{"id":"https://openalex.org/W2162743771","doi":null,"title":"Reverse transcription-PCR analysis of laser-captured cells points to potential paracrine and autocrine actions of neurotrophins in pancreatic cancer.","display_name":"Reverse transcription-PCR analysis of laser-captured cells points to potential paracrine and autocrine actions of neurotrophins in pancreatic cancer.","publication_year":2003,"publication_date":"2003-11-01","ids":{"openalex":"https://openalex.org/W2162743771","mag":"2162743771","pmid":"https://pubmed.ncbi.nlm.nih.gov/14613990"},"language":"en","primary_location":{"id":"pmid:14613990","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14613990","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053429239","display_name":"Knut Ketterer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Knut Ketterer","raw_affiliation_strings":["Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of California, Irvine, California 92697, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of California, Irvine, California 92697, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111947545","display_name":"Shyam D Rao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shyam Rao","raw_affiliation_strings":["University of California at Irvine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California at Irvine","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110132975","display_name":"Helmut Friess","orcid":"https://orcid.org/0000-0001-6029-5857","observed_orcids":["https://orcid.org/0000-0001-6029-5857"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Helmut Friess","raw_affiliation_strings":["Heidelberg University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heidelberg University","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043030783","display_name":"John H. Weiss","orcid":"https://orcid.org/0000-0001-9323-7813","observed_orcids":["https://orcid.org/0000-0001-9323-7813"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Weiss","raw_affiliation_strings":["University of California at Irvine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California at Irvine","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036032282","display_name":"Markus Wolfgang B\u00fcchler","orcid":"https://orcid.org/0000-0002-3666-5675","observed_orcids":["https://orcid.org/0000-0002-3666-5675"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Markus W B\u00fcchler","raw_affiliation_strings":["Heidelberg University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heidelberg University","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052428479","display_name":"Murray Korc","orcid":"https://orcid.org/0000-0003-1566-0899","observed_orcids":["https://orcid.org/0000-0003-1566-0899"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Murray Korc","raw_affiliation_strings":["University of California at Irvine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California at Irvine","institution_ids":["https://openalex.org/I204250578"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.9941,"has_fulltext":false,"cited_by_count":128,"citation_normalized_percentile":{"value":0.90527308,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"9","issue":"14","first_page":"5127","last_page":"36"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.6294000148773193,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.6294000148773193,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.28610000014305115,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12626","display_name":"Cancer, Stress, Anesthesia, and Immune Response","score":0.034299999475479126,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neurotrophins","display_name":"neurotrophins","score":0.9980000257492065},{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.9950000047683716},{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.7950000166893005},{"id":"https://openalex.org/keywords/neurotrophin-receptors","display_name":"neurotrophin receptors","score":0.8709999918937683},{"id":"https://openalex.org/keywords/paracrine-signaling","display_name":"paracrine signaling","score":0.753000020980835},{"id":"https://openalex.org/keywords/autocrine-signaling","display_name":"autocrine signaling","score":0.9909999966621399},{"id":"https://openalex.org/keywords/nerve-growth-factor","display_name":"nerve growth factor","score":0.8100000023841858},{"id":"https://openalex.org/keywords/brain-derived-neurotrophic-factor","display_name":"brain-derived neurotrophic factor","score":0.9990000128746033},{"id":"https://openalex.org/keywords/neurotrophin-3","display_name":"neurotrophin-3","score":0.8820000290870667},{"id":"https://openalex.org/keywords/neurotrophin-4-5","display_name":"neurotrophin-4/5","score":0.9950000047683716},{"id":"https://openalex.org/keywords/trkb","display_name":"TrkB","score":0.6890000104904175},{"id":"https://openalex.org/keywords/trkc","display_name":"TrkC","score":0.8410000205039978},{"id":"https://openalex.org/keywords/trka","display_name":"TrkA","score":0.8299999833106995},{"id":"https://openalex.org/keywords/p75-neurotrophin-receptor","display_name":"p75 