{"id":"https://openalex.org/W2162909320","doi":"https://doi.org/10.1034/j.1600-065x.2001.790119.x","title":"A novel human homolog of eosinophil major basic protein","display_name":"A novel human homolog of eosinophil major basic protein","publication_year":2001,"publication_date":"2001-02-01","ids":{"openalex":"https://openalex.org/W2162909320","doi":"https://doi.org/10.1034/j.1600-065x.2001.790119.x","mag":"2162909320","pmid":"https://pubmed.ncbi.nlm.nih.gov/11292023"},"language":"en","primary_location":{"id":"doi:10.1034/j.1600-065x.2001.790119.x","doi":"https://doi.org/10.1034/j.1600-065x.2001.790119.x","is_oa":false,"landing_page_url":"https://doi.org/10.1034/j.1600-065x.2001.790119.x","pdf_url":null,"source":{"id":"https://openalex.org/S133112385","display_name":"Immunological Reviews","issn_l":"0105-2896","issn":["0105-2896","1600-065X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunological Reviews","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078086876","display_name":"Douglas A. Plager","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Douglas A. Plager","raw_affiliation_strings":["Department of Immunology, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA. plager.douglas@mayo.edu","Department of Immunology, Mayo Clinic and Mayo Foundation, Rochester, MN USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA. plager.douglas@mayo.edu","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Immunology, Mayo Clinic and Mayo Foundation, Rochester, MN USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087227866","display_name":"Cheryl R. Adolphson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cheryl R. Adolphson","raw_affiliation_strings":["Department of Immunology, Mayo Clinic and Mayo Foundation, Rochester, MN USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Mayo Clinic and Mayo Foundation, Rochester, MN USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089757484","display_name":"Gerald J. Gleich","orcid":"https://orcid.org/0000-0002-6317-0811","observed_orcids":["https://orcid.org/0000-0002-6317-0811"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gerald J. Gleich","raw_affiliation_strings":["Department of Immunology, Mayo Clinic and Mayo Foundation, Rochester, MN USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Mayo Clinic and Mayo Foundation, Rochester, MN USA","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5078086876"],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":0.5976,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.70765067,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"179","issue":"1","first_page":"192","last_page":"202"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.8827999830245972,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.8827999830245972,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12600","display_name":"Eosinophilic Disorders and Syndromes","score":0.03180000185966492,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.028599999845027924,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/eosinophil-major-basic-protein","display_name":"eosinophil major basic protein","score":0.9919999837875366},{"id":"https://openalex.org/keywords/eosinophils","display_name":"eosinophils","score":0.7639999985694885},{"id":"https://openalex.org/keywords/basophils","display_name":"basophils","score":0.871999979019165},{"id":"https://openalex.org/keywords/gene-duplication","display_name":"gene duplication","score":0.7820000052452087},{"id":"https://openalex.org/keywords/c-ebp-binding-site","display_name":"C/EBP binding site","score":0.9470000267028809},{"id":"https://openalex.org/keywords/promoter-analysis","display_name":"promoter analysis","score":0.5540000200271606},{"id":"https://openalex.org/keywords/protein-charge","display_name":"protein charge","score":0.7480000257492065},{"id":"https://openalex.org/keywords/host-defense","display_name":"host defense","score":0.460999995470047}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8344330787658691},{"id":"https://openalex.org/C2777037409","wikidata":"https://www.wikidata.org/wiki/Q107238","display_name":"Eosinophil","level":3,"score":0.6645177602767944},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5989475846290588},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5652902722358704},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.48626601696014404},{"id":"https://openalex.org/C7602840","wikidata":"https://www.wikidata.org/wiki/Q746284","display_name":"Gene duplication","level":3,"score":0.4757922887802124},{"id":"https://openalex.org/C171897839","wikidata":"https://www.wikidata.org/wiki/Q417841","display_name":"Protein family","level":3,"score":0.4284493923187256},{"id":"https://openalex.org/C199216141","wikidata":"https://www.wikidata.org/wiki/Q4995178","display_name":"Conserved sequence","level":4,"score":0.4222673177719116},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.41167736053466797},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4101516604423523},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.40544575452804565},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3191966414451599},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001853","descriptor_name":"Bone