/keywords/periodontal-pathogens","display_name":"periodontal pathogens","score":0.6919999718666077}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7136528491973877},{"id":"https://openalex.org/C2776714187","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Protease","level":3,"score":0.704369068145752},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6833105087280273},{"id":"https://openalex.org/C82553315","wikidata":"https://www.wikidata.org/wiki/Q14905312","display_name":"MASP1","level":5,"score":0.6726059913635254},{"id":"https://openalex.org/C2777422794","wikidata":"https://www.wikidata.org/wiki/Q2534751","display_name":"Treponema denticola","level":4,"score":0.6654781103134155},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.6016746759414673},{"id":"https://openalex.org/C2778401398","wikidata":"https://www.wikidata.org/wiki/Q383836","display_name":"Chymotrypsin","level":4,"score":0.5942459106445312},{"id":"https://openalex.org/C2777807008","wikidata":"https://www.wikidata.org/wiki/Q87324999","display_name":"Serine protease","level":4,"score":0.5898958444595337},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5655998587608337},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.48840755224227905},{"id":"https://openalex.org/C173188278","wikidata":"https://www.wikidata.org/wiki/Q18052595","display_name":"TMPRSS6","level":5,"score":0.44161444902420044},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4142211377620697},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.30784958600997925},{"id":"https://openalex.org/C2780340462","wikidata":"https://www.wikidata.org/wiki/Q127450","display_name":"Trypsin","level":3,"score":0.2501072287559509},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.0675635039806366},{"id":"https://openalex.org/C2780183776","wikidata":"https://www.wikidata.org/wiki/Q3214147","display_name":"Porphyromonas gingivalis","level":3,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002918","descriptor_name":"Chymotrypsin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005798","descriptor_name":"Genes, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010447","descriptor_name":"Peptide Hydrolases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013381","descriptor_name":"Subtilisins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014208","descriptor_name":"Treponema","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D014208","descriptor_name":"Treponema","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1128/iai.64.12.5178-5186.1996","doi":"https://doi.org/10.1128/iai.64.12.5178-5186.1996","is_oa":false,"landing_page_url":"https://doi.org/10.1128/iai.64.12.5178-5186.1996","pdf_url":null,"source":{"id":"https://openalex.org/S128227336","display_name":"Infection and Immunity","issn_l":"0019-9567","issn":["0019-9567","1070-6313","1098-5522"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and Immunity","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:149871","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC174505","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:174505","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/174505","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infect Immun","raw_type":"Text"},{"id":"pmid:8945563","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8945563","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and immunity","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.603.8984","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.603.8984","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://iai.asm.org/content/64/12/5178.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:149871","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC174505","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W1495102483","https://openalex.org/W1538268336","https://openalex.org/W1550745757","https://openalex.org/W1590566005","https://openalex.org/W1605306079","https://openalex.org/W1752912400","https://openalex.org/W1774057927","https://openalex.org/W1776082650","https://openalex.org/W1832876371","https://openalex.org/W1848056131","https://openalex.org/W1853990356","https://openalex.org/W1859540183","https://openalex.org/W1869416713","https://openalex.org/W1910376298","https://openalex.org/W1910823726","https://openalex.org/W1924604077","https://openalex.org/W1934605765","https://openalex.org/W1938414864","https://openalex.org/W1942106386","https://openalex.org/W1948717875","https://openalex.org/W1959569047","https://openalex.org/W1981342015","https://openalex.org/W2042096080","https://openalex.org/W2049479819","https://openalex.org/W2063450941","https://openalex.org/W2072531733","https://openalex.org/W2096854938","https://openalex.org/W2100775273","https://openalex.org/W2101108802","https://openalex.org/W2101634048","https://openalex.org/W2103713894","https://openalex.org/W2122134295","https://openalex.org/W2127114685","https://openalex.org/W2127864555","https://openalex.org/W2128113743","https://openalex.org/W2128573889","https://openalex.org/W2138270253","https://openalex.org/W2145185419","https://openalex.org/W2147342050","https://openalex.org/W2148401329","https://openalex.org/W2163185263","https://openalex.org/W2170800254","https://openalex.org/W2402113139","https://openalex.org/W2410946526"],"related_works":["https://openalex.org/W1910823726","https://openalex.org/W2145185419","https://openalex.org/W1981551012","https://openalex.org/W1853990356","https://openalex.org/W2122134295","https://openalex.org/W2046559910","https://openalex.org/W2122925787","https://openalex.org/W2109471895","https://openalex.org/W1973846011","https://openalex.org/W2096854938"],"abstract_inverted_index":{"A":[0],"chymotrypsin-like":[1,199],"protease":[2,26,49,58,184],"from":[3],"Treponema":[4],"denticola":[5],"ATCC":[6],"35405":[7],"was":[8,44,131],"purified":[9,14],"by":[10,162],"chromatographic":[11],"techniques.":[12],"The":[13,25,71,121,150,170,186],"enzyme":[15,72],"consisted":[16],"of":[17,53,105,137,148,156,179,189,206],"three":[18],"polypeptides":[19],"(38,":[20],"43,":[21],"and":[22,34,39,43,63,76,86,99,114,119,140,165,204],"72":[23],"kDa).":[24],"exhibited":[27,175],"specificity":[28],"for":[29,96,111,127,142],"peptide":[30,159],"bonds":[31],"containing":[32],"phenylalanine":[33],"proline":[35],"at":[36],"the":[37,51,81,97,103,108,112,128,166,180,190,194,202,207],"P1":[38],"P2":[40],"positions,":[41],"respectively,":[42],"classified":[45],"as":[46,61],"a":[47,143,157,163,198],"serine":[48,183],"on":[50,68],"basis":[52,104],"inhibition":[54],"studies.":[55],"Naturally":[56],"occurring":[57],"inhibitors":[59],"such":[60],"alpha1-antitrypsin":[62],"alpha1-antichymotrypsin":[64],"had":[65],"no":[66],"effect":[67],"enzymatic":[69],"activity.":[70],"degraded":[73],"fibronectin,":[74],"alpha1-antitrypsin,":[75],"gelatin":[77],"while":[78],"weakly":[79],"degrading":[80],"immunoglobulin":[82],"G":[83],"heavy":[84],"chain":[85],"type":[87],"IV":[88],"collagen.":[89],"N-terminal":[90],"amino":[91,172],"acid":[92,173],"sequences":[93],"were":[94,117],"determined":[95],"43-":[98,113],"72-kDa":[100,115,129,195],"proteins.":[101],"On":[102],"these":[106],"sequences,":[107],"genes":[109],"coding":[110],"proteins":[116],"isolated":[118],"sequenced.":[120],"open":[122],"reading":[123],"frame":[124],"which":[125],"codes":[126,141],"protein":[130,144,151,168,196,209],"designated":[132],"prtP.":[133],"This":[134],"gene":[135],"consists":[136],"2,169":[138],"bp":[139],"with":[145,177],"an":[146],"Mr":[147],"77,471.":[149],"appeared":[152],"to":[153],"be":[154],"composed":[155],"signal":[158],"region":[160],"followed":[161],"prosequence":[164],"mature":[167],"domain.":[169],"deduced":[171,187],"sequence":[174,191],"similarity":[176],"that":[178,193],"Bacillus":[181],"subtilis":[182],"subtilisin.":[185],"properties":[188],"suggest":[192],"is":[197],"protease.":[200],"However,":[201],"nature":[203],"function":[205],"43-kDa":[208],"have":[210],"not":[211],"yet":[212],"been":[213],"determined.":[214]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