neurotrophin receptor","score":0.902999997138977},{"id":"https://openalex.org/keywords/tumor-cell-proliferation","display_name":"tumor cell proliferation","score":0.7919999957084656},{"id":"https://openalex.org/keywords/desmoplastic-stroma","display_name":"desmoplastic stroma","score":0.8339999914169312}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.708943784236908},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.6799352169036865},{"id":"https://openalex.org/C125965507","wikidata":"https://www.wikidata.org/wiki/Q1516595","display_name":"Laser capture microdissection","level":4,"score":0.6716592311859131},{"id":"https://openalex.org/C128240485","wikidata":"https://www.wikidata.org/wiki/Q786998","display_name":"Autocrine signalling","level":3,"score":0.6417208313941956},{"id":"https://openalex.org/C7876069","wikidata":"https://www.wikidata.org/wiki/Q14873666","display_name":"Paracrine signalling","level":3,"score":0.5439784526824951},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.514644980430603},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5035855174064636},{"id":"https://openalex.org/C92020748","wikidata":"https://www.wikidata.org/wiki/Q420457","display_name":"Neurotrophin","level":3,"score":0.4916561245918274},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.44829583168029785},{"id":"https://openalex.org/C185856081","wikidata":"https://www.wikidata.org/wiki/Q14916286","display_name":"Glial cell line-derived neurotrophic factor","level":4,"score":0.42680448293685913},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3660152554512024},{"id":"https://openalex.org/C160539049","wikidata":"https://www.wikidata.org/wiki/Q3064187","display_name":"Neurotrophic factors","level":3,"score":0.36580175161361694},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3476450443267822},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.1531084179878235},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13428044319152832},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005727","descriptor_name":"Ganglia, Spinal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007834","descriptor_name":"Lasers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009412","descriptor_name":"Nerve Fibers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009414","descriptor_name":"Nerve Growth Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009414","descriptor_name":"Nerve Growth Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017154","descriptor_name":"Stromal Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017475","descriptor_name":"Receptors, Nerve Growth Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017475","descriptor_name":"Receptors, Nerve Growth Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018920","descriptor_name":"Coculture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019208","descriptor_name":"Brain-Derived Neurotrophic Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019208","descriptor_name":"Brain-Derived Neurotrophic Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019898","descriptor_name":"Autocrine Communication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019899","descriptor_name":"Paracrine Communication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020800","descriptor_name":"Receptor, Nerve Growth Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020812","descriptor_name":"Receptor, trkC","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020812","descriptor_name":"Receptor, trkC","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020813","descriptor_name":"Receptor, trkB","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020813","descriptor_name":"Receptor, trkB","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020917","descriptor_name":"Receptor, trkA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020917","descriptor_name":"Receptor, trkA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020933","descriptor_name":"Neurotrophin 3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020933","descriptor_name":"Neurotrophin 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044584","descriptor_name":"Carcinoma, Ductal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044584","descriptor_name":"Carcinoma, Ductal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044584","descriptor_name":"Carcinoma, Ductal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:14613990","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14613990","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"},{"id":"mag:2162743771","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14613990","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4544780084","display_name":"EPIDERMAL GROWTH FACTOR RECEPTORS AND PANCREATIC