{"id":"https://openalex.org/W2162967657","doi":"https://doi.org/10.1016/j.tig.2007.03.008","title":"Positive and negative selection on the mitochondrial genome","display_name":"Positive and negative selection on the mitochondrial genome","publication_year":2007,"publication_date":"2007-04-06","ids":{"openalex":"https://openalex.org/W2162967657","doi":"https://doi.org/10.1016/j.tig.2007.03.008","mag":"2162967657","pmid":"https://pubmed.ncbi.nlm.nih.gov/17418445"},"language":"en","primary_location":{"id":"doi:10.1016/j.tig.2007.03.008","doi":"https://doi.org/10.1016/j.tig.2007.03.008","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.tig.2007.03.008","pdf_url":null,"source":{"id":"https://openalex.org/S139283865","display_name":"Trends in Genetics","issn_l":"0168-9525","issn":["0168-9525","1362-4555"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in Genetics","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035799601","display_name":"Colin D. Meiklejohn","orcid":"https://orcid.org/0000-0003-2708-8316","observed_orcids":["https://orcid.org/0000-0003-2708-8316"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Colin D. Meiklejohn","raw_affiliation_strings":["Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, USA","institution_ids":["https://openalex.org/I27804330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089550120","display_name":"Kristi L. Montooth","orcid":"https://orcid.org/0000-0001-9456-6694","observed_orcids":["https://orcid.org/0000-0001-9456-6694"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristi L. Montooth","raw_affiliation_strings":["Department of Ecology and Evolutionary Biology, Brown University, Providence, RI02912, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ecology and Evolutionary Biology, Brown University, Providence, RI02912, USA","institution_ids":["https://openalex.org/I27804330"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041097296","display_name":"David M. Rand","orcid":"https://orcid.org/0000-0001-6817-3459","observed_orcids":["https://orcid.org/0000-0001-6817-3459"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David M. Rand","raw_affiliation_strings":["Department of Ecology and Evolutionary Biology, Brown University, Providence, RI02912, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ecology and Evolutionary Biology, Brown University, Providence, RI02912, USA","institution_ids":["https://openalex.org/I27804330"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5041097296"],"corresponding_institution_ids":["https://openalex.org/I27804330"],"apc_list":{"value":7030,"currency":"USD","value_usd":7030},"apc_paid":null,"fwci":1.681,"has_fulltext":false,"cited_by_count":352,"citation_normalized_percentile":{"value":0.83939138,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"23","issue":"6","first_page":"259","last_page":"263"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.6758000254631042,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.6758000254631042,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10751","display_name":"Forensic and Genetic Research","score":0.18029999732971191,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10012","display_name":"Genetic diversity and population structure","score":0.09679999947547913,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mitochondrial-dna","display_name":"mitochondrial DNA","score":0.9160000085830688},{"id":"https://openalex.org/keywords/positive-selection","display_name":"positive selection","score":0.9679999947547913},{"id":"https://openalex.org/keywords/negative-selection","display_name":"negative selection","score":0.996999979019165},{"id":"https://openalex.org/keywords/neutral-theory-of-molecular-evolution","display_name":"neutral theory of molecular evolution","score":0.781000018119812},{"id":"https://openalex.org/keywords/effective-population-size","display_name":"effective population size","score":0.7820000052452087},{"id":"https://openalex.org/keywords/genetic-drift","display_name":"genetic drift","score":0.9810000061988831},{"id":"https://openalex.org/keywords/mitochondrial-fitness","display_name":"mitochondrial fitness","score":0.9309999942779541}],"concepts":[{"id":"https://openalex.org/C149904235","wikidata":"https://www.wikidata.org/wiki/Q7049620","display_name":"Nonsynonymous substitution","level":4,"score":0.9191257953643799},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8622082471847534},{"id":"https://openalex.org/C24586158","wikidata":"https://www.wikidata.org/wiki/Q27075","display_name":"Mitochondrial DNA","level":3,"score":0.7741734981536865},{"id":"https://openalex.org/C7386963","wikidata":"https://www.wikidata.org/wiki/Q3954859","display_name":"Negative selection","level":4,"score":0.7592583894729614},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6187824606895447},{"id":"https://openalex.org/C1570309","wikidata":"https://www.wikidata.org/wiki/Q1055017","display_name":"Neutral theory of molecular evolution","level":3,"score":0.5985544323921204},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.54730623960495},{"id":"https://openalex.org/C3641667","wikidata":"https://www.wikidata.org/wiki/Q1295959","display_name":"Effective population size","level":4,"score":0.5296998620033264},{"id":"https://openalex.org/C166393388","wikidata":"https://www.wikidata.org/wiki/Q856529","display_name":"Molecular evolution","level":4,"score":0.5082554221153259},{"id":"https://openalex.org/C85721925","wikidata":"https://www.wikidata.org/wiki/Q31151","display_name":"Population genetics","level":3,"score":0.5045102834701538},{"id":"https://openalex.org/C80990810","wikidata":"https://www.wikidata.org/wiki/Q486420","display_name":"Genetic