{"id":"https://openalex.org/W2162829883","doi":"https://doi.org/10.1517/14712598.2015.1066330","title":"Using stem cells to produce insulin","display_name":"Using stem cells to produce insulin","publication_year":2015,"publication_date":"2015-07-09","ids":{"openalex":"https://openalex.org/W2162829883","doi":"https://doi.org/10.1517/14712598.2015.1066330","mag":"2162829883","pmid":"https://pubmed.ncbi.nlm.nih.gov/26156425"},"language":"en","primary_location":{"id":"doi:10.1517/14712598.2015.1066330","doi":"https://doi.org/10.1517/14712598.2015.1066330","is_oa":false,"landing_page_url":"https://doi.org/10.1517/14712598.2015.1066330","pdf_url":null,"source":{"id":"https://openalex.org/S57380513","display_name":"Expert Opinion on Biological Therapy","issn_l":"1471-2598","issn":["1471-2598","1744-7682"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Biological Therapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10261/123726","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034880669","display_name":"Bernat Soria","orcid":"https://orcid.org/0000-0002-2356-0380","observed_orcids":["https://orcid.org/0000-0002-2356-0380"]},"institutions":[{"id":"https://openalex.org/I4210092133","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Diabetes y Enfermedades Metab\u00f3licas Asociadas","ror":"https://ror.org/00dwgct76","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4210092133","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210150311","display_name":"Centro Andaluz de Biolog\u00eda Molecular y Medicina Regenerativa","ror":"https://ror.org/03nb7bx92","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210150311","https://openalex.org/I79238269"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Bernat Soria","raw_affiliation_strings":["a 1 CABIMER, Andalusian Center for Molecular Biology and Regenerative Medicine , Avda. Americo Vespucio s/n, 41092 Seville, Spain bernat.soria@cabimer.es ; karim.hmadcha@cabimer.es","b 2 CIBERDEM, Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders , 08036 Barcelona, Spain","CIBERDEM, Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders, 08036 Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a 1 CABIMER, Andalusian Center for Molecular Biology and Regenerative Medicine , Avda. Americo Vespucio s/n, 41092 Seville, Spain bernat.soria@cabimer.es ; karim.hmadcha@cabimer.es","institution_ids":["https://openalex.org/I4210150311"]},{"raw_affiliation_string":"b 2 CIBERDEM, Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders , 08036 Barcelona, Spain","institution_ids":["https://openalex.org/I4210092133"]},{"raw_affiliation_string":"CIBERDEM, Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders, 08036 Barcelona, Spain","institution_ids":["https://openalex.org/I4210092133"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073061508","display_name":"Benoit R. Gauthier","orcid":"https://orcid.org/0000-0001-8146-7486","observed_orcids":["https://orcid.org/0000-0001-8146-7486"]},"institutions":[{"id":"https://openalex.org/I4210150311","display_name":"Centro Andaluz de Biolog\u00eda Molecular y Medicina Regenerativa","ror":"https://ror.org/03nb7bx92","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210150311","https://openalex.org/I79238269"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Benoit R Gauthier","raw_affiliation_strings":["a 1 CABIMER, Andalusian Center for Molecular Biology and Regenerative Medicine , Avda. Americo Vespucio s/n, 41092 Seville, Spain bernat.soria@cabimer.es ; karim.hmadcha@cabimer.es"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a 1 CABIMER, Andalusian Center for Molecular Biology and Regenerative Medicine , Avda. Americo Vespucio s/n, 41092 Seville, Spain bernat.soria@cabimer.es ; karim.hmadcha@cabimer.es","institution_ids":["https://openalex.org/I4210150311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087451743","display_name":"Franz Mart\u0131\u0301n","orcid":"https://orcid.org/0000-0002-5745-8704","observed_orcids":["https://orcid.org/0000-0002-5745-8704"]},"institutions":[{"id":"https://openalex.org/I4210092133","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Diabetes y Enfermedades Metab\u00f3licas Asociadas","ror":"https://ror.org/00dwgct76","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4210092133","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210150311","display_name":"Centro Andaluz de Biolog\u00eda Molecular y Medicina Regenerativa","ror":"https://ror.org/03nb7bx92","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210150311","https://openalex.org/I79238269"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Franz