{"id":"https://openalex.org/W2162891008","doi":null,"title":"Non-phosphorylated b-catenin in Wnt signaling","display_name":"Non-phosphorylated b-catenin in Wnt signaling","publication_year":2002,"publication_date":"2002-05-14","ids":{"openalex":"https://openalex.org/W2162891008","mag":"2162891008"},"language":"en","primary_location":{"id":"pmh:uu:oai:dspace.library.uu.nl:1874/421","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/421","pdf_url":"https://dspace.library.uu.nl/handle/1874/421","source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://dspace.library.uu.nl/handle/1874/421","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090782164","display_name":"Mascha van Noort","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Mascha van Noort","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5090782164"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12835","display_name":"FOXO transcription factor regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta-catenin","display_name":"\u03b2-catenin","score":0.9089999794960022},{"id":"https://openalex.org/keywords/wnt-signaling","display_name":"Wnt signaling","score":0.953000009059906},{"id":"https://openalex.org/keywords/gsk-3beta-phosphorylation","display_name":"GSK3\u03b2 phosphorylation","score":0.7350000143051147},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.8949999809265137},{"id":"https://openalex.org/keywords/beta-catenin-degradation","display_name":"\u03b2-catenin degradation","score":0.6909999847412109},{"id":"https://openalex.org/keywords/ubiquitination","display_name":"ubiquitination","score":0.8930000066757202},{"id":"https://openalex.org/keywords/proteasome","display_name":"proteasome","score":0.6790000200271606},{"id":"https://openalex.org/keywords/apc","display_name":"APC","score":0.35100001096725464},{"id":"https://openalex.org/keywords/axin","display_name":"Axin","score":0.8019999861717224},{"id":"https://openalex.org/keywords/frizzled-receptors","display_name":"Frizzled receptors","score":0.7020000219345093},{"id":"https://openalex.org/keywords/tcf-transcription-factors","display_name":"TCF transcription factors","score":0.7599999904632568},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.6890000104904175},{"id":"https://openalex.org/keywords/dephosphorylation","display_name":"dephosphorylation","score":0.6779999732971191}],"concepts":[{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.87430340051651},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.7791779637336731},{"id":"https://openalex.org/C160110348","wikidata":"https://www.wikidata.org/wiki/Q5048387","display_name":"Casein kinase 1","level":4,"score":0.5529640913009644},{"id":"https://openalex.org/C2778237340","wikidata":"https://www.wikidata.org/wiki/Q14883378","display_name":"Adenomatous polyposis coli","level":4,"score":0.5516583919525146},{"id":"https://openalex.org/C30145163","wikidata":"https://www.wikidata.org/wiki/Q384104","display_name":"Catenin","level":4,"score":0.5317220687866211},{"id":"https://openalex.org/C2779324961","wikidata":"https://www.wikidata.org/wiki/Q1634046","display_name":"Beta-catenin","level":4,"score":0.5070436000823975},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5039758086204529},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.49094799160957336},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.47801482677459717},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4756333827972412},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4489462077617645},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33919569849967957},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2536090910434723},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.23563840985298157},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.17701393365859985},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.08541923761367798},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.08289995789527893}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:uu:oai:dspace.library.uu.nl:1874/421","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/421","pdf_url":"https://dspace.library.uu.nl/handle/1874/421","source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},{"id":"pmh:oai:dspace.library.uu.nl:1874/421","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/421","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},{"id":"mag:2162891008","doi":null,"is_oa":false,"landing_page_url":"https://dspace.library.uu.nl/bitstream/handle/1874/421/full.pdf;sequence=1","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