{"id":"https://openalex.org/W2162663647","doi":"https://doi.org/10.1158/0008-5472.can-05-0920","title":"Intrapulmonary IFN-\u03b2 Gene Therapy Using an Adenoviral Vector Is Highly Effective in a Murine Orthotopic Model of Bronchogenic Adenocarcinoma of the Lung","display_name":"Intrapulmonary IFN-\u03b2 Gene Therapy Using an Adenoviral Vector Is Highly Effective in a Murine Orthotopic Model of Bronchogenic Adenocarcinoma of the Lung","publication_year":2005,"publication_date":"2005-09-15","ids":{"openalex":"https://openalex.org/W2162663647","doi":"https://doi.org/10.1158/0008-5472.can-05-0920","mag":"2162663647","pmid":"https://pubmed.ncbi.nlm.nih.gov/16166316"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.can-05-0920","doi":"https://doi.org/10.1158/0008-5472.can-05-0920","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-05-0920","pdf_url":"https://aacrjournals.org/cancerres/article-pdf/65/18/8379/2534292/8379-8387.pdf","source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://aacrjournals.org/cancerres/article-pdf/65/18/8379/2534292/8379-8387.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060880109","display_name":"Michael J. Wilderman","orcid":"https://orcid.org/0000-0003-1597-7247","observed_orcids":["https://orcid.org/0000-0003-1597-7247"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael J. Wilderman","raw_affiliation_strings":["Thoracic Oncology Research Laboratory, University of Pennsylvania Medical School, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thoracic Oncology Research Laboratory, University of Pennsylvania Medical School, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100714101","display_name":"Jing Sun","orcid":"https://orcid.org/0000-0002-4161-6835","observed_orcids":["https://orcid.org/0000-0002-4161-6835"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jing Sun","raw_affiliation_strings":["Thoracic Oncology Research Laboratory, University of Pennsylvania Medical School, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thoracic Oncology Research Laboratory, University of Pennsylvania Medical School, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010486501","display_name":"Arminder Singh Jassar","orcid":"https://orcid.org/0000-0001-5412-3506","observed_orcids":["https://orcid.org/0000-0001-5412-3506"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arminder S. Jassar","raw_affiliation_strings":["Thoracic Oncology Research Laboratory, University of Pennsylvania Medical School, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thoracic Oncology Research Laboratory, University of Pennsylvania Medical School, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108571467","display_name":"Veena Kapoor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Veena Kapoor","raw_affiliation_strings":["Thoracic Oncology Research Laboratory, University of Pennsylvania Medical School, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thoracic Oncology Research Laboratory, University of Pennsylvania Medical School, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101845369","display_name":"Mohamed K. Khan","orcid":"https://orcid.org/0000-0003-2789-7623","observed_orcids":["https://orcid.org/0000-0003-2789-7623"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohamed Khan","raw_affiliation_strings":["Thoracic Oncology Research Laboratory, University of Pennsylvania Medical School, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thoracic Oncology Research Laboratory, University of Pennsylvania Medical School, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037072010","display_name":"Anil Vachani","orcid":"https://orcid.org/0000-0002-3871-8697","observed_orcids":["https://orcid.org/0000-0002-3871-8697"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anil Vachani","raw_affiliation_strings":["Thoracic Oncology Research Laboratory, University of Pennsylvania Medical School, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thoracic Oncology Research Laboratory, University of Pennsylvania Medical School, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101401185","display_name":"Eiji Suzuki","orcid":"https://orcid.org/0000-0002-4980-964X","observed_orcids":["https://orcid.org/0000-0002-4980-964X"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eiji Suzuki","raw_affiliation_strings":["Thoracic Oncology Research Laboratory, University of Pennsylvania Medical School, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thoracic Oncology Research Laboratory, University of Pennsylvania Medical School, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030993116","display_name":"Paul A. Kinniry","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul A. Kinniry","raw_affiliation_strings":["Thoracic Oncology Research Laboratory, University of Pennsylvania Medical School, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thoracic Oncology Research Laboratory, University of Pennsylvania Medical School, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022802228","display_name":"Daniel H. Sterman","orcid":"https://orcid.org/0009-0004-0170-2722","observed_orcids":["https://orcid.org/0009-0004-0170-2722"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel H. Sterman","raw_affiliation_strings":["Thoracic Oncology Research Laboratory, University of Pennsylvania Medical School, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thoracic Oncology