Mart\u00edn","raw_affiliation_strings":["a 1 CABIMER, Andalusian Center for Molecular Biology and Regenerative Medicine , Avda. Americo Vespucio s/n, 41092 Seville, Spain bernat.soria@cabimer.es ; karim.hmadcha@cabimer.es","b 2 CIBERDEM, Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders , 08036 Barcelona, Spain","CIBERDEM, Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders, 08036 Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a 1 CABIMER, Andalusian Center for Molecular Biology and Regenerative Medicine , Avda. Americo Vespucio s/n, 41092 Seville, Spain bernat.soria@cabimer.es ; karim.hmadcha@cabimer.es","institution_ids":["https://openalex.org/I4210150311"]},{"raw_affiliation_string":"b 2 CIBERDEM, Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders , 08036 Barcelona, Spain","institution_ids":["https://openalex.org/I4210092133"]},{"raw_affiliation_string":"CIBERDEM, Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders, 08036 Barcelona, Spain","institution_ids":["https://openalex.org/I4210092133"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049896333","display_name":"Juan Rigoberto Tejedo","orcid":"https://orcid.org/0000-0002-8434-7516","observed_orcids":["https://orcid.org/0000-0002-8434-7516"]},"institutions":[{"id":"https://openalex.org/I4210092133","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Diabetes y Enfermedades Metab\u00f3licas Asociadas","ror":"https://ror.org/00dwgct76","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4210092133","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210150311","display_name":"Centro Andaluz de Biolog\u00eda Molecular y Medicina Regenerativa","ror":"https://ror.org/03nb7bx92","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210150311","https://openalex.org/I79238269"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Juan R Tejedo","raw_affiliation_strings":["a 1 CABIMER, Andalusian Center for Molecular Biology and Regenerative Medicine , Avda. Americo Vespucio s/n, 41092 Seville, Spain bernat.soria@cabimer.es ; karim.hmadcha@cabimer.es","b 2 CIBERDEM, Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders , 08036 Barcelona, Spain","CIBERDEM, Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders, 08036 Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a 1 CABIMER, Andalusian Center for Molecular Biology and Regenerative Medicine , Avda. Americo Vespucio s/n, 41092 Seville, Spain bernat.soria@cabimer.es ; karim.hmadcha@cabimer.es","institution_ids":["https://openalex.org/I4210150311"]},{"raw_affiliation_string":"b 2 CIBERDEM, Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders , 08036 Barcelona, Spain","institution_ids":["https://openalex.org/I4210092133"]},{"raw_affiliation_string":"CIBERDEM, Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders, 08036 Barcelona, Spain","institution_ids":["https://openalex.org/I4210092133"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015958030","display_name":"Francisco Javier Bedoya","orcid":"https://orcid.org/0000-0003-0262-7029","observed_orcids":["https://orcid.org/0000-0003-0262-7029"]},"institutions":[{"id":"https://openalex.org/I4210092133","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Diabetes y Enfermedades Metab\u00f3licas Asociadas","ror":"https://ror.org/00dwgct76","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4210092133","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210150311","display_name":"Centro Andaluz de Biolog\u00eda Molecular y Medicina Regenerativa","ror":"https://ror.org/03nb7bx92","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210150311","https://openalex.org/I79238269"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Francisco J Bedoya","raw_affiliation_strings":["a 1 CABIMER, Andalusian Center for Molecular Biology and Regenerative Medicine , Avda. Americo Vespucio s/n, 41092 Seville, Spain bernat.soria@cabimer.es ; karim.hmadcha@cabimer.es","b 2 CIBERDEM, Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders , 08036 Barcelona, Spain","CIBERDEM, Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders, 08036 Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a 1 CABIMER, Andalusian Center for Molecular Biology and Regenerative Medicine , Avda. Americo Vespucio s/n, 41092 Seville, Spain bernat.soria@cabimer.es ; karim.hmadcha@cabimer.es","institution_ids":["https://openalex.org/I4210150311"]},{"raw_affiliation_string":"b 2 CIBERDEM, Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders , 08036 Barcelona, Spain","institution_ids":["https://openalex.org/I4210092133"]},{"raw_affiliation_string":"CIBERDEM, Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders, 08036 Barcelona, Spain","institution_ids":["https://openalex.org/I4210092133"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072317202","display_name":"Anabel Rojas","orcid":"https://orcid.org/0000-0003-0733-8277","observed_orcids":["https://orcid.org/0000-0003-0733-8277"]},"institutions":[{"id":"https://openalex.org/I4210092133","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Diabetes y Enfermedades Metab\u00f3licas Asociadas","ror":"https://ror.org/00dwgct76","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4210092133","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210150311","display_name":"Centro Andaluz de Biolog\u00eda Molecular y Medicina Regenerativa","ror":"https://ror.org/03nb7bx92","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210150311","https://openalex.org/I79238269"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Anabel Rojas","raw_affiliation_strings":["a 1 CABIMER, Andalusian Center for Molecular Biology and Regenerative Medicine , Avda. Americo Vespucio s/n, 41092 Seville, Spain bernat.soria@cabimer.es ; karim.hmadcha@cabimer.es","b 2 CIBERDEM, Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders , 08036 Barcelona, Spain","CIBERDEM, Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders, 08036 Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a 1 CABIMER, Andalusian Center for Molecular Biology and Regenerative Medicine , Avda. Americo Vespucio s/n, 41092 Seville, Spain bernat.soria@cabimer.es ; karim.hmadcha@cabimer.es","institution_ids":["https://openalex.org/I4210150311"]},{"raw_affiliation_string":"b 2 CIBERDEM, Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders , 08036 Barcelona, Spain","institution_ids":["https://openalex.org/I4210092133"]},{"raw_affiliation_string":"CIBERDEM, Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders, 08036 Barcelona, Spain","institution_ids":["https://openalex.org/I4210092133"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072346483","display_name":"Abdelkrim Hmadcha","orcid":"https://orcid.org/0000-0002-4105-3702","observed_orcids":["https://orcid.org/0000-0002-4105-3702"]},"institutions":[{"id":"https://openalex.org/I4210092133","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Diabetes y Enfermedades Metab\u00f3licas Asociadas","ror":"https://ror.org/00dwgct76","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4210092133","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210150311","display_name":"Centro Andaluz de Biolog\u00eda Molecular y Medicina Regenerativa","ror":"https://ror.org/03nb7bx92","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210150311","https://openalex.org/I79238269"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Abdelkrim Hmadcha","raw_affiliation_strings":["a 1 CABIMER, Andalusian Center for Molecular Biology and Regenerative Medicine , Avda. Americo Vespucio s/n, 41092 Seville, Spain bernat.soria@cabimer.es ; karim.hmadcha@cabimer.es","b 2 CIBERDEM, Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders , 08036 Barcelona, Spain","CIBERDEM, Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders, 08036 Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a 1 CABIMER, Andalusian Center for Molecular Biology and Regenerative Medicine , Avda. Americo Vespucio s/n, 41092 Seville, Spain bernat.soria@cabimer.es ; karim.hmadcha@cabimer.es","institution_ids":["https://openalex.org/I4210150311"]},{"raw_affiliation_string":"b 2 CIBERDEM, Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders , 08036 Barcelona, Spain","institution_ids":["https://openalex.org/I4210092133"]},{"raw_affiliation_string":"CIBERDEM, Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders, 08036 Barcelona, Spain","institution_ids":["https://openalex.org/I4210092133"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.5416,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.94784023,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"15","issue":"10","first_page":"1469","last_page":"1489"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insulin-producing-cells","display_name":"insulin-producing cells","score":0.9259999990463257},{"id":"https://openalex.org/keywords/beta-cell-replacement-therapy","display_name":"beta cell replacement therapy","score":0.6890000104904175},{"id":"https://openalex.org/keywords/pluripotent-stem-cells","display_name":"pluripotent stem