:uu:oai:dspace.library.uu.nl:1874/421","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/421","pdf_url":"https://dspace.library.uu.nl/handle/1874/421","source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},"sustainable_development_goals":[{"score":0.4043000042438507,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321800","display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","ror":"https://ror.org/04jsz6e67"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2162891008.pdf","grobid_xml":"https://content.openalex.org/works/W2162891008.grobid-xml"},"referenced_works_count":82,"referenced_works":["https://openalex.org/W64959330","https://openalex.org/W93114066","https://openalex.org/W153332747","https://openalex.org/W1484025944","https://openalex.org/W1487877558","https://openalex.org/W1503968406","https://openalex.org/W1504655784","https://openalex.org/W1532353086","https://openalex.org/W1532597512","https://openalex.org/W1544046482","https://openalex.org/W1580962701","https://openalex.org/W1589352523","https://openalex.org/W1601657500","https://openalex.org/W1635607892","https://openalex.org/W1780096456","https://openalex.org/W1833591189","https://openalex.org/W1854996193","https://openalex.org/W1922040470","https://openalex.org/W1950889292","https://openalex.org/W1964223904","https://openalex.org/W1964739066","https://openalex.org/W1966034049","https://openalex.org/W1967137553","https://openalex.org/W1973422080","https://openalex.org/W1975516052","https://openalex.org/W1975993620","https://openalex.org/W1979618971","https://openalex.org/W1979993283","https://openalex.org/W1980955976","https://openalex.org/W1981661934","https://openalex.org/W1989215255","https://openalex.org/W1993496373","https://openalex.org/W1994700168","https://openalex.org/W1994822723","https://openalex.org/W1997368786","https://openalex.org/W1999328200","https://openalex.org/W1999582446","https://openalex.org/W2014748872","https://openalex.org/W2017668082","https://openalex.org/W2023099007","https://openalex.org/W2023273217","https://openalex.org/W2027431258","https://openalex.org/W2030945799","https://openalex.org/W2033228162","https://openalex.org/W2036864436","https://openalex.org/W2048185792","https://openalex.org/W2051032088","https://openalex.org/W2051788298","https://openalex.org/W2052086914","https://openalex.org/W2052690509","https://openalex.org/W2055824128","https://openalex.org/W2062409437","https://openalex.org/W2062911730","https://openalex.org/W2066078074","https://openalex.org/W2066497759","https://openalex.org/W2071191421","https://openalex.org/W2076551313","https://openalex.org/W2077845288","https://openalex.org/W2078591745","https://openalex.org/W2081985759","https://openalex.org/W2088516964","https://openalex.org/W2088681495","https://openalex.org/W2088807962","https://openalex.org/W2097098623","https://openalex.org/W2100070586","https://openalex.org/W2107429711","https://openalex.org/W2119077641","https://openalex.org/W2119355841","https://openalex.org/W2121745326","https://openalex.org/W2122955072","https://openalex.org/W2132475598","https://openalex.org/W2138069069","https://openalex.org/W2142522741","https://openalex.org/W2144300167","https://openalex.org/W2146167376","https://openalex.org/W2148883613","https://openalex.org/W2149497955","https://openalex.org/W2156172510","https://openalex.org/W2158569397","https://openalex.org/W2178503716","https://openalex.org/W2332035597","https://openalex.org/W2472955934"],"related_works":["https://openalex.org/W2077845288","https://openalex.org/W3115598794","https://openalex.org/W7096643689","https://openalex.org/W1532109414","https://openalex.org/W2570022106","https://openalex.org/W2062096656","https://openalex.org/W7095801523","https://openalex.org/W7096806854","https://openalex.org/W7099338688","https://openalex.org/W7099039176"],"abstract_inverted_index":{"The":[0,319,356],"Wnt":[1,54,138,213,475],"signaling":[2,139,200,214,261,349,493,516],"cascade":[3],"plays":[4],"an":[5,511],"important":[6,192],"role":[7,211],"in":[8,38,93,124,141,217,246,254,265,294,339,353,388,423,480,482],"development":[9,509],"and":[10,35,47,60,70,91,215,230,368,401,406,440,486],"carcinogenesis.":[11],"Under":[12],"non-signaling":[13],"conditions,":[14],"a":[15,80,85,103],"large":[16],"cytoplasmic":[17],"complex,":[18],"consisting":[19],"of":[20,27,41,87,102,132,144,175,187,212,220,237,267,274,290,335,347,351,436,465,495,510,519,524],"the":[21,24,28,39,51,62,75,88,100,113,130,142,156,163,184,199,210,218,238,247,291,300,305,325,331,344,348,366,397,411,433,446,453,463,492,496,500,508,515,525],"kinase":[22],"GSK-3?,":[23],"gene":[25,32,95],"product":[26],"adenomatous":[29],"poliposis":[30],"coli":[31],"(APC),":[33],"axin":[34],"?