{"id":"https://openalex.org/W2162906828","doi":"https://doi.org/10.1128/iai.73.8.5101-5105.2005","title":"Inter-Alpha-Inhibitor Proteins Are Endogenous Furin Inhibitors and Provide Protection against Experimental Anthrax Intoxication","display_name":"Inter-Alpha-Inhibitor Proteins Are Endogenous Furin Inhibitors and Provide Protection against Experimental Anthrax Intoxication","publication_year":2005,"publication_date":"2005-07-23","ids":{"openalex":"https://openalex.org/W2162906828","doi":"https://doi.org/10.1128/iai.73.8.5101-5105.2005","mag":"2162906828","pmid":"https://pubmed.ncbi.nlm.nih.gov/16041026","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1201260"},"language":"en","primary_location":{"id":"doi:10.1128/iai.73.8.5101-5105.2005","doi":"https://doi.org/10.1128/iai.73.8.5101-5105.2005","is_oa":false,"landing_page_url":"https://doi.org/10.1128/iai.73.8.5101-5105.2005","pdf_url":null,"source":{"id":"https://openalex.org/S128227336","display_name":"Infection and Immunity","issn_l":"0019-9567","issn":["0019-9567","1070-6313","1098-5522"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and Immunity","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1201260","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025379878","display_name":"Steven M. Opal","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Steven M. Opal","raw_affiliation_strings":["Center for Biodefense and Emerging Pathogens"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Biodefense and Emerging Pathogens","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018788642","display_name":"Andrew W. Artenstein","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrew W. Artenstein","raw_affiliation_strings":["Center for Biodefense and Emerging Pathogens"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Biodefense and Emerging Pathogens","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070673432","display_name":"Patricia A. Cristofaro","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Patricia A. Cristofaro","raw_affiliation_strings":["Center for Biodefense and Emerging Pathogens"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Biodefense and Emerging Pathogens","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064737676","display_name":"Jhung W. Jhung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801290373","display_name":"Memorial Hospital of Rhode Island","ror":"https://ror.org/04c0a2j77","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801290373"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jhung W. Jhung","raw_affiliation_strings":["Department of Pathology, Memorial Hospital of Rhode Island, Brown Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Memorial Hospital of Rhode Island, Brown Medical School","institution_ids":["https://openalex.org/I2801290373"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110192921","display_name":"John E. Palardy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John E. Palardy","raw_affiliation_strings":["Center for Biodefense and Emerging Pathogens"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Biodefense and Emerging Pathogens","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057334371","display_name":"Nicholas A. Parejo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nicholas A. Parejo","raw_affiliation_strings":["Center for Biodefense and Emerging Pathogens"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Biodefense and Emerging Pathogens","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064312491","display_name":"Yow\u2010Pin Lim","orcid":"https://orcid.org/0000-0003-2697-7963","observed_orcids":["https://orcid.org/0000-0003-2697-7963"]},"institutions":[{"id":"https://openalex.org/I4210142502","display_name":"ProThera Biologics (United States)","ror":"https://ror.org/03yzb9c23","country_code":"US","type":"company","lineage":["https://openalex.org/I4210142502"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yow-Pin Lim","raw_affiliation_strings":["ProThera Biologics, East Providence, Rhode Island"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ProThera Biologics, East Providence, Rhode Island","institution_ids":["https://openalex.org/I4210142502"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5025379878"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1335,"has_fulltext":false,"cited_by_count":43,"citation_normalized_percentile":{"value":0.75487648,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"73","issue":"8","first_page":"5101","last_page":"5105"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11515","display_name":"Bacillus and Francisella bacterial research","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11515","display_name":"Bacillus and Francisella bacterial research","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11274","display_name":"Botulinum Toxin and Related Neurological Disorders","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12477","display_name":"Toxin Mechanisms and Immunotoxins","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inter-alpha-inhibitor-proteins","display_name":"inter-alpha