cells","score":0.8709999918937683},{"id":"https://openalex.org/keywords/embryonic-stem-cells","display_name":"embryonic stem cells","score":0.9210000038146973},{"id":"https://openalex.org/keywords/pancreatic-progenitors","display_name":"pancreatic progenitors","score":0.640999972820282},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.8889999985694885},{"id":"https://openalex.org/keywords/stem-cell-differentiation","display_name":"stem cell differentiation","score":0.6650000214576721},{"id":"https://openalex.org/keywords/clinical-translation","display_name":"clinical translation","score":0.5170000195503235}],"concepts":[{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.7124041318893433},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.649996817111969},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.6288924813270569},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.5954341888427734},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.5216134786605835},{"id":"https://openalex.org/C10882517","wikidata":"https://www.wikidata.org/wiki/Q15268054","display_name":"Cell therapy","level":3,"score":0.4367194175720215},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.4249695837497711},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42205536365509033},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3948996663093567},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3935878276824951},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.24947795271873474},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.20337900519371033},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2013188600540161},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0792509913444519},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000078790","descriptor_name":"Insulin Secretion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000078790","descriptor_name":"Insulin Secretion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000078790","descriptor_name":"Insulin Secretion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":false},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":false},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":false},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D053687","descriptor_name":"Adult Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D053687","descriptor_name":"Adult Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D053687","descriptor_name":"Adult Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1517/14712598.2015.1066330","doi":"https://doi.org/10.1517/14712598.2015.1066330","is_oa":false,"landing_page_url":"https://doi.org/10.1517/14712598.2015.1066330","pdf_url":null,"source":{"id":"https://openalex.org/S57380513","display_name":"Expert Opinion on Biological Therapy","issn_l":"1471-2598","issn":["1471-2598","1744-7682"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Biological Therapy","raw_type":"journal-article"},{"id":"pmid:26156425","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26156425","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert opinion on biological therapy","raw_type":"Journal Article"},{"id":"pmh:oai:digital.csic.es:10261/123726","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10261/123726","pdf_url":null,"source":{"id":"https://openalex.org/S4306400616","display_name":"DIGITAL.CSIC (Spanish National Research Council (CSIC))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I134820265","host_organization_name":"Consejo Superior de Investigaciones Cient\u00edficas","host_organization_lineage":["https://openalex.org/I134820265"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Art\u00edculo"}],"best_oa_location":{"id":"pmh:oai:digital.csic.es:10261/123726","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10261/123726","pdf_url":null,"source":{"id":"https://openalex.org/S4306400616","display_name":"DIGITAL.CSIC (Spanish National Research Council (CSIC))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I134820265","host_organization_name":"Consejo Superior de Investigaciones