{"id":"https://openalex.org/W2162818680","doi":"https://doi.org/10.1530/erc-13-0274","title":"Circulating IGF system and treatment outcome in epithelial ovarian cancer","display_name":"Circulating IGF system and treatment outcome in epithelial ovarian cancer","publication_year":2013,"publication_date":"2013-11-22","ids":{"openalex":"https://openalex.org/W2162818680","doi":"https://doi.org/10.1530/erc-13-0274","mag":"2162818680","pmid":"https://pubmed.ncbi.nlm.nih.gov/24273235"},"language":"en","primary_location":{"id":"doi:10.1530/erc-13-0274","doi":"https://doi.org/10.1530/erc-13-0274","is_oa":true,"landing_page_url":"https://doi.org/10.1530/erc-13-0274","pdf_url":"https://erc.bioscientifica.com/downloadpdf/journals/erc/21/2/217.pdf","source":{"id":"https://openalex.org/S193349529","display_name":"Endocrine Related Cancer","issn_l":"1351-0088","issn":["1351-0088","1479-6821"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine-Related Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://erc.bioscientifica.com/downloadpdf/journals/erc/21/2/217.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076512663","display_name":"Yu-Fang Huang","orcid":"https://orcid.org/0000-0002-3832-1294","observed_orcids":["https://orcid.org/0000-0002-3832-1294"]},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]},{"id":"https://openalex.org/I4210158999","display_name":"National Cheng Kung University Hospital","ror":"https://ror.org/04zx3rq17","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210158999"]},{"id":"https://openalex.org/I91807558","display_name":"National Cheng Kung University","ror":"https://ror.org/01b8kcc49","country_code":"TW","type":"education","lineage":["https://openalex.org/I91807558"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yu-Fang Huang","raw_affiliation_strings":["Department of Obstetrics and Gynecology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 70403, Taiwan Department of Obstetrics and Gynecology, National Taiwan University, Taipei, Taiwan Center for Gene Regulation and Signal Transduction Research, National Cheng Kung University, Tainan, Taiwan","Department of Obstetrics and Gynecology, National Cheng Kung University Hospital, College of Medicine,","National Cheng Kung University, Tainan 70403, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 70403, Taiwan Department of Obstetrics and Gynecology, National Taiwan University, Taipei, Taiwan Center for Gene Regulation and Signal Transduction Research, National Cheng Kung University, Tainan, Taiwan","institution_ids":["https://openalex.org/I16733864","https://openalex.org/I4210158999","https://openalex.org/I91807558"]},{"raw_affiliation_string":"Department of Obstetrics and Gynecology, National Cheng Kung University Hospital, College of Medicine,","institution_ids":["https://openalex.org/I4210158999"]},{"raw_affiliation_string":"National Cheng Kung University, Tainan 70403, Taiwan","institution_ids":["https://openalex.org/I91807558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107072099","display_name":"Wen\u2010Fang Cheng","orcid":"https://orcid.org/0000-0002-3282-6304","observed_orcids":["https://orcid.org/0000-0002-3282-6304"]},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]},{"id":"https://openalex.org/I91807558","display_name":"National Cheng Kung University","ror":"https://ror.org/01b8kcc49","country_code":"TW","type":"education","lineage":["https://openalex.org/I91807558"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Wen-Fang Cheng","raw_affiliation_strings":["Department of Obstetrics and Gynecology , National Taiwan University , Taipei , Taiwan","National Cheng Kung University , Tainan 70403 , Taiwan","Department of Obstetrics and Gynecology, National Taiwan University, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology , National Taiwan University , Taipei , Taiwan","institution_ids":["https://openalex.org/I16733864"]},{"raw_affiliation_string":"National Cheng Kung University , Tainan 70403 , Taiwan","institution_ids":["https://openalex.org/I91807558"]},{"raw_affiliation_string":"Department of Obstetrics and Gynecology, National Taiwan University, Taipei, Taiwan","institution_ids":["https://openalex.org/I16733864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110267894","display_name":"Yu-Peng Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158999","display_name":"National Cheng Kung University Hospital","ror":"https://ror.org/04zx3rq17","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210158999"]},{"id":"https://openalex.org/I91807558","display_name":"National Cheng Kung University","ror":"https://ror.org/01b8kcc49","country_code":"TW","type":"education","lineage":["https://openalex.org/I91807558"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yu-Peng Wu","raw_affiliation_strings":["Department of Obstetrics and Gynecology , National Cheng Kung University Hospital , College of Medicine ,","Department of Obstetrics and Gynecology, National Cheng Kung University Hospital, College of Medicine,","National Cheng Kung