inhibitor proteins","score":0.9850000143051147},{"id":"https://openalex.org/keywords/furin","display_name":"furin","score":0.9440000057220459},{"id":"https://openalex.org/keywords/serine-protease-inhibitors","display_name":"serine protease inhibitors","score":0.7590000033378601},{"id":"https://openalex.org/keywords/anthrax-lethal-toxin","display_name":"anthrax lethal toxin","score":0.8519999980926514},{"id":"https://openalex.org/keywords/protective-antigen","display_name":"protective antigen","score":0.6029999852180481},{"id":"https://openalex.org/keywords/peritoneal-macrophages","display_name":"peritoneal macrophages","score":0.8529999852180481},{"id":"https://openalex.org/keywords/survival-protection","display_name":"survival protection","score":0.45399999618530273}],"concepts":[{"id":"https://openalex.org/C2777265534","wikidata":"https://www.wikidata.org/wiki/Q14916427","display_name":"Furin","level":3,"score":0.9624027013778687},{"id":"https://openalex.org/C2777807008","wikidata":"https://www.wikidata.org/wiki/Q87324999","display_name":"Serine protease","level":4,"score":0.7166182994842529},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6337363719940186},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.6219383478164673},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.5400818586349487},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.5265831351280212},{"id":"https://openalex.org/C2781143361","wikidata":"https://www.wikidata.org/wiki/Q55761529","display_name":"Protease inhibitor (pharmacology)","level":5,"score":0.47549447417259216},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4689590036869049},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4670366942882538},{"id":"https://openalex.org/C41810244","wikidata":"https://www.wikidata.org/wiki/Q1935986","display_name":"Anthrax toxin","level":5,"score":0.44383159279823303},{"id":"https://openalex.org/C2776414213","wikidata":"https://www.wikidata.org/wiki/Q183290","display_name":"Serine","level":3,"score":0.4373355507850647},{"id":"https://openalex.org/C2776714187","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Protease","level":3,"score":0.4252844750881195},{"id":"https://openalex.org/C182220744","wikidata":"https://www.wikidata.org/wiki/Q7251226","display_name":"Proteases","level":3,"score":0.41547706723213196},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3814668357372284},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.37723010778427124},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2684028744697571},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18829819560050964},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.16934308409690857},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.06904909014701843},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.0},{"id":"https://openalex.org/C123894998","wikidata":"https://www.wikidata.org/wiki/Q425158","display_name":"Fusion protein","level":4,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000510","descriptor_name":"Alpha-Globulins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000510","descriptor_name":"Alpha-Globulins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000510","descriptor_name":"Alpha-Globulins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000881","descriptor_name":"Anthrax","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000881","descriptor_name":"Anthrax","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000881","descriptor_name":"Anthrax","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000942","descriptor_name":"Antigens, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000942","descriptor_name":"Antigens, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000942","descriptor_name":"Antigens, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001408","descriptor_name":"Bacillus anthracis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001408","descriptor_name":"Bacillus anthracis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001408","descriptor_name":"Bacillus anthracis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001427","descriptor_name":"Bacterial Toxins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D001427","descriptor_name":"Bacterial Toxins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D001427","descriptor_name":"Bacterial Toxins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D017737","descriptor_name":"Macrophages, Peritoneal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017737","descriptor_name":"Macrophages, Peritoneal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017737","descriptor_name":"Macrophages, Peritoneal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045683","descriptor_name":"Furin","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D045683","descriptor_name":"Furin","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D045683","descriptor_name":"Furin","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1128/iai.73.8.5101-5105.2005","doi":"https://doi.org/10.1128/iai.73.8.5101-5105.2005","is_oa":false,"landing_page_url":"https://doi.org/10.1128/iai.73.8.5101-5105.2005","pdf_url":null,"source":{"id":"https://openalex.org/S128227336","display_name":"Infection