Research Laboratory, University of Pennsylvania Medical School, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102926741","display_name":"Larry R. Kaiser","orcid":"https://orcid.org/0000-0002-5035-7484","observed_orcids":["https://orcid.org/0000-0002-5035-7484"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Larry R. Kaiser","raw_affiliation_strings":["Thoracic Oncology Research Laboratory, University of Pennsylvania Medical School, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thoracic Oncology Research Laboratory, University of Pennsylvania Medical School, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005953721","display_name":"Steven \u039c. Albelda","orcid":"https://orcid.org/0000-0002-6598-3752","observed_orcids":["https://orcid.org/0000-0002-6598-3752"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven M. Albelda","raw_affiliation_strings":["Thoracic Oncology Research Laboratory, University of Pennsylvania Medical School, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thoracic Oncology Research Laboratory, University of Pennsylvania Medical School, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":null,"apc_paid":null,"fwci":1.5883,"has_fulltext":true,"cited_by_count":48,"citation_normalized_percentile":{"value":0.82779926,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"65","issue":"18","first_page":"8379","last_page":"8387"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.008700000122189522,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12996","display_name":"Bacterial Cancer Therapy","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interferon-beta","display_name":"interferon-beta","score":0.8080000281333923},{"id":"https://openalex.org/keywords/adenovirus-vectors","display_name":"adenoviral vector","score":0.7149999737739563},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.8820000290870667},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.8320000171661377},{"id":"https://openalex.org/keywords/bronchogenic-adenocarcinoma","display_name":"bronchogenic adenocarcinoma","score":0.9190000295639038},{"id":"https://openalex.org/keywords/orthotopic-tumor-model","display_name":"orthotopic tumor model","score":0.8240000009536743},{"id":"https://openalex.org/keywords/kras-g12d","display_name":"KRAS G12D","score":0.8519999980926514},{"id":"https://openalex.org/keywords/cre-recombinase","display_name":"Cre recombinase","score":0.7739999890327454},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.8479999899864197},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.9760000109672546},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.9950000047683716},{"id":"https://openalex.org/keywords/tumor-cell-killing","display_name":"tumor cell killing","score":0.7979999780654907}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6051021814346313},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.5350011587142944},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.5328863859176636},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5264045596122742},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.5227984189987183},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.5009069442749023},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.48260724544525146},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.4591374695301056},{"id":"https://openalex.org/C32470452","wikidata":"https://www.wikidata.org/wiki/Q2298489","display_name":"Viral vector","level":4,"score":0.4583420753479004},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.40849751234054565},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.37154093384742737},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.34703969955444336},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3234318792819977},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2660810351371765},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16941848397254944},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09532344341278076},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.08595126867294312},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000256","descriptor_name":"Adenoviridae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002283","descriptor_name":"Carcinoma, Bronchogenic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002283","descriptor_name":"Carcinoma, Bronchogenic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002283","descriptor_name":"Carcinoma, Bronchogenic","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D002283","descriptor_name":"Carcinoma, Bronchogenic","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011905","descriptor_name":"Genes, ras","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013602","descriptor_name":"T-Lymphocytes, Cytotoxic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D016899","descriptor_name":"Interferon-beta","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016899","descriptor_name":"Interferon-beta","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1158/0008-5472.can-05-0920","doi":"https://doi.org/10.1158/0008-5472.can-05-0920","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-05-0920","pdf_url":"https://aacrjournals.org/cancerres/article-pdf/65/18/8379/2534292/8379-8387.pdf","source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},{"id":"pmid:16166316","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16166316","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.can-05-0920","doi":"https://doi.org/10.1158/0008-5472.can-05-0920","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-05-0920","pdf_url":"https://aacrjournals.org/cancerres/article-pdf/65/18/8379/2534292/8379-8387.pdf","source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5319125166","display_name":"Immuno/Immuno-Gene Therapies for Thoracic Malignancies","funder_award_id":"P01CA066726","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2162663647.pdf","grobid_xml":"https://content.openalex.org/works/W2162663647.