-catenin,":[36,520],"results":[37,92,140],"phosphorylation":[40,166,185,296,437,447,470],"\u00df-catenin.":[42],"Phosphorylated":[43],"?-catenin":[44,65,154,176,188,216,245,295,308,336,352,415,530],"is":[45,66,107,110,177,189,309,448,472],"ubiquitinated":[46],"subsequently":[48,429],"degraded":[49],"by":[50,297,373,474],"proteasome.":[52],"Upon":[53],"binding":[55],"to":[56,74,120,208,232,287,304,314,323,361,431,450],"its":[57,194],"receptors":[58],"Frz":[59],"LRP,":[61],"complex":[63],"dissociates,":[64],"no":[67],"longer":[68],"degraded,":[69],"accumulates.":[71],"It":[72,249],"translocates":[73],"nucleus,":[76],"where":[77],"it":[78],"forms":[79],"bipartite":[81],"transcription":[82],"factor":[83],"with":[84,228,277,377,410,521],"member":[86],"TCF":[89],"family":[90],"target":[94],"transcription.":[96],"In":[97,202,282,458,503],"this":[98,505],"thesis":[99,506],"generation":[101],"monoclonal":[104],"antibody":[105,512],"(?ABC)":[106],"described,":[108],"which":[109,327,370,385,395,469,522],"specific":[111,513],"for":[112,180,193,198,243,399,514],"N-terminally":[114],"non-phosphorylated":[115,145,244],"?-catenin.":[116,133,146],"This":[117],"tool":[118],"proved":[119],"be":[121,315,324,362],"very":[122],"useful":[123],"answering":[125],"some":[126,523],"remaining":[127],"questions":[128,528],"about":[129],"regulation":[131,531],"First":[134],"we":[135,170,205,285,342,461],"established,":[136],"that":[137,151,165,172,183,235,253,445],"accumulation":[143,174],"Another":[147],"widely":[148],"accepted":[149],"idea,":[150],"GSK-3?":[152,374],"phosphorylates":[153],"at":[155,452],"N-terminus":[157],"was":[158,250,262,302,321,359,396,416],"proven":[159,322],"as":[160,162,337,417,419],"well":[161],"notion":[164],"precedes":[167],"ubiquitination.":[168],"Secondly,":[169],"showed":[171],"mere":[173],"not":[178,190],"sufficient":[179],"signaling,":[181],"rather":[182],"status":[186,471],"only":[191,263],"degradation":[195],"but":[196],"also":[197],"capacity.":[201],"chapter":[203,459],"4":[204],"used":[206,430],"?ABC":[207,229,278,439],"investigate":[209],"pathogenesis":[219],"breast":[221,225,255],"carcinoma.":[222],"We":[223,442],"stained":[224],"tumor":[226,256],"samples":[227,239],"found":[231,264,387,422,479],"our":[233],"surprise":[234],"70%":[236],"tested,":[240],"were":[241,375,383,386,408,428],"positive":[242],"nucleus.":[248],"reported":[251],"previously":[252],"cell":[257,269,272],"lines,":[258],"?-catenin/Tcf":[259],"mediated":[260],"1":[266],"26":[268],"lines.":[270],"Testing":[271],"lysates":[273],"theses":[275],"lines":[276],"confirmed":[279],"these":[280,483],"data.":[281],"Chapter":[283],"5,":[284],"tried":[286],"unravel":[288],"more":[289],"mechanisms":[292],"involved":[293],"GSK-3?.":[298],"First,":[299],"answer":[301],"given":[303,332],"question":[306,330],"whether":[307],"actively":[310],"dephosphorylated":[311],"or":[312,381],"needs":[313],"synthesized":[316],"de":[317],"novo.":[318],"latter":[320],"case,":[326],"made":[328],"us":[329],"half":[333,345,357],"life":[334,346,358],"stated":[338],"literature.":[340],"Therefore":[341],"determined":[343],"pool":[350],"two":[354,466],"ways.":[355],"estimated":[360],"17":[363],"minutes.":[364],"Next":[365],"serines":[367,468,484],"threonine,":[369],"are":[371,532],"phosphorylated":[372],"substituted":[376,409],"aspartic":[378,412],"acid":[379,391,413],"residues":[380],"mutations":[382,421,478],"introduced":[384],"tumors.":[389,424],"Aspartic":[390],"can":[392],"mimic":[393],"phosphorylation,":[394],"case":[398],"S37":[400],"T41,":[402],"however,":[403,488],"when":[404],"S33":[405],"S45":[407],"residues,":[414],"active":[418,517],"all":[420],"These":[425],"mutant":[426],"constructs":[427],"determine":[432],"relative":[434],"order":[435],"using":[438],"?S29NP.":[441],"could":[443],"show":[444],"likely":[449],"start":[451],"3\u0092":[454],"serine,":[455],"moving":[456],"upwards.":[457],"6":[460],"describe":[462],"presence":[464],"additional":[467],"regulated":[473],"signaling.":[476],"Introducing":[477],"tumors":[481],"23":[485],"29,":[487],"did":[489],"neither":[490],"increase":[491],"activity":[494],"protein":[497],"nor":[498],"enhance":[499],"transformational":[501],"potential.":[502],"conclusion":[504],"describes":[507],"form":[518],"still":[526],"unanswered":[527],"concerning":[529],"answered.":[533]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
