{"id":"https://openalex.org/W2162801973","doi":"https://doi.org/10.3324/haematol.11891","title":"Karyotype at diagnosis is the major prognostic factor predicting relapse-free survival for patients with Philadelphia chromosome-positive acute lymphoblastic leukemia treated with imatinib-combined chemotherapy","display_name":"Karyotype at diagnosis is the major prognostic factor predicting relapse-free survival for patients with Philadelphia chromosome-positive acute lymphoblastic leukemia treated with imatinib-combined chemotherapy","publication_year":2008,"publication_date":"2008-01-26","ids":{"openalex":"https://openalex.org/W2162801973","doi":"https://doi.org/10.3324/haematol.11891","mag":"2162801973","pmid":"https://pubmed.ncbi.nlm.nih.gov/18223280"},"language":"en","primary_location":{"id":"doi:10.3324/haematol.11891","doi":"https://doi.org/10.3324/haematol.11891","is_oa":true,"landing_page_url":"https://doi.org/10.3324/haematol.11891","pdf_url":null,"source":{"id":"https://openalex.org/S2752781272","display_name":"Haematologica","issn_l":"0390-6078","issn":["0390-6078","1592-8721"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317774","host_organization_name":"Ferrata Storti Foundation","host_organization_lineage":["https://openalex.org/P4310317774"],"host_organization_lineage_names":["Ferrata Storti Foundation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haematologica","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3324/haematol.11891","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024134742","display_name":"Masamitsu Yanada","orcid":"https://orcid.org/0000-0003-1602-9775","observed_orcids":["https://orcid.org/0000-0003-1602-9775"]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"M. Yanada","raw_affiliation_strings":["Nagoya University Graduate School of Medicine, Nagoya, Japan. myanada@mdanderson.org","From the Nagoya University Graduate School of Medicine, Nagoya;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nagoya University Graduate School of Medicine, Nagoya, Japan. myanada@mdanderson.org","institution_ids":["https://openalex.org/I60134161"]},{"raw_affiliation_string":"From the Nagoya University Graduate School of Medicine, Nagoya;","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083548120","display_name":"J. Takeuchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I104946051","display_name":"Nihon University","ror":"https://ror.org/05jk51a88","country_code":"JP","type":"education","lineage":["https://openalex.org/I104946051"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"J. Takeuchi","raw_affiliation_strings":["Nihon University School of Medicine, Tokyo;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nihon University School of Medicine, Tokyo;","institution_ids":["https://openalex.org/I104946051"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010994282","display_name":"Isamu Sugiura","orcid":"https://orcid.org/0000-0002-4430-7544","observed_orcids":["https://orcid.org/0000-0002-4430-7544"]},"institutions":[{"id":"https://openalex.org/I4210145862","display_name":"Toyohashi Municipal Hospital","ror":"https://ror.org/03h3tds63","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210145862"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"I. Sugiura","raw_affiliation_strings":["Toyohashi Municipal Hospital, Toyohashi;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Toyohashi Municipal Hospital, Toyohashi;","institution_ids":["https://openalex.org/I4210145862"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084880219","display_name":"Hideki Akiyama","orcid":"https://orcid.org/0000-0001-5788-8555","observed_orcids":["https://orcid.org/0000-0001-5788-8555"]},"institutions":[{"id":"https://openalex.org/I3020605285","display_name":"Tokyo Metropolitan Komagome Hospital","ror":"https://ror.org/04eqd2f30","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I3020605285"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H. Akiyama","raw_affiliation_strings":["Tokyo Metropolitan Komagome Hospital, Tokyo;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tokyo Metropolitan Komagome Hospital, Tokyo;","institution_ids":["https://openalex.org/I3020605285"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111484615","display_name":"Noriko Usui","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I115498069","display_name":"Jikei University School of Medicine","ror":"https://ror.org/039ygjf22","country_code":"JP","type":"education","lineage":["https://openalex.org/I115498069"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"N. Usui","raw_affiliation_strings":["Jikei University School of Medicine, Tokyo;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jikei University School of Medicine, Tokyo;","institution_ids":["https://openalex.org/I115498069"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053310296","display_name":"F. Yagasaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8588240","display_name":"Saitama Medical University","ror":"https://ror.org/04zb31v77","country_code":"JP","type":"education","lineage":["https://openalex.org/I8588240"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"F. Yagasaki","raw_affiliation_strings":["Saitama Medical University, Saitama;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Saitama Medical University, Saitama;","institution_ids":["https://openalex.org/I8588240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070745575","display_name":"Kazuhiro