Marrow","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002880","descriptor_name":"Chromosomes, Human, Pair 11","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003594","descriptor_name":"Cytoplasmic Granules","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003602","descriptor_name":"Cytotoxicity, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004804","descriptor_name":"Eosinophils","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006373","descriptor_name":"Helminthiasis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006967","descriptor_name":"Hypersensitivity","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010920","descriptor_name":"Placenta","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D010920","descriptor_name":"Placenta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012260","descriptor_name":"Ribonucleases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017385","descriptor_name":"Sequence Homology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020440","descriptor_name":"Gene Duplication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047091","descriptor_name":"Eosinophil Granule Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047093","descriptor_name":"Eosinophil Major Basic Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1034/j.1600-065x.2001.790119.x","doi":"https://doi.org/10.1034/j.1600-065x.2001.790119.x","is_oa":false,"landing_page_url":"https://doi.org/10.1034/j.1600-065x.2001.790119.x","pdf_url":null,"source":{"id":"https://openalex.org/S133112385","display_name":"Immunological Reviews","issn_l":"0105-2896","issn":["0105-2896","1600-065X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunological Reviews","raw_type":"journal-article"},{"id":"pmid:11292023","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11292023","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunological reviews","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1189270403","display_name":null,"funder_award_id":"AI 34577","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4981684286","display_name":null,"funder_award_id":"AI 09728","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1769437549","https://openalex.org/W2001257438","https://openalex.org/W2156309972","https://openalex.org/W2011479229","https://openalex.org/W1491148615","https://openalex.org/W1581466203","https://openalex.org/W2045489340","https://openalex.org/W7095377528","https://openalex.org/W71969623","https://openalex.org/W2043054419"],"abstract_inverted_index":{"Eosinophil":[0],"major":[1],"basic":[2],"protein":[3],"(MBP)":[4],"contributes":[5],"to":[6,30,57,119],"host":[7],"defense":[8],"and":[9,21,39,42,49,62,75,77,96,121,137,171,208],"disease":[10],"pathophysiology.":[11],"Chromosome":[12],"11":[13],"contains":[14],"the":[15,28,58,131,152,209,212],"genes":[16],"for":[17,68,93,216,220],"human":[18,38],"MBP1":[19,41,98],"(hMBP1)":[20],"a":[22,52,101,114,199],"second":[23],"novel":[24],"MBP,":[25],"hMBP2,":[26,50,94],"in":[27,70,85,110,126,141,151,182],"centromere":[29],"11q12":[31],"region.":[32],"Interestingly,":[33],"greater":[34],"similarity":[35],"exists":[36],"between":[37,47],"murine":[40,97],"MBP2":[43],"orthologs,":[44],"respectively,":[45],"than":[46,163],"hMBP1":[48,69,120],"suggesting":[51],"gene":[53],"duplication":[54],"event":[55],"prior":[56],"divergence":[59],"of":[60,90,133,189,211],"humans":[61],"mice.":[63],"There":[64],"is":[65,82,123,150,158],"abundant":[66],"mRNA":[67,81],"both":[71],"bone":[72,86],"marrow":[73,87],"(eosinophils":[74],"basophils)":[76],"placenta,":[78],"but":[79,178],"hMBP2":[80,127,149,157],"present":[83],"only":[84],"(eosinophils).":[88],"Comparison":[89],"proximal":[91],"promoters":[92],"hMBP1,":[95,148,203],"(mMBP1)":[99],"shows":[100],"conserved":[102,125,134],"GATA":[103],"transcription":[104],"factor":[105],"binding":[106,116,139],"site":[107,117],"(functionally":[108],"active":[109],"hMBP1).":[111],"However,":[112,156],"whether":[113],"C/EBP":[115],"common":[118,200],"mMBP1":[122],"functionally":[124],"remains":[128,145],"unresolved.":[129],"Similarly,":[130],"role":[132],"putative":[135],"IK2":[136],"STAT":[138],"sites":[140],"MBP":[142],"transcriptional":[143],"control":[144],"unknown.":[146],"Like":[147],"eosinophil":[153],"secondary":[154],"granule.":[155],"two-fold":[159],"less":[160,180],"positively":[161],"charged":[162],"hMBP":[164],"(+8":[165],"versus":[166],"+16":[167],"at":[168],"neutral":[169],"pH),":[170],"this":[172],"difference":[173],"may":[174],"explain":[175],"hMBP2's":[176,190,204],"similar,":[177],"often":[179],"potent,":[181],"vitro":[183],"biological":[184],"activities.":[185],"Overall,":[186],"while":[187],"conservation":[188],"amino":[191],"acid":[192],"sequence":[193],"(63%":[194],"identity":[195],"with":[196,202],"hMBP1)":[197],"suggests":[198],"function(s)":[201],"substantially":[205],"reduced":[206],"charge":[207],"existence":[210],"similar":[213],"mMBP2":[214],"argue":[215],"additional,":[217],"unique":[218],"functions":[219],"hMBP2.":[221]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