and Immunity","issn_l":"0019-9567","issn":["0019-9567","1070-6313","1098-5522"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and Immunity","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1201260","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1201260","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infect Immun","raw_type":"Text"},{"id":"pmid:16041026","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16041026","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and immunity","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.690.9957","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.690.9957","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1201260/pdf/2051-04.pdf?origin%3Dpublication_detail","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1201260","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1201260","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infect Immun","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.800000011920929}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4283351404","display_name":"Novel Approaches to the Inhibition of Anthrax Toxin","funder_award_id":"R21AI053426","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5178270753","display_name":null,"funder_award_id":"R21-AI53426-01","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320309070","display_name":"Brown University","ror":"https://ror.org/05gq02987"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W113368119","https://openalex.org/W1595995045","https://openalex.org/W1652278102","https://openalex.org/W1749453950","https://openalex.org/W1820585906","https://openalex.org/W1982236738","https://openalex.org/W1994877079","https://openalex.org/W1995910871","https://openalex.org/W2004593684","https://openalex.org/W2018796656","https://openalex.org/W2019588048","https://openalex.org/W2025339373","https://openalex.org/W2026648244","https://openalex.org/W2033433776","https://openalex.org/W2044903961","https://openalex.org/W2046957124","https://openalex.org/W2051352346","https://openalex.org/W2072834264","https://openalex.org/W2101355256","https://openalex.org/W2103828083","https://openalex.org/W2105680347","https://openalex.org/W2105925178","https://openalex.org/W2118488619","https://openalex.org/W2118991879","https://openalex.org/W2138436678","https://openalex.org/W2142574334","https://openalex.org/W2151133360","https://openalex.org/W2159322980","https://openalex.org/W2159903171","https://openalex.org/W2170752710","https://openalex.org/W2183146713","https://openalex.org/W2340636240","https://openalex.org/W2789853064","https://openalex.org/W4229857880","https://openalex.org/W4255260655"],"related_works":["https://openalex.org/W2041701146","https://openalex.org/W2169118476","https://openalex.org/W2109982243","https://openalex.org/W2004593684","https://openalex.org/W2073313072","https://openalex.org/W1971934520","https://openalex.org/W1597424783","https://openalex.org/W2080468601","https://openalex.org/W2019581564","https://openalex.org/W6904811651"],"abstract_inverted_index":{"Inter-alpha-inhibitor":[0],"protein":[1],"(IalphaIp)":[2],"functions":[3],"as":[4],"an":[5,105,134],"endogenous":[6],"serine":[7,31],"protease":[8],"inhibitor":[9],"in":[10,52,110],"human":[11,130],"plasma,":[12],"and":[13,40,54],"IalphaIp":[14,26,48,83,91,131],"levels":[15],"diminish":[16],"rapidly":[17],"during":[18],"acute":[19],"inflammatory":[20],"states.":[21],"One":[22],"potential":[23],"target":[24],"for":[25,34,60],"is":[27],"furin,":[28],"a":[29],"cell-associated":[30],"endopeptidase":[32],"essential":[33],"the":[35,41,79,121],"activation":[36],"of":[37,43,82,94],"protective":[38,86],"antigen":[39],"formation":[42],"anthrax":[44,141],"lethal":[45],"toxin":[46],"(LT).":[47],"blocks":[49,78],"furin":[50],"activity":[51,81],"vitro":[53],"provides":[55],"significant":[56],"protection":[57],"against":[58,88,140],"cytotoxicity":[59],"murine":[61],"peritoneal":[62],"macrophages":[63],"exposed":[64],"to":[65,67,98,104],"up":[66],"500":[68],"ng/ml":[69],"LT.":[70],"A":[71],"monoclonal":[72],"antibody":[73],"(MAb),":[74],"69.31,":[75],"that":[76,129],"specifically":[77],"enzymatic":[80],"eliminates":[84],"its":[85],"effect":[87],"LT-induced":[89],"cytotoxicity.":[90],"(30":[92],"mg/kg":[93],"body":[95],"weight)":[96],"administered":[97],"BALB/c":[99],"mice":[100],"1":[101],"hour":[102],"prior":[103],"intravenous":[106],"LT":[107],"challenge":[108],"resulted":[109],"71%":[111],"survival":[112],"after":[113],"7":[114],"days":[115],"compared":[116],"with":[117],"no":[118],"survivors":[119],"among":[120],"control":[122],"animals":[123],"(P":[124],"<":[125],"0.001).":[126],"We":[127],"conclude":[128],"may":[132],"be":[133],"effective":[135],"preventative":[136],"or":[137],"therapeutic":[138],"agent":[139],"intoxication.":[142]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}