University, Tainan 70403, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology , National Cheng Kung University Hospital , College of Medicine ,","institution_ids":["https://openalex.org/I4210158999"]},{"raw_affiliation_string":"Department of Obstetrics and Gynecology, National Cheng Kung University Hospital, College of Medicine,","institution_ids":["https://openalex.org/I4210158999"]},{"raw_affiliation_string":"National Cheng Kung University, Tainan 70403, Taiwan","institution_ids":["https://openalex.org/I91807558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108383399","display_name":"Ya-Min Cheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158999","display_name":"National Cheng Kung University Hospital","ror":"https://ror.org/04zx3rq17","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210158999"]},{"id":"https://openalex.org/I91807558","display_name":"National Cheng Kung University","ror":"https://ror.org/01b8kcc49","country_code":"TW","type":"education","lineage":["https://openalex.org/I91807558"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Ya-Min Cheng","raw_affiliation_strings":["Department of Obstetrics and Gynecology , National Cheng Kung University Hospital , College of Medicine ,","Department of Obstetrics and Gynecology, National Cheng Kung University Hospital, College of Medicine,","National Cheng Kung University, Tainan 70403, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology , National Cheng Kung University Hospital , College of Medicine ,","institution_ids":["https://openalex.org/I4210158999"]},{"raw_affiliation_string":"Department of Obstetrics and Gynecology, National Cheng Kung University Hospital, College of Medicine,","institution_ids":["https://openalex.org/I4210158999"]},{"raw_affiliation_string":"National Cheng Kung University, Tainan 70403, Taiwan","institution_ids":["https://openalex.org/I91807558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086128788","display_name":"Keng\u2010Fu Hsu","orcid":"https://orcid.org/0000-0002-2698-4971","observed_orcids":["https://orcid.org/0000-0002-2698-4971"]},"institutions":[{"id":"https://openalex.org/I4210158999","display_name":"National Cheng Kung University Hospital","ror":"https://ror.org/04zx3rq17","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210158999"]},{"id":"https://openalex.org/I91807558","display_name":"National Cheng Kung University","ror":"https://ror.org/01b8kcc49","country_code":"TW","type":"education","lineage":["https://openalex.org/I91807558"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Keng-Fu Hsu","raw_affiliation_strings":["Department of Obstetrics and Gynecology , National Cheng Kung University Hospital , College of Medicine ,","Department of Obstetrics and Gynecology, National Cheng Kung University Hospital, College of Medicine,","National Cheng Kung University, Tainan 70403, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology , National Cheng Kung University Hospital , College of Medicine ,","institution_ids":["https://openalex.org/I4210158999"]},{"raw_affiliation_string":"Department of Obstetrics and Gynecology, National Cheng Kung University Hospital, College of Medicine,","institution_ids":["https://openalex.org/I4210158999"]},{"raw_affiliation_string":"National Cheng Kung University, Tainan 70403, Taiwan","institution_ids":["https://openalex.org/I91807558"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073351431","display_name":"Cheng-Yang Chou","orcid":"https://orcid.org/0000-0003-4244-1421","observed_orcids":["https://orcid.org/0000-0003-4244-1421"]},"institutions":[{"id":"https://openalex.org/I4210158999","display_name":"National Cheng Kung University Hospital","ror":"https://ror.org/04zx3rq17","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210158999"]},{"id":"https://openalex.org/I91807558","display_name":"National Cheng Kung University","ror":"https://ror.org/01b8kcc49","country_code":"TW","type":"education","lineage":["https://openalex.org/I91807558"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Cheng-Yang Chou","raw_affiliation_strings":["Center for Gene Regulation and Signal Transduction Research , National Cheng Kung University , Tainan , Taiwan","Department of Obstetrics and Gynecology , National Cheng Kung University Hospital , College of Medicine ,","Center for Gene Regulation and Signal Transduction Research, National Cheng Kung University, Tainan, Taiwan","Department of Obstetrics and Gynecology, National Cheng Kung University Hospital, College of Medicine,","National Cheng Kung University, Tainan 70403, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Gene Regulation and Signal Transduction Research , National Cheng Kung University , Tainan , Taiwan","institution_ids":["https://openalex.org/I91807558"]},{"raw_affiliation_string":"Department of Obstetrics and Gynecology , National Cheng Kung University Hospital , College of Medicine ,","institution_ids":["https://openalex.org/I4210158999"]},{"raw_affiliation_string":"Center for Gene Regulation and Signal Transduction