Nishii","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I178574317","display_name":"Mie University","ror":"https://ror.org/01529vy56","country_code":"JP","type":"education","lineage":["https://openalex.org/I178574317"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K. Nishii","raw_affiliation_strings":["Mie University School of Medicine, Tsu;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mie University School of Medicine, Tsu;","institution_ids":["https://openalex.org/I178574317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103131907","display_name":"Yasunori Ueda","orcid":"https://orcid.org/0000-0002-4487-5808","observed_orcids":["https://orcid.org/0000-0002-4487-5808"]},"institutions":[{"id":"https://openalex.org/I4210089671","display_name":"Kurashiki Central Hospital","ror":"https://ror.org/00947s692","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210089671"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Y. Ueda","raw_affiliation_strings":["Kurashiki Central Hospital, Kurashiki;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kurashiki Central Hospital, Kurashiki;","institution_ids":["https://openalex.org/I4210089671"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063485086","display_name":"M. Takeuchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405282719","display_name":"National Hospital Organization Minami-Okayama Medical Center","ror":"https://ror.org/00c60fh73","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137409","https://openalex.org/I4405282719"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M. Takeuchi","raw_affiliation_strings":["National Hospital Organization Minami-Okayama Medical Center, Okayama;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Hospital Organization Minami-Okayama Medical Center, Okayama;","institution_ids":["https://openalex.org/I4405282719"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108622738","display_name":"Shuich Miyawaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133122","display_name":"Gunma Saiseikai Maebashi Hospital","ror":"https://ror.org/033js5093","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210133122"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"S. Miyawaki","raw_affiliation_strings":["Saiseikai Maebashi Hospital, Maebashi;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Saiseikai Maebashi Hospital, Maebashi;","institution_ids":["https://openalex.org/I4210133122"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112162446","display_name":"A Maruta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387152949","display_name":"Kanagawa Cancer Center","ror":"https://ror.org/00aapa202","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4387152949"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"A. Maruta","raw_affiliation_strings":["Kanagawa Cancer Center, Yokohama;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kanagawa Cancer Center, Yokohama;","institution_ids":["https://openalex.org/I4387152949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071023244","display_name":"Hiroto Narimatsu","orcid":"https://orcid.org/0000-0002-5302-5872","observed_orcids":["https://orcid.org/0000-0002-5302-5872","https://orcid.org/0000-0002-0383-4911"]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H. Narimatsu","raw_affiliation_strings":["From the Nagoya University Graduate School of Medicine, Nagoya;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Nagoya University Graduate School of Medicine, Nagoya;","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070702322","display_name":"Yasushi Miyazaki","orcid":"https://orcid.org/0000-0003-3683-7147","observed_orcids":["https://orcid.org/0000-0003-3683-7147"]},"institutions":[{"id":"https://openalex.org/I43777268","display_name":"Nagasaki University","ror":"https://ror.org/058h74p94","country_code":"JP","type":"education","lineage":["https://openalex.org/I43777268"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Y. Miyazaki","raw_affiliation_strings":["Nagasaki University Graduate School of Biomedical Sciences, Nagasaki;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nagasaki University Graduate School of Biomedical Sciences, Nagasaki;","institution_ids":["https://openalex.org/I43777268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013146671","display_name":"Shigeki Ohtake","orcid":"https://orcid.org/0000-0003-0112-6564","observed_orcids":["https://orcid.org/0000-0003-0112-6564"]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"S. Ohtake","raw_affiliation_strings":["Kanazawa University Graduate School of Medical Science, Kanazawa;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kanazawa University Graduate School of Medical Science, Kanazawa;","institution_ids":["https://openalex.org/I10091056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062828203","display_name":"Itsuro Jinnai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8588240","display_name":"Saitama Medical University","ror":"https://ror.org/04zb31v77","country_code":"JP","type":"education","lineage":["https://openalex.org/I8588240"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"I. Jinnai","raw_affiliation_strings":["Saitama Medical University, Saitama;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Saitama Medical