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W108161811","https://openalex.org/W193094849","https://openalex.org/W1482195803","https://openalex.org/W1494220200","https://openalex.org/W1501348451","https://openalex.org/W1558828789","https://openalex.org/W1611210979","https://openalex.org/W1638465953","https://openalex.org/W1886008466","https://openalex.org/W1967228746","https://openalex.org/W1985542149","https://openalex.org/W2014999901","https://openalex.org/W2016006434","https://openalex.org/W2031112206","https://openalex.org/W2045625397","https://openalex.org/W2048953142","https://openalex.org/W2049109254","https://openalex.org/W2049998759","https://openalex.org/W2058680827","https://openalex.org/W2061025799","https://openalex.org/W2062524655","https://openalex.org/W2064744205","https://openalex.org/W2068863562","https://openalex.org/W2087011337","https://openalex.org/W2089142941","https://openalex.org/W2089738808","https://openalex.org/W2093915058","https://openalex.org/W2095170304","https://openalex.org/W2099019634","https://openalex.org/W2110044798","https://openalex.org/W2112834292","https://openalex.org/W2113180936","https://openalex.org/W2117114937","https://openalex.org/W2125639528","https://openalex.org/W2127401704","https://openalex.org/W2131367075","https://openalex.org/W2144637577","https://openalex.org/W2150996807","https://openalex.org/W2156551589","https://openalex.org/W2161830096","https://openalex.org/W2166663717","https://openalex.org/W2187034687","https://openalex.org/W2317403542","https://openalex.org/W2332123736","https://openalex.org/W2333148719","https://openalex.org/W2399630682","https://openalex.org/W7075739058"],"related_works":["https://openalex.org/W2072983432","https://openalex.org/W2286989419","https://openalex.org/W2013259164","https://openalex.org/W1965991214","https://openalex.org/W2054423183","https://openalex.org/W2150996807","https://openalex.org/W2750314483","https://openalex.org/W1966419276","https://openalex.org/W2565533210","https://openalex.org/W1513314415"],"abstract_inverted_index":{"Given":[0],"previous":[1],"work":[2],"showing":[3,212],"that":[4,47,182,190],"an":[5,28,55],"adenoviral":[6],"vector":[7,82],"expressing":[8,57],"IFN-beta":[9],"(Ad.IFNbeta)":[10],"was":[11,25,173],"highly":[12],"effective":[13],"in":[14,27,109,216],"eradicating":[15],"i.p.":[16],"mesothelioma":[17],"tumors,":[18],"the":[19,35,70,110,206],"antitumor":[20,214],"efficacy":[21],"of":[22,31,34,54,79,112,117,152,208,229],"this":[23,217],"agent":[24],"evaluated":[26],"orthotopic":[29,218],"model":[30],"bronchogenic":[32],"adenocarcinoma":[33],"lung.":[36],"These":[37,210],"transgenic":[38],"mice":[39,63,113,126,137,153],"have":[40],"a":[41,80,92,227],"conditionally":[42],"expressed,":[43],"oncogenic":[44],"K-rasG12D":[45,61],"allele":[46],"can":[48],"be":[49],"activated":[50],"by":[51,129,140],"intratracheal":[52],"administration":[53],"adenovirus":[56],"Cre":[58],"recombinase":[59],"(Ad.Cre).":[60],"mutant":[62],"were":[64,73,106,157],"given":[65,75],"Ad.Cre":[66],"intranasally":[67,86],"to":[68,114,150,168,231],"activate":[69],"oncogene.":[71],"Mice":[72],"then":[74],"10(9)":[76],"plaque-forming":[77],"units":[78],"control":[81],"(Ad.LacZ)":[83],"or":[84,194],"Ad.IFNbeta":[85,156,183,230],"3":[87],"and":[88,177,189],"4":[89],"weeks":[90],"later,":[91],"time":[93],"when":[94],"lung":[95,104,219,236],"tumors":[96,105],"had":[97],"been":[98],"established.":[99],"Cells":[100],"derived":[101],"from":[102],"K-ras-mutated":[103],"also":[107],"grown":[108],"flanks":[111],"study":[115],"mechanisms":[116],"therapeutic":[118],"responses.":[119],"In":[120,147,165,175],"two":[121],"separate":[122],"experiments,":[123],"untreated":[124],"tumor-bearing":[125],"all":[127,138],"died":[128,139],"day":[130,141],"57":[131],"(median":[132,143],"survival,":[133,144],"49":[134],"days).":[135,146],"Ad.LacZ-treated":[136],"71":[142],"65":[145],"contrast,":[148],"90%":[149],"100%":[151],"treated":[154],"with":[155,170,203],"long-term":[158],"survivors":[159],"(>120":[160],"days;":[161],"P":[162],"<":[163],"0.001).":[164],"addition,":[166],"immunity":[167],"re-challenge":[169],"tumor":[171,179,186],"cells":[172],"induced.":[174],"vitro":[176],"flank":[178],"studies":[180],"showed":[181],"induced":[184],"direct":[185],"cell":[187,235],"killing":[188],"depleting":[191],"natural":[192],"killer":[193],"CD8+":[195],"T":[196,201],"cells,":[197,202],"but":[198],"not":[199],"CD4+":[200],"antibodies":[204],"attenuated":[205],"effect":[207],"Ad.IFNbeta.":[209],"studies,":[211],"remarkable":[213],"activity":[215],"cancer":[220],"model,":[221],"provide":[222],"strong":[223],"preclinical":[224],"support":[225],"for":[226],"trial":[228],"treat":[232],"human":[233],"non-small":[234],"cancer.":[237]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}