{"id":"https://openalex.org/W2162657751","doi":"https://doi.org/10.1073/pnas.0712401105","title":"Magnesium deficiency accelerates cellular senescence in cultured human fibroblasts","display_name":"Magnesium deficiency accelerates cellular senescence in cultured human fibroblasts","publication_year":2008,"publication_date":"2008-04-07","ids":{"openalex":"https://openalex.org/W2162657751","doi":"https://doi.org/10.1073/pnas.0712401105","mag":"2162657751","pmid":"https://pubmed.ncbi.nlm.nih.gov/18391207","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2311331"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.0712401105","doi":"https://doi.org/10.1073/pnas.0712401105","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0712401105","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2311331","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013840188","display_name":"David W. Killilea","orcid":"https://orcid.org/0000-0002-8929-6527","observed_orcids":["https://orcid.org/0000-0002-8929-6527"]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David W. Killilea","raw_affiliation_strings":["Nutrition and Metabolism Center, Children's Hospital Oakland Research Institute, Oakland, CA 94609; and Department of Molecular and Cellular Biology, University of California, Berkeley, CA 94720"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nutrition and Metabolism Center, Children's Hospital Oakland Research Institute, Oakland, CA 94609; and Department of Molecular and Cellular Biology, University of California, Berkeley, CA 94720","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110195895","display_name":"Bruce N. Ames","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bruce N. Ames","raw_affiliation_strings":["Nutrition and Metabolism Center, Children's Hospital Oakland Research Institute, Oakland, CA 94609; and Department of Molecular and Cellular Biology, University of California, Berkeley, CA 94720"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nutrition and Metabolism Center, Children's Hospital Oakland Research Institute, Oakland, CA 94609; and Department of Molecular and Cellular Biology, University of California, Berkeley, CA 94720","institution_ids":["https://openalex.org/I95457486"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I95457486"],"apc_list":null,"apc_paid":null,"fwci":8.9441,"has_fulltext":false,"cited_by_count":140,"citation_normalized_percentile":{"value":0.98090433,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"105","issue":"15","first_page":"5768","last_page":"5773"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12280","display_name":"Magnesium in Health and Disease","score":0.6342999935150146,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12280","display_name":"Magnesium in Health and Disease","score":0.6342999935150146,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.35839998722076416,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypomagnesemia","display_name":"hypomagnesemia","score":1.0},{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":0.996999979019165},{"id":"https://openalex.org/keywords/human-fibroblasts","display_name":"human fibroblasts","score":0.8700000047683716},{"id":"https://openalex.org/keywords/replicative-lifespan","display_name":"replicative lifespan","score":0.8600000143051147},{"id":"https://openalex.org/keywords/senescence-associated-beta-galactosidase","display_name":"senescence-associated \u03b2-galactosidase","score":0.9319999814033508},{"id":"https://openalex.org/keywords/p16ink4a","display_name":"p16INK4a","score":0.9980000257492065},{"id":"https://openalex.org/keywords/p21","display_name":"p21","score":0.9950000047683716},{"id":"https://openalex.org/keywords/telomere-shortening","display_name":"telomere shortening","score":0.9909999966621399},{"id":"https://openalex.org/keywords/oxygen-partial-pressure","display_name":"oxygen partial pressure","score":0.8009999990463257},{"id":"https://openalex.org/keywords/age-related-diseases","display_name":"age-related diseases","score":0.8360000252723694},{"id":"https://openalex.org/keywords/imr-90-cells","display_name":"IMR-90 cells","score":0.7639999985694885}],"concepts":[{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.7478330731391907},{"id":"https://openalex.org/C543218039","wikidata":"https://www.wikidata.org/wiki/Q660","display_name":"Magnesium","level":2,"score":0.7042779326438904},{"id":"https://openalex.org/C2780381497","wikidata":"https://www.wikidata.org/wiki/Q463418","display_name":"Fibroblast","level":3,"score":0.6164053678512573},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5418054461479187},{"id":"https://openalex.org/C177336024","wikidata":"https://www.wikidata.org/wiki/Q14872779","display_name":"Telomere","level":3,"score":0.4879900813102722},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.47784850001335144},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.46540457010269165},{"id":"https://openalex.org/C2780880258","wikidata":"https://www.wikidata.org/wiki/Q3771629","display_name":"Magnesium deficiency (plants)","level":3,"score":0.4601609706878662},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4572787284851074},{"id":"https://openalex.org/C2908780919","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Cellular Aging","level":4,"score":0.41100168228149414},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.40041983127593994},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.312382310628891},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2414759397506714},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20118024945259094},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19417527318000793},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008275","descriptor_name":"Magnesium Deficiency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016615","descriptor_name":"Telomere","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016922","descriptor_name":"Cellular Senescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050759","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p21","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1073/pnas.0712401105","doi":"https://doi.org/10.1073/pnas.0712401105","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0712401105","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2311331","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2311331","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:18391207","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18391207","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2311331","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2311331","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[{"score":0.8999999761581421,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4883186798","display_name":null,"funder_award_id":"P60 MD 00222-01","funder_id":"https://openalex.org/F4320337534","funder_display_name":"National Institute on Minority Health and Health Disparities"},{"id":"https://openalex.org/G8533896133","display_name":"NCMHD Center of Excellence in Nutritional Genomics","funder_award_id":"P60MD000222","funder_id":"https://openalex.org/F4320337534","funder_display_name":"National Institute on Minority Health and Health Disparities"}],"funders":[{"id":"https://openalex.org/F4320337534","display_name":"National Institute on Minority Health and Health Disparities","ror":"https://ror.org/0493hgw16"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":59,"referenced_works":["https://openalex.org/W145367462","https://openalex.org/W172863054","https://openalex.org/W1523325879","https://openalex.org/W1775613062","https://openalex.org/W1842064230","https://openalex.org/W1965381662","https://openalex.org/W1966826646","https://openalex.org/W1970458349","https://openalex.org/W1975417138","https://openalex.org/W1978775178","https://openalex.org/W1985761011","https://openalex.org/W1992235199","https://openalex.org/W1996898252","https://openalex.org/W1997289184","https://openalex.org/W2004604872","https://openalex.org/W2010406601","https://openalex.org/W2016490634","https://openalex.org/W2018723329","https://openalex.org/W2020595943","https://openalex.org/W2022552518","https://openalex.org/W2024209230","https://openalex.org/W2024619097","https://openalex.org/W2024786978","https://openalex.org/W2029061627","https://openalex.org/W2034546431","https://openalex.org/W2038093700","https://openalex.org/W2039231719","https://openalex.org/W2042255954","https://openalex.org/W2043192013","https://openalex.org/W2047804720","https://openalex.org/W2047922146","https://openalex.org/W2049903344","https://openalex.org/W2050551830","https://openalex.org/W2054873136","https://openalex.org/W2058591962","https://openalex.org/W2063369951","https://openalex.org/W2071786676","https://openalex.org/W2074525890","https://openalex.org/W2076877526","https://openalex.org/W2085707549","https://openalex.org/W2086188302","https://openalex.org/W2093267247","https://openalex.org/W2094285393","https://openalex.org/W2103111068","https://openalex.org/W2104908670","https://openalex.org/W2111450457","https://openalex.org/W2120926079","https://openalex.org/W2121739926","https://openalex.org/W2125168868","https://openalex.org/W2131201144","https://openalex.org/W2132069122","https://openalex.org/W2136281548","https://openalex.org/W2136466648","https://openalex.org/W2137296676","https://openalex.org/W2147646689","https://openalex.org/W2155237820","https://openalex.org/W2328583280","https://openalex.org/W2405382408","https://openalex.org/W4298674970"],"related_works":["https://openalex.org/W2106868919","https://openalex.org/W2891810643","https://openalex.org/W7166100741","https://openalex.org/W4300840013","https://openalex.org/W4391679944","https://openalex.org/W1523733768","https://openalex.org/W1589289703","https://openalex.org/W2027138069","https://openalex.org/W2095370504","https://openalex.org/W4409657745"],"abstract_inverted_index":{"Magnesium":[0],"inadequacy":[1,190],"affects":[2],"more":[3],"than":[4],"half":[5],"of":[6,46,169],"the":[7,21,44,68,72,125,166],"U.S.":[8],"population":[9],"and":[10,108,140,143],"is":[11],"associated":[12],"with":[13,99,148],"increased":[14,136,141],"risk":[15],"for":[16,117],"many":[17],"age-related":[18,195],"diseases,":[19],"yet":[20],"underlying":[22],"mechanisms":[23],"are":[24],"unknown.":[25],"Altered":[26],"cellular":[27,81,179],"physiology":[28],"has":[29],"been":[30],"demonstrated":[31],"after":[32],"acute":[33],"exposure":[34,48],"to":[35,49,66],"severe":[36],"magnesium":[37,51,171,189],"deficiency,":[38],"but":[39,86],"few":[40],"reports":[41],"have":[42],"addressed":[43],"consequences":[45],"long-term":[47,69,167],"moderate":[50],"deficiency":[52],"in":[53,63,80,93,96,132,159,173],"human":[54,58,174],"cells.":[55,73],"Therefore,":[56],"IMR-90":[57,119,128],"fibroblasts":[59,75,120],"were":[60,121],"continuously":[61],"cultured":[62,95,131],"magnesium-deficient":[64,97,133,163],"conditions":[65,134],"determine":[67],"effects":[70],"on":[71],"These":[74],"did":[76,87],"not":[77,122],"demonstrate":[78],"differences":[79],"viability":[82],"or":[83,193],"plating":[84],"efficiency":[85],"exhibit":[88],"a":[89,184],"decreased":[90],"replicative":[91],"lifespan":[92],"populations":[94,130,161],"compared":[98,147],"standard":[100,151],"media":[101,152],"conditions,":[102],"both":[103],"at":[104],"ambient":[105],"(20%":[106],"O(2))":[107,111],"physiological":[109],"(5%":[110],"oxygen":[112],"tension.":[113],"The":[114],"growth":[115],"rates":[116],"immortalized":[118],"affected":[123],"under":[124],"same":[126],"conditions.":[127,153],"fibroblast":[129,175],"had":[135],"senescence-associated":[137],"beta-galactosidase":[138],"activity":[139],"p16(INK4a)":[142],"p21(WAF1)":[144],"protein":[145],"expression":[146],"cultures":[149,176],"from":[150,162],"Telomere":[154],"attrition":[155],"was":[156,177],"also":[157],"accelerated":[158,178],"cell":[160],"cultures.":[164],"Thus,":[165],"consequence":[168],"inadequate":[170],"availability":[172],"senescence,":[180],"which":[181,187],"may":[182],"be":[183],"mechanism":[185],"through":[186],"chronic":[188],"could":[191],"promote":[192],"exacerbate":[194],"disease.":[196]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":19},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