University, Saitama;","institution_ids":["https://openalex.org/I8588240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066277266","display_name":"Keitaro Matsuo","orcid":"https://orcid.org/0000-0003-1761-6314","observed_orcids":["https://orcid.org/0000-0003-1761-6314"]},"institutions":[{"id":"https://openalex.org/I4210133851","display_name":"Aichi Cancer Center","ror":"https://ror.org/03kfmm080","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210133851"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K. Matsuo","raw_affiliation_strings":["Aichi Cancer Center, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aichi Cancer Center, Nagoya, Japan","institution_ids":["https://openalex.org/I4210133851"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084655190","display_name":"Takashi Naoe","orcid":"https://orcid.org/0000-0001-5300-8223","observed_orcids":["https://orcid.org/0000-0001-5300-8223"]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T. Naoe","raw_affiliation_strings":["From the Nagoya University Graduate School of Medicine, Nagoya;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Nagoya University Graduate School of Medicine, Nagoya;","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063488239","display_name":"R Ohno","orcid":"https://orcid.org/0009-0005-9972-5013","observed_orcids":["https://orcid.org/0009-0005-9972-5013"]},"institutions":[{"id":"https://openalex.org/I4210133851","display_name":"Aichi Cancer Center","ror":"https://ror.org/03kfmm080","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210133851"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"R. Ohno","raw_affiliation_strings":["Aichi Cancer Center, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aichi Cancer Center, Nagoya, Japan","institution_ids":["https://openalex.org/I4210133851"]}]},{"author_position":"last","author":{"id":null,"display_name":"for the Japan Adult Leukemia Study Group","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"for the Japan Adult Leukemia Study Group","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":14,"corresponding_author_ids":["https://openalex.org/A5024134742"],"corresponding_institution_ids":["https://openalex.org/I60134161"],"apc_list":{"value":2000,"currency":"EUR","value_usd":2157},"apc_paid":{"value":2000,"currency":"EUR","value_usd":2157},"fwci":6.3797,"has_fulltext":true,"cited_by_count":64,"citation_normalized_percentile":{"value":0.96921903,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"93","issue":"2","first_page":"287","last_page":"290"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.00570000009611249,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/philadelphia-chromosome-positive-acute-lymphoblastic-leukemia","display_name":"Philadelphia chromosome-positive acute lymphoblastic leukemia","score":0.9959999918937683},{"id":"https://openalex.org/keywords/imatinib","display_name":"imatinib","score":0.8550000190734863},{"id":"https://openalex.org/keywords/relapse-free-survival","display_name":"relapse-free survival","score":0.9039999842643738},{"id":"https://openalex.org/keywords/karyotype","display_name":"karyotype","score":0.8080000281333923},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9369999766349792},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.5519999861717224},{"id":"https://openalex.org/keywords/treatment-failure","display_name":"treatment failure","score":0.6600000262260437}],"concepts":[{"id":"https://openalex.org/C2777583451","wikidata":"https://www.wikidata.org/wiki/Q177094","display_name":"Imatinib","level":3,"score":0.8241616487503052},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7734361886978149},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.731907308101654},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6183461546897888},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5927634835243225},{"id":"https://openalex.org/C2778904597","wikidata":"https://www.wikidata.org/wiki/Q1129111","display_name":"Philadelphia chromosome","level":4,"score":0.5850754380226135},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.5708171129226685},{"id":"https://openalex.org/C2909962599","wikidata":"https://www.wikidata.org/wiki/Q180664","display_name":"Lymphoblastic Leukemia","level":3,"score":0.5220986604690552},{"id":"https://openalex.org/C53226629","wikidata":"https://www.wikidata.org/wiki/Q189967","display_name":"Karyotype","level":4,"score":0.5054886341094971},{"id":"https://openalex.org/C194409129","wikidata":"https://www.wikidata.org/wiki/Q103824","display_name":"Hematology","level":2,"score":0.4260578155517578},{"id":"https://openalex.org/C3019719930","wikidata":"https://www.wikidata.org/wiki/Q3910099","display_name":"Predictive value","level":2,"score":0.4248875379562378},{"id":"https://openalex.org/C2781107101","wikidata":"https://www.wikidata.org/wiki/Q180664","display_name":"Acute lymphocytic leukemia","level":4,"score":0.4232650399208069},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.3316088914871216},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.3293144106864929},{"id":"https://openalex.org/C138626823","wikidata":"https://www.wikidata.org/wiki/Q916504","display_name":"Chromosomal translocation","level":3,"score":0.17537307739257812},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11982139945030212},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.080502450466156},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07705479860305786},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000068877","descriptor_name":"Imatinib