drift","level":4,"score":0.4985778331756592},{"id":"https://openalex.org/C138025448","wikidata":"https://www.wikidata.org/wiki/Q7662597","display_name":"Synonymous substitution","level":5,"score":0.4943230152130127},{"id":"https://openalex.org/C49735019","wikidata":"https://www.wikidata.org/wiki/Q4115005","display_name":"Selective sweep","level":5,"score":0.4862593412399292},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.4635929465293884},{"id":"https://openalex.org/C26589402","wikidata":"https://www.wikidata.org/wiki/Q7068267","display_name":"Nucleotide diversity","level":5,"score":0.46144264936447144},{"id":"https://openalex.org/C137848329","wikidata":"https://www.wikidata.org/wiki/Q804635","display_name":"Balancing selection","level":4,"score":0.4479059875011444},{"id":"https://openalex.org/C146249460","wikidata":"https://www.wikidata.org/wiki/Q2914991","display_name":"Fixation (population genetics)","level":3,"score":0.42523646354675293},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.40885335206985474},{"id":"https://openalex.org/C68873052","wikidata":"https://www.wikidata.org/wiki/Q349856","display_name":"Genetic variation","level":3,"score":0.40528300404548645},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3674389719963074},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.3317919969558716},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.32160377502441406},{"id":"https://openalex.org/C87253356","wikidata":"https://www.wikidata.org/wiki/Q1106472","display_name":"Codon usage bias","level":4,"score":0.22983604669570923},{"id":"https://openalex.org/C197754878","wikidata":"https://www.wikidata.org/wiki/Q80711","display_name":"Haplotype","level":4,"score":0.1098971962928772},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004272","descriptor_name":"DNA, Mitochondrial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012641","descriptor_name":"Selection, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040961","descriptor_name":"Genetic Drift","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050259","descriptor_name":"Genes, Mitochondrial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.tig.2007.03.008","doi":"https://doi.org/10.1016/j.tig.2007.03.008","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.tig.2007.03.008","pdf_url":null,"source":{"id":"https://openalex.org/S139283865","display_name":"Trends in Genetics","issn_l":"0168-9525","issn":["0168-9525","1362-4555"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in Genetics","raw_type":"journal-article"},{"id":"pmid:17418445","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17418445","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in genetics : TIG","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1279257902","display_name":null,"funder_award_id":"GM 076812","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3404670308","display_name":"Nuclear-Mitochondrial Fitness Interactions in Drosophila","funder_award_id":"R01GM067862","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6343908385","display_name":null,"funder_award_id":"GM 072399","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7660788523","display_name":"Drosophila energetics and mito-nuclear function","funder_award_id":"F32GM076812","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8467294329","display_name":null,"funder_award_id":"GM 067862","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8948471649","display_name":"The evolution of gene expression in Drosophila","funder_award_id":"F32GM072399","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337400","display_name":"Division of Environmental Biology","ror":"https://ror.org/03g87he71"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1523840112","https://openalex.org/W1932538605","https://openalex.org/W1947714123","https://openalex.org/W1949557888","https://openalex.org/W1982603712","https://openalex.org/W1990442358","https://openalex.org/W1994760550","https://openalex.org/W2005058463","https://openalex.org/W2009620498","https://openalex.org/W2024239836","https://openalex.org/W2035082999","https://openalex.org/W2044961839","https://openalex.org/W2050948314","https://openalex.org/W2078935281","https://openalex.org/W2084323021","https://openalex.org/W2093016244","https://openalex.org/W2097301372","https://openalex.org/W2116346080","https://openalex.org/W2118020384","https://openalex.org/W2121199768","https://openalex.org/W2124653005","https://openalex.org/W2129666171","https://openalex.org/W2135749187","https://openalex.org/W2142053228","https://openalex.org/W2152195140","https://openalex.org/W2155603170","https://openalex.org/W2155670634","https://openalex.org/W2163958331","https://openalex.org/W2168263001","https://openalex.org/W2313090123","https://openalex.org/W4232591682","https://openalex.org/W4240547766","https://openalex.org/W4251304755","https://openalex.org/W4296219518","https://openalex.org/W7058703507"],"related_works":["https://openalex.org/W1982972392","https://openalex.org/W2990160317","https://openalex.org/W1965090926","https://openalex.org/W2145882912","https://openalex.org/W1962163551","https://openalex.org/W2045595543","https://openalex.org/W1026266615","https://openalex.org/W2146709918","https://openalex.org/W2080844913","https://openalex.org/W2253599539"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":15},{"year":2024,"cited_by_count":18},{"year":2023,"cited_by_count":16},{"year":2022,"cited_by_count":21},{"year":2021,"cited_by_count":18},{"year":2020,"cited_by_count":22},{"year":2019,"cited_by_count":24},{"year":2018,"cited_by_count":23},{"year":2017,"cited_by_count":23},{"year":2016,"cited_by_count":18},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":20},{"year":2013,"cited_by_count":24},{"year":2012,"cited_by_count":19}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}