Research, National Cheng Kung University, Tainan, Taiwan","institution_ids":["https://openalex.org/I91807558"]},{"raw_affiliation_string":"Department of Obstetrics and Gynecology, National Cheng Kung University Hospital, College of Medicine,","institution_ids":["https://openalex.org/I4210158999"]},{"raw_affiliation_string":"National Cheng Kung University, Tainan 70403, Taiwan","institution_ids":["https://openalex.org/I91807558"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.5938,"has_fulltext":true,"cited_by_count":43,"citation_normalized_percentile":{"value":0.93792042,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"21","issue":"2","first_page":"217","last_page":"229"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.9351000189781189,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.9351000189781189,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.06300000101327896,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epithelial-ovarian-cancer","display_name":"epithelial ovarian cancer","score":0.9990000128746033},{"id":"https://openalex.org/keywords/igf-system","display_name":"IGF system","score":0.8510000109672546},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.8629999756813049},{"id":"https://openalex.org/keywords/igf-ii","display_name":"insulin-like growth factor II","score":1.0},{"id":"https://openalex.org/keywords/igfbp-2","display_name":"IGFBP-2","score":0.9539999961853027},{"id":"https://openalex.org/keywords/igfbp-3","display_name":"IGFBP-3","score":1.0},{"id":"https://openalex.org/keywords/circulating-biomarkers","display_name":"circulating biomarkers","score":0.8379999995231628},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7390000224113464},{"id":"https://openalex.org/keywords/cancer-mortality","display_name":"cancer mortality","score":0.699999988079071},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.7689999938011169},{"id":"https://openalex.org/keywords/cytoreduction","display_name":"cytoreduction","score":0.7329999804496765},{"id":"https://openalex.org/keywords/serous-histology","display_name":"serous histology","score":0.7400000095367432},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.7059999704360962},{"id":"https://openalex.org/keywords/platinum-based-chemotherapy","display_name":"platinum-based chemotherapy","score":0.5360000133514404}],"concepts":[{"id":"https://openalex.org/C2778279177","wikidata":"https://www.wikidata.org/wiki/Q18027678","display_name":"IGFBP3","level":4,"score":0.8602582216262817},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8345009684562683},{"id":"https://openalex.org/C150173356","wikidata":"https://www.wikidata.org/wiki/Q6144101","display_name":"Serous fluid","level":2,"score":0.7369971871376038},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.7217989563941956},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6345510482788086},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6235331296920776},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.6178301572799683},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.5718348026275635},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.5313147902488708},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.4997570514678955},{"id":"https://openalex.org/C57742111","wikidata":"https://www.wikidata.org/wiki/Q7168","display_name":"Histology","level":2,"score":0.48243555426597595},{"id":"https://openalex.org/C2992773878","wikidata":"https://www.wikidata.org/wiki/Q7645976","display_name":"Epithelial ovarian cancer","level":4,"score":0.4581088721752167},{"id":"https://openalex.org/C144301174","wikidata":"https://www.wikidata.org/wiki/Q7893852","display_name":"Univariate analysis","level":3,"score":0.45784372091293335},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.4200909435749054},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.376792848110199},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.24450036883354187},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.20330730080604553},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.10599002242088318},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.06654679775238037},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077216","descriptor_name":"Carcinoma, Ovarian Epithelial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077216","descriptor_name":"Carcinoma, Ovarian Epithelial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077216","descriptor_name":"Carcinoma, Ovarian Epithelial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007334","descriptor_name":"Insulin-Like Growth Factor I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007334","descriptor_name":"Insulin-Like Growth Factor I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007334","descriptor_name":"Insulin-Like Growth Factor I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007335","descriptor_name":"Insulin-Like Growth Factor II","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007335","descriptor_name":"Insulin-Like Growth Factor