{"id":"https://openalex.org/W2162755729","doi":null,"title":"Pharmacokinetics of pirfenidone after topical administration in rabbit eye.","display_name":"Pharmacokinetics of pirfenidone after topical administration in rabbit eye.","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W2162755729","mag":"2162755729","pmid":"https://pubmed.ncbi.nlm.nih.gov/21866212","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3159682"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:2165288","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3159682","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3159682","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102898359","display_name":"Guoying Sun","orcid":"https://orcid.org/0000-0003-3318-390X","observed_orcids":["https://orcid.org/0000-0003-3318-390X"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4391768270","display_name":"State Key Laboratory of Ophthalmology","ror":"https://ror.org/003mfbe21","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768270"]},{"id":"https://openalex.org/I4401726874","display_name":"Zhongshan Ophthalmic Center, Sun Yat-sen University","ror":"https://ror.org/02z2yec16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I157773358","https://openalex.org/I4401726874"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guoying Sun","raw_affiliation_strings":["State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4391768270","https://openalex.org/I4401726874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072095183","display_name":"Xianchai Lin","orcid":"https://orcid.org/0000-0002-9483-4043","observed_orcids":["https://orcid.org/0000-0002-9483-4043"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xianchai Lin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101663416","display_name":"Hua Zhong","orcid":"https://orcid.org/0000-0001-9604-4523","observed_orcids":["https://orcid.org/0000-0001-9604-4523"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hua Zhong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101475006","display_name":"Yangfan Yang","orcid":"https://orcid.org/0000-0001-9021-9652","observed_orcids":["https://orcid.org/0000-0001-9021-9652","https://orcid.org/0000-0002-0007-6481"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yangfan Yang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101729158","display_name":"Xuan Qiu","orcid":"https://orcid.org/0000-0002-1721-7893","observed_orcids":["https://orcid.org/0000-0002-1721-7893"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xuan Qiu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013935299","display_name":"Chengtian Ye","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chengtian Ye","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083220985","display_name":"Kaili Wu","orcid":"https://orcid.org/0000-0003-3606-683X","observed_orcids":["https://orcid.org/0000-0003-3606-683X","https://orcid.org/0000-0002-3938-7164"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kaili Wu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5046082086","display_name":"Minbin Yu","orcid":"https://orcid.org/0000-0002-3938-7164","observed_orcids":["https://orcid.org/0000-0002-3938-7164"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Minbin Yu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.4204,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.82049461,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"17","issue":null,"first_page":"2191","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.7426999807357788,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.7426999807357788,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11826","display_name":"Ocular Infections and Treatments","score":0.10189999639987946,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13467","display_name":"Drug-Induced Ocular Toxicity","score":0.05920000001788139,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pirfenidone","display_name":"pirfenidone","score":1.0},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.847000002861023},{"id":"https://openalex.org/keywords/topical-ocular-administration","display_name":"topical ocular administration","score":0.8560000061988831},{"id":"https://openalex.org/keywords/glaucoma-filtering-surgery","display_name":"glaucoma filtration surgery","score":0.7900000214576721},{"id":"https://openalex.org/keywords/wound-healing-modulation","display_name":"wound healing modulation","score":0.7540000081062317},{"id":"https://openalex.org/keywords/tenon-s-fibroblasts","display_name":"Tenon's fibroblasts","score":0.8880000114440918},{"id":"https://openalex.org/keywords/ocular-tissue-distribution","display_name":"ocular tissue distribution","score":0.7419999837875366},{"id":"https://openalex.org/keywords/aqueous-humor","display_name":"aqueous humor","score":0.9440000057220459},{"id":"https://openalex.org/keywords/vitreous-body","display_name":"vitreous humor","score":0.859000027179718},{"id":"https://openalex.org/keywords/rabbit-eye","display_name":"rabbit eye","score":0.49000000953674316}],"concepts":[{"id":"https://openalex.org/C2779832356","wikidata":"https://www.wikidata.org/wiki/Q2060696","display_name":"Pirfenidone","level":4,"score":0.9431582093238831},{"id":"https://openalex.org/C2777100477","wikidata":"https://www.wikidata.org/wiki/Q193107","display_name":"Sclera","level":2,"score":0.8080636262893677},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.7672150135040283},{"id":"https://openalex.org/C2776882836","wikidata":"https://www.wikidata.org/wiki/Q168291","display_name":"Cornea","level":2,"score":0.7380404472351074},{"id":"https://openalex.org/C2775984611","wikidata":"https://www.wikidata.org/wiki/Q273554","display_name":"Conjunctiva","level":2,"score":0.6988884806632996},{"id":"https://openalex.org/C22979827","wikidata":"https://www.wikidata.org/wiki/Q5137311","display_name":"Cmax","level":3,"score":0.6530203819274902},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5812183618545532},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5507909655570984},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.495187908411026},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.3679083287715912},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34899216890335083},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.22869369387626648},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.22580167651176453},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14727914333343506},{"id":"https://openalex.org/C2778341716","wikidata":"https://www.wikidata.org/wiki/Q2290446","display_name":"Idiopathic