{"id":"https://openalex.org/W2162658751","doi":"https://doi.org/10.1186/1742-4690-9-s2-p172","title":"TLR7/9 antagonist reduces HIV-1-induced immune activation","display_name":"TLR7/9 antagonist reduces HIV-1-induced immune activation","publication_year":2012,"publication_date":"2012-09-01","ids":{"openalex":"https://openalex.org/W2162658751","doi":"https://doi.org/10.1186/1742-4690-9-s2-p172","mag":"2162658751"},"language":"en","primary_location":{"id":"doi:10.1186/1742-4690-9-s2-p172","doi":"https://doi.org/10.1186/1742-4690-9-s2-p172","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1742-4690-9-s2-p172","pdf_url":"https://retrovirology.biomedcentral.com/counter/pdf/10.1186/1742-4690-9-S2-P172","source":{"id":"https://openalex.org/S54115554","display_name":"Retrovirology","issn_l":"1742-4690","issn":["1742-4690"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Retrovirology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://retrovirology.biomedcentral.com/counter/pdf/10.1186/1742-4690-9-S2-P172","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084243027","display_name":"Jason Y.H. Chang","orcid":"https://orcid.org/0000-0002-2238-8232","observed_orcids":["https://orcid.org/0000-0002-2238-8232"]},"institutions":[{"id":"https://openalex.org/I2802422659","display_name":"Ragon Institute of MGH, MIT and Harvard","ror":"https://ror.org/053r20n13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I136199984","https://openalex.org/I2802422659","https://openalex.org/I4210087915","https://openalex.org/I48633490","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"J Chang","raw_affiliation_strings":["Ragon Institute of MGH, MIT and Harvard, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ragon Institute of MGH, MIT and Harvard, Boston, MA, USA","institution_ids":["https://openalex.org/I2802422659","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053527304","display_name":"Robert J. Lindsay","orcid":"https://orcid.org/0000-0003-2803-5793","observed_orcids":["https://orcid.org/0000-0003-2803-5793"]},"institutions":[{"id":"https://openalex.org/I2802422659","display_name":"Ragon Institute of MGH, MIT and Harvard","ror":"https://ror.org/053r20n13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I136199984","https://openalex.org/I2802422659","https://openalex.org/I4210087915","https://openalex.org/I48633490","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"RJ Lindsay","raw_affiliation_strings":["Ragon Institute of MGH, MIT and Harvard, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ragon Institute of MGH, MIT and Harvard, Boston, MA, USA","institution_ids":["https://openalex.org/I2802422659","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065285560","display_name":"Erin Doyle","orcid":"https://orcid.org/0000-0001-9380-2819","observed_orcids":["https://orcid.org/0000-0001-9380-2819"]},"institutions":[{"id":"https://openalex.org/I2802422659","display_name":"Ragon Institute of MGH, MIT and Harvard","ror":"https://ror.org/053r20n13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I136199984","https://openalex.org/I2802422659","https://openalex.org/I4210087915","https://openalex.org/I48633490","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"EH Doyle","raw_affiliation_strings":["Ragon Institute of MGH, MIT and Harvard, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ragon Institute of MGH, MIT and Harvard, Boston, MA, USA","institution_ids":["https://openalex.org/I2802422659","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001780375","display_name":"Vladimir D. Vrbanac","orcid":"https://orcid.org/0000-0002-0593-1723","observed_orcids":["https://orcid.org/0000-0002-0593-1723"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"V Vrbanac","raw_affiliation_strings":["Massachusetts General Hospital, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111981724","display_name":"EN Seung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"EN Seung","raw_affiliation_strings":["Massachusetts General Hospital, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091400670","display_name":"Timothy E. Dudek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802422659","display_name":"Ragon Institute of MGH, MIT and Harvard","ror":"https://ror.org/053r20n13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I136199984","https://openalex.org/I2802422659","https://openalex.org/I4210087915","https://openalex.org/I48633490","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T Dudek","raw_affiliation_strings":["Ragon Institute of MGH, MIT and Harvard, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ragon Institute of MGH, MIT and Harvard, Boston, MA, USA","institution_ids":["https://openalex.org/I2802422659","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028135379","display_name":"RJ Bosch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"RJ Bosch","raw_affiliation_strings":["Harvard