CANCER","funder_award_id":"R01CA040162","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W43051898","https://openalex.org/W163624266","https://openalex.org/W305309622","https://openalex.org/W1525488097","https://openalex.org/W1528949747","https://openalex.org/W1576886106","https://openalex.org/W1664741673","https://openalex.org/W1885155229","https://openalex.org/W1888695200","https://openalex.org/W1941609444","https://openalex.org/W1974661600","https://openalex.org/W1976128207","https://openalex.org/W1977258975","https://openalex.org/W1981692950","https://openalex.org/W1992692555","https://openalex.org/W1994447237","https://openalex.org/W1999477756","https://openalex.org/W2021002193","https://openalex.org/W2034134249","https://openalex.org/W2040094076","https://openalex.org/W2045304682","https://openalex.org/W2051089689","https://openalex.org/W2051221464","https://openalex.org/W2051330399","https://openalex.org/W2053287079","https://openalex.org/W2054292890","https://openalex.org/W2056789545","https://openalex.org/W2063695629","https://openalex.org/W2065903778","https://openalex.org/W2067012378","https://openalex.org/W2089124684","https://openalex.org/W2091448816","https://openalex.org/W2093724553","https://openalex.org/W2095495430","https://openalex.org/W2095971921","https://openalex.org/W2100487936","https://openalex.org/W2112948888","https://openalex.org/W2114918609","https://openalex.org/W2120666858","https://openalex.org/W2124366353","https://openalex.org/W2125716220","https://openalex.org/W2126617351","https://openalex.org/W2128960139","https://openalex.org/W2134812217","https://openalex.org/W2149215821","https://openalex.org/W2160081126","https://openalex.org/W2163468299","https://openalex.org/W2164658118","https://openalex.org/W2404247204","https://openalex.org/W2411478723","https://openalex.org/W2413282004"],"related_works":["https://openalex.org/W2095971921","https://openalex.org/W2065903778","https://openalex.org/W2160081126","https://openalex.org/W1600101851","https://openalex.org/W1980383847","https://openalex.org/W2002174350","https://openalex.org/W4400185197","https://openalex.org/W2324535690","https://openalex.org/W2051221464","https://openalex.org/W2314254153"],"abstract_inverted_index":{"PURPOSE:":[0],"Neurotrophins":[1],"(NTs)":[2],"can":[3],"stimulate":[4,46],"cell":[5,11,47,80,143,157,220,254],"proliferation":[6,217],"and":[7,13,28,32,41,61,63,71,73,82,84,104,117,125,169,189,233,260],"differentiation":[8],"in":[9,17,35,77,100,109,126,140,174,194,202,227,231,239,243,265,282],"various":[10],"types,":[12],"play":[14],"a":[15,279],"role":[16],"certain":[18],"human":[19],"cancers.":[20],"In":[21],"this":[22,219],"study":[23],"we":[24],"analyzed":[25],"the":[26,64,141,167,195,203,216,228,234,240,246],"expression":[27,52],"localization":[29],"of":[30,53,160,166,182,207,218,225,236,248,263],"NTs":[31,124,153,188,226,249,264],"their":[33,43,190],"receptors":[34,65,136,168,191,238],"microdissected":[36],"pancreatic":[37,78,85,155,252],"cancer":[38,79,110,142,156,196,241,253],"tissue":[39,89],"samples,":[40,103],"studied":[42,76],"ability":[44,247],"to":[45,250,257],"growth.":[48,158],"EXPERIMENTAL":[49],"DESIGN:":[50],"The":[51,223],"nerve":[54,118],"growth":[55,121],"factor,":[56,59],"brain-derived":[57],"neurotrophic":[58],"NT-3,":[60],"NT-4/5,":[62],"tropomyosin":[66,146],"receptor":[67,147],"kinase":[68,148],"A,":[69],"B,":[70],"C,":[72],"P75":[74],"was":[75,98,150],"lines,":[81,144],"normal":[83,179],"ductal":[86],"adenocarcinoma":[87],"(PDAC)":[88],"samples":[90,162,185],"by":[91],"quantitative":[92],"reverse":[93],"transcription-PCR.":[94],"Laser":[95],"capture":[96],"microdissection":[97],"performed":[99],"21":[101],"PDAC":[102,175,232],"mRNA":[105],"levels":[106],"were":[107,132,137,172,192,199],"determined":[108],"cells,":[111,113,242],"acinar":[112],"desmoplastic":[114],"stroma":[115],"areas,":[116],"fibers.":[119],"Cell":[120],"assays":[122],"with":[123,128,178,211,245],"coculture":[127],"dorsal":[129,208],"root":[130,209],"ganglia":[131,210],"performed.":[133],"RESULTS:":[134],"NT":[135,237,275],"differentially":[138],"expressed":[139,193],"whereas":[145],"C":[149],"not":[151],"detectable.":[152],"modulated":[154],"Analysis":[159,181],"nonmicrodissected":[161],"revealed":[163,186],"that":[164,187,273],"all":[165],"tested":[170],"ligands":[171],"overexpressed":[173],"when":[176],"compared":[177],"pancreas.":[180],"laser":[183],"captured":[184],"cells":[197,213],"but":[198],"especially":[200],"abundant":[201],"intratumoral":[204,229],"nerves.":[205],"Coculture":[206],"T3M4":[212],"significantly":[214],"enhanced":[215],"line.":[221],"CONCLUSION:":[222],"abundance":[224],"nerves":[230],"presence":[235],"conjunction":[244],"modulate":[251],"growth,":[255],"point":[256],"potential":[258,281],"paracrine":[259],"autocrine":[261],"effects":[262],"PDAC.":[266,283],"Thus,":[267],"our":[268],"findings":[269],"provide":[270],"additional":[271],"evidence":[272],"blocking":[274],"actions":[276],"may":[277],"have":[278],"therapeutic":[280]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}