Cient\u00edficas","host_organization_lineage":["https://openalex.org/I134820265"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Art\u00edculo"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":190,"referenced_works":["https://openalex.org/W143234905","https://openalex.org/W176352299","https://openalex.org/W1518467556","https://openalex.org/W1522919673","https://openalex.org/W1562751564","https://openalex.org/W1568038787","https://openalex.org/W1601405552","https://openalex.org/W1604189667","https://openalex.org/W1721336579","https://openalex.org/W1830287761","https://openalex.org/W1889370896","https://openalex.org/W1894212043","https://openalex.org/W1913923004","https://openalex.org/W1925655957","https://openalex.org/W1956442799","https://openalex.org/W1965813410","https://openalex.org/W1969522715","https://openalex.org/W1973453325","https://openalex.org/W1974024889","https://openalex.org/W1974393255","https://openalex.org/W1975384753","https://openalex.org/W1982327008","https://openalex.org/W1984380128","https://openalex.org/W1984477435","https://openalex.org/W1985724122","https://openalex.org/W1988862392","https://openalex.org/W1991182557","https://openalex.org/W1992715308","https://openalex.org/W1993222615","https://openalex.org/W1994075387","https://openalex.org/W1995095187","https://openalex.org/W1995224791","https://openalex.org/W1995812738","https://openalex.org/W1996195786","https://openalex.org/W1996589682","https://openalex.org/W1997127825","https://openalex.org/W1997543204","https://openalex.org/W1999144877","https://openalex.org/W1999557882","https://openalex.org/W2001153618","https://openalex.org/W2004087103","https://openalex.org/W2005688198","https://openalex.org/W2006838330","https://openalex.org/W2007260996","https://openalex.org/W2008227148","https://openalex.org/W2009225279","https://openalex.org/W2009710060","https://openalex.org/W2009760139","https://openalex.org/W2010832962","https://openalex.org/W2012219406","https://openalex.org/W2015316095","https://openalex.org/W2016174782","https://openalex.org/W2016836972","https://openalex.org/W2020375403","https://openalex.org/W2022089464","https://openalex.org/W2023183151","https://openalex.org/W2023523730","https://openalex.org/W2024665756","https://openalex.org/W2024932219","https://openalex.org/W2026284192","https://openalex.org/W2026503236","https://openalex.org/W2026641491","https://openalex.org/W2026689198","https://openalex.org/W2026937301","https://openalex.org/W2027836023","https://openalex.org/W2028711069","https://openalex.org/W2030294791","https://openalex.org/W2032472678","https://openalex.org/W2034104198","https://openalex.org/W2034224176","https://openalex.org/W2034292123","https://openalex.org/W2034540804","https://openalex.org/W2035209944","https://openalex.org/W2036334886","https://openalex.org/W2037411209","https://openalex.org/W2038404321","https://openalex.org/W2040158161","https://openalex.org/W2040207288","https://openalex.org/W2041739600","https://openalex.org/W2046008078","https://openalex.org/W2046703988","https://openalex.org/W2048056915","https://openalex.org/W2048255936","https://openalex.org/W2049326750","https://openalex.org/W2050677481","https://openalex.org/W2050804153","https://openalex.org/W2052721366","https://openalex.org/W2054361177","https://openalex.org/W2055001415","https://openalex.org/W2055710769","https://openalex.org/W2057361172","https://openalex.org/W2059267070","https://openalex.org/W2061489553","https://openalex.org/W2063733864","https://openalex.org/W2065186500","https://openalex.org/W2065459869","https://openalex.org/W2068883252","https://openalex.org/W2069619429","https://openalex.org/W2069863598","https://openalex.org/W2069984314","https://openalex.org/W2070103781","https://openalex.org/W2073803015","https://openalex.org/W2075855216","https://openalex.org/W2076343609","https://openalex.org/W2076770967","https://openalex.org/W2080741429","https://openalex.org/W2081490620","https://openalex.org/W2082798078","https://openalex.org/W2083246499","https://openalex.org/W2084078316","https://openalex.org/W2085721222","https://openalex.org/W2086692735","https://openalex.org/W2086708078","https://openalex.org/W2087007752","https://openalex.org/W2087485736","https://openalex.org/W2087644204","https://openalex.org/W2088381487","https://openalex.org/W2089688272","https://openalex.org/W2090830096","https://openalex.org/W2095904762","https://openalex.org/W2096133535","https://openalex.org/W2097544480","https://openalex.org/W2097573911","https://openalex.org/W2098338322","https://openalex.org/W2100715279","https://openalex.org/W2101072639","https://openalex.org/W2101091882","https://openalex.org/W2101391555","https://openalex.org/W2103794486","https://openalex.org/W2106004510","https://openalex.org/W2106219965","https://openalex.org/W2107336884","https://openalex.org/W2108963354","https://openalex.org/W2110447217","https://openalex.org/W2110760195","https://openalex.org/W2110789198","https://openalex.org/W2112842207","https://openalex.org