School of Public Health, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard School of Public Health, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035887532","display_name":"Melissa Precopio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210142714","display_name":"Idera Pharmaceuticals (United States)","ror":"https://ror.org/03zts9g74","country_code":"US","type":"company","lineage":["https://openalex.org/I4210142714"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M Precopio","raw_affiliation_strings":["Idera Pharmaceuticals Inc., Cambridge, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Idera Pharmaceuticals Inc., Cambridge, MA, USA","institution_ids":["https://openalex.org/I4210142714"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088791437","display_name":"Ekambar R. Kandimalla","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210142714","display_name":"Idera Pharmaceuticals (United States)","ror":"https://ror.org/03zts9g74","country_code":"US","type":"company","lineage":["https://openalex.org/I4210142714"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E Kandimalla","raw_affiliation_strings":["Idera Pharmaceuticals Inc., Cambridge, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Idera Pharmaceuticals Inc., Cambridge, MA, USA","institution_ids":["https://openalex.org/I4210142714"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018732153","display_name":"Andrew Martin Tager","orcid":"https://orcid.org/0000-0002-5826-918X","observed_orcids":["https://orcid.org/0000-0002-5826-918X"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A Tager","raw_affiliation_strings":["Massachusetts General Hospital, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042817775","display_name":"Marcus A. Altfeld","orcid":"https://orcid.org/0000-0001-5972-2997","observed_orcids":["https://orcid.org/0000-0001-5972-2997"]},"institutions":[{"id":"https://openalex.org/I2802422659","display_name":"Ragon Institute of MGH, MIT and Harvard","ror":"https://ror.org/053r20n13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I136199984","https://openalex.org/I2802422659","https://openalex.org/I4210087915","https://openalex.org/I48633490","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M Altfeld","raw_affiliation_strings":["Ragon Institute of MGH, MIT and Harvard, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ragon Institute of MGH, MIT and Harvard, Boston, MA, USA","institution_ids":["https://openalex.org/I2802422659","https://openalex.org/I63966007"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5084243027"],"corresponding_institution_ids":["https://openalex.org/I2802422659","https://openalex.org/I63966007"],"apc_list":{"value":2890,"currency":"USD","value_usd":2890},"apc_paid":{"value":2890,"currency":"USD","value_usd":2890},"fwci":0.0,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.19303279,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"9","issue":"S2","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1","display_name":"HIV-1","score":0.8690000176429749},{"id":"https://openalex.org/keywords/immune-activation","display_name":"immune activation","score":0.8130000233650208},{"id":"https://openalex.org/keywords/interferon-alpha","display_name":"interferon-alpha","score":0.7979999780654907},{"id":"https://openalex.org/keywords/t-cell-activation","display_name":"T cell activation","score":0.7720000147819519},{"id":"https://openalex.org/keywords/cd38","display_name":"CD38","score":0.8619999885559082},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.953000009059906},{"id":"https://openalex.org/keywords/monocytes","display_name":"monocytes","score":0.8180000185966492},{"id":"https://openalex.org/keywords/hiv-transmission","display_name":"HIV transmission","score":0.503000020980835},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.4560000002384186}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7403439283370972},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.670540452003479},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.546943724155426},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5409857034683228},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4991602897644043},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4237947463989258},{"id":"https://openalex.org/C2779836521","wikidata":"https://www.wikidata.org/wiki/Q14914081","display_name":"TLR7","level":5,"score":0.41848549246788025},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.41334718465805054},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3861938416957855},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20323380827903748},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.18427357077598572},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.11797294020652771},{"id":"https://openalex.org/C2776709828","wikidata":"https://www.wikidata.org/wiki/Q408004","display_name":"Toll-like