pulmonary fibrosis","level":3,"score":0.090354323387146},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.08769622445106506}],"mesh":[{"descriptor_ui":"D000287","descriptor_name":"Administration, Topical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001082","descriptor_name":"Aqueous Humor","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003228","descriptor_name":"Conjunctiva","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003315","descriptor_name":"Cornea","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005901","descriptor_name":"Glaucoma","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D006207","descriptor_name":"Half-Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011728","descriptor_name":"Pyridones","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011728","descriptor_name":"Pyridones","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D011728","descriptor_name":"Pyridones","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012590","descriptor_name":"Sclera","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013508","descriptor_name":"Ophthalmologic Surgical Procedures","qualifier_ui":"Q000534","qualifier_name":"rehabilitation","is_major_topic":true},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014822","descriptor_name":"Vitreous Body","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":5,"locations":[{"id":"pmh:oai:europepmc.org:2165288","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3159682","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3159682","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3159682","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Vis","raw_type":"Text"},{"id":"pmid:21866212","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21866212","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular vision","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.289.6103","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.289.6103","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/7f/67/Mol_Vis_2011_Aug_13_17_2191-2196.tar.gz","raw_type":"text"},{"id":"mag:2162755729","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21866212","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2165288","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3159682","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W27771297","https://openalex.org/W415169725","https://openalex.org/W1493760002","https://openalex.org/W1976957021","https://openalex.org/W1985720621","https://openalex.org/W1989399186","https://openalex.org/W1990180574","https://openalex.org/W1991507710","https://openalex.org/W2005968813","https://openalex.org/W2007624423","https://openalex.org/W2008587410","https://openalex.org/W2018534552","https://openalex.org/W2023903257","https://openalex.org/W2028643690","https://openalex.org/W2029181407","https://openalex.org/W2030837762","https://openalex.org/W2032622848","https://openalex.org/W2047047519","https://openalex.org/W2057266151","https://openalex.org/W2059017633","https://openalex.org/W2062387633","https://openalex.org/W2062857098","https://openalex.org/W2075659939","https://openalex.org/W2088377079","https://openalex.org/W2119951132","https://openalex.org/W2142941142","https://openalex.org/W2146248292","https://openalex.org/W2152237318","https://openalex.org/W2157429545","https://openalex.org/W2163147529","https://openalex.org/W2331546129","https://openalex.org/W2340174723","https://openalex.org/W2472801988","https://openalex.org/W4406056548"],"related_works":["https://openalex.org/W7098909408","https://openalex.org/W2914421535","https://openalex.org/W1990673243","https://openalex.org/W3121789561","https://openalex.org/W2033538268","https://openalex.org/W2338029131","https://openalex.org/W3112996183","https://openalex.org/W2940345362","https://openalex.org/W1275423691","https://openalex.org/W3111205808"],"abstract_inverted_index":{"PURPOSE:":[0],"Pirfenidone":[1,50],"(5-methyl-1-phenyl-2-[1H]-pyridone)":[2],"is":[3],"a":[4],"new,":[5],"broad-spectrum":[6],"agent":[7],"that":[8],"has":[9],"an":[10,188],"inhibition":[11],"effect":[12],"on":[13],"the":[14,27,39,57,80,120],"proliferation,":[15],"migration,":[16],"and":[17,24,76,82,97,114,137,148,162],"collagen":[18],"contraction":[19],"of":[20,31,41,89,117,129,169,184,193],"human":[21],"Tenon's":[22],"fibroblasts,":[23],"thus":[25],"modulating":[26],"wound":[28,194],"healing":[29,195],"process":[30],"glaucoma":[32,198],"filtering":[33],"surgical":[34,200],"site.":[35,201],"This":[36],"study":[37],"investigated":[38],"pharmacokinetics":[40],"topically":[42],"administered":[43],"pirfenidone":[44,90,118,130,170,185],"(0.5%)":[45],"in":[46,91,131,173,179,197],"rabbit":[47,180],"eyes.":[48],"METHODS:":[49],"solution":[51],"(50":[52],"\u03bcl)":[53],"was":[54,111,157],"instilled":[55],"into":[56],"rabbit's":[58],"conjunctival":[59],"sac.":[60],"The":[61,87,124,152],"rabbits":[62],"were":[63,85,99,139],"quickly":[64],"sacrificed":[65],"at":[66],"2,":[67],"5,":[68],"8,":[69],"10,":[70],"15,":[71],"20,":[72],"30,":[73],"60,":[74],"90,":[75],"120":[77],"min":[78],"after":[79,176],"administration":[81,183],"ocular":[83,122,174],"tissues":[84,156,175],"obtained.":[86],"concentrations":[88,127,168],"conjunctiva,":[92,133],"sclera,":[93,134],"cornea,":[94,132],"aqueous":[95,135],"humor,":[96,136],"vitreous":[98,138],"determined":[100],"by":[101],"high":[102],"performance":[103],"liquid":[104],"chromatography.":[105],"RESULTS:":[106],"After":[107],"topical":[108,177],"administration,":[109],"there":[110],"wide":[112],"distribution":[113],"fast":[115],"clearance":[116],"among":[119],"various":[121],"tissues.":[123],"mean":[125],"maximum":[126],"(C(max))":[128],"9.64":[140],"mg/g,":[141,143,145],"9.62":[142],"2.13":[144],"34.88":[146],"mg/l":[147],"0.52":[149],"mg/l,":[150],"respectively.":[151,165],"half-life":[153],"for":[154,191],"these":[155],"18.26,":[158],"34.16,":[159],"15.71,":[160],"70.91,":[161],"39.48":[163],"min,":[164],"CONCLUSIONS:":[166],"Measurable":[167],"are":[171],"achieved":[172],"application":[178],"model.":[181],"Topical":[182],"may":[186],"be":[187],"effective":[189],"approach":[190],"modulation":[192],"responses":[196],"filtration":[199]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}