Mesylate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D001549","descriptor_name":"Benzamides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007621","descriptor_name":"Karyotyping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010677","descriptor_name":"Philadelphia Chromosome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014184","descriptor_name":"Transplantation, Homologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018380","descriptor_name":"Hematopoietic Stem Cell Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018572","descriptor_name":"Disease-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054198","descriptor_name":"Precursor Cell Lymphoblastic Leukemia-Lymphoma","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D054198","descriptor_name":"Precursor Cell Lymphoblastic Leukemia-Lymphoma","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D054198","descriptor_name":"Precursor Cell Lymphoblastic Leukemia-Lymphoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D054198","descriptor_name":"Precursor Cell Lymphoblastic Leukemia-Lymphoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.3324/haematol.11891","doi":"https://doi.org/10.3324/haematol.11891","is_oa":true,"landing_page_url":"https://doi.org/10.3324/haematol.11891","pdf_url":null,"source":{"id":"https://openalex.org/S2752781272","display_name":"Haematologica","issn_l":"0390-6078","issn":["0390-6078","1592-8721"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317774","host_organization_name":"Ferrata Storti Foundation","host_organization_lineage":["https://openalex.org/P4310317774"],"host_organization_lineage_names":["Ferrata Storti Foundation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haematologica","raw_type":"journal-article"},{"id":"pmid:18223280","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18223280","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haematologica","raw_type":"Clinical Trial, Phase II"},{"id":"pmh:oai:doaj.org/article:5e4b4da313874836a8be830d424b4481","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/5e4b4da313874836a8be830d424b4481","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Haematologica, Vol 93, Iss 2 (2008)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3324/haematol.11891","doi":"https://doi.org/10.3324/haematol.11891","is_oa":true,"landing_page_url":"https://doi.org/10.3324/haematol.11891","pdf_url":null,"source":{"id":"https://openalex.org/S2752781272","display_name":"Haematologica","issn_l":"0390-6078","issn":["0390-6078","1592-8721"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317774","host_organization_name":"Ferrata Storti Foundation","host_organization_lineage":["https://openalex.org/P4310317774"],"host_organization_lineage_names":["Ferrata Storti Foundation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haematologica","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W585439232","https://openalex.org/W1972723665","https://openalex.org/W1994309500","https://openalex.org/W2000116184","https://openalex.org/W2010474569","https://openalex.org/W2041353685","https://openalex.org/W2051262530","https://openalex.org/W2054251966","https://openalex.org/W2063898537","https://openalex.org/W2080380323","https://openalex.org/W2087090648","https://openalex.org/W2089360398","https://openalex.org/W2095713049","https://openalex.org/W2099616647","https://openalex.org/W2105098746","https://openalex.org/W2109292561","https://openalex.org/W2139499066","https://openalex.org/W2148854558","https://openalex.org/W2153701773","https://openalex.org/W2220697339","https://openalex.org/W2237775825"],"related_works":["https://openalex.org/W2564813147","https://openalex.org/W2052283488","https://openalex.org/W1931165463","https://openalex.org/W2761908341","https://openalex.org/W2925190659","https://openalex.org/W2101757639","https://openalex.org/W2346950917","https://openalex.org/W2547613927","https://openalex.org/W1973000511","https://openalex.org/W2766992351"],"abstract_inverted_index":{"To":[0],"identify":[1],"factors":[2],"associated":[3],"with":[4,10],"relapse-free":[5],"survival":[6],"(RFS),":[7],"80":[8],"patients":[9,34,45],"newly":[11],"diagnosed":[12],"Philadelphia":[13],"chromosome-positive":[14],"acute":[15],"lymphoblastic":[16],"leukemia,":[17],"enrolled":[18],"in":[19,70],"a":[20],"phase":[21],"II":[22],"study":[23],"of":[24,32,43,53,66,88],"imatinib-combined":[25],"chemotherapy,":[26],"were":[27],"analyzed.":[28],"The":[29,51],"median":[30],"follow-up":[31],"surviving":[33],"was":[35,55],"26.7":[36],"months":[37],"(maximum,":[38],"52.5":[39],"months).":[40],"Twenty-eight":[41],"out":[42],"77":[44],"who":[46],"had":[47],"achieved":[48],"CR":[49],"relapsed.":[50],"probability":[52],"RFS":[54,82],"50.5%":[56],"at":[57,74],"2":[58],"years.":[59],"Multivariate":[60],"analysis":[61],"revealed":[62],"that":[63],"the":[64,86],"presence":[65],"secondary":[67],"chromosome":[68],"aberrations":[69],"addition":[71],"to":[72],"t(9;22)":[73],"diagnosis":[75],"constitute":[76],"an":[77],"independent":[78],"predictive":[79],"value":[80],"for":[81],"(p=0.027),":[83],"and":[84],"increase":[85],"risk":[87],"treatment":[89],"failure":[90],"by":[91],"2.8-fold.":[92]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}