receptor","level":4,"score":0.09143415093421936}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1186/1742-4690-9-s2-p172","doi":"https://doi.org/10.1186/1742-4690-9-s2-p172","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1742-4690-9-s2-p172","pdf_url":"https://retrovirology.biomedcentral.com/counter/pdf/10.1186/1742-4690-9-S2-P172","source":{"id":"https://openalex.org/S54115554","display_name":"Retrovirology","issn_l":"1742-4690","issn":["1742-4690"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Retrovirology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3441975","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3441975","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Retrovirology","raw_type":"Text"},{"id":"pmh:oai:dash.harvard.edu:1/10536954","doi":null,"is_oa":true,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:10536954","pdf_url":null,"source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1186/1742-4690-9-s2-p172","doi":"https://doi.org/10.1186/1742-4690-9-s2-p172","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1742-4690-9-s2-p172","pdf_url":"https://retrovirology.biomedcentral.com/counter/pdf/10.1186/1742-4690-9-S2-P172","source":{"id":"https://openalex.org/S54115554","display_name":"Retrovirology","issn_l":"1742-4690","issn":["1742-4690"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Retrovirology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2162658751.pdf","grobid_xml":"https://content.openalex.org/works/W2162658751.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2273375376","https://openalex.org/W7097233952","https://openalex.org/W2097131701","https://openalex.org/W1989339029","https://openalex.org/W2047325790","https://openalex.org/W2071850662","https://openalex.org/W1984098480","https://openalex.org/W2242807836","https://openalex.org/W2586226836","https://openalex.org/W2085953900"],"abstract_inverted_index":{"T":[0,27,138,182,233,241],"cell":[1,28,139,183,234],"immune":[2,55,235,279,293],"activation":[3,29,140,236,294],"is":[4],"a":[5,73,256,269,274],"strong":[6],"predictor":[7],"of":[8,41,62,115,155,227,247,263,277],"HIV-1":[9,13,126,225],"disease":[10],"progression":[11],"and":[12,15,51,69,91,127,147,181,202,211,245],"transmission,":[14],"IFN-alpha":[16,49],"production":[17,50,197],"following":[18,145,162],"TLR7":[19,42],"stimulation":[20,43,159,192],"has":[21],"been":[22],"associated":[23,290],"with":[24,87,93,125,133,150,193,220,250,268,291],"elevated":[25],"CD8":[26],"(Meier":[30],"et":[31],"al.,":[32],"Nat":[33],"Med":[34],"2009).":[35],"We":[36],"therefore":[37],"hypothesized":[38],"that":[39],"modulation":[40],"could":[44],"be":[45],"used":[46,66],"to":[47,111,157,205,231,255],"manipulate":[48],"subsequently":[52],"reduce":[53],"HIV-1-associated":[54,278],"activation.":[56,280],"TLR7/9-specific":[57],"antagonists":[58],"developed":[59],"for":[60],"treatment":[61,149,167,219,246],"auto-immune":[63],"diseases":[64],"were":[65,80,106,122,142,185],"in":[67,70,72,118,163,187,217,243,259,273,286,295],"vitro":[68,218],"vivo":[71,161,164,191],"humanized":[74,199,228,265],"mouse":[75],"model.":[76],"Humanized":[77,120],"BLT":[78,266],"mice":[79,86,110,121,200,229,249,267],"generated":[81],"by":[82,170,198,216],"transplanting":[83],"irradiated":[84],"NOD/SCID/\u03b3c":[85],"human":[88,94,178,209,240],"fetal":[89],"thymus":[90],"injected":[92],"hematopoietic":[95],"stem":[96],"cells":[97,105,242],"isolated":[98],"from":[99,108,136,208],"matching":[100],"liver":[101],"tissue.":[102],"Following":[103],"reconstitution,":[104],"harvested":[107],"the":[109,113,116,151,188,221,251],"examine":[112],"effects":[114],"antagonist":[117,135,166,223,253,271],"vitro.":[119],"also":[123],"infected":[124,248],"then":[128],"either":[129],"treated":[130],"or":[131],"untreated":[132],"TLR7/9":[134,165,222,252,270],"Idera.":[137],"markers":[141],"examined":[143],"pre-infection,":[144],"infection":[146,226],"during":[148],"antagonist.":[152],"Additionally,":[153],"responsiveness":[154],"DCs":[156,201],"TLR7/8":[158,194],"ex":[160],"was":[168,213],"assessed":[169],"intracellular":[171],"cytokine":[172,196],"staining.":[173],"16-20":[174],"weeks":[175],"after":[176],"transplant,":[177],"DC,":[179],"monocyte":[180],"populations":[184],"detectable":[186],"mice.":[189],"Ex":[190],"induced":[195],"monocytes":[203],"similar":[204],"those":[206],"observed":[207],"PBMCs":[210],"this":[212],"significantly":[214],"blocked":[215],"(P<0.05).":[224],"led":[230,254],"increased":[232],"marker":[237],"CD38":[238,260],"on":[239],"vivo,":[244],"significant":[257,275],"reduction":[258,276],"expression.":[261],"Treatment":[262],"HIV-1-infected":[264],"resulted":[272],"This":[281],"may":[282],"have":[283],"important":[284],"implications":[285],"reducing":[287],"viral":[288],"transmission":[289],"higher":[292],"HIV-1.":[296]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}