{"id":"https://openalex.org/W2162708599","doi":"https://doi.org/10.1111/j.1460-9568.1996.tb01594.x","title":"Chronic NMDA Receptor Antagonism During Retinotopic Map Formation Depresses CaM Kinase II Differentiation in Rat Superior Colliculus","display_name":"Chronic NMDA Receptor Antagonism During Retinotopic Map Formation Depresses CaM Kinase II Differentiation in Rat Superior Colliculus","publication_year":1996,"publication_date":"1996-07-01","ids":{"openalex":"https://openalex.org/W2162708599","doi":"https://doi.org/10.1111/j.1460-9568.1996.tb01594.x","mag":"2162708599","pmid":"https://pubmed.ncbi.nlm.nih.gov/8758939"},"language":"en","primary_location":{"id":"doi:10.1111/j.1460-9568.1996.tb01594.x","doi":"https://doi.org/10.1111/j.1460-9568.1996.tb01594.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1460-9568.1996.tb01594.x","pdf_url":null,"source":{"id":"https://openalex.org/S171130801","display_name":"European Journal of Neuroscience","issn_l":"0953-816X","issn":["0953-816X","1460-9568"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109121263","display_name":"Alfred J. Scheetz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"A. J. Scheetz","raw_affiliation_strings":["Yale University, Department of Biology, New Haven, CT 06520, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale University, Department of Biology, New Haven, CT 06520, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018359506","display_name":"Glen T. Prusky","orcid":"https://orcid.org/0000-0001-9658-8598","observed_orcids":["https://orcid.org/0000-0001-9658-8598"]},"institutions":[{"id":"https://openalex.org/I107949126","display_name":"University of Lethbridge","ror":"https://ror.org/044j76961","country_code":"CA","type":"education","lineage":["https://openalex.org/I107949126"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Glen T. Prusky","raw_affiliation_strings":["University of Lethbridge, Department of Psychology, 4401 University Drive, Lethbridge, Alberta T1K 3M4, Canada","Yale University, Department of Biology, New Haven, CT 06520, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Lethbridge, Department of Psychology, 4401 University Drive, Lethbridge, Alberta T1K 3M4, Canada","institution_ids":["https://openalex.org/I107949126"]},{"raw_affiliation_string":"Yale University, Department of Biology, New Haven, CT 06520, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075834199","display_name":"Martha Constantine\u2010Paton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martha Constantine\u2010Paton","raw_affiliation_strings":["Yale University, Department of Biology, New Haven, CT 06520, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale University, Department of Biology, New Haven, CT 06520, USA","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5109121263"],"corresponding_institution_ids":["https://openalex.org/I32971472"],"apc_list":{"value":3560,"currency":"USD","value_usd":3560},"apc_paid":null,"fwci":1.0009,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.74550041,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"8","issue":"7","first_page":"1322","last_page":"1328"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.00860000029206276,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nmda-receptor-antagonism","display_name":"NMDA receptor antagonism","score":0.9860000014305115},{"id":"https://openalex.org/keywords/cam-kinase-ii","display_name":"CaM kinase II","score":0.7839999794960022},{"id":"https://openalex.org/keywords/superior-colliculus","display_name":"superior colliculus","score":0.9449999928474426},{"id":"https://openalex.org/keywords/synaptic-maturation","display_name":"synapse maturation","score":0.968999981880188},{"id":"https://openalex.org/keywords/postnatal-development","display_name":"postnatal development","score":0.6840000152587891},{"id":"https://openalex.org/keywords/2-amino-5-phosphonovalerate","display_name":"2-amino-5-phosphonovalerate","score":0.9100000262260437},{"id":"https://openalex.org/keywords/subcellular-enzyme-localization","display_name":"enzyme subcellular localization","score":0.621999979019165},{"id":"https://openalex.org/keywords/protein-kinase-substrates","display_name":"kinase substrates","score":0.5709999799728394},{"id":"https://openalex.org/keywords/synaptic-differentiation","display_name":"synaptic differentiation","score":0.30399999022483826}],"concepts":[{"id":"https://openalex.org/C67018056","wikidata":"https://www.wikidata.org/wiki/Q414896","display_name":"NMDA receptor","level":3,"score":0.7274518013000488},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.5373863577842712},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.535548210144043},{"id":"https://openalex.org/C2781416072","wikidata":"https://www.wikidata.org/wiki/Q1109417","display_name":"Superior colliculus","level":2,"score":0.5154922604560852},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.47067055106163025},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.38198721408843994},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.36286139488220215},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35467010736465454},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3397604823112488},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.24471169710159302}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001931","descriptor_name":"Brain Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009475","descriptor_name":"Neurons, Afferent","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D012165","descriptor_name":"Retinal