II","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007335","descriptor_name":"Insulin-Like Growth Factor II","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009375","descriptor_name":"Neoplasms, Glandular and Epithelial","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009375","descriptor_name":"Neoplasms, Glandular and Epithelial","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009375","descriptor_name":"Neoplasms, Glandular and Epithelial","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009375","descriptor_name":"Neoplasms, Glandular and Epithelial","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009375","descriptor_name":"Neoplasms, Glandular and Epithelial","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009375","descriptor_name":"Neoplasms, Glandular and Epithelial","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009375","descriptor_name":"Neoplasms, Glandular and Epithelial","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D009375","descriptor_name":"Neoplasms, Glandular and Epithelial","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D009375","descriptor_name":"Neoplasms, Glandular and Epithelial","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D009375","descriptor_name":"Neoplasms, Glandular and Epithelial","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D009375","descriptor_name":"Neoplasms, Glandular and Epithelial","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D009375","descriptor_name":"Neoplasms, Glandular and Epithelial","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017024","descriptor_name":"Chemotherapy, Adjuvant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017024","descriptor_name":"Chemotherapy, Adjuvant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017024","descriptor_name":"Chemotherapy, Adjuvant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018572","descriptor_name":"Disease-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018572","descriptor_name":"Disease-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018572","descriptor_name":"Disease-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018971","descriptor_name":"Insulin-Like Growth Factor Binding Protein 2","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D018971","descriptor_name":"Insulin-Like Growth Factor Binding Protein 2","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D018971","descriptor_name":"Insulin-Like Growth Factor Binding Protein 2","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D018972","descriptor_name":"Insulin-Like Growth Factor Binding Protein 3","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D018972","descriptor_name":"Insulin-Like Growth Factor Binding Protein 3","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D018972","descriptor_name":"Insulin-Like Growth Factor Binding Protein 3","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057234","descriptor_name":"Preoperative Period","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057234","descriptor_name":"Preoperative Period","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057234","descriptor_name":"Preoperative Period","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1530/erc-13-0274","doi":"https://doi.org/10.1530/erc-13-0274","is_oa":true,"landing_page_url":"https://doi.org/10.1530/erc-13-0274","pdf_url":"https://erc.bioscientifica.com/downloadpdf/journals/erc/21/2/217.pdf","source":{"id":"https://openalex.org/S193349529","display_name":"Endocrine Related Cancer","issn_l":"1351-0088","issn":["1351-0088","1479-6821"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine-Related Cancer","raw_type":"journal-article"},{"id":"pmid:24273235","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24273235","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine-related cancer","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1530/erc-13-0274","doi":"https://doi.org/10.1530/erc-13-0274","is_oa":true,"landing_page_url":"https://doi.org/10.1530/erc-13-0274","pdf_url":"https://erc.bioscientifica.com/downloadpdf/journals/erc/21/2/217.pdf","source":{"id":"https://openalex.org/S193349529","display_name":"Endocrine Related Cancer","issn_l":"1351-0088","issn":["1351-0088","1479-6821"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine-Related Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8799999952316284}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320322933","display_name":"National Cheng Kung University Hospital","ror":"https://ror.org/04zx3rq17"},{"id":"https://openalex.org/F4320324663","display_name":"National Cheng Kung University","ror":"https://ror.org/01b8kcc49"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2162818680.pdf","grobid_xml":"https://content.openalex.org/works/W2162818680.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W1904552623","https://openalex.org/W1977424304","https://openalex.org/W1980870023","https://openalex.org/W1992048053","https://openalex.org/W1996832816","https://openalex.org/W1998893299","https://openalex.org/W2010491075","https://openalex.org/W2019607817","https://openalex.org/W2038015391","https://openalex.org/W2042752592","https://openalex.org/W2049853609","https://openalex.org/W2053793483","https://openalex.org/W2060965633","https://openalex.org/W2072213084","https://openalex.org/W2072291699","https://openalex.org/W2073211186","https://openalex.org/W2077594233","https://openalex.org/W2078874563","https://openalex.org/W2081263829","https://openalex.org/W2083964372","https://openalex.org/W2087481795","https://openalex.org/W2089171551","https://openalex.org/W2090313011","https://openalex.org/W2093998980","https://openalex.org/W2096698259","https://openalex.org/W2097265582","https://openalex.org/W2098421558","https://openalex.org/W2099052946","https://openalex.org/W2104422483","https://openalex.org/W2109449896","https://openalex.org/W2111792530","https://openalex.org/W2111843196","https://openalex.org/W2113895678","https://openalex.org/W2128868545","https://openalex.org/W2130202432","https://openalex.org/W2131593373","https://openalex.org/W2132577252","https://openalex.org/W2133289313","https://openalex.org/W2135737149","https://openalex.org/W2135749247","https://openalex.org/W2151472455","https://openalex.org/W2151686833","https://openalex.org/W2163833439","https://openalex.org/W2165151551","https://openalex.org/W2165948908","https://openalex.org/W2168673222","https://openalex.org/W2170275689","https://openalex.org/W2170377257","https://openalex.org/W2171694243","https://openalex.org/W2441681936","https://openalex.org/W3021777772","https://openalex.org/W3028515504","https://openalex.org/W3035130918","https://openalex.org/W4212835986","https://openalex.org/W4246296957"],"related_works":["https://openalex.org/W2982417076","https://openalex.org/W3216038065","https://openalex.org/W2080565864","https://openalex.org/W4293147495","https://openalex.org/W2006344570","https://openalex.org/W2169606653","https://openalex.org/W2043640895","https://openalex.org/W2035026116","https://openalex.org/W1605137393","https://openalex.org/W2280645111"],"abstract_inverted_index":{"Aggressive":[0],"epithelial":[1],"ovarian":[2],"cancers":[3],"(EOCs)":[4],"frequently":[5],"progress":[6],"and":[7,53,82,102,109,122,132,142,155,167,171,184,188,194,234],"become":[8],"fatal,":[9],"even":[10],"when":[11],"cytoreduction":[12],"surgery":[13],"plus":[14],"platinum-based":[15],"chemotherapy":[16],"are":[17],"performed.":[18],"Thus,":[19],"the":[20,46,89,243,250],"early":[21,150,224],"detection":[22],"of":[23,48,70,85,94,120,208,226,231,245],"high-risk":[24],"subgroups":[25],"is":[26],"important":[27],"in":[28,59,88,130],"order":[29],"to":[30,44],"provide":[31],"opportunities":[32],"for":[33],"better":[34,177],"treatment":[35,57],"outcomes,":[36],"using":[37,106,126],"alternative":[38],"therapeutic":[39],"strategies.":[40],"This":[41],"study":[42],"aimed":[43],"explore":[45],"expression":[47],"circulating":[49],"IGF":[50],"system":[51],"components":[52],"their":[54],"relationship":[55],"with":[56,65,148,163,180,205,249],"outcome":[58],"EOC.":[60],"We":[61],"included":[62],"228":[63],"patients":[64,179],"a":[66,246],"median":[67],"follow-up":[68],"time":[69],"44":[71],"months":[72],"at":[73,238],"two":[74],"tertiary":[75],"centers.":[76],"There":[77],"were":[78,104,110,124,145,161,175,202],"68":[79],"cancer":[80,86,151],"deaths":[81],"108":[83],"cases":[84],"progression":[87,123],"cohort.":[90],"Preoperative":[91],"serum":[92,199],"levels":[93,144,160,192,201,237],"total":[95],"IGF1,":[96,140],"IGF2,":[97,141],"IGF-binding":[98],"protein":[99],"2":[100],"(IGFBP2),":[101],"IGFBP3":[103,143,191],"analyzed":[105],"an":[107,114,149,164,223],"ELISA":[108],"then":[111],"converted":[112],"into":[113],"IGF1:IGFBP3":[115],"molar":[116],"ratio.":[117],"The":[118,229],"risks":[119],"mortality":[121,209],"estimated":[125],"Cox":[127],"regression":[128],"models":[129],"univariate":[131],"multivariate":[133,197],"analyses.":[134],"Our":[135],"results":[136],"showed":[137],"that":[138,217],"high":[139,181],"significantly":[146,176,203],"associated":[147,162,204],"stage,":[152],"non-serous":[153],"histology,":[154],"optimal":[156],"cytoreduction.":[157],"High":[158],"IGFBP2":[159,200,218,233],"advanced":[165],"stage":[166],"serous":[168],"histology.":[169],"Overall":[170],"progression-free":[172],"survival":[173],"durations":[174],"among":[178],"IGF1":[182,236],"(P=0.003":[183,187],"P=0.001),":[185],"IGF2":[186],"P=0.02),":[189],"or":[190],"(P=0.02":[193],"P=0.008).":[195],"In":[196],"analysis,":[198],"increased":[206],"risk":[207],"(hazard":[210],"ratio=1.84,":[211],"95%":[212],"CI:":[213],"1.07-3.18,":[214],"P=0.03),":[215],"indicating":[216],"could":[219,240],"be":[220],"used":[221],"as":[222],"predictor":[225],"EOC-related":[227],"mortality.":[228],"combination":[230],"elevated":[232],"reduced":[235],"diagnosis":[239],"further":[241],"facilitate":[242],"identification":[244],"patient":[247],"subgroup":[248],"worst":[251],"prognosis.":[252]},"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}