/W2114552310","https://openalex.org/W2117349375","https://openalex.org/W2119249252","https://openalex.org/W2119546366","https://openalex.org/W2120514632","https://openalex.org/W2123369690","https://openalex.org/W2125121177","https://openalex.org/W2126780067","https://openalex.org/W2126792448","https://openalex.org/W2127791120","https://openalex.org/W2131757911","https://openalex.org/W2132046208","https://openalex.org/W2132289617","https://openalex.org/W2134183254","https://openalex.org/W2135491747","https://openalex.org/W2137424064","https://openalex.org/W2137987484","https://openalex.org/W2138100580","https://openalex.org/W2138130169","https://openalex.org/W2138271428","https://openalex.org/W2142986021","https://openalex.org/W2144107141","https://openalex.org/W2144112229","https://openalex.org/W2145065991","https://openalex.org/W2146127531","https://openalex.org/W2148078342","https://openalex.org/W2148890861","https://openalex.org/W2149895222","https://openalex.org/W2150674406","https://openalex.org/W2152483590","https://openalex.org/W2154532011","https://openalex.org/W2155869778","https://openalex.org/W2156490774","https://openalex.org/W2156696529","https://openalex.org/W2159850172","https://openalex.org/W2160051083","https://openalex.org/W2160216824","https://openalex.org/W2163592665","https://openalex.org/W2164051346","https://openalex.org/W2165631890","https://openalex.org/W2166421062","https://openalex.org/W2167977281","https://openalex.org/W2168967248","https://openalex.org/W2169337437","https://openalex.org/W2170441682","https://openalex.org/W2171087970","https://openalex.org/W2171118724","https://openalex.org/W2323566388","https://openalex.org/W2409608948","https://openalex.org/W2482929663","https://openalex.org/W2750187408","https://openalex.org/W2951464790","https://openalex.org/W3144759594"],"related_works":["https://openalex.org/W2126478593","https://openalex.org/W2036028623","https://openalex.org/W4295681237","https://openalex.org/W2998117225","https://openalex.org/W3110176598","https://openalex.org/W2153972175","https://openalex.org/W2283234068","https://openalex.org/W1972411942","https://openalex.org/W2620502781","https://openalex.org/W2099136912"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Tremendous":[1],"progress":[2],"has":[3],"been":[4],"made":[5],"in":[6,23,129,155,159,169],"generating":[7],"insulin-producing":[8,44,63,127,141],"cells":[9,45,123,128],"from":[10],"pluripotent":[11],"stem":[12,122],"cells.":[13,64,142],"The":[14],"best":[15],"outcome":[16],"of":[17,35,75,88,120,140,151,164,172,180,190],"the":[18,24,33,47,67,97,104,109,118,149,170,178,181,188,192],"refined":[19],"protocols":[20],"became":[21],"apparent":[22],"first":[25],"clinical":[26,173],"trial":[27],"announced":[28],"by":[29],"ViaCyte,":[30],"based":[31,116],"on":[32,117],"implantation":[34],"pancreatic":[36],"progenitors":[37],"that":[38,99,177],"would":[39],"further":[40],"mature":[41],"into":[42,124],"functional":[43,84,196],"inside":[46],"patient's":[48],"body.":[49],"AREAS":[50],"COVERED:":[51],"Several":[52],"groups,":[53],"including":[54],"ours,":[55],"have":[56,70,100],"contributed":[57],"to":[58,61,80,90,136],"improve":[59],"strategies":[60],"generate":[62],"Of":[65],"note,":[66],"latest":[68],"results":[69],"gained":[71],"a":[72,78,82,130,152,162],"substantial":[73],"amount":[74],"interest":[76],"as":[77],"method":[79],"create":[81],"potentially":[83],"and":[85,126,132,183,195],"limitless":[86],"supply":[87],"\u03b2-cell":[89,113,197],"revert":[91],"diabetes":[92,156],"mellitus.":[93],"This":[94],"review":[95],"analyzes":[96],"accomplishments":[98],"taken":[101],"place":[102],"over":[103],"last":[105],"few":[106],"decades,":[107],"summarizes":[108],"state-of-art":[110],"methods":[111],"for":[112],"replacement":[114],"therapies":[115],"differentiation":[119],"embryonic":[121],"glucose-responsive":[125],"dish":[131],"discusses":[133],"alternative":[134],"approaches":[135],"obtain":[137],"new":[138,153],"sources":[139],"EXPERT":[143],"OPINION:":[144],"Undoubtedly,":[145],"recent":[146],"events":[147],"preface":[148],"beginning":[150],"era":[154],"therapy.":[157],"However,":[158],"our":[160],"opinion,":[161],"number":[163],"significant":[165],"hurdles":[166],"still":[167],"stand":[168],"way":[171],"application.":[174],"We":[175],"believe":[176],"combination":[179],"private":[182],"public":[184],"sectors":[185],"will":[186],"accelerate":[187],"process":[189],"obtaining":[191],"desired":[193],"safe":[194],"surrogates.":[198]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}