Ganglion Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013347","descriptor_name":"Subcellular Fractions","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013477","descriptor_name":"Superior Colliculi","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D013477","descriptor_name":"Superior Colliculi","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D013477","descriptor_name":"Superior Colliculi","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D014795","descriptor_name":"Visual Pathways","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015763","descriptor_name":"2-Amino-5-phosphonovalerate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016194","descriptor_name":"Receptors, N-Methyl-D-Aspartate","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D017871","descriptor_name":"Calcium-Calmodulin-Dependent Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054732","descriptor_name":"Calcium-Calmodulin-Dependent Protein Kinase Type 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1460-9568.1996.tb01594.x","doi":"https://doi.org/10.1111/j.1460-9568.1996.tb01594.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1460-9568.1996.tb01594.x","pdf_url":null,"source":{"id":"https://openalex.org/S171130801","display_name":"European Journal of Neuroscience","issn_l":"0953-816X","issn":["0953-816X","1460-9568"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Neuroscience","raw_type":"journal-article"},{"id":"pmid:8758939","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8758939","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The European journal of neuroscience","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4062759862","display_name":null,"funder_award_id":"EY06039","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G5654798820","display_name":"DEVELOPMENTAL REGULATION OF GLUTAMATE RECEPTOR FUNCTION","funder_award_id":"R01NS032290","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1523015514","https://openalex.org/W1546522923","https://openalex.org/W1599213556","https://openalex.org/W1672187686","https://openalex.org/W1710482752","https://openalex.org/W1953807893","https://openalex.org/W1964039942","https://openalex.org/W1984260965","https://openalex.org/W2011900561","https://openalex.org/W2027679341","https://openalex.org/W2035391953","https://openalex.org/W2045194954","https://openalex.org/W2057050792","https://openalex.org/W2058200799","https://openalex.org/W2061366000","https://openalex.org/W2070430778","https://openalex.org/W2070941196","https://openalex.org/W2089104876","https://openalex.org/W2090507418","https://openalex.org/W2093294658","https://openalex.org/W2094397616","https://openalex.org/W2122625397","https://openalex.org/W2166720190","https://openalex.org/W2171941207"],"related_works":["https://openalex.org/W2059338140","https://openalex.org/W2057050792","https://openalex.org/W2011900561","https://openalex.org/W2130096458","https://openalex.org/W2289277734","https://openalex.org/W4301106040","https://openalex.org/W7064459076","https://openalex.org/W2050710574","https://openalex.org/W2037212801","https://openalex.org/W2013114831"],"abstract_inverted_index":{"We":[0],"examined":[1],"the":[2,10,24,48,64,85,125,128,147,151,162,185],"effects":[3,177],"of":[4,14,54,99,124,127,146,199],"chronic":[5],"NMDA":[6,111,200],"receptor":[7,112],"antagonism":[8,113,198],"on":[9],"normal":[11],"postnatal":[12,29],"differentiation":[13],"calcium-":[15],"and":[16,66,79,165],"calmodulin-dependent":[17],"kinase":[18,21,35,42,81,107,119,155],"II":[19,36,43,82,108,120,156],"(CaM":[20],"II)":[22],"in":[23,47,62,84,91,96,131,150,173,181],"rat":[25],"superior":[26,56,101,134,138],"colliculus.":[27,135],"At":[28,69],"day":[30],"(P)":[31],"zero,":[32],"most":[33,145],"CaM":[34,41,80,106,118,154],"protein,":[37],"as":[38,40],"well":[39],"activity,":[44],"was":[45,72,88,149,158],"detected":[46],"soluble":[49,67,77,152,163],"fraction.":[50],"In":[51,136],"vitro":[52,97,174],"phosphorylation":[53,98],"P0":[55,92,132],"colliculus":[57,102,139],"revealed":[58,103],"several":[59],"prominent":[60],"substrates":[61,169],"both":[63],"particulate":[65,74,86,93],"fractions.":[68],"P19":[70,100,137],"there":[71],"more":[73,105],"enzyme":[75,129],"than":[76,90],"enzyme,":[78],"activity":[83,157],"fraction":[87],"higher":[89],"tissue.":[94],"Additionally,":[95],"many":[104,123],"substrates.":[109],"Chronic":[110],"with":[114,141,184],"2-amino-5-phosphonovalerate":[115],"(DL-AP5)":[116],"caused":[117],"to":[121,161],"retain":[122],"characteristics":[126],"found":[130],"untreated":[133],"treated":[140,183],"LD-AP5":[142],"from":[143],"birth,":[144],"protein":[148],"fraction,":[153,164],"largely":[159],"restricted":[160],"only":[166],"a":[167],"few":[168],"were":[170,178],"observed":[171,180],"by":[172,197],"phosphorylation.":[175],"These":[176,189],"not":[179],"tissue":[182],"inactive":[186],"isomer,":[187],"L-AP5.":[188],"results":[190],"suggest":[191],"that":[192],"synaptic":[193],"maturation":[194],"is":[195],"slowed":[196],"receptors":[201],"during":[202],"retinotopic":[203],